aa 861 and Brain Edema
aa 861 has been researched along with Brain Edema in 6 studies
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone: structure given in first source
docebenone : A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 7.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 3.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "Forebrain ischemia was induced by 4-vessel occlusion." | 1.29 | LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA-861, CV-3988. ( Kimura, J; Namura, Y; Shio, H, 1994) |
| "Cerebral ischemia was accompanied by cerebral edema early after reperfusion." | 1.27 | Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema. ( Inamura, K; Kanda, Y; Kaseki, H; Katayama, Y; Minamisawa, H; Shimizu, J; Shiratori, T; Terashi, A; Yoshino, Y, 1988) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Namura, Y | 1 |
| Shio, H | 1 |
| Kimura, J | 1 |
| Yamasaki, Y | 1 |
| Shozuhara, H | 1 |
| Onodera, H | 1 |
| Kogure, K | 1 |
| Baskaya, MK | 1 |
| Hu, Y | 1 |
| Donaldson, D | 1 |
| Maley, M | 1 |
| Rao, AM | 1 |
| Prasad, MR | 1 |
| Dempsey, RJ | 1 |
| Shirakura, S | 1 |
| Sano, J | 1 |
| Karasawa, A | 1 |
| Kubo, K | 1 |
| Mabe, H | 1 |
| Nagai, H | 1 |
| Suzuka, T | 1 |
| Minamisawa, H | 1 |
| Terashi, A | 1 |
| Katayama, Y | 1 |
| Kanda, Y | 1 |
| Shimizu, J | 1 |
| Shiratori, T | 1 |
| Inamura, K | 1 |
| Kaseki, H | 1 |
| Yoshino, Y | 1 |
Other Studies
6 other studies available for aa 861 and Brain Edema
| Article | Year |
|---|---|
LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA-861, CV-3988.
Topics: Animals; Benzoquinones; Brain Edema; Brain Ischemia; Injections, Intraperitoneal; Leukotriene B4; Le | 1994 |
Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation.
Topics: Animals; Benzoquinones; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Cortex; Cerebral Infa | 1994 |
Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia.
Topics: Animals; Benzoquinones; Brain Edema; Brain Ischemia; Disease Models, Animal; Dose-Response Relations | 1996 |
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats.
Topics: Animals; Arachidonic Acid; Benzoquinones; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Calcium | 1992 |
Role of brain tissue leukotriene in brain oedema following cerebral ischaemia: effect of a 5-lipoxygenase inhibitor, AA-861.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Body Water; Brain Chemistry; Brain Edem | 1990 |
Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzoquinones; Body Water; Brain; Brain Edema; Cerebrovascula | 1988 |