Harringtonine and Myelodysplastic-Syndromes

Harringtonine has been researched along with Myelodysplastic-Syndromes* in 1 studies

Other Studies

1 other study(ies) available for Harringtonine and Myelodysplastic-Syndromes

Article	Year
[Expression of survivin mRNA in HHT-induced cell apoptosis of hematological malignancy cell lines]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2006, Volume: 35, Issue:2 To investigate the expression of survivin mRNA in hematological malignancy cells and its correlation with HHT-induced cell apoptosis.. Hematological malignancy cell lines MUTZ-1, K562, Jurkat, RPMI and HL60 were treated with HHT in vitro. Cell apoptosis was observed by flow cytometry (FCM) and the expression of surviving and XIAP mRNA was evaluated with semi-quantitative RT-PCR.. The expression of survivin mRNA on cell lines was negatively correlated to HHT-induced cell apoptotic rate (r=-0.980, P=0.003). There were no significant differences in XIAP expression among these 5 cell lines.. Survivin could be used as a new marker for drug-sensitivity and a new target for treatment of hematological malignancies. Topics: Apoptosis; Harringtonines; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; K562 Cells; Microtubule-Associated Proteins; Myelodysplastic Syndromes; Neoplasm Proteins; RNA, Messenger; Survivin; Tumor Cells, Cultured	2006

Article

Year

[Expression of survivin mRNA in HHT-induced cell apoptosis of hematological malignancy cell lines].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2006, Volume: 35, Issue:2

To investigate the expression of survivin mRNA in hematological malignancy cells and its correlation with HHT-induced cell apoptosis.. Hematological malignancy cell lines MUTZ-1, K562, Jurkat, RPMI and HL60 were treated with HHT in vitro. Cell apoptosis was observed by flow cytometry (FCM) and the expression of surviving and XIAP mRNA was evaluated with semi-quantitative RT-PCR.. The expression of survivin mRNA on cell lines was negatively correlated to HHT-induced cell apoptotic rate (r=-0.980, P=0.003). There were no significant differences in XIAP expression among these 5 cell lines.. Survivin could be used as a new marker for drug-sensitivity and a new target for treatment of hematological malignancies.

Topics: Apoptosis; Harringtonines; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; K562 Cells; Microtubule-Associated Proteins; Myelodysplastic Syndromes; Neoplasm Proteins; RNA, Messenger; Survivin; Tumor Cells, Cultured

2006