Echinocystic-acid-3-glucoside has been researched along with Ovarian-Neoplasms* in 1 studies
1 other study(ies) available for Echinocystic-acid-3-glucoside and Ovarian-Neoplasms
| Article | Year |
|---|---|
Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells.
Triterpenoids echinocystic acid and its glycosides, isolated from several Eclipta prostrata, have been reported to possess various biological activities such as anti-inflammatory, anti-bacterial, and anti-diabetic activity. However, the cytotoxicity of the triterpenoids in human cancer cells and their molecular mechanism of action are poorly understood. In the present study, we found that eclalbasaponin II with one glucose moiety has potent cytotoxicity in three ovarian cancer cells and two endometrial cancer cells compared to an aglycone echinocystic acid and eclalbasaponin I with two glucose moiety. Eclalbasaponin II treatment dose-dependently increased sub G Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Oleanolic Acid; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Saponins; TOR Serine-Threonine Kinases | 2016 |