9,10-dimethyl-1,2-benzanthracene has been researched along with Skin Neoplasms in 1423 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 390 (27.41) | 18.7374 |
| 1990's | 388 (27.27) | 18.2507 |
| 2000's | 339 (23.82) | 29.6817 |
| 2010's | 278 (19.54) | 24.3611 |
| 2020's | 28 (1.97) | 2.80 |
| Authors | Studies |
|---|---|
| A Abu-Siniyeh, A; F Khabour, O; H Alzoubi, K; M Mhaidat, N; S Alkofahi, A | 1 |
| González-Rodríguez, M; Hiihtola, L; Järvinen, TAH; Junttila, IS; Kummola, L; Määttä, J; Parviainen, L; Pemmari, T; Salomaa, T; Salonen, N; Vähätupa, M | 1 |
| Dang, Y; Guo, C; Li, Y; Liang, Y; Liu, M; Shi, Y; Wang, C; Xiang, W; Xu, P; Ye, X; Zhang, X | 1 |
| Ghadi, DS; Joshi, P; Waghmare, SK | 1 |
| Manoharan, S; Muralinaidu, R; Neelakandan, M; Thara, JM | 1 |
| Abdellaoui, M; Abrazi, Y; Cheraiet, Z; Gary, A; Kadi, A; Kadi, Y; Kherfi, H; Messarah, M | 1 |
| Dhanusu Sivakalai, S; Sowndhar Rajan, B; Vellaichamy, E | 1 |
| Bhan Tiku, A; Kumar, R | 1 |
| Abd Hamid, R; Md Roduan, MR; Mohtarrudin, N | 1 |
| Järvinen, TAH; Junttila, I; Pemmari, T; Pesu, M; Vähätupa, M | 1 |
| Cai, H; Hua, Z; Huang, H; Shi, J; Wei, Y; Zhang, L | 1 |
| Akhtar, S; Ghosh, R; Kumar Mandal, T; Maiti, P; Manna, D; Mondal, S | 1 |
| Furukawa, F; Ishida, Y; Kimura, A; Kondo, T; Kuninaka, Y; Mukaida, N; Nosaka, M; Yamamoto, Y | 1 |
| Illam, SP; Nair, A; Narayanankutty, A; Raghavamenon, AC; Upaganlawar, A | 1 |
| Aniqa, A; Dogra, S; Kaur, S; Sadwal, S | 1 |
| Alyoussef, A | 1 |
| Hu, X; Wang, L; Zhang, L; Zhang, T | 1 |
| Belmonte, B; Best, K; Botto, M; Castro Seoane, R; Fossati-Jimack, L; Gulino, A; Jackson, WD; Köhl, J; Strid, J; Tian, K | 1 |
| Kreft, M; Krotenberg Garcia, A; Ramovs, V; Sonnenberg, A | 1 |
| Al Matouq, J; Bloom, C; Hansen, LA; Holmes, M; Holmes, TR; Lovas, S; Madson, JG; Nicola, L; Palermo, NY; Rudd, JC; Sioda, N | 1 |
| Kisacam, MA; Kocamuftuoglu, GO; Ozan, IE; Ozan, S; Yaman, M | 1 |
| Athar, M; Elmets, CA; Nasti, TH; Sherwani, MA; Timares, L; Yusuf, N | 1 |
| Chiou, YS; Chou, PY; Ho, CT; Lee, PS; Nagabhushanam, K; Pan, MH | 1 |
| Alahmadi, TA; Chen, W; Gao, H; Lei, Y; Liu, H; Peng, H; Xiao, W | 1 |
| Brakebusch, C; Li, H | 1 |
| Aida, E; Hara, S; Kamei, D; Kuwata, H; Nakatani, Y; Ochiai, T; Sasaki, Y | 1 |
| Aboudkhil, S; Bouyahya, A; El Antri, S; El Yaagoubi, OM; Filali, H; Lahmadi, A; Samaki, H | 1 |
| Bajpai, D; Brooks, SR; Cataisson, C; Hasneen, K; Inoue, Y; Kellett, M; Mehdizadeh, S; Morasso, MI; Motegi, SI; Overmiller, A; Palazzo, E; Sawaya, A; Uchiyama, A; Yuspa, SH | 1 |
| Aird, KM; Buj, R; Chen, CW; Dahl, ES; Hobbs, RP; Imamura-Kawasawa, Y; Kossenkov, AV; Leon, KE; Lesko, E; Tangudu, NK | 1 |
| Huang, J; Liu, S; Lu, F; Wang, Z; Xiao, S; Xue, M | 1 |
| Khan, AA | 1 |
| Callejas-Valera, JL; Cimas, FJ; Fernandez-Aroca, DM; Garcia-Gil, E; García-Olmo, DC; Gutkind, JS; Hernández-Losa, J; Marcos, P; Melgar-Rojas, P; Ortega-Muelas, M; Pascual-Serra, R; Ramón Y Cajal, S; Roche, O; Ruiz-Hidalgo, MJ; Sanchez-Prieto, R | 1 |
| Chugh, NA; Kaur, N; Koul, A | 1 |
| Bai, R; Bode, AM; Dong, Z; Langfald, A; Lee, MH; Oi, N; Yamamoto, H | 1 |
| Huang, W; Liu, Z; Ma, H; Wang, F; Xu, X; Zhang, X | 1 |
| Anguish, LJ; Coonrod, SA; Horibata, S; McElwee, JL; McLean, D; Mohanan, S; Mukai, C; Sams, K; Yan, A | 1 |
| Hamid, RA; Md Roduan, MR; Mohtarrudin, N; Sulaiman, H | 1 |
| Patial, V; Sharma, S; Sk, UH | 1 |
| Ajith, TA; Antonawich, F; Janardhanan, KK; Veena, RK | 1 |
| Alexander-Savino, C; Chen, L; Gillespie, K; Gilmore, ES; Hayden, MS; Oleksyn, D; Poligone, B; Zhao, J | 1 |
| Liu, P; Wang, D | 1 |
| Faustino-Rocha, AI; Ferreira, L; Ferreira, R; Gama, A; Neuparth, MJ; Oliveira, PA; Rodrigues, D; Vitorino, R | 1 |
| Ahn, JS; Cha-Molstad, H; Choi, TW; Han, HJ; Hong, JT; Hwang, J; Kim, BY; Kim, HJ; Kwon, YT; Lee, HG; Lee, KH; Lee, Y; Mun, J; Soung, NK | 1 |
| Choi, WJ; Keum, YS; Lee, J; Mailar, K; Yoo, OK | 1 |
| Bodman-Smith, K; Daaboul, HE; Dagher, C; Daher, CF; El-Sibai, M; Mroueh, MA; Shebaby, WN; Taleb, RI | 1 |
| Kong, YH; Xu, SP | 1 |
| Balmain, A; Del Rosario, R; Harris, S; Kandyba, E; Reeves, MQ | 1 |
| Balaiya, V; Johnson, LK; Koster, MI; Lakshmanachetty, S | 1 |
| Hall, JR; House, JS; Jima, DD; Messenger, ZJ; Smart, RC; Tam, HW; Tokarz, DA | 1 |
| Asfaha, S; Boland, K; Gordon, D; Jin, G; Johnson, K; Lad, S; Londono, D; Morris, RJ; Park, H; Patterson, KS; Readio, N; Singh, A; Trempus, C; Wang, TC; Yang, X | 1 |
| Ganapathy, S; Gopalakrishnan, T; Namasivayam, N; Veeran, V | 1 |
| Banu, N; Bilal, N; Hasan, S; Suhail, N | 1 |
| Cataisson, C; Day, CP; Flowers, B; Fraser, E; Li, L; Sanchez, V; Yuspa, SH | 1 |
| Gubareva, EA; Maidin, MA; Panchenko, AV; Tyndyk, ML; Vinogradova, LA | 1 |
| Al Habeeb, A; Bai, X; Cho, HR; Liu, M; Lu, C; Post, A; Wang, Y; Xiang, YY | 1 |
| Alyoussef, A; Taha, M | 1 |
| Ishibashi, T; Maoka, T; Ohmori, A; Osawa, A; Shindo, K; Suzuki, N; Tokuda, H; Yasui, H | 1 |
| Dharmesh, SM; Rao, AR; Ravishankar, GA; Sankar, KU; Sarada, R; Sindhuja, HN | 1 |
| Arimoto-Kobayashi, S; Kamiya, T; Negishi, T; Okamoto, G; Yuhara, Y; Zhang, X | 1 |
| Bochkov, VN; Böhm, F; Dummer, R; Gruber, F; Hohl, D; Huber, M; Pfister, HJ; Rolfs, F; Schäfer, M; Tschachler, E; Werner, S | 1 |
| Furukawa, F; Kawabe, M; Numano, T; Suguro, M; Taguchi, F; Tsutsumi, H; Urano, K | 1 |
| Amaral, L; Engi, H; Hamilton, G; Hohmann, J; Maoka, T; Molnar, J; Mucsi, I; Olszewski, U; Suzuiki, N; Tokuda, H; Vasas, A | 1 |
| Cescon, D; Chio, II; Dominguez-Brauer, C; Elia, AJ; Ghazarian, D; Gorrini, C; Haight, J; Hao, Z; Harris, IS; Inoue, S; Itsumi, M; Li, WY; Mak, TW; McCracken, S; Melino, G; Penn, LJ; Sasaki, M; Silvester, J; Snow, B; Ueda, T; Wakeham, A; Yamamoto, K; You-Ten, A; Zhou, L | 1 |
| Arora, N; Bansal, MP; Koul, A | 4 |
| Hamid, RA; Khaza'ai, H; Yazan, LS; Yeong, LT | 1 |
| Hong, JI; Jung, BG; Kim, TH; Ko, JH; Lee, BJ; Lee, JA; Park, YS | 1 |
| Ashkenazi, A; Bricker, N; Chaudhuri, A; Couto, S; Cupp, J; French, D; Liu, J; Modrusan, Z; Paler Martinez, A; Wilson, NS; Yang, B; Zhu, C | 1 |
| Hanausek, M; Junco, JJ; Kowalczyk, MC; Kowalczyk, P; Slaga, TJ; Tolstykh, O; Walaszek, Z | 1 |
| Nakae, D; Nakajima, J; Yasukawa, K | 1 |
| Badeaux, MA; Fischer, SM; Gong, S; Jeter, CR; Kusewitt, D; Liu, B; Rundhaug, J; Suraneni, MV; Tang, DG; Yang, T | 1 |
| Ichiishi, E; Iida, A; Kapadia, GJ; Konoshima, T; Rao, GS; Sridhar, R; Suzuki, N; Takasaki, M; Tokuda, H | 1 |
| DeFeo-Mattox, K; Gilmour, SK; Hayes, CS; Woster, PM | 1 |
| Kale, RK; Kumar, N; Tiku, AB | 1 |
| Fujiwara, K; Ghosh, S; Liang, P; Morien, E; Nagase, H; Soma, M | 1 |
| Gao, L; Li, X; Wang, J | 1 |
| Antsiferova, M; Feyerabend, TB; Förster, A; Hartmann, K; Hohl, D; Huber, M; Martin, C; Rodewald, HR; Werner, S | 1 |
| Chen, X; Fagin, JA; Johnson, LK; Knauf, JA; Makarewicz, JM | 1 |
| Ali, F; Khan, AQ; Khan, R; Lateef, MA; Maqbool, T; Sultana, S | 1 |
| Ali, H; Dixit, S | 1 |
| Baban, B; Chandler, P; DuHadaway, JB; Keough, MP; Mandik-Nayak, L; Mellor, AL; Merlo, LM; Metz, R; Muller, AJ; Pigott, E; Prendergast, GC; Rust, S; Smith, C | 1 |
| Blankenstein, T; Bozrova, SV; Chashchina, AA; Drutskaya, MS; Kammertoens, T; Nedospasov, SA; Qin, Z; Quarcoo, D; Rothe, M | 1 |
| Hogg, N; McNeill, E | 1 |
| Maurer, M; Metz, M; Siebenhaar, F | 1 |
| Subramanian, V; Tumala, A; Vellaichamy, E; Venkatesan, B | 1 |
| Chawsheen, HA; Colburn, NH; Gerard, M; Jiang, H; Mishra, M; Toledano, MB; Wei, Q; Wu, L; Young, MR | 1 |
| Darido, C; Jane, SM; Mlacki, M; Wilanowski, T | 1 |
| Korinfsky, JP; Maria, C; Moreno, TR; Plapler, H; Santos, I | 1 |
| Albrecht, PP; Amin, S; Bility, MT; Borland, MG; Gonzalez, FJ; Krishnan, P; Lee, C; Lin, JM; Marcus, CB; Perdew, GH; Peters, JM; Shan, W | 1 |
| Christiansen, H; Dittmann, K; Frommhold, A; Hahn, H; Heß, I; König, S; Lühder, F; Nitzki, F; Reifenberger, J; Schulz-Schaeffer, W; Uhmann, A; Zabel, S | 1 |
| Borcan, F; Coricovac, D; Crăiniceanu, Z; Danciu, C; Dehelean, CA; Munteanu, M; Oprean, C; Soica, C; Trandafirescu, C | 1 |
| Chen, W; Fan, F; Liu, Y; Liu, Z; Lu, Y; Pei, C; Ruan, J; Shan, Y; Shen, C; Tao, L; Tian, C; Wang, A; Wang, S; Wu, H; Zheng, S; Zhou, L | 1 |
| Gupta, KP; Tiwari, P | 1 |
| Guo, S; He, X; Lan, H; Lan, T; Li, J; Li, W; Qi, C; Wang, L; Wei, P; Yang, Y; Ye, J; Zhang, Q | 1 |
| Cipolat, S; Hoste, E; Natsuga, K; Quist, SR; Watt, FM | 1 |
| Argade, A; Chatterjee, A; Deshpande, SS; Jain, MR; Mohapatra, J; Shah, GB; Sharma, M | 1 |
| Kim, C; Pasparakis, M | 1 |
| Bauer, O; Groner, Y; Hantisteanu, S; Lotem, J | 1 |
| Aoto, Y; Goitsuka, R; Hachiya, T; Hirose, S; Isogai, E; Katsuragi, Y; Kominami, R; Nakamura, T; Okumura, K; Saito, M; Sakakibara, Y; Wakabayashi, Y | 1 |
| García-Fernández, RA; García-Iglesias, MJ; Pérez-Martínez, C | 1 |
| Fujimoto, H; Fukuda, I; Lee, KM; Nishino, T; Okubo, C; Tsuji, H; Yoshimura, H | 1 |
| Subramanian, V; Vellaichamy, E | 1 |
| Catapang, A; Dennis, EA; Dumlao, DS; Fischer, SM; Herschman, HR; Ishikawa, TO; Jiao, J; Magyar, CE; Mikulec, C; Norris, PC | 1 |
| Hart, RP; Huang, MT; Huang, Y; Kong, AN; Lee, JH; Lu, Y; Pung, D; Ramirez, C; Shu, L; Su, ZY; Verzi, M; Yang, AY; Zhang, C | 1 |
| Asano, R; Iizuka, H; Nakae, Y; Nakajima, S; Ogasawara, K; Sakata, I; Takahashi, H | 1 |
| Chaturvedi, U; Desai, GS; Dhara, SK; Kumar, A; Kumar, GV; Kumar, S; Rajmani, RS; Sahoo, AP; Santra, L; Saxena, S; Singh, LV; Tiwari, AK | 1 |
| Jeena, K; Kuttan, R; Liju, VB | 1 |
| Becker, JC; Zur Hausen, A | 1 |
| Bürgler, CD; Filler, RB; Fraser, JA; Girardi, M; Golubets, K; Kucher, CL; Lewis, JM; Liao, H; Tigelaar, RE; Zhao, PY | 1 |
| Campanelli, AP; Cavassani, KA; da Silva, JS; de Freitas, LT; de Oliveira, CE; Garlet, GP; Gasparoto, TH; Hori, JI; Pinheiro, CR; Schillaci, R; Zamboni, DS | 1 |
| Ahn, J; Barber, GN; Konno, H; Konno, K; Ruiz, P; Xia, T | 1 |
| Aggarwal, V; Monga, J; Nongalleima, K; Sharma, M; Suthar, SK | 1 |
| Gerritsen, HC; Sterenborg, HJ; Thomas, G; Truong, H; van Voskuilen, J | 1 |
