a-803467 and Fibromyalgia

a-803467 has been researched along with Fibromyalgia* in 1 studies

Other Studies

1 other study(ies) available for a-803467 and Fibromyalgia

ArticleYear
Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.
    Molecular pain, 2014, Jun-23, Volume: 10

    Tissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown.. Here we showed that a single intramuscular acid injection induced a priming effect on muscle nociceptors of mice. The primed muscle nociceptors were plastic and permitted the development of long-lasting chronic hyperalgesia induced by a second acid insult. The plastic changes of muscle nociceptors were modality-specific and required the activation of acid-sensing ion channel 3 (ASIC3) or transient receptor potential cation channel V1 (TRPV1). Activation of ASIC3 was associated with increased activity of tetrodotoxin (TTX)-sensitive voltage-gated sodium channels but not protein kinase Cϵ (PKCϵ) in isolectin B4 (IB4)-negative muscle nociceptors. In contrast, increased activity of TTX-resistant voltage-gated sodium channels with ASIC3 or TRPV1 activation in NaV1.8-positive muscle nociceptors was required for the development of chronic hyperalgesia. Accordingly, compared to wild type mice, NaV1.8-null mice showed briefer acid-induced hyperalgesia (5 days vs. >27 days).. ASIC3 activation may manifest a new type of nociceptor priming in IB4-negative muscle nociceptors. The activation of ASIC3 and TRPV1 as well as enhanced NaV1.8 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

    Topics: Acid Sensing Ion Channels; Acute Pain; Aniline Compounds; Animals; Cells, Cultured; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibromyalgia; Furans; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; NAV1.8 Voltage-Gated Sodium Channel; Sodium Channel Blockers; TRPV Cation Channels

2014