N-(4Z-7Z-10Z-13Z-16Z-19Z)-docosahexaenoylethanolamine and Disease-Models--Animal

Traumatic brain injury (TBI) is a major concern for public health worldwide, affecting 55 million people and being the leading cause of death and disability. To improve the outcomes and effectiveness of treatment for these patients, we conducted a study on the potential therapeutic use of N-docosahexaenoylethanolamine (synaptamide) in mice using the weight-drop injury (WDI) TBI model. Our study focused on exploring synaptamide's effects on neurodegeneration processes and changes in neuronal and glial plasticity. Our findings showed that synaptamide could prevent TBI-associated working memory decline and neurodegenerative changes in the hippocampus, and it could alleviate decreased adult hippocampal neurogenesis. Furthermore, synaptamide regulated the production of astro- and microglial markers during TBI, promoting the anti-inflammatory transformation of the microglial phenotype. Additional effects of synaptamide in TBI include stimulating antioxidant and antiapoptotic defense, leading to the downregulation of the Bad pro-apoptotic marker. Our data suggest that synaptamide has promising potential as a therapeutic agent to prevent the long-term neurodegenerative consequences of TBI and improve the quality of life.

Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred C57BL; Quality of Life

The search for methods of cognitive impairment treatment and prevention in neurological and neurodegenerative diseases is an urgent task of modern neurobiology. It is now known that various diseases, accompanied by dementia, exhibit a pronounced neuroinflammation. Considering the significant docosahexaenoic and eicosapentaenoic polyunsaturated fatty acids' therapeutic potential, we decided to investigate and compare anti-inflammatory activity of their

Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Brain-Derived Neurotrophic Factor; Cytokines; Disease Models, Animal; Ethanolamines; Immunohistochemistry; Inflammation; Inflammation Mediators; Lipopolysaccharides; Mice; Microglia; Treatment Outcome

Chronic neuropathic pain is a condition that causes both sensory disturbances and a variety of functional disorders, indicating the involvement of various brain structures in pain pathogenesis. One of the factors underlying chronic neuropathic pain is neuroinflammation, which is accompanied by microglial activation and pro-inflammatory factor release.

Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Cell Line; Constriction; Cytokines; Decapodiformes; Disease Models, Animal; Docosahexaenoic Acids; Ethanolamines; Hippocampus; Inflammation; Lipids; Male; Mice; Microglia; Neuralgia; Neurogenesis; Neurons; Rats, Wistar; Sciatic Nerve

Topics: Animals; Disease Models, Animal; Docosahexaenoic Acids; Encephalitis; Ethanolamines; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Microglia; Neuronal Plasticity; Neurons