Imidazosagatriazinone and Erectile-Dysfunction

Imidazosagatriazinone has been researched along with Erectile-Dysfunction* in 1 studies

Other Studies

1 other study(ies) available for Imidazosagatriazinone and Erectile-Dysfunction

Article	Year
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors. Bioorganic & medicinal chemistry letters, 2002, Mar-25, Volume: 12, Issue:6 2-aryl-substituted imidazo[5,1-f][1,2,4]triazin-4(3H)-ones represent a new class of potent cGMP-PDE 5 inhibitors that prove to be superior to other purine-isosteric inhibitors. Subnanomolar inhibitors of PDE 5 with activity in in vivo models for erectile dysfunction have been identified. BAY 38-9456 (Vardenafil-hydrochloride) has been selected for clinical studies in the indication of erectile dysfunction. Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Erectile Dysfunction; Imidazoles; Inhibitory Concentration 50; Male; Protein Binding; Rabbits; Structure-Activity Relationship; Triazines	2002

Article

Year

Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.

Bioorganic & medicinal chemistry letters, 2002, Mar-25, Volume: 12, Issue:6

2-aryl-substituted imidazo[5,1-f][1,2,4]triazin-4(3H)-ones represent a new class of potent cGMP-PDE 5 inhibitors that prove to be superior to other purine-isosteric inhibitors. Subnanomolar inhibitors of PDE 5 with activity in in vivo models for erectile dysfunction have been identified. BAY 38-9456 (Vardenafil-hydrochloride) has been selected for clinical studies in the indication of erectile dysfunction.

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Erectile Dysfunction; Imidazoles; Inhibitory Concentration 50; Male; Protein Binding; Rabbits; Structure-Activity Relationship; Triazines

2002