LSM-20825 and Hepatitis-C

LSM-20825 has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for LSM-20825 and Hepatitis-C

Article	Year
Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. European journal of medicinal chemistry, 2016, Nov-10, Volume: 123 A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ∼450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50 value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range. Topics: Antiviral Agents; Computer-Aided Design; Drug Design; Hepacivirus; Hepatitis C; Libraries, Digital; Pyrimidines; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication	2016

Article

Year

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.

European journal of medicinal chemistry, 2016, Nov-10, Volume: 123

A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ∼450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50 value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.

Topics: Antiviral Agents; Computer-Aided Design; Drug Design; Hepacivirus; Hepatitis C; Libraries, Digital; Pyrimidines; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication

2016