PB28 has been researched along with Cocaine-Related-Disorders* in 1 studies
1 other study(ies) available for PB28 and Cocaine-Related-Disorders
| Article | Year |
|---|---|
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.
Cocaine's toxicity can be mitigated by blocking its interaction with sigma-1 receptors. The involvement of sigma-2 receptors remains unclear. To investigate their potential role, we have designed compounds through a convergent synthesis utilizing a highly selective sigma-1 ligand and elements of a selective sigma-2 ligand. Among the synthesized compounds was produced a subnanomolar sigma-2 ligand with an 11-fold preference over sigma-1 receptors. These compounds may be useful in developing effective pharmacotherapies for cocaine toxicity. Topics: Animals; Anticonvulsants; Brain; Cocaine; Cocaine-Related Disorders; In Vitro Techniques; Ligands; Mice; Oxazoles; Piperazines; Radioligand Assay; Rats; Receptors, sigma; Seizures; Sigma-1 Receptor; Structure-Activity Relationship; Thiazoles | 2008 |