9-benzyl-2-chloro-6-(2-furyl)purine has been researched along with Tuberculosis* in 2 studies
2 other study(ies) available for 9-benzyl-2-chloro-6-(2-furyl)purine and Tuberculosis
| Article | Year |
|---|---|
6-Oxo and 6-thio purine analogs as antimycobacterial agents.
6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate to good inhibitory activity. N(9)-substitution apparently enhances the anti-mycobacterial activity in the purine series described herein. Several 2-amino and 2-chloro purine analogs were also synthesized that showed moderate inhibitory activity against Mtb. Topics: Animals; Antitubercular Agents; Cell Survival; Chlorocebus aethiops; Humans; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Purines; Sulfhydryl Compounds; Tuberculosis; Vero Cells | 2013 |
Synthesis, structure, and antimycobacterial activity of 6-[1(3H)-isobenzofuranylidenemethyl]purines and analogs.
6-Benzofuryl-, styryl, benzyl, and furfurylpurines as well as 6-[1(3H)-isobenzofuranylidenemethyl]purines have been synthesized and their activities against Mycobacterium tuberculosis (Mtb) determined. Several compounds displayed profound antimycobacterial activity in combination with low toxicity towards mammalian cells. NMR and X-ray crystallography were employed to determine the detailed structures and the results were supported by quantum chemical calculations. Topics: Animals; Antitubercular Agents; Cell Survival; Chlorocebus aethiops; Crystallography, X-Ray; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Purines; Structure-Activity Relationship; Tuberculosis; Vero Cells | 2009 |