| Andresen, BT; Chang, A; Huang, KM; Huang, Y; Jackson, EK; Kanassatega, RS; Liu, MM; Orlando, R; Parsa, C; Thakkar, A; Yeung, S | 1 |
| Bradish, JR; DaSilva-Arnold, SC; Konger, RL; Ocana, JA; Rashid, B; Rezania, S; Richey, JD; Sahu, RP; Travers, JB; Warren, SJ | 1 |
| Kooi, OK; Ling, CY; Mohtarrudin, N; Othman, F; Rodzi, R; Suhaili, Z; Zakaria, ZA | 1 |
| Ali, N; Ali, R; Hasan, SK; Khan, AQ; Khan, R; Majed, F; Mehdi, SJ; Nafees, S; Rashid, S; Sultana, S | 1 |
| Gupta, KP; Pandey, M; Qadri, SS; Sahay, S; Tiwari, P | 2 |
| Fukamachi, K; Hayashi, K; Inoue, Y; Ito, S; Kakugawa, Y; Kato, H; Kishimoto, A; Kiyonari, H; Momoi, Y; Nishio, M; Nomura, M; Ogoh, H; Sakamoto, Y; Sakayori, M; Sato, I; Shima, H; Suganuma, M; Suzuki, A; Suzuki, M; Tanuma, N; Watanabe, T; Yamashita, Y | 1 |
| Bryant, CJ; Caddye, E; Caunt, CJ; Davidson, J; Delavaine, L; East, P; Keyse, SM; Kidger, AM; Rushworth, LK; Stewart, G; van Schelven, S | 1 |
| Bernabéu, C; del Castillo, G; Langa, C; Martín-Villar, E; Pérez-Gómez, E; Quintanilla, M; Renart, J; Sánchez-Blanco, E; Valbuena-Diez, AC | 1 |
| Naseem, I; Salman, M | 1 |
| Brylka, H; Kraus, A; Niemann, C; Petersson, M; Reuter, K; Schettina, P | 1 |
| Ghosh, S; Khuda-Bukhsh, AR; Mukherjee, A; Sikdar, S | 1 |
| Amberg, N; Glitzner, E; Holcmann, M; Novoszel, P; Sibilia, M; Stulnig, G | 1 |
| Athar, M; Cochran, JB; Elmets, CA; Fineberg, NS; Kim, HK; Nasti, TH; Rudemiller, KJ; Timares, L; Tsuruta, Y | 1 |
| Fuchs, E; Oristian, D; Oshimori, N | 1 |
| Callaway, D; Curiel, TJ; Dao, V; Dodds, S; Hasty, P; Hurez, V; Liu, A; Liu, Y; Pandeswara, S; Sharp, ZD | 1 |
| Carr, TD; Feehan, RP; Hall, MN; Rüegg, MA; Shantz, LM | 1 |
| Calés, C; Cano, A; Gridley, T; Molina-Ortiz, P; Montenegro, Y; Morales, S; Moreno-Bueno, G; Peinado, H; Pérez-Moreno, MA; Portillo, F; Santos, V; Villarejo, A | 1 |
| Athar, M; Cochran, JB; Elmets, CA; McKay, KM; Nasti, TH; Timares, L; Tsuruta, Y; Yusuf, N | 1 |
| Benetti, R; Blasco, MA; Buemi, V; Dinami, R; Jordi, F; Petti, E; Schoeftner, S | 1 |
| Ahmad, I; Athar, M; Chowdhury, S; Elmets, CA; Mohiuddin, H; Nasti, TH; Timares, L; Xu, H; Yusuf, N | 1 |
| Chen, C; Fan, F; Lin, C; Liu, Y; Liu, Z; Lu, Y; Shen, C; Sun, L; Tao, Y; Wang, A; Wang, S; Wei, Z; Wu, H; Zhao, L; Zhu, P; Zhu, Z | 1 |
| Hall, RP; He, Y; Huang, Q; Kato, TA; Li, CY; Li, F; Liu, X | 1 |
| Brady, M; Brennan-Crispi, DM; Hossain, C; Mahoney, MG; Riobo, NA; Sahu, J | 1 |
| Cao, Y; Chen, C; Fan, F; Lin, C; Liu, Z; Lu, Y; Shan, Y; Shen, C; Sun, L; Tao, Y; Wang, A; Wang, S; Wei, Z; Wu, H; Zheng, S; Zhu, P | 1 |
| Gu, X; Jin, R; Li, G; Li, T; Li, W; Ren, A; Shi, R; Zhang, C; Zhao, Y | 1 |
| DiGiovanni, J; Rho, O; Srivastava, J; Youssef, RM | 1 |
| Alarifi, S; Ali, D; Ali, H; Alkahtani, S; Alqahtani, SM; Dixit, S | 1 |
| Järvinen, TA; Laitinen, AM; May, U; Nieminen, K; Prince, S; Uusitalo-Järvinen, H; Vähätupa, M | 1 |
| Colaço, B; Faustino-Rocha, AI; Ferreira, R; Gama, A; Gomes, PS; Oliveira, PA; Pires, MJ; Rodrigues, D | 1 |
| Blanpain, C; Boeckx, B; Lambrechts, D; Latil, M; Nassar, D | 1 |
| Fujiwara, K; Ikeda, M; Inazawa, J; Nagase, H; Ozaki, T; Ozaki, Y; Soma, M; Terui, T | 1 |
| Ahmad, A; Ashraf, GM; Banu, N; Bilal, N; Hasan, S; Suhail, N | 1 |
| Bao, R; Bechill, J; Bindokas, VP; Faber, PW; Lingen, MW; Spiotto, MT; Zhong, R | 1 |
| Beck, A; Fletcher, S; Goldstein, J; Horsley, V; Lin, S; Roberts, N; Roth, E; Suárez-Fariñas, M; Tadeu, A; Wu, C; Zeiss, C; Zwick, R | 1 |
| Goyal, PK; Sharma, J; Singh, R | 1 |
| Adams, DJ; Balmain, A; Chin, D; Delrosario, R; Halliwill, KD; Hewinson, J; Hirst, G; Jen, KY; McCreery, MQ; Vuong, P | 1 |
| Bauer, SJ; Havighurst, TC; Kim, K; Singh, A; Verma, AK; Wheeler, DL | 1 |
| Abdul Hamid, R; Khaza'ai, H; Mohtarrudin, N; Saiful Yazan, L; Yeong, LT | 1 |
| Babu, TD; Divya, MK; Lincy, L; Meera, N; Raghavamenon, AC; Salini, S; Seema, M | 1 |
| Agostinelli, S; Bianchi, L; Campione, E; Costanza, G; Di Stefani, A; Doldo, E; Giunta, A; Mazzaglia, D; Orlandi, A; Passeri, D; Tarquini, C | 1 |
| de Gruijl, FR; Gerritsen, HC; Song, JY; Sterenborg, HJ; Thomas, G; Truong, H; Tuk, B | 1 |
| Alameda, JP; Bravo, A; Casanova, ML; Navarro, M; Page, A; Paramio, JM; Ramirez, A; Suarez-Cabrera, C | 1 |
| Hermeking, H; Lodygin, D; Verdoodt, B; Winter, M | 1 |
| Garg, ML; Koul, A; Mohanty, BP; Sati, J | 1 |
| Baderca, F; Borcan, F; Coricovac, D; Danciu, C; Dehelean, CA; Pavel, I; Pinzaru, I; Soica, C; Spandidos, DA; Tsatsakis, AM | 1 |
| Hu, YQ; Wang, J; Wu, JH | 1 |
| Alitalo, K; Harjunen, V; Heljasvaara, R; Holopainen, T; Honkanen, HK; Izzi, V; Petäistö, T; Pihlajaniemi, T | 1 |
| Balmain, A; Del Rosario, R; Ginzinger, D; Halliwill, KD; Kang, HC; Quigley, DA | 1 |
| Curiel, TJ; Dao, V; Gelfond, JA; Hurez, V; Liu, A; Liu, Y; Pandeswara, S; Svatek, RS | 1 |
| Berx, G; Declercq, W; Denecker, G; Devos, M; Gilbert, B; Haigh, J; Hochepied, T; Lambert, J; Lemeire, K; Leurs, K; Libbrecht, L; Lippens, S; Mc Guire, C; Van Den Broecke, C; Vandenabeele, P; Vuylsteke, M | 1 |
| Asai, M; Asai, N; Enomoto, A; Kato, T; Mii, S; Murakumo, Y; Nagino, M; Shiraki, Y; Sunagawa, M; Takahashi, M | 1 |
| K, DM; Lawrence, L; Menon, S; Padikkala, J; Sivaram, VP | 1 |
| Bodman-Smith, K; Boukamp, P; Daher, CF; El-Sibai, M; Mroueh, MA; Shebaby, WN; Taleb, RI | 1 |
| Bai, R; Bode, AM; Dong, Z; Min, E; Moriyama, K; Oi, N; Ryu, J; Yamamoto, H; Yu, DH; Zykova, TA | 1 |
| Cano, A; de Diego, JI; Hardisson, D; Mendiola, M; Moreno-Bueno, G; Nistal, M; Peinado, H; Pérez-Gómez, E; Portillo, F; Quintanilla, M; Santos, V | 1 |
| Bailey, SL; Gurley, KE; Hoon-Kim, K; Kelly-Spratt, KS; Kemp, CJ | 1 |
| Conti, CJ; De Siervi, A; Macias, E; Miliani de Marval, PL; Rodriguez-Puebla, ML; Senderowicz, AM | 1 |
| Kato, N; Lu, T; Monttinen, ES; Xu, Y | 1 |
| Chaudhary, R; Goyal, PK; Jahan, S | 2 |
| Abraham, A; Cibin, TR; Gayathri Devi, D; Ramaiah, D | 1 |
| Afaq, F; Mukhtar, H; Sarfaraz, S; Siddiqui, IA; Syed, DN | 1 |
| George, J; Kalra, N; Prasad, S; Roy, P; Shukla, Y | 1 |
| Alias, LM; Balakrishnan, S; Manoharan, S; Ramachandran, CR; Vellaichamy, L | 1 |
| Kale, RK; Singh, B | 2 |
| Hori, Y; Iigo, M; Imai, T; Kitahashi, T; Sugimura, T; Takahashi, M; Takasuka, N; Wakabayashi, K; Yoshimi, N | 1 |
| Anders, J; Berry, A; Cataisson, C; Flores-Obando, RE; Hansen, LA; Lo, YC; Patel, R; Strain, K; Virador, VM; Yuspa, SH; Zakhari, J | 1 |
| Cabrera, WK; De Franco, M; De Souza, VR; Dragani, TA; Galvan, A; Ibañez, OM; Massa, S; Ribeiro, OG; Starobinas, N; Vorraro, F | 1 |
| Amornphimoltham, P; Gutkind, JS; Leelahavanichkul, K; Molinolo, A; Patel, V | 1 |
| Das, I; Saha, T | 1 |
| Karibasappa, GS; Pakhale, SS; Ramchandani, AG | 1 |
| Cataisson, C; Hennings, H; Jay, S; Ohman, R; Patel, G; Pearson, A; Tsien, M; Wright, L; Yuspa, SH | 1 |
| Elmets, CA; Meleth, S; Nasti, TH; Yusuf, N | 1 |
| Katiyar, SK; Meeran, SM; Punathil, T; Vaid, M | 1 |
| Alam, MS; Athar, M; Chaudhary, SC; Siddiqui, MS | 3 |
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| Kuttan, R; Unnikrishnan, MC | 1 |
| Baker, RS; Steinel, HH | 2 |
| Koch, WH; Kornhauser, A; Lambert, LA; Wamer, WG | 1 |
| Fischer, SM; Patamalai, B; Patrick, KE; Slaga, TJ | 1 |
| Bhisey, RA; Veturkar, PL | 1 |
| Goel, HC; Rao, AR; Sadhana, AS | 1 |
| Glasø, M; Wetteland, P | 1 |
| Bangrazi, C; Biozzi, G; Covelli, V; Doria, G; Mouton, D; Neveu, T; Saran, A | 1 |
| Conti, CJ; DiGiovanni, J; Flynn, LM; Monks, TJ; Walker, SE | 1 |
| Belman, S; Bosland, MC; Estensen, RD; Savarese, K; Sellakumar, A | 1 |
| Fialkow, PJ; Reddy, AL | 5 |
| Hashiba, H; Hashimoto, Y; Kuroki, T; Nose, K; Tajima, O | 1 |
| Fukuoka, M; Furukawa, F; Hasegawa, R; Hayashi, Y; Imaida, K; Sato, H; Takahashi, M; Takamura, N; Toyoda, K | 1 |
| Belman, S; Perchellet, EM; Perchellet, JP | 1 |
| Boehm-Wilcox, C; Bosnic, M; Reeve, VE | 1 |
| Tabara, M; Watanabe, M | 1 |
| Dietel, M; Hilz, H; Ludwig, A; Müller, K; Schäfer, G | 1 |
| Donawho, C; Kripke, ML | 1 |
| Binder, RL; Cunniff, JJ; Maurer, JK; Newmann, EA; Sundberg, JP | 1 |
| Fujiki, H; Furuya-Suguri, H; Fusetani, N; Kato, Y; Suganuma, M; Sugimura, T; Yasumoto, S; Yoshizawa, S | 1 |
| Hasegawa, T; Iwashima, A; Nishino, A; Nishino, H; Okuyama, T; Shibata, S; Takata, M; Takayasu, J; Tokuda, H; Ueyama, H | 1 |
| Nikitin, AIu; Pozharisskiĭ, KM | 1 |
| Christensen, SB; Fujiki, H; Hakii, H; Nakayasu, M; Scheuer, PJ; Suganuma, M; Sugimura, T; Tahira, T | 1 |
| Baird, WM; Carlson, GP; Morse, MA | 2 |
| East, CJ; Kulesz-Martin, MF; Penetrante, R | 1 |
| Cheng, CK; Krieg, TM; Mehrel, T; Roop, DR; Yuspa, SH | 1 |
| Aldaz, CM; Chesner, J; Conti, CJ; Larcher, F; Roop, DR; Slaga, TJ; Trono, D; Whitehead, T | 1 |
| Fischer, SM; Morris, RJ; Slaga, TJ; Tacker, KC | 1 |
| Fitzgerald, DJ; Klann, RC; Piccoli, C; Slaga, TJ; Yamasaki, H | 1 |
| Aldaz, CM; Conti, CJ | 1 |
| Glasø, M; Hovig, T; Iversen, OH | 1 |
| Birt, DF; Choi, B; Pelling, JC; White, LT | 1 |
| Perchellet, JP; Satyamoorthy, K | 1 |
| Bonfil, RD; Conti, CJ; Klein-Szanto, AJ; Larcher, F | 1 |
| Aldaz, CM; Conti, CJ; Miller, DR; Rotstein, J; Slaga, TJ; Viaje, A | 1 |
| Cantu, AR; Colby, A; Pavone, A; Reiners, JJ; Rupp, T | 1 |
| Halliday, GM; Muller, HK; Ruby, JC | 1 |
| DiGiovanni, J; Naito, M | 1 |
| Akhurst, R; Bailleul, B; Balmain, A; Brown, K; Fee, F; Ramsden, M | 1 |
| Miller, DR; Morris, RJ; O'Connell, JF; Patskan, GP; Slaga, TJ; Tacker, K; Viaje, AV | 1 |
| Fujiki, H; Kobayashi, M; Suganuma, M; Suguri, H; Takagi, K; Yoshizawa, S | 1 |
| Li, MH; Liu, JG | 1 |
| Bickers, DR; Das, M; Mukhtar, H | 1 |
| Amtmann, E; Fürstenberger, G; Marks, F; Sauer, G | 1 |
| Becher, H; Chouroulinkov, I; Day, NE; Lasne, C; Lowy, R; Wahrendorf, J; Yamasaki, H | 1 |
| Fürstenberger, G; Fusenig, NE; Kaina, B; Marks, F; Petrusevska, RT; Schurich, B | 1 |
| Conti, CJ; DiGiovanni, J; Ewing, MW; Phillips, JL; Slaga, TJ | 1 |
| Birt, DF; Pelling, JC; Schweickert, L; Tibbels, MG | 1 |
| Bhide, S; Kulkarni, J; Lalitha, VS | 1 |
