a-40926 and Streptococcal-Infections

A40926 antibiotics are new glycopeptides which are much more active than other members of this class against Neisseria gonorrhoeae. Their activity against Gram-positive bacteria, including coagulase-negative Staphylococci, is similar to that of other glycopeptides. An A40926 preparation containing factors A and B ("A40926 A + B complex") was hydrolyzed to the aglycone and to the mannosyl and N-acylaminoglucuronyl aglycones. The mannosyl aglycone and the aglycone were less active than A40926 A + B complex against Streptococci and Gram-positive anaerobes and lost the anti-gonorrheal activity. In contrast, the N-acylaminoglucuronyl aglycones were as active as the parent complex against these Gram-positive bacteria and were moderately active against N. gonorrhoeae. The aglycone and, even more so, the N-acylaminoglucuronyl aglycones, had better activity than the parent complex against coagulase-negative Staphylococci. In experimental septicemia in the mouse, A40926 A + B complex and its derivatives had activity proportional to their MIC for the test organism.

Topics: Animals; Anti-Bacterial Agents; Chromatography, Affinity; Chromatography, High Pressure Liquid; Glycopeptides; Hydrolysis; Mice; Microbial Sensitivity Tests; Molecular Structure; Neisseria; Peptides; Peptides, Cyclic; Staphylococcus; Streptococcal Infections; Streptococcus; Streptococcus pyogenes; Teicoplanin