CDN1163 has been researched along with Parkinson-Disease--Secondary* in 1 studies
1 other study(ies) available for CDN1163 and Parkinson-Disease--Secondary
| Article | Year |
|---|---|
A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats.
Endoplasmic reticulum (ER) stress is intimately linked to Parkinson's disease (PD) pathophysiology. Disrupted intracellular calcium homeostasis is a major cause of the ER stress seen in dopaminergic neurons, leading to the cell death and subsequent loss of movement and coordination in patients. Dysfunctional calcium handling proteins play a major role in the promulgation of ER stress in PD. Specifically, compromised sarco/endoplasmic reticulum Ca Topics: Aminoquinolines; Animals; Benzamides; Calcium; Cell Death; Drug Discovery; Dyskinesias; Endoplasmic Reticulum Stress; Enzyme Activators; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2017 |