N-(4-phenylmethoxyphenyl)methanesulfonamide and Prostatic-Neoplasms

Androgen receptor (AR) antagonists have been widely used for the treatment of prostate cancer (PCa). As a link between the AR and its transcriptional function, the activation function 2 (AF2) region has recently been revealed as a novel targeting site for developing AR antagonists. Here, we reported a series of

Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Binding Sites; Cell Proliferation; Gene Expression; Humans; Male; Mice, SCID; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Protein Transport; Receptors, Androgen; Structure-Activity Relationship; Sulfonamides; Xenograft Model Antitumor Assays