9-oxo-15-hydroxy-delta-7-10-13-prostatrienoic-acid-methyl-ester has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for 9-oxo-15-hydroxy-delta-7-10-13-prostatrienoic-acid-methyl-ester and Leukemia-P388
| Article | Year |
|---|---|
Use of lipid microspheres as a drug carrier for antitumour drugs.
9-Oxo-15-hydroxy-delta 7,10,13-prostatrienoic acid methyl ester (delta 7-PGA1), an antitumour drug was incorporated into lipid microspheres of 0.2 micron diameter (lipo-delta 7-PGA1). In in-vivo experiments, lipo-delta 7-PGA1 had a significantly greater antitumour activity than free delta 7-PGA1 against P388 leukaemia. Lipo-delta 7-PGA1 slightly, but significantly, prolonged the survival time of mice inoculated with L1210 leukaemia, whereas free delta 7-PGA1 did not. Against MM46 ascites tumour, the survival time after treatment with 10 mg kg-1 of lipo-delta 7-PGA1 was significantly greater than that after the same dose of free delta 7-PGA1. The results suggest that lipid microspheres can be used as drug delivery carriers for lipid soluble antitumour agents. Topics: Animals; Antineoplastic Agents; Cell Line; Drug Compounding; Leukemia L1210; Leukemia P388; Lipids; Male; Mice; Mice, Inbred C3H; Microspheres; Neoplasm Transplantation; Neoplasms, Experimental; Prostaglandins A, Synthetic | 1986 |