Page last updated: 2024-10-21

aa 861 and Asthma

aa 861 has been researched along with Asthma in 9 studies

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone: structure given in first source
docebenone : A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"A very small number of patients with asthma show symptomatic improvement after administration of aspirin and other cyclooxygenase inhibitors."7.69Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. ( Chida, K; Hayakawa, H; Imokawa, S; Sato, A; Taniguchi, M; Toyoshima, M, 1995)
"A very small number of patients with asthma show symptomatic improvement after administration of aspirin and other cyclooxygenase inhibitors."3.69Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. ( Chida, K; Hayakawa, H; Imokawa, S; Sato, A; Taniguchi, M; Toyoshima, M, 1995)
"The effects of 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861), a selective 5-lipoxygenase inhibitor, on immunological or non-immunological release of slow reacting substance of anaphylaxis (SRS-A) and histamine and its effects on experimental asthma were investigated."3.67Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species. ( Kohno, SW; Nanbu, F; Negi, H; Ohata, K; Taira, M; Yamamura, H, 1988)
"Etodolac was found to have no effect on 5-lipoxygenase activity."1.29Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs. ( Hamada, K; Inoue, K; Kimura, K; Shibata, Y; Ueda, F, 1994)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's5 (55.56)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Musser, JH1
Kreft, AF1
Ashida, Y1
Saijo, T1
Kuriki, H1
Makino, H1
Terao, S1
Maki, Y1
Fujimoto, K1
Kubo, K1
Shinozaki, S1
Okada, K1
Matsuzawa, Y1
Kobayashi, T1
Sugane, K1
Imokawa, S1
Sato, A1
Taniguchi, M1
Toyoshima, M1
Hayakawa, H1
Chida, K1
Inoue, K1
Hamada, K1
Ueda, F1
Shibata, Y1
Kimura, K1
Makino, S1
Yamamura, H1
Taira, M1
Negi, H1
Nanbu, F1
Kohno, SW1
Ohata, K1
Saga, T1
Fujimura, M1
Sasaki, F1
Nakatsumi, Y1
Takahashi, Y1
Hifumi, S1
Taga, K1
Mifune, J1
Tanaka, T1
Matsuda, T1

Reviews

1 review available for aa 861 and Asthma

ArticleYear
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.
    Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

    Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Eosinophils; Humans; Inflammation; Leukotriene Antagon

1992

Other Studies

8 other studies available for aa 861 and Asthma

ArticleYear
Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor.
    Prostaglandins, 1983, Volume: 26, Issue:6

    Topics: Animals; Arachidonate Lipoxygenases; Asthma; Benzoquinones; Edema; Female; Guinea Pigs; Histamine Re

1983
Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep.
    Respiration physiology, 1995, Volume: 100, Issue:1

    Topics: Airway Resistance; Animals; Antigens; Asthma; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveo

1995
Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1995, Volume: 75, Issue:2

    Topics: Acute Disease; Aspirin; Asthma; Benzoquinones; Humans; Lipoxygenase Inhibitors; Male; Middle Aged

1995
Effect of anti-inflammatory agent etodolac on antigen-induced contractions of the trachea and lung parenchyma of guinea pigs.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:6

    Topics: Animals; Asthma; Benzoquinones; Disease Models, Animal; Etodolac; Guinea Pigs; Immunization, Passive

1994
[Eicosanoids in bronchial asthma].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:6

    Topics: Acrylates; Arachidonic Acids; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Chromones; Cycloo

1990
Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species.
    Japanese journal of pharmacology, 1988, Volume: 47, Issue:3

    Topics: Animals; Asthma; Benzoquinones; Calcimycin; Chromatography, High Pressure Liquid; Female; Guinea Pig

1988
[Etiology and treatment of intractable asthma--non-immunological features].
    Nihon Kyobu Shikkan Gakkai zasshi, 1988, Volume: 26, Issue:3

    Topics: Adult; Animals; Aspirin; Asthma; Benzoquinones; Drug Hypersensitivity; Female; Guinea Pigs; Humans;

1988
Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.
    Thorax, 1986, Volume: 41, Issue:12

    Topics: Acetylcholine; Acrylates; Adult; Aged; Asthma; Benzoquinones; Bronchi; Bronchial Provocation Tests;

1986