AKB48 and Inflammation

AKB48 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for AKB48 and Inflammation

Article	Year
Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro. Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 55 Synthetic cannabinoids were introduced into market in early 2000s; since these "legal highs" are dramatically popular among youth, it becomes a deadly problem. Synthetic cannabinoids have high affinity to cannabinoid receptors; leading to various clinical symptoms. AKB48 (Apinaca) has been classified as a third-generation synthetic cannabinoid for the first time in 2014. The toxicity profile of AKB48 is unclear due to little information that mainly obtained from clinical and forensic cases; however, it is believed to be similar with other psychoactive substances. Thus, we aimed to investigate the possible toxicity mechanisms of AKB48 in SH-SY5Y (human bone marrow neuroblastoma) cell line. IC Topics: Adamantane; Cannabinoids; Cell Line, Tumor; Humans; Indazoles; Inflammation; Interleukin-6; Mitogen-Activated Protein Kinase 8; Neurotoxicity Syndromes; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha	2019

Article

Year

Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro.

Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 55

Synthetic cannabinoids were introduced into market in early 2000s; since these "legal highs" are dramatically popular among youth, it becomes a deadly problem. Synthetic cannabinoids have high affinity to cannabinoid receptors; leading to various clinical symptoms. AKB48 (Apinaca) has been classified as a third-generation synthetic cannabinoid for the first time in 2014. The toxicity profile of AKB48 is unclear due to little information that mainly obtained from clinical and forensic cases; however, it is believed to be similar with other psychoactive substances. Thus, we aimed to investigate the possible toxicity mechanisms of AKB48 in SH-SY5Y (human bone marrow neuroblastoma) cell line. IC

Topics: Adamantane; Cannabinoids; Cell Line, Tumor; Humans; Indazoles; Inflammation; Interleukin-6; Mitogen-Activated Protein Kinase 8; Neurotoxicity Syndromes; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2019