aa 861 and Asthma
aa 861 has been researched along with Asthma in 9 studies
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone: structure given in first source
docebenone : A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A very small number of patients with asthma show symptomatic improvement after administration of aspirin and other cyclooxygenase inhibitors." | 7.69 | Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. ( Chida, K; Hayakawa, H; Imokawa, S; Sato, A; Taniguchi, M; Toyoshima, M, 1995) |
| "A very small number of patients with asthma show symptomatic improvement after administration of aspirin and other cyclooxygenase inhibitors." | 3.69 | Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. ( Chida, K; Hayakawa, H; Imokawa, S; Sato, A; Taniguchi, M; Toyoshima, M, 1995) |
| "The effects of 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861), a selective 5-lipoxygenase inhibitor, on immunological or non-immunological release of slow reacting substance of anaphylaxis (SRS-A) and histamine and its effects on experimental asthma were investigated." | 3.67 | Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species. ( Kohno, SW; Nanbu, F; Negi, H; Ohata, K; Taira, M; Yamamura, H, 1988) |
| "Etodolac was found to have no effect on 5-lipoxygenase activity." | 1.29 | Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs. ( Hamada, K; Inoue, K; Kimura, K; Shibata, Y; Ueda, F, 1994) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Musser, JH | 1 |
| Kreft, AF | 1 |
| Ashida, Y | 1 |
| Saijo, T | 1 |
| Kuriki, H | 1 |
| Makino, H | 1 |
| Terao, S | 1 |
| Maki, Y | 1 |
| Fujimoto, K | 1 |
| Kubo, K | 1 |
| Shinozaki, S | 1 |
| Okada, K | 1 |
| Matsuzawa, Y | 1 |
| Kobayashi, T | 1 |
| Sugane, K | 1 |
| Imokawa, S | 1 |
| Sato, A | 1 |
| Taniguchi, M | 1 |
| Toyoshima, M | 1 |
| Hayakawa, H | 1 |
| Chida, K | 1 |
| Inoue, K | 1 |
| Hamada, K | 1 |
| Ueda, F | 1 |
| Shibata, Y | 1 |
| Kimura, K | 1 |
| Makino, S | 1 |
| Yamamura, H | 1 |
| Taira, M | 1 |
| Negi, H | 1 |
| Nanbu, F | 1 |
| Kohno, SW | 1 |
| Ohata, K | 1 |
| Saga, T | 1 |
| Fujimura, M | 1 |
| Sasaki, F | 1 |
| Nakatsumi, Y | 1 |
| Takahashi, Y | 1 |
| Hifumi, S | 1 |
| Taga, K | 1 |
| Mifune, J | 1 |
| Tanaka, T | 1 |
| Matsuda, T | 1 |
Reviews
1 review available for aa 861 and Asthma
| Article | Year |
|---|---|
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Eosinophils; Humans; Inflammation; Leukotriene Antagon | 1992 |
Other Studies
8 other studies available for aa 861 and Asthma
| Article | Year |
|---|---|
Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor.
Topics: Animals; Arachidonate Lipoxygenases; Asthma; Benzoquinones; Edema; Female; Guinea Pigs; Histamine Re | 1983 |
Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep.
Topics: Airway Resistance; Animals; Antigens; Asthma; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveo | 1995 |
Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin.
Topics: Acute Disease; Aspirin; Asthma; Benzoquinones; Humans; Lipoxygenase Inhibitors; Male; Middle Aged | 1995 |
Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs.
Topics: Animals; Asthma; Benzoquinones; Disease Models, Animal; Etodolac; Guinea Pigs; Immunization, Passive | 1994 |
[Eicosanoids in bronchial asthma].
Topics: Acrylates; Arachidonic Acids; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Chromones; Cycloo | 1990 |
Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
Topics: Animals; Asthma; Benzoquinones; Calcimycin; Chromatography, High Pressure Liquid; Female; Guinea Pig | 1988 |
[Etiology and treatment of intractable asthma--non-immunological features].
Topics: Adult; Animals; Aspirin; Asthma; Benzoquinones; Drug Hypersensitivity; Female; Guinea Pigs; Humans; | 1988 |
Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.
Topics: Acetylcholine; Acrylates; Adult; Aged; Asthma; Benzoquinones; Bronchi; Bronchial Provocation Tests; | 1986 |