| Aldaz, CM; Conti, CJ; Larcher, F; Slaga, TJ; Trono, D | 1 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Imaida, K; Sato, H; Takahashi, M; Toyoda, K | 1 |
| Fuwa, T; Itakura, Y; Iwashima, A; Matsuura, H; Nishino, H | 1 |
| Gill, TJ; Shinozuka, H; Yokota, K | 1 |
| Dlugosz, AA; Dzubow, L; Gilmour, SK; Hietala, O; O'Brien, TG; O'Donnell, K | 1 |
| De Luca, LM; Shores, RL; Spangler, EF; Wenk, ML | 1 |
| Athar, M; Khan, WA; Mukhtar, H | 1 |
| Athar, M; Bickers, DR; Lloyd, JR; Mukhtar, H | 1 |
| Blumberg, PM; Hennings, H; Sharkey, NA; Yuspa, SH | 1 |
| Fujiki, H; Hoshina, S; Jiang, W; Kahn, SM; Kanazawa, H; Manam, S; Suganuma, M; Sugimura, T; Weinstein, IB; Yoshizawa, S | 1 |
| Anisimov, V; Likhachev, A; Loktionov, A; Napalkov, N; Tomatis, L; Zabezhinski, M | 2 |
| Kim, YS; Park, KK | 1 |
| Hecker, E; Schmidt, R | 1 |
| Kuttan, R; Soudamini, KK | 1 |
| Bucana, C; Kripke, ML; Romerdahl, CA; Stephens, LC | 1 |
| Fairman, DK; Lewbart, ML; Pashko, LL; Polansky, M; Schwartz, AG | 1 |
| Aizu, E; Hosoda, Y; Kato, R; Kiyoto, I; Nakadate, T; Yamamoto, S | 1 |
| Konoshima, T; Kozuka, M; Tanabe, M; Tokuda, H | 1 |
| Indo, K; Miyaji, H | 1 |
| Burns, F; Garte, SJ; Housey, GM; Kirschmeier, P; Troll, W; Weinstein, IB | 1 |
| Ito, Y; Kanaoka, T; Tokuda, H; Yoshida, O | 1 |
| Greenhalgh, DA; Harper, JR; Lacal, JC; Reynolds, SH; Strickland, JE; Yuspa, SH | 1 |
| Chiba, M; Klein-Szanto, AJ; Maley, MA | 1 |
| Digiovanni, DM; Fries, JW; Klein-Szanto, AJ; O'Connell, JF; Slaga, TJ | 2 |
| Fujiki, H; Hakii, H; Horiuchi, T; Nakayasu, M; Suganuma, M; Sugimura, T; Takayama, S | 1 |
| Cabral, JR; Galendo, D; Hollstein, M; Martel, N; Tomatis, L; Yamasaki, H | 1 |
| Bagg, BJ; Hultin, TA; McCormick, DL | 1 |
| Nishino, H | 1 |
| Fujiki, H; Iwashima, A; Konishi, S; Nishino, H; Okabe, H; Okamoto, H; Shibata, S; Sugimura, T; Takizawa, H; Yoshioka, K | 1 |
| Chida, K; Kuroki, T; Munakata, K; Murakami, Y | 1 |
| Graem, N | 1 |
| Atkinson, B; Bondi, E; Clark, WH; Elder, DE; Guerry, D; Herlyn, D; Koprowski, H | 1 |
| Hakaim, AG; Jacoby, WT; O'Connell, JF; Weiss, HS | 1 |
| Fujiki, H; Iwashima, A; Kitagawa, K; Nishino, H | 1 |
| Kanno, J; Kasuga, T; Matsubara, O | 2 |
| Bowden, GT; Gensler, HL; Sim, DA | 1 |
| Fürstenberger, G; Kinzel, V; Loehrke, H; Marks, F | 1 |
| Aimi, N; Endo, Y; Fujiki, H; Hakii, H; Hitotsuyanagi, Y; Ninomiya, M; Paik, NS; Sakai, S; Shudo, K; Suganuma, M | 1 |
| Bock, KW; Fusenig, NE; Irmscher, G; Lilienblum, W | 1 |
| Scribner, JD; Scribner, NK; Woodworth, BA | 1 |
| Barbacid, M | 1 |
| Balmain, A; Brown, K; Quintanilla, M; Ramsden, M | 1 |
| DiGiovanni, J; Fisher, EP; Sawyer, TW | 2 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Miyakawa, Y; Sato, H; Takahashi, M | 1 |
| Kallioinen, M; Stenbäck, F; Wasenius, VM | 1 |
| Asokan, P; Bickers, DR; Das, M; Don, PS; Krueger, GG; Mukhtar, H | 1 |
| Blumenson, L; Kulesz-Martin, M; Lisafeld, B | 1 |
| Gragtmans, NJ; Jevcak, JJ; Mitchel, RE; Morrison, DP | 1 |
| Fujiki, H; Nitta, K; Takeuchi, M | 1 |
| Jacoby, WT; Weiss, HS | 1 |
| Klehr, NW; Sturm, E; Wiskemann, A | 1 |
| Chernova, TA; Melikiants, AG | 1 |
| Elegbede, JA; Elson, CE; Gould, MN; Maltzman, TH; Tanner, MA; Verma, AK | 1 |
| Devor, D; Hennings, H; Rehm, S; Ward, JM; Wenk, ML | 1 |
| Hashimoto, Y; Shudo, K | 1 |
| Abney, NL; Guislain, YL; Perchellet, EM; Perchellet, JP; Thomas, RM | 1 |
| Anderson, LM; Rice, JM | 2 |
| Hecker, E; Schmidt, R; Sorg, B | 1 |
| Aalto, ML; Collan, Y; Kosma, VM; Männistö, P; Naukkarinen, A | 1 |
| Berkelhammer, J; Oxenhandler, RW | 1 |
| Caldwell, M; Fialkow, PJ; Reddy, AL | 1 |
| Anisimov, V; Becher, H; Likhachev, A; Loktionov, A; Napalkov, N; Ovsyannikov, A; Tomatis, L; Wahrendorf, J; Zabezhinski, M | 1 |
| Edler, L; Goerttler, K; Loehrke, H; Schweizer, J | 1 |
| Akbar, S; Hussain, Z; Nisa, M; Tariq, M | 1 |
| Sugimura, T | 1 |
| Fujiki, H; Morino, K; Suganuma, M; Sugimura, T; Takayama, S | 1 |
| Aldaz, CM; Conti, CJ; Klein-Szanto, AJ; Slaga, TJ | 1 |
| Fujiki, H; Hecker, E; Hirota, M; Horiuchi, T; Suganuma, M; Sugimura, T; Suttajit, M; Wongchai, V; Yoshioka, A | 1 |
| Cohen, SM; Hasegawa, R; St John, M; Tibbels, TS | 1 |
| Baird, WM; DiGiovanni, J; Fisher, EP; Smolarek, TA | 1 |
| Conti, CJ; DiGiovanni, J; Kruszewski, FH | 1 |
| Hecker, E | 1 |
| Scherneck, S; Wunderlich, V | 1 |
| Hendrix, MJ; Huerta, CC; Persky, B | 1 |
| Chang, K; DiGiovanni, J; Harvey, RG; Sawyer, TW | 1 |
| Fischer, SM; Neades, R; Pelling, JC; Schweickert, L; Strawhecker, J | 1 |
| Maggini, M; Morpurgo, G | 1 |
| Bhisey, RA; Borges, A; Veturkar, PL | 1 |
| Gragtmans, NJ; Mitchel, RE; Morrison, DP | 2 |
| Grimm, NK; Ha, YL; Pariza, MW | 1 |
| Balaschak, M; Greenhalgh, DA; Hennings, H; Koceva-Chyla, A; Restrepo, C; Strickland, JE; Yuspa, SH | 1 |
| Conti, CJ; Fries, JW; Miller, DR; Morris, R; Slaga, TJ; Viaje, A | 1 |
| Ootsuyama, A; Tanooka, H | 1 |
| Hibasami, H; Maekawa, S; Nakashima, K; Sakurai, M; Tsukada, T | 1 |
| Fujiki, H; Hirota, M; Nakayasu, M; Ojika, M; Suganuma, M; Sugimura, T; Suguri, H; Wakamatsu, K; Yamada, K; Yoshizawa, S | 1 |
| Elmets, CA; Khan, WA; Klemme, JC; Mukhtar, H | 1 |
| Bickers, DR; Bik, DP; Das, M; Khan, WA; Mukhtar, H; Wang, ZY | 1 |
| Colby, AB; Reiners, JJ | 1 |
| Chenicek, KJ; DiGiovanni, J; Naito, M; Naito, Y | 1 |
| Neades, R; Pelling, JC; Strawhecker, J | 1 |
| Deamant, FD; Iannaccone, PM | 1 |
| Chao, WR; Dawson, MI | 1 |
| Elhence, BR; Gupta, A; Khanna, P; Lahiri, VL; Mehrotra, KN; Singh, K; Wahal, PK | 1 |
| Fujiki, H; Hitotsuyanagi, Y; Ninomiya, M; Sakai, S; Shudo, K; Suganuma, M; Sugimura, T; Takayama, S; Yamashita, K; Yoshizawa, S | 1 |
| Antony, M; Kumar, S; Mehrotra, NK; Shukla, Y | 1 |
| Rotstein, JB; Slaga, TJ | 1 |
| Chouroulinkov, I; Grover, P; Lasne, C; Phillips, D | 1 |
| Conney, AH; Huang, MT; Smart, RC; Wong, CQ | 1 |
| Iversen, OH; Ljunggren, S; Olsen, WM | 1 |
| DiGiovanni, J; Kruszewski, FH; O'Brien, TG; O'Donnell, K | 1 |
| Kensler, TW; Taffe, BG | 1 |
| Antony, M; Kumar, S; Mehrotra, NK | 1 |
| Anderson, LM; Giner-Sorolla, A; Hagiwara, A; Kovatch, RM; Rehm, S; Rice, JM; Riggs, CW | 1 |
| Conti, CJ; DiGiovanni, J; Ewing, MW; Kruszewski, FH; Slaga, TJ | 1 |
| Fujiki, H; Murata, M; Suganuma, M; Suguri, H; Takagi, K; Uda, N; Wakamatsu, K; Yamada, K; Yasumoto, T; Yoshizawa, S | 1 |
| Gómez, S; Vicente, V | 1 |
| Xia, QJ; Yang, S | 1 |
| Nakagawa, S; Takeuchi, M; Takido, M; Yasukawa, K | 1 |
| Bowden, GT; Breathnach, R; Finch, J; Krieg, P; Matrisian, L; O'Connell, JF; Ostrowski, LE; Patskan, G; Phillips, J; Slaga, TJ | 1 |
| Burns, PD; Conway, T; Cope, FO; Johnston, D; Murphy, P; Triggs, G; Wagner, FJ; Wille, JJ | 1 |
| Hard, GC; Pashko, LL; Rovito, RJ; Schwartz, AG; Sobel, EL; Williams, JR | 1 |
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| Colburn, NH; Diwan, BA; Rice, JM; Spangler, EF; Ward, JM | 1 |
| Kilkenny, AE; Morgan, D; Spangler, EF; Yuspa, SH | 1 |
| Kawamura, H; Strickland, JE; Yuspa, SH | 1 |
| Alworth, WL; Slaga, TJ | 1 |
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| Hayashi, Y; Iwata, K; Kitajima, H; Konishi, S; Sato, S; Takizawa, H | 1 |
| Hashimura, T; Yoshida, O | 1 |
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| Egner, PA; Kensler, TW | 1 |
| Baggiolini, E; Chang, RL; Conney, AH; Huang, MT; Partridge, JJ; Uskokovic, M; Wood, AW | 1 |
| Fürstenberger, G; Kinzel, V; Marks, F; Schwarz, M | 1 |
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37 review(s) available for 9,10-dimethyl-1,2-benzanthracene and Skin Neoplasms
| Article | Year |
|---|---|
Skin cancer chemoprevention by α-santalol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Mice; Mice, Mutant Strains; Phytotherapy; Plant Oils; Polycyclic Sesquiterpenes; Santalum; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Avian Leukosis Virus; Avian Proteins; Cell Line, Tumor; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Humans; Melanocytes; Melanoma; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Receptors, Virus; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2011 |
Non-melanoma skin cancer in mouse and man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Genes, p53; Genes, ras; Humans; Melanoma; Mice; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Papilloma; Risk Assessment; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2013 |
Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Brassica; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Isothiocyanates; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin; Skin Neoplasms; Sulfoxides; Tetradecanoylphorbol Acetate; Thiocyanates; Time Factors | 2006 |
Phorbol ester tumor promoters and lymphocyte proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Lymphocyte Activation; Lymphocytes; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Carcinogenesis and aging.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Carcinogens; Cell Transformation, Viral; Diethylstilbestrol; Disease Susceptibility; DNA Repair; Estrogens; Female; Gastrointestinal Neoplasms; Humans; Liver; Longevity; Lung Neoplasms; Male; Neoplasms; Neoplasms, Radiation-Induced; Sarcoma, Experimental; Sex Factors; Skin Neoplasms; Ultraviolet Rays | 1983 |
The paradigm of two-stage carcinogenesis: a critical attitude.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Drug Interactions; Hyperplasia; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasms; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1984 |
Biotransformation and bioactivation of 7, 12-dimethylbenz[a]anthracene (7, 12-DMBA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Glands; Animals; Benz(a)Anthracenes; Breast; Carcinogens; Female; Humans; Liver; Lung; Methylcholanthrene; Mice; Mutagens; Organ Specificity; Oxidation-Reduction; Rats; Skin; Skin Neoplasms; Structure-Activity Relationship | 1980 |
Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Carcinogens; Cell Communication; Cell Differentiation; Cell Division; Cocarcinogenesis; DNA; Indomethacin; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Transgenic approaches to the analysis of ras and p53 function in multistage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Genes, p53; Genes, ras; Mice; Mice, Transgenic; Mutation; Neoplasms, Radiation-Induced; Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Catalase; Cricetinae; Humans; Mice; Rats; Skin Neoplasms; Superoxide Dismutase | 1995 |
Role of the epidermal growth factor receptor and transforming growth factor alpha in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Disease Progression; ErbB Receptors; Mice; Models, Biological; Papilloma; Phorbol Esters; Precancerous Conditions; Skin Neoplasms; Transforming Growth Factor alpha | 1994 |
Green tea and skin--anticarcinogenic effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Dermatitis; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1994 |
Histopathology of human intraepithelial neoplasia with implications for chemoprevention strategy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Anticarcinogenic Agents; Epithelium; Female; Humans; Mice; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms | 1993 |
Genetic susceptibility to tumor progression in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Crosses, Genetic; Disease Progression; Disease Susceptibility; Hyperplasia; Mice; Mice, Inbred SENCAR; Mice, Inbred Strains; Papilloma; Precancerous Conditions; Skin; Skin Neoplasms | 1996 |
Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Epidermal Growth Factor; ErbB Receptors; Gene Targeting; Hair; Mice; Mice, Knockout; Mice, Mutant Strains; Multigene Family; Mutagenesis, Insertional; Papilloma; Recombination, Genetic; Signal Transduction; Skin Neoplasms; Transforming Growth Factor alpha; Vibrissae; Wound Healing | 1994 |
Upregulation of E2F transcription factors in chemically induced mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F3 Transcription Factor; E2F4 Transcription Factor; E2F5 Transcription Factor; Female; Mice; Papilloma; Retinoblastoma-Binding Protein 1; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor DP1; Transcription Factors; Up-Regulation | 1999 |
Speculations on the role of ultraviolet radiation in the development of malignant melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Croton Oil; Humans; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Skin Neoplasms; Transplantation, Isogeneic; Ultraviolet Rays | 1979 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
Cutaneous chemical carcinogenesis: past, present, and future.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Carcinogens; Cell Division; Cells, Cultured; Chemical Phenomena; Chemistry; Croton Oil; Culture Media; Disease Models, Animal; DNA, Neoplasm; Drug Synergism; Kinetics; Methylnitronitrosoguanidine; Mice; Ornithine Decarboxylase; RNA, Neoplasm; Skin Neoplasms | 1976 |
Studies and perspectives of signal transduction in the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Communication; Humans; Keratinocytes; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Immunobiology of primary murine melanomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Melanoma; Mice; Mice, Inbred C3H; Phorbol Esters; Skin Neoplasms; Ultraviolet Rays | 1992 |
Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinoma; Epithelium; Humans; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Differential gene expression during tumor promotion and progression in the mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA; Gene Expression Regulation, Neoplastic; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Multiple Primary; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ubiquitins | 1991 |
Ultraviolet radiation and the development of non-melanoma and melanoma skin cancer: clinical and experimental evidence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Humans; Melanoma; Mice; Neoplasms, Radiation-Induced; Skin Neoplasms; Sunlight; Ultraviolet Rays | 1991 |
ras activation in human tumors and in animal model systems.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; DNA Damage; DNA Mutational Analysis; DNA, Neoplasm; Enzyme Activation; Female; Gamma Rays; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Keratoacanthoma; Lymphoma; Mice; Neoplasms, Radiation-Induced; Neutrons; Polymerase Chain Reaction; Proto-Oncogene Proteins p21(ras); Rabbits; Skin Neoplasms; Thymus Neoplasms | 1991 |
Modification of multistage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Mice; Precancerous Conditions; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1991 |
Chemoprevention of mammary cancer by retinoids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Drug Synergism; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms, Hormone-Dependent; Organ Specificity; Rats; Retinoids; Skin Neoplasms; Species Specificity | 1990 |
The premalignant nature of mouse skin papillomas: histopathologic, cytogenetic, and biochemical evidence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Disorders; Karyotyping; Keratins; Mice; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Genetic background and development of skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Disease Susceptibility; Guinea Pigs; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbol Esters; Rats; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1989 |
Development of murine skin neoplasia studied with enzymes used as cell markers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinoma; Fibrosarcoma; Mice; Papilloma; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
The action of oncogenes and growth factors in tumour initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Gene Expression Regulation; Genes, ras; Methylnitronitrosoguanidine; Mice; Mutation; Oncogenes; Restriction Mapping; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1989 |
Investigations of multistage carcinogenesis: applications of in vitro-in vivo studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Methylnitronitrosoguanidine; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Oncogenes and human cancer: cause or consequence?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Chromosome Mapping; Gene Expression Regulation; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes; Proto-Oncogenes; Rats; Retroviridae; Skin Neoplasms | 1986 |
Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adolescent; Adult; Animals; Bacteria; Bacterial Physiological Phenomena; beta Carotene; Canthaxanthin; Carotenoids; Child; Child, Preschool; Diet; Humans; Infant; Light; Neoplasms; Neoplasms, Experimental; Photochemistry; Photosensitivity Disorders; Porphyrias; Protoporphyrins; Skin Diseases; Skin Neoplasms; Sunburn; Sunlight; Ultraviolet Rays | 1986 |
SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Disease Models, Animal; Drug Evaluation, Preclinical; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Three stage carcinogenesis in mouse skin--recent results and present status of an advanced model system of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms | 1987 |
1386 other study(ies) available for 9,10-dimethyl-1,2-benzanthracene and Skin Neoplasms
| Article | Year |
|---|---|
Anticancer and antimutagenic activity of Silybum marianum L. and Eucalyptus camaldulensis Dehnh. against skin cancer induced by DMBA: In vitro and in vivo models.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Carcinogens; Carcinoma; Cell Proliferation; Drug Screening Assays, Antitumor; Eucalyptus; Humans; In Vitro Techniques; Lymphocytes; Mice; Oxidative Stress; Plant Extracts; Plant Leaves; Silybum marianum; Skin; Skin Neoplasms; Tumor Burden | 2021 |
IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Mice; Mice, Knockout; Papilloma; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 2022 |
P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Catenin; Carcinogenesis; Hyperplasia; Keratinocytes; Mice; Receptors, Purinergic P2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wnt Signaling Pathway; YAP-Signaling Proteins | 2022 |
Isolation of cancer stem cells from skin squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Humans; Mice; Neoplastic Stem Cells; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2022 |
Tumor preventive and antioxidant efficacy of chlorogenic acid-loaded chitosan nanoparticles in experimental skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogenesis; Carcinoma, Squamous Cell; Chitosan; Chlorogenic Acid; Mice; Nanoparticles; Skin Neoplasms | 2023 |
Oral Intake of Combined Natural Immunostimulants Suppresses the 7,12-DMBA/ Croton Oil Induced Two-step Skin Carcinogenesis in Swiss Albino Mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Animals; Antioxidants; beta-Glucans; Carcinogenesis; Catalase; Croton Oil; Hydrogen Peroxide; Hyperplasia; Mice; Papilloma; Skin Neoplasms; Superoxide Dismutase | 2023 |
C-type natriuretic peptide (CNP) inhibits 7,12-Dimethylbenz[a]anthracene (DMBA)/Croton oil-induced skin tumor growth by modulating inflammation in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Anti-Inflammatory Agents; Body Weight; Croton; Croton Oil; Inflammation; Mice; Natriuretic Peptide, C-Type; Skin Neoplasms | 2023 |
Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Croton Oil; Flavanones; Mice; Plant Extracts; Skin Neoplasms | 2020 |
Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Female; Furans; Kidney; Lactones; Liver; Mice; Mice, Inbred ICR; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Female; Humans; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinogens; Cell Line; Cytokines; Female; Flavonoids; Mice, Inbred ICR; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2020 |
Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Calcium Channel Blockers; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Dihydropyridines; Male; Mice; Organ Size; Skin Neoplasms; Tumor Cells, Cultured | 2020 |
Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Movement; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Humans; Male; Mice; Mice, Inbred C57BL; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor-Associated Macrophages; Wnt3A Protein | 2020 |
Curcumin Enriched VCO Protects against 7,12-Dimethyl Benz[a] Anthracene-Induced Skin Papilloma in Mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Coconut Oil; Curcumin; Mice; Papilloma; Plant Extracts; Skin Neoplasms; Tumor Microenvironment | 2021 |
Chemopreventive activity of hydroethanolic
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Mice; Murraya; Plant Extracts; Plant Leaves; Skin Neoplasms | 2021 |
Evaluating antitumor activity of antiglypican-3 therapy in experimentally induced skin cancer in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogenesis; Carcinogens; Drug Screening Assays, Antitumor; Glypicans; Humans; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms | 2021 |
β-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-κB-associated signaling events in the mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Mice; NF-kappa B; Sesquiterpenes; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2020 |
C3 Drives Inflammatory Skin Carcinogenesis Independently of C5.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Complement Activation; Complement C3; Complement C5; Complement Membrane Attack Complex; Disease Models, Animal; Disease Progression; Humans; Mice; Mice, Knockout; Mice, Transgenic; Neoplasms, Experimental; Receptor, Anaphylatoxin C5a; Receptors, Complement; Signal Transduction; Skin; Skin Neoplasms; Tumor Escape | 2021 |
Integrin α3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Epidermis; Humans; Integrin alpha3beta1; Kalinin; Keratinocytes; Mice; Neoplasms, Experimental; Signal Transduction; Skin Neoplasms; Spheroids, Cellular; Tetradecanoylphorbol Acetate; Tetraspanin 24 | 2021 |
Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; cdc25 Phosphatases; Cell Line, Tumor; Cytoplasm; Female; Humans; Keratinocytes; Male; Mice; Mice, Knockout; Neoplasms, Experimental; Protein Multimerization; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2021 |
Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, Reverse Inflammation, and Metabolic Alteration.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Borates; Carcinogens; Fructose; Inflammation; Mice; Mice, Inbred BALB C; Skin; Skin Neoplasms | 2021 |
Regulatory T Cells Play an Important Role in the Prevention of Murine Melanocytic Nevi and Melanomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CD4 Antigens; CD8 Antigens; Female; Humans; Immune Tolerance; Male; Melanoma, Experimental; Mice; Mice, Knockout; Nevus, Pigmented; Skin; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 2021 |
3'-Hydroxypterostilbene Inhibits 7,12-Dimethylbenz[a]anthracene (DMBA)/12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Mouse Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Cyclooxygenase 2; Drug Eruptions; Female; Gene Expression Regulation; Humans; Keratinocytes; Mice, Inbred ICR; Ornithine Decarboxylase; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2021 |
Chemopreventive effect of dieckol against 7,12-dimethylbenz(a)anthracene induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Antioxidants; Benzofurans; Biomarkers; Carcinogenesis; Mice; Skin Neoplasms | 2021 |
Analyzing skin tumor development in mice by the DMBA/TPA model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Humans; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cyclooxygenase 2; Cytokines; Dinoprostone; Mice; Mice, Inbred BALB C; Prostaglandin-E Synthases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Antitumor Effect of
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Caco-2 Cells; Chymotrypsin; Drug Evaluation, Preclinical; Female; Humans; Inula; Mice; Molecular Docking Simulation; Papilloma; Plant Extracts; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Skin Neoplasms; Toxicity Tests | 2021 |
Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aged; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; ErbB Receptors; Female; Homeodomain Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Grading; Receptor, ErbB-2; Signal Transduction; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Transcription Factors | 2021 |
DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; DNA Methylation; Epigenesis, Genetic; Female; Fibroblasts; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin-1alpha; Membrane Proteins; Mice; Microscopy, Fluorescence; Papilloma; Phenotype; Secretory Pathway; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Chemoprotective Effect of Boeravinone B against DMBA/Croton Oil Induced Skin Cancer via Reduction of Inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Croton Oil; Cytokines; Flavonoids; Inflammation; Inflammation Mediators; Mice; Skin Neoplasms; Tumor Burden | 2021 |
Pro-apoptotic activity of nano-escheriosome based oleic acid conjugate against 7,12-dimethylbenz(a)anthracene (DMBA) induced cutaneous carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Liposomes; Male; Mice; Models, Animal; Nanoparticles; Oleic Acid; Papilloma; Skin Neoplasms | 2017 |
E1a is an exogenous in vivo tumour suppressor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenovirus E1A Proteins; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Female; HCT116 Cells; Humans; Melanoma, Experimental; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Burden; Tumor Suppressor Proteins | 2017 |
Folic Acid Modulates DMBA/TPA-Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Epidermis; Folic Acid; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Proliferating Cell Nuclear Antigen; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin B Complex | 2018 |
LTA4H regulates cell cycle and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Cycle; Cyclin-Dependent Kinase 2; Epoxide Hydrolases; G1 Phase; Humans; Mice; Phosphorylation; Proliferating Cell Nuclear Antigen; Pyridines; Skin Neoplasms | 2017 |
α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Carcinogens; Dose-Response Relationship, Drug; Female; Inflammation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Random Allocation; Signal Transduction; Skin Neoplasms; TOR Serine-Threonine Kinases; Xanthones | 2017 |
PAD2 overexpression in transgenic mice augments malignancy and tumor-associated inflammation in chemically initiated skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Male; Mice; Mice, Transgenic; Papilloma; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2017 |
Annona muricata leaves extracts prevent DMBA/TPA-induced skin tumorigenesis via modulating antioxidants enzymes system in ICR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Annona; Antioxidants; Carcinogenesis; Furans; Lactones; Male; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2017 |
Dendrimer conjugated estramustine nanocrystalline 'Dendot': An effective inhibitor of DMBA-TPA induced papilloma formation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Proliferation; Dendrimers; Estramustine; Female; Intestines; Kidney; Liver; Mice; Nanoparticles; Papilloma; Skin Neoplasms; Stomach; Tetradecanoylphorbol Acetate | 2017 |
Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Animals; Carcinogens; Croton Oil; Dietary Supplements; Female; Free Radical Scavengers; Inflammation; Lipid Peroxidation; Mice; Molybdenum; N-Formylmethionine; Palladium; Papilloma; Rhodium; Ruthenium; Skin Neoplasms; Thioctic Acid; Vitamin B Complex | 2017 |
PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Genes, Tumor Suppressor; Humans; Keratinocytes; Mice; Mice, Knockout; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction; Skin Neoplasms | 2018 |
Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Diterpenes; Down-Regulation; Epidermis; Female; Hyperplasia; Inflammation; Melanoma; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
Intense Pulsed Light: Friend or Foe? Molecular Evidence to Clarify Doubts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Disease Models, Animal; Female; Glycolysis; Intense Pulsed Light Therapy; Keratins; Mice; Mice, Inbred ICR; Oxidative Stress; Random Allocation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinogenesis; Colchicine; Disease Models, Animal; Fluorouracil; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Tubulin Modulators | 2018 |
Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Humans; Lactones; Male; Mice; Mice, Hairless; Molecular Structure; NF-E2-Related Factor 2; Oxidative Stress; Skin Neoplasms; Structure-Activity Relationship | 2018 |
The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogenesis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Female; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Sesquiterpenes; Skin Neoplasms; Treatment Outcome | 2018 |
Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Cytokines; Drug Administration Schedule; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Mice; Phenols; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2018 |
Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Lineage; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Clonal Evolution; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Genetic Predisposition to Disease; Male; Mice, Transgenic; Mutation; Neoplasms, Experimental; Phenotype; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Burden | 2018 |
TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Mice, Knockout; Mice, Nude; Phosphoproteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Transcription Factors; Tumor Burden; Tumor Suppressor Proteins; Wnt Signaling Pathway | 2018 |
