a-286982 and Myocardial-Infarction

a-286982 has been researched along with Myocardial-Infarction* in 1 studies

Other Studies

1 other study(ies) available for a-286982 and Myocardial-Infarction

Article	Year
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides. Journal of medicinal chemistry, 2001, Aug-30, Volume: 44, Issue:18 The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-ring) as a site for modification. Improvement in potency and, more importantly, in the physical properties and pharmacokinetic profiles of the leading compounds resulted from this modification. One of the best compounds (11f) is also shown to reduce myocardial infarct size in rat. Topics: Amides; Animals; Cardiovascular Agents; Cell Adhesion; Cell Line; Cinnamates; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Myocardial Infarction; Myocardium; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship; Sulfides	2001

Article

Year

Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.

Journal of medicinal chemistry, 2001, Aug-30, Volume: 44, Issue:18

The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-ring) as a site for modification. Improvement in potency and, more importantly, in the physical properties and pharmacokinetic profiles of the leading compounds resulted from this modification. One of the best compounds (11f) is also shown to reduce myocardial infarct size in rat.

Topics: Amides; Animals; Cardiovascular Agents; Cell Adhesion; Cell Line; Cinnamates; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Myocardial Infarction; Myocardium; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship; Sulfides

2001