a-967079 and Cancer-Pain

Breast carcinoma causes severe pain, which decreases the quality of life of patients. Current treatments produce adverse effects and have limited efficacy. Transient potential receptor ankyrin 1 (TRPA1) is related to the onset of cancer and neuropathic pain. The aim of this study was to evaluate the involvement of TRPA1 in a model of breast carcinoma. We injected 4T1 cells in the fourth caudal mammary fat pad of female BALB/c mice, and after 20 days we observed mechanical and cold allodynia and spontaneous nociception behavior (mouse grimace scale detection, MGS). TRPA1 selective antagonist (HC-030031 or A-967079) administration or intrathecal administration of TRPA1 antisense (AS) oligonucleotide was performed. The activity of NADPH oxidase, superoxide dismutase (SOD) and hydrogen peroxide (H

Topics: Acetanilides; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Cancer Pain; Cell Line, Tumor; Female; Hydrogen Peroxide; Hyperalgesia; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; NADPH Oxidases; Nociception; Oximes; Paclitaxel; Purines; Sciatic Nerve; Skin; Superoxide Dismutase; Thioctic Acid; TRPA1 Cation Channel