a-70450 has been researched along with Candidiasis* in 1 studies
1 review(s) available for a-70450 and Candidiasis
| Article | Year |
|---|---|
Candida proteases and their inhibition: prospects for antifungal therapy.
The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed. Topics: Antifungal Agents; Aspartic Acid Endopeptidases; Candidiasis; Fungal Proteins; HIV Protease Inhibitors; Humans; Models, Molecular; Molecular Conformation; Piperazines; Protease Inhibitors; Structure-Activity Relationship | 2001 |