Harringtonine has been researched along with Myelodysplastic-Syndromes* in 1 studies
1 other study(ies) available for Harringtonine and Myelodysplastic-Syndromes
Article | Year |
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[Expression of survivin mRNA in HHT-induced cell apoptosis of hematological malignancy cell lines].
To investigate the expression of survivin mRNA in hematological malignancy cells and its correlation with HHT-induced cell apoptosis.. Hematological malignancy cell lines MUTZ-1, K562, Jurkat, RPMI and HL60 were treated with HHT in vitro. Cell apoptosis was observed by flow cytometry (FCM) and the expression of surviving and XIAP mRNA was evaluated with semi-quantitative RT-PCR.. The expression of survivin mRNA on cell lines was negatively correlated to HHT-induced cell apoptotic rate (r=-0.980, P=0.003). There were no significant differences in XIAP expression among these 5 cell lines.. Survivin could be used as a new marker for drug-sensitivity and a new target for treatment of hematological malignancies. Topics: Apoptosis; Harringtonines; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; K562 Cells; Microtubule-Associated Proteins; Myelodysplastic Syndromes; Neoplasm Proteins; RNA, Messenger; Survivin; Tumor Cells, Cultured | 2006 |