MS-417 and Multiple-Myeloma

MS-417 has been researched along with Multiple-Myeloma* in 1 studies

Other Studies

1 other study(ies) available for MS-417 and Multiple-Myeloma

Article	Year
Methylpyrrole inhibitors of BET bromodomains. Bioorganic & medicinal chemistry letters, 2017, 05-15, Volume: 27, Issue:10 An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Further modifications to the methylpyrrole core provided compounds with improved properties and enhanced activity in a mouse model of multiple myeloma. Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Design; Half-Life; Humans; Mice; Molecular Dynamics Simulation; Multiple Myeloma; Nuclear Proteins; Pyrroles; Structure-Activity Relationship; Transcription Factors; Transplantation, Heterologous	2017

Article

Year

Methylpyrrole inhibitors of BET bromodomains.

Bioorganic & medicinal chemistry letters, 2017, 05-15, Volume: 27, Issue:10

An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Further modifications to the methylpyrrole core provided compounds with improved properties and enhanced activity in a mouse model of multiple myeloma.

Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Design; Half-Life; Humans; Mice; Molecular Dynamics Simulation; Multiple Myeloma; Nuclear Proteins; Pyrroles; Structure-Activity Relationship; Transcription Factors; Transplantation, Heterologous

2017