Compounds > N-cycloheptyl-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide

N-cycloheptyl-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide and Hypertension

N-cycloheptyl-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for N-cycloheptyl-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide and Hypertension

ArticleYear
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors.

    Topics: Amides; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Epoxide Hydrolases; Fluorescent Dyes; Humans; Hydrogen Bonding; Hypertension; Inflammation; Inhibitory Concentration 50; Microscopy, Fluorescence; Models, Chemical; Solubility; Structure-Activity Relationship

2012