a-83586c and Colonic-Neoplasms

a-83586c has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for a-83586c and Colonic-Neoplasms

Article	Year
Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription. Chemical communications (Cambridge, England), 2010, Jun-21, Volume: 46, Issue:23 Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit beta-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations. Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colonic Neoplasms; Depsipeptides; E2F Transcription Factors; Humans; Peptides; Transcription Factor 4; Transcription Factors; Transcription, Genetic	2010

Article

Year

Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription.

Chemical communications (Cambridge, England), 2010, Jun-21, Volume: 46, Issue:23

Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit beta-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colonic Neoplasms; Depsipeptides; E2F Transcription Factors; Humans; Peptides; Transcription Factor 4; Transcription Factors; Transcription, Genetic

2010