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes; Mice; Mice, Knockout; ras Proteins; Receptors, Death Domain; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2018 |
Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Bone Morphogenetic Protein 5; Cell Movement; Cell Plasticity; Cell Transformation, Neoplastic; Coculture Techniques; Epithelial Cells; Female; Hair Follicle; HMGB1 Protein; Keratinocytes; Keratins; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Papilloma; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2018 |
Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Male; Mice; Monoterpenes; Random Allocation; Skin Neoplasms; Treatment Outcome; Xenobiotics | 2019 |
Pre-Exposure to Chronic Unpredictable Stress Suppresses the Chemopreventive Potential of Aloe Vera (Av) Leaf Gel Against 7,12-Dimethylbenz(a)anthracene (DMBA) Induced Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Chemoprevention; Male; Mice; Plant Preparations; Random Allocation; Skin Neoplasms; Stress, Physiological; Tetradecanoylphorbol Acetate | 2019 |
Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; NF-kappa B; Nicotinic Acids; Nitriles; Piperidines; Pyrrolidines; Skin; Skin Neoplasms | 2019 |
[Role of clock proteins in skin carcinogenesis in 14-month-old SHR mice maintained under disrupted light regimen].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ARNTL Transcription Factors; Cell Transformation, Neoplastic; CLOCK Proteins; Cryptochromes; Gene Expression Regulation, Neoplastic; Lighting; Male; Mice; Neoplasm Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
XB130 deficiency enhances carcinogen-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Female; Genes, Tumor Suppressor; Inflammation; Male; Mice; Mice, Knockout; Microfilament Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Blocking Wnt as a therapeutic target in mice model of skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogenesis; Croton Oil; Cytokines; Drug Screening Assays, Antitumor; Epidermis; Fibrosis; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasms, Experimental; NF-kappa B; Skin Neoplasms; Wnt Proteins; Wnt Signaling Pathway | 2019 |
Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Canthaxanthin; Carotenoids; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Lipid Peroxidation; Mice; Mice, Inbred ICR; Molecular Structure; Paracoccus; Singlet Oxygen; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Viral Matrix Proteins | 2013 |
Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Biological Availability; Carcinogens; Chlorophyta; Esters; Monophenol Monooxygenase; Rats; Rats, Wistar; Skin Neoplasms; Vitamin A; Xanthophylls | 2013 |
Chemopreventive effects of the juice of Vitis coignetiae Pulliat on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Fruit; Mice; Mice, Inbred SENCAR; Phenols; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2013 |
Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Antioxidants; Carcinogenesis; Female; Genes, Tumor Suppressor; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Peroxiredoxin VI; Reactive Oxygen Species; Skin Neoplasms | 2013 |
Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra-short-term skin carcinogenesis bioassay using rasH2 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Carcinogenesis; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Breast Neoplasms; Carcinogens; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Fibroblasts; Humans; Lung; Mice; Mice, Inbred ICR; Morpholines; Papilloma; Piperazines; Siloxanes; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate | 2013 |
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Female; Genes, ras; Keratinocytes; Male; Mice; Mice, Knockout; Nuclear Proteins; Oncogene Protein p21(ras); Protein Inhibitors of Activated STAT; Proto-Oncogene Proteins c-myc; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2013 |
Modulatory effects of Azadirachta indica leaf extract on cutaneous and hepatic biochemical status during promotion phase of DMBA/TPA-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Azadirachta; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Cytochromes b5; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Mice; Micronucleus Tests; Neoplasms, Experimental; Phytotherapy; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xenobiotics | 2013 |
Isolation of a quinone-rich fraction from Ardisia crispa roots and its attenuating effects on murine skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ardisia; Benzoquinones; Carcinogens; Cell Transformation, Neoplastic; Female; Gas Chromatography-Mass Spectrometry; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Skin Neoplasms | 2013 |
Fermented Prunus mume with probiotics inhibits 7,12-dimethylbenz[a]anthracene and 12-o-tetradecanoyl phorbol-13-acetate induced skin carcinogenesis through alleviation of oxidative stress.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Cell Proliferation; Cell Transformation, Neoplastic; Diet; Female; Fermentation; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Oxidative Stress; Plant Preparations; Probiotics; Prunus; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2013 |
Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Movement; Fibrosarcoma; Genotype; Hepatocyte Growth Factor; Interferon Type I; Macrophages, Peritoneal; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Skin Neoplasms; Th1-Th2 Balance; Toll-Like Receptor 4; Transcriptional Activation; Transcriptome | 2013 |
Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Proliferation; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Glucaric Acid; Humans; Interleukin-6; Mice; Mice, Inbred SENCAR; Phytochemicals; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2013 |
Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cannabinoids; Cocarcinogenesis; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Molecular Structure; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2013 |
In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Movement; Epithelium; Female; Homeodomain Proteins; Humans; Keratinocytes; Male; Mice; Mice, Transgenic; Nanog Homeobox Protein; Papilloma; Phenotype; Skin; Skin Neoplasms; Tongue; Wound Healing | 2013 |
Chemoprevention of skin cancer: effect of Lawsonia inermis L. (Henna) leaf powder and its pigment artifact, lawsone in the Epstein- Barr virus early antigen activation assay and in two-stage mouse skin carcinogenesis models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Administration, Oral; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Carcinogenesis; Cell Line, Tumor; Female; Herpesvirus 4, Human; Humans; Lawsonia Plant; Male; Naphthoquinones; Papilloma; Plant Extracts; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2013 |
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Hair Follicle; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Reactive Oxygen Species; Skin Neoplasms; Structure-Activity Relationship | 2014 |
Chemopreventive effect of Lagenaria siceraria in two stages DMBA plus croton oil induced skin papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemoprevention; Croton Oil; Cucurbitaceae; Male; Medicine, Traditional; Mice; Phytotherapy; Plant Extracts; Skin Neoplasms | 2013 |
Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-2 | 2015 |
Study on extraction process of tannins from Semen Cuscutae and their anti-papilloma activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Croton Oil; Cuscuta; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred Strains; Papilloma; Phytotherapy; Plant Extracts; Seeds; Skin Neoplasms; Tannins | 2013 |
Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activins; Animals; Carcinogens; Carcinoma, Squamous Cell; Chemotaxis; Female; Humans; Injections, Intralesional; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neovascularization, Pathologic; Neutrophil Infiltration; Papilloma; Proto-Oncogene Proteins c-kit; Recombinant Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2013 |
Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Enzyme Inhibitors; Farnesyltranstransferase; Gene Dosage; Gene Knock-In Techniques; Genes, ras; Humans; Mice, Mutant Strains; Mutation; Papilloma; Piperidines; Pyridines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Apoptosis; Calendula; Carcinogenesis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Chemoprevention; Eclipta; Female; Free Radicals; Immunologic Surveillance; Inflammation; Langerhans Cells; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trigonella; Tumor Suppressor Protein p53 | 2014 |
Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Berberine Alkaloids; Carcinogens; Catalase; Cell Transformation, Neoplastic; Chemoprevention; Croton Oil; Disease Models, Animal; DNA Damage; Glutathione; Mice; Oxidative Stress; Plant Extracts; Skin Neoplasms; Superoxide Dismutase; Tinospora | 2013 |
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytokines; Dendritic Cells; Female; Gene Expression Regulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Knockout; Papilloma; Signal Transduction; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate; Th1-Th2 Balance | 2014 |
IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytokines; Interleukin-13 Receptor alpha1 Subunit; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Knockout; Papilloma; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
S100A9 has a protective role in inflammation-induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calgranulin A; Calgranulin B; Carcinogenesis; Cell Transformation, Neoplastic; Dimerization; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2014 |
