9-10-epoxy-7-8-9-10-tetrahydrobenzo(a)pyrene and Precancerous-Conditions

9-10-epoxy-7-8-9-10-tetrahydrobenzo(a)pyrene has been researched along with Precancerous-Conditions* in 1 studies

Other Studies

1 other study(ies) available for 9-10-epoxy-7-8-9-10-tetrahydrobenzo(a)pyrene and Precancerous-Conditions

Article	Year
Inversion of enantioselectivity in glutathione conjugation of 9,10-dihydrobenzo[a]pyrene 7,8-oxide in hepatic cytosol of rats following induction of hepatic hyperplastic nodules by chemical carcinogens. Cancer letters, 1987, Volume: 38, Issue:1-2 Enantiomers of 9,10-dihydrobenzo[a]pyrene 7,8-oxide (DBPO) were stereoselectivity conjugated with glutathione (GSH) specifically at benzylic carbon (C7) in normal Sprague--Dawley (SD) rat liver cytosol: (7R,8S)-(+)- greater than (7S,8R)-(-)-DBPOs. In contrast, in liver cytosol of SD rats bearing hepatic hyperplastic nodules induced with chemical carcinogens, (7S,8R)-(-)-DBPO was preferentially conjugated with GSH to (7R,8S)-(+)-DBPO. GSH S-transferases (GSTs) having sub-unit protein 4 were strongly suggested to play an important role in the preferential conjugation of (7R,8S)-(+)-DBPO in the normal rat liver cytosol, while the preferential conjugation of (7S,8R)-(-)-DBPO in the liver cytosol of the rat bearing hepatic hyperplastic nodules, was most likely to be attributable to GST 7-7, a characteristically induced protein in the hepatic hyperplastic nodules. Topics: Animals; Benzopyrenes; Cytosol; Glutathione; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Stereoisomerism	1987

Article

Year

Inversion of enantioselectivity in glutathione conjugation of 9,10-dihydrobenzo[a]pyrene 7,8-oxide in hepatic cytosol of rats following induction of hepatic hyperplastic nodules by chemical carcinogens.

Cancer letters, 1987, Volume: 38, Issue:1-2

Enantiomers of 9,10-dihydrobenzo[a]pyrene 7,8-oxide (DBPO) were stereoselectivity conjugated with glutathione (GSH) specifically at benzylic carbon (C7) in normal Sprague--Dawley (SD) rat liver cytosol: (7R,8S)-(+)- greater than (7S,8R)-(-)-DBPOs. In contrast, in liver cytosol of SD rats bearing hepatic hyperplastic nodules induced with chemical carcinogens, (7S,8R)-(-)-DBPO was preferentially conjugated with GSH to (7R,8S)-(+)-DBPO. GSH S-transferases (GSTs) having sub-unit protein 4 were strongly suggested to play an important role in the preferential conjugation of (7R,8S)-(+)-DBPO in the normal rat liver cytosol, while the preferential conjugation of (7S,8R)-(-)-DBPO in the liver cytosol of the rat bearing hepatic hyperplastic nodules, was most likely to be attributable to GST 7-7, a characteristically induced protein in the hepatic hyperplastic nodules.

Topics: Animals; Benzopyrenes; Cytosol; Glutathione; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Stereoisomerism

1987