a-304121 and Body-Weight

a-304121 has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for a-304121 and Body-Weight

ArticleYear
Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121.
    Life sciences, 2006, Aug-29, Volume: 79, Issue:14

    Blockade of presynaptic histamine H(3) receptors with potent and selective ligands improves cognitive function in rodents and there is significant interest in developing such drugs for long-term symptomatic treatment of CNS disorders such as attention deficit hyperactivity disorder (ADHD). Unfortunately, little is known about the effects of repeated exposure to H(3) receptor antagonists/inverse agonists. We therefore investigated the effects of acute and repeated daily administration of two potent, brain penetrating H(3) receptor antagonists/inverse agonists, ciproxifan and A-304121, on rat body weight, food and water intake, core temperature and locomotor activity, as well as H(3) receptor density and gene expression levels. Methylphenidate, used clinically for the treatment of ADHD, was included as an additional comparator. Ciproxifan, an imidazole-based compound, decreased food intake over the first 10 days and locomotor activity acutely, but these effects were lost after further repeated administration. The ex vivo binding studies revealed increased H(3) receptor density in rats following repeated administration of ciproxifan for 10 or 15 days; however, H(3) receptor gene expression was not changed. In contrast, rats treated with the non-imidazole, A-304121, did not differ from controls on any measure during the observation period, while rats treated with methylphenidate exhibited hyperthermia and hyperactivity. The implications for potential long-term treatment with H(3) receptor antagonists in CNS disorders such as ADHD are discussed.

    Topics: Animals; Body Temperature; Body Weight; Central Nervous System Stimulants; Drinking; Drug Tolerance; Eating; Gene Expression; Histamine Agonists; Histamine Antagonists; Imidazoles; Male; Methylphenidate; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3

2006