Mast cells protect from skin tumor development and limit tumor growth during cutaneous de novo carcinogenesis in a Kit-dependent mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adoptive Transfer; Animals; Carcinogenesis; Cell Count; Cell Degranulation; Cytoprotection; Disease Models, Animal; Female; Granulocytes; Macrophages; Mast Cells; Mice; Proto-Oncogene Proteins c-kit; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden | 2014 |
Topical application of Gallic acid suppresses the 7,12-DMBA/Croton oil induced two-step skin carcinogenesis by modulating anti-oxidants and MMP-2/MMP-9 in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antioxidants; Carcinogens; Croton Oil; Gallic Acid; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Papilloma; Skin Neoplasms | 2014 |
Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Membrane Permeability; Cell Proliferation; Epidermis; Fluorescent Antibody Technique; Immunoenzyme Techniques; Mast Cells; Mice; Mice, Knockout; Papilloma; Real-Time Polymerase Chain Reaction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured | 2014 |
Induction of neoplastic cells in rat skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biopsy; Carcinogens; Epidermis; Hydrocarbons; Keratosis; Male; Neoplasms, Radiation-Induced; Rats; Rats, Wistar; Reference Values; Skin Neoplasms; Sunlight; Time Factors; Ultraviolet Rays | 2014 |
Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin Immunoprecipitation; Dermis; Female; Fibroblasts; Humans; Immunoenzyme Techniques; Keratinocytes; Mice; Mice, Knockout; PPAR delta; PPAR-beta; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin Neoplasms | 2014 |
DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinogenesis; Carcinogens; Carcinoma, Basal Cell; CD4-Positive T-Lymphocytes; Disease Models, Animal; Epidermis; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Patched Receptors; Patched-1 Receptor; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2014 |
The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Synergism; Female; gamma-Cyclodextrins; Humans; Melanoma; Mice; Oleanolic Acid; Skin Neoplasms; Solubility; Triterpenes; Ultraviolet Rays; Ursolic Acid | 2014 |
Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Carotenoids; Chemoprevention; Female; Glutathione; Lipid Peroxidation; Lycopene; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; DNA Methylation; Down-Regulation; Female; Histone Deacetylases; Mice; MicroRNAs; Promoter Regions, Genetic; Skin Neoplasms; Time Factors; Up-Regulation | 2014 |
Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basement Membrane; Blood Vessels; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type IV; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neoplasm Invasiveness; Nerve Tissue Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden | 2014 |
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Communication; Cell Differentiation; Cell Transformation, Neoplastic; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Keratinocytes; Membrane Proteins; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; NK Cell Lectin-Like Receptor Subfamily K; Papilloma; Permeability; Plakins; Protein Precursors; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymic Stromal Lymphopoietin; Time Factors | 2014 |
Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; ADAM Proteins; ADAM17 Protein; Animals; Antineoplastic Agents; Cocarcinogenesis; Cytokines; Dose-Response Relationship, Drug; Edema; Female; Hydroxamic Acids; Mice, Inbred BALB C; Pyrrolidinones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Epidermal p65/NF-κB signalling is essential for skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Gene Deletion; Keratinocytes; Mice; NF-kappa B; Signal Transduction; Skin; Skin Neoplasms; Transcription Factor RelA | 2014 |
Carcinogen-induced skin tumor development requires leukocytic expression of the transcription factor Runx3.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Core Binding Factor Alpha 3 Subunit; Cytokines; Disease Models, Animal; Flow Cytometry; Immunoblotting; Immunohistochemistry; Leukocytes; Mice; Mice, Knockout; Polymerase Chain Reaction; Pyridines; Skin Neoplasms | 2014 |
Meis1 regulates epidermal stem cells and is required for skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult Stem Cells; Animals; Carcinogens; Carcinoma; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Gene Expression Regulation, Neoplastic; Hair Follicle; Homeodomain Proteins; Keratinocytes; Mice; Mice, Transgenic; Multipotent Stem Cells; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
In vivo long-term effects of retinoic acid exposure in utero on induced tumours in adult mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Keratoacanthoma; Male; Mice; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome; Tretinoin | 2014 |
Comparison of dermal tumor promotion activity of cigarette smoke condensate from prototype (heated) cigarette and reference (combusted) cigarette in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred SENCAR; Organ Size; Skin; Skin Neoplasms; Smoking; Tobacco Products | 2014 |
Atrial natriuretic peptide (ANP) inhibits DMBA/croton oil induced skin tumor growth by modulating NF-κB, MMPs, and infiltrating mast cells in swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Atrial Natriuretic Factor; C-Reactive Protein; Catalase; Cell Count; Croton Oil; Isoenzymes; L-Lactate Dehydrogenase; Mast Cells; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; NF-kappa B; Skin; Skin Neoplasms; Superoxide Dismutase; Tumor Burden | 2014 |
Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Proliferation; Cyclooxygenase 2; Eicosanoids; Epidermis; Epithelial Cells; Gene Deletion; Gene Targeting; Hyperplasia; Keratinocytes; Lipid Metabolism; Macrophages; Mice; Myeloid Cells; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; CpG Islands; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome; Inflammation; Mice; Sequence Analysis, DNA; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2014 |
Photodynamic therapy using a novel irradiation source, LED lamp, is similarly effective to photodynamic therapy using diode laser or metal-halide lamp on DMBA- and TPA-induced mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Lasers, Semiconductor; Mice; Mice, Hairless; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Non-Structural protein 1 (NS1) gene of Canine Parvovirus-2 regresses chemically induced skin tumors in Wistar rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Dog Diseases; Dogs; Genetic Therapy; Male; Mitotic Index; Parvovirus, Canine; Rats; Rats, Wistar; Skin Neoplasms; Treatment Outcome; Viral Nonstructural Proteins | 2014 |
Chemopreventive activity of turmeric essential oil and possible mechanisms of action.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Croton Oil; Curcuma; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Oils, Volatile; Papilloma; Plant Extracts; Rats; Rats, Wistar; Skin; Skin Neoplasms | 2014 |
Cells of origin in skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinoma, Basal Cell; CD4-Positive T-Lymphocytes; Epidermis; Patched Receptors; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cytochrome P-450 CYP1B1; Disease Models, Animal; Keratinocytes; Langerhans Cells; Mice; Mice, Knockout; Mutagens; Skin Neoplasms | 2015 |
Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Female; Inflammasomes; Lymph Nodes; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Skin Neoplasms | 2014 |
Inflammation-driven carcinogenesis is mediated through STING.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cytokines; Exodeoxyribonucleases; Female; Humans; Membrane Proteins; Mice; Mice, Knockout; Phosphoproteins; Skin Neoplasms | 2014 |
Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Administration, Topical; Animals; Antioxidants; Biomarkers; Carcinoma, Squamous Cell; Catechin; Dinoprostone; Drug Evaluation, Preclinical; Emulsions; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
In vivo nonlinear optical imaging to monitor early microscopic changes in a murine cutaneous squamous cell carcinoma model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Humans; Mice; Nonlinear Dynamics; Optical Imaging; Skin; Skin Neoplasms | 2015 |
Prevention of skin carcinogenesis by the β-blocker carvedilol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenergic beta-Antagonists; Animals; Anticarcinogenic Agents; Atenolol; Carbazoles; Carvedilol; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Isoproterenol; Mice; Mutation; Neoplasm Transplantation; Propanolamines; Skin Neoplasms; Transcription Factor AP-1 | 2015 |
Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Disease Models, Animal; Ear; Epidermis; Inflammation; Mice; Mice, Inbred C57BL; Phorbol Esters; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-kit; Receptors, G-Protein-Coupled; Skin Neoplasms | 2014 |
Chemopreventive activity of methanol extract of Melastoma malabathricum leaves in DMBA-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogenesis; Croton Oil; Curcumin; Female; Melastomataceae; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms | 2014 |
Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Croton; Cyclooxygenase 2; Disease Progression; Drug Evaluation, Preclinical; Female; Glutathione; Hydrogen Peroxide; Interleukin-6; Lipid Peroxidation; Mice; Nitric Oxide Synthase Type II; Plant Oils; Proliferating Cell Nuclear Antigen; Skin; Skin Neoplasms; Tannins; Xanthine Oxidase | 2015 |
Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Biological Products; Butyric Acid; Carcinogenesis; Caspases; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c1; Cytoplasm; Drug Interactions; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Glucaric Acid; Mice; Mitochondria; Niacinamide; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Skin Neoplasms | 2015 |
Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cells, Cultured; Keratinocytes; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; NF-kappa B; Phosphoprotein Phosphatases; Signal Transduction; Skin; Skin Neoplasms | 2015 |
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Nucleus; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Mice; Mice, Knockout; Plasminogen Activator Inhibitor 2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Carcinogenesis; Cell Movement; Cell Proliferation; DNA, Complementary; Endoglin; Enzyme Activation; Female; HEK293 Cells; Hepatocyte Growth Factor; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Prognosis; Proto-Oncogene Proteins c-met; Receptors, Cell Surface; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2015 |
Riboflavin as adjuvant with cisplatin: study in mouse skin cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Body Weight; Carcinoma, Squamous Cell; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Glutathione; Kidney; Liver; Male; Malondialdehyde; Mice; Photosensitizing Agents; Random Allocation; Riboflavin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinogenesis; Carcinogens; Cell Lineage; Cell Proliferation; Cell Separation; Cell Transformation, Neoplastic; Crosses, Genetic; Disease Progression; DNA Damage; Epidermis; Flow Cytometry; Humans; Lymphoid Enhancer-Binding Factor 1; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Phenotype; Sebaceous Gland Neoplasms; Skin Neoplasms; Stem Cells; Tumor Suppressor Protein p53; Ultraviolet Rays | 2015 |
Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Autophagy; Cell Line, Tumor; DNA Damage; Humans; Melanoma; Mice; Phytotherapy; Plant Extracts; Ruta; Skin Neoplasms | 2015 |
Mouse models of nonmelanoma skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Culture Techniques; DNA; Epidermis; Humans; Keratinocytes; Mice; Skin Neoplasms; Staining and Labeling; Tamoxifen; Tetradecanoylphorbol Acetate | 2015 |
Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cancer Vaccines; Carcinogens; CD8-Positive T-Lymphocytes; Cytokines; Dendritic Cells; DNA Mutational Analysis; Epitopes; Female; Genes, ras; HEK293 Cells; Humans; Immunotherapy, Adoptive; Mice, Inbred C3H; Mice, Inbred Strains; Point Mutation; Skin Neoplasms; T-Lymphocytes, Cytotoxic; Treatment Outcome; Tumor Burden | 2015 |
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Glutathione; Head and Neck Neoplasms; Heterografts; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; NF-E2-Related Factor 2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2015 |
Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogenesis; Carcinogens; Cells, Cultured; Chemoprevention; DNA Damage; Down-Regulation; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Sirolimus; Skin Neoplasms | 2015 |
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Carrier Proteins; Caspase 3; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chemoprevention; Keratinocytes; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Ultraviolet Rays | 2015 |
Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Differentiation; Cell Proliferation; Cells, Cultured; Fluorescent Antibody Technique; Hematopoiesis; Immunoenzyme Techniques; Inflammation; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Progenitor Cells; Neoplasms, Experimental; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Snail Family Transcription Factors; Transcription Factors | 2015 |
A murine model for the development of melanocytic nevi and their progression to melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Cell Separation; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Disease Progression; Melanoma; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Nevus, Pigmented; ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Epidermis; Female; Histones; Humans; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mutation; ras Proteins; Repressor Proteins; Skin Neoplasms; Telomere; Telomere Homeostasis; Telomere Shortening | 2015 |
In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Female; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Immune Tolerance; Mice; Mice, Inbred C3H; Skin Neoplasms | 2015 |
Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capsaicin; Carcinogenesis; Cyclooxygenase 2; Female; Hyperplasia; Inflammation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2015 |
Caspase-3 promotes genetic instability and carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Breast; Caspase 3; Cells, Cultured; Endodeoxyribonucleases; Epithelial Cells; Female; Genome; Genomic Instability; Humans; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Dermis; Desmoglein 2; Epidermis; Gene Knock-In Techniques; Genes, Reporter; Genetic Predisposition to Disease; Genotype; Hair Follicle; Hedgehog Proteins; Hyperplasia; Keratinocytes; Mice; Mice, Transgenic; Papilloma; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate; Time Factors | 2015 |
Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma; Chemoprevention; Cyclooxygenase 2; Dermatitis; Female; Glutathione; Inflammation; Menthol; Mice, Inbred ICR; Neoplasms, Experimental; Oxidative Stress; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activating Transcription Factor 2; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Carrier Proteins; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 4; Epidermis; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Mice; Mice, Inbred DBA; Naphthoquinones; Proto-Oncogene Proteins c-fos; Pyridines; Signal Transduction; Skin Neoplasms; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Transcriptional Activation | 2015 |
Twist1 regulates keratinocyte proliferation and skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Keratinocytes; Mice; Mice, Transgenic; Nuclear Proteins; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Twist-Related Protein 1 | 2016 |
Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Azadirachta; Croton Oil; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Female; Male; Mice; Oxidative Stress; Skin Neoplasms; Stigmasterol | 2015 |
Resistance of R-Ras knockout mice to skin tumour induction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Proliferation; Dermis; Genetic Association Studies; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Knockout; Papilloma; ras Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
The effects of intense pulsed light in a mouse model of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Female; Intense Pulsed Light Therapy; Mice, Inbred DBA; Precancerous Conditions; Skin Neoplasms | 2016 |
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Clonal Evolution; Exome; Female; Genes, ras; Genomics; Humans; Mice; Mutation; Skin Neoplasms | 2015 |
The oncogenic role of GASC1 in chemically induced mouse skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Line, Tumor; Cell Survival; Female; Genetic Association Studies; Genetic Predisposition to Disease; Jumonji Domain-Containing Histone Demethylases; Male; Mice, Inbred C57BL; Mice, Knockout; Oncogenes; Papilloma; Skin Neoplasms; Tumor Burden | 2015 |
Chronic unpredictable stress (CUS) enhances the carcinogenic potential of 7,12-dimethylbenz(a)anthracene (DMBA) and accelerates the onset of tumor development in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cold Temperature; DNA Damage; Male; Mice; Oxidative Stress; Reactive Oxygen Species; Restraint, Physical; Skin Neoplasms; Stress, Psychological | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Carcinoma, Verrucous; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Disease Progression; DNA Transposable Elements; Female; Humans; Mice; Mice, Transgenic; Mouth Neoplasms; Mutagenesis, Insertional; Neoplasm Invasiveness; Oncogenes; Papilloma; Papillomaviridae; Receptor, Notch1; Skin Neoplasms; Specific Pathogen-Free Organisms; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Uterine Cervical Neoplasms | 2015 |
Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP2E1; DNA Damage; Hair Follicle; Keratinocytes; Mice; Mice, Knockout; NFATC Transcription Factors; Papilloma; Skin; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2015 |
Chemomodulatory Potential of Flaxseed Oil Against DMBA/Croton Oil-Induced Skin Carcinogenesis in Mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogenesis; Carcinogens; Catalase; Croton Oil; Disease Models, Animal; Glutathione; Linseed Oil; Lipid Peroxidation; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Plant Extracts; Skin; Skin Neoplasms | 2016 |
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Clonal Evolution; Crosses, Genetic; Disease Progression; DNA Copy Number Variations; Epithelial-Mesenchymal Transition; Female; Humans; Male; Mice; Mutation; Phylogeny; ras Proteins; Skin Neoplasms | 2015 |
Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Survival; Female; Male; Mice; Mice, Knockout; Mice, Transgenic; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2016 |
Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Ardisia; Cell Transformation, Neoplastic; Chemical Fractionation; Chemoprevention; Curcumin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plant Roots; Quinones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2015 |
Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Blotting, Western; Butyric Acid; Glucaric Acid; Mice; MicroRNAs; Niacinamide; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Skin Neoplasms | 2016 |
Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Catalase; Cell Transformation, Neoplastic; Croton Oil; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Glutathione; Magnoliopsida; Male; Methanol; Mice, Inbred