AMG-208 has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for AMG-208 and Neoplasms
| Article | Year |
|---|---|
Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.
Receptor tyrosine kinase c-Met acts as an alternative angiogenic pathway in the process and contents of cancers. A series of imidazopyridine derivatives were designed and synthesized according to the established docking studies as possible c-Met inhibitors. Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochemical enzymatic screens and cellular pharmacology studies. Especially, compound 7g exhibited the most inhibitory activity against c-Met with IC Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Molecular Docking Simulation; Neoplasms; Proto-Oncogene Proteins c-met; Pyridines; Structure-Activity Relationship | 2017 |