Avocadyne and Leukemia--Myeloid--Acute

Avocatin-B (Avo-B), an avocado-derived 1:1 mixture of the polyhydroxylated alcohols avocadyne (AYNE) and avocadene, eliminated leukemia cells by suppressing fatty acid oxidation (FAO) in vivo and in vitro while sparing healthy blood cells. In this study, we identified AYNE as the most potent FAO inhibitor within the Avo-B mixture capable of inducing cell death in leukemia cells lines (IC

Topics: Fatty Acids; Humans; Leukemia, Myeloid, Acute; Lipid Metabolism; Persea; Polyketides

Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.

Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cell Survival; Fatty Acids; Humans; Leukemia, Myeloid, Acute; Lipid Metabolism; Mice; Mice, SCID; Mitochondria; Oxidation-Reduction; Persea; Polyketides; Stereoisomerism; Structure-Activity Relationship