N-(4-chlorophenyl)-7-8-dimethoxy-1-oxo-2-benzothiopyran-3-carboxamide has been researched along with Trypanosomiasis* in 1 studies
1 other study(ies) available for N-(4-chlorophenyl)-7-8-dimethoxy-1-oxo-2-benzothiopyran-3-carboxamide and Trypanosomiasis
| Article | Year |
|---|---|
Isothiocoumarin-3-carboxylic acid derivatives: synthesis, anticancer and antitrypanosomal activity evaluation.
A series of new isothiocoumarin-3-carboxylic acids derivatives had been obtained based on the 5-arylidenerhodanines hydrolysis. Anticancer activity screening allowed identification of 7,8-dimethoxy-1-oxo-1H-isothiochromene-3-carboxylic acid (4-phenylthiazol-2-yl)-amide (30) with the highest level of antimitotic activity (GI50NCI-H322M/NSC Lung Cancer = 1.28 μM). Evaluation of the antitrypanosomal activity against Trypanosoma brucei brucei showed that investigated compounds did not exhibit significant antiparasitic effects. Additionally, the most pharmacologically attractive compounds were non-toxic and well tolerated by the experimental animals. Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Coumarins; Drug Screening Assays, Antitumor; Humans; Neoplasms; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis | 2014 |