a-65186 has been researched along with Hemolysis* in 2 studies
2 other study(ies) available for a-65186 and Hemolysis
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Prevention of hemolysis-induced organ damage by nutritional activation of the vagal anti-inflammatory reflex*.
Acute hemolysis is associated with organ damage, inflammation, and impaired vascular function. Stimulation of the cholecystokinin-1 receptor-dependent vagal anti-inflammatory reflex with lipid-rich enteral nutrition was demonstrated to prevent tissue damage and attenuate inflammation. This study investigates the effects of nutritional activation of the vagal anti-inflammatory reflex on organ integrity, systemic inflammation, and microcirculation during hemolysis.. Prospective randomized controlled study.. University research unit.. Male Sprague-Dawley rats.. Intravascular hemolysis was simulated by infusion of prelysed erythrocytes. Animals were fasted or received lipid-rich enteral nutrition. Pegylated (PEG)-CCK9A, A70104 (a cholecystokinin-1 receptor antagonist), and chlorisondamine (a nicotinic acetylcholine receptor antagonist) were applied to investigate involvement of the vagal reflex.. Nutritional intervention reduced hemolysis-related renal tubular cell damage, hepatocyte damage, ileal leakage of horseradish peroxidase, and bacterial translocation compared with food deprivation (all p < 0.05). Also circulating interleukin (IL)-6 levels were decreased by enteral nutrition (p < 0.05). Blockage of the cholecystokinin-1 receptor or the nicotinic acetylcholine receptor reversed the protective nutritional effects compared with vehicle (p < 0.05), whereas PEG-CCK9 mimicked the impact of enteral feeding in fasted animals (p < 0.05). Furthermore, nutritional intervention increased renal, hepatic, and intestinal blood flow compared with fasting (all p < 0.05), as evaluated using fluorescent microspheres.. Nutritional activation of the vagal anti-inflammatory reflex preserves tissue integrity and attenuates systemic inflammation in a rodent model of acute hemolysis. In addition, lipid-rich nutrition improves renal, hepatic, and intestinal microcirculation. These findings implicate stimulation of the autonomic nervous system by nutritional means as a potential therapy to prevent complications of acute hemolysis. (Crit Care Med 2013; 41:e361-e367). Topics: Animals; Chlorisondamine; Dietary Fats; Digestive System; Food; Hemolysis; Inflammation; Inflammation Mediators; Male; Microcirculation; Nicotinic Antagonists; Quinolines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Vagus Nerve | 2013 |
A little fat every day keeps the doctor away*.
Topics: Animals; Digestive System; Food; Hemolysis; Inflammation; Male; Quinolines; Receptors, Cholecystokinin; Vagus Nerve | 2013 |