9-hydroxycanthin-6-one and Lung-Neoplasms

9-hydroxycanthin-6-one has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 9-hydroxycanthin-6-one and Lung-Neoplasms

Article	Year
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of natural products, 2003, Volume: 66, Issue:10 Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines. Topics: Alkaloids; Anti-HIV Agents; Antimalarials; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbolines; Drug Screening Assays, Antitumor; Eurycoma; Female; Humans; Lung Neoplasms; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Tumor Cells, Cultured	2003

Article

Year

Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.

Journal of natural products, 2003, Volume: 66, Issue:10

Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

Topics: Alkaloids; Anti-HIV Agents; Antimalarials; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbolines; Drug Screening Assays, Antitumor; Eurycoma; Female; Humans; Lung Neoplasms; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Tumor Cells, Cultured

2003