Imidazosagatriazinone has been researched along with Erectile-Dysfunction* in 1 studies
1 other study(ies) available for Imidazosagatriazinone and Erectile-Dysfunction
Article | Year |
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Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.
2-aryl-substituted imidazo[5,1-f][1,2,4]triazin-4(3H)-ones represent a new class of potent cGMP-PDE 5 inhibitors that prove to be superior to other purine-isosteric inhibitors. Subnanomolar inhibitors of PDE 5 with activity in in vivo models for erectile dysfunction have been identified. BAY 38-9456 (Vardenafil-hydrochloride) has been selected for clinical studies in the indication of erectile dysfunction. Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Erectile Dysfunction; Imidazoles; Inhibitory Concentration 50; Male; Protein Binding; Rabbits; Structure-Activity Relationship; Triazines | 2002 |