Jasmone and Prostatic-Neoplasms

Advanced prostate cancer cells are typically hormone independent, resistant to apoptosis and do not respond to chemotherapeutic agents. The ability of methyl jasmonate (MJ) and cis-jasmone (CJ) to inhibit growth in hormone independent prostate cancer cell lines, PC-3 and DU-145, was evaluated. CJ and MJ inhibited cell growth, induced cell cycle arrest and apoptosis. Detailed studies with the PC-3 cell line revealed that 2 mM CJ or MJ treatment resulted in caspase 3 activation and Tumor Necrosis Factor Receptor 1 (TNFR1) activation, all hallmarks of apoptosis. These phytochemicals could be useful in the management of advanced prostate cancer.

Topics: Acetates; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Male; Oxylipins; Prostatic Neoplasms; Receptors, Tumor Necrosis Factor, Type I