abbott-41988 and Hypertension

abbott-41988 has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for abbott-41988 and Hypertension

Article	Year
New antihypertensive cannabinoids. Journal of medicinal chemistry, 1983, Volume: 26, Issue:2 A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and gamma-hydroxybutyryl derivatives were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, in contrast to the strongly CNS-depressant action characteristic of the N-propargyl analogues. Topics: Animals; Antihypertensive Agents; Blood Pressure; Cannabinoids; Heart Rate; Hypertension; Indicators and Reagents; Magnetic Resonance Spectroscopy; Rats; Structure-Activity Relationship	1983

Article

Year

Journal of medicinal chemistry, 1983, Volume: 26, Issue:2

A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and gamma-hydroxybutyryl derivatives were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, in contrast to the strongly CNS-depressant action characteristic of the N-propargyl analogues.

Topics: Animals; Antihypertensive Agents; Blood Pressure; Cannabinoids; Heart Rate; Hypertension; Indicators and Reagents; Magnetic Resonance Spectroscopy; Rats; Structure-Activity Relationship

1983