Src-Inhibitor-1 and Colonic-Neoplasms

Src-Inhibitor-1 has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for Src-Inhibitor-1 and Colonic-Neoplasms

Article	Year
Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors. Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24 A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. Topics: Aniline Compounds; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured	2000

Article

Year

Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.

Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells.

Topics: Aniline Compounds; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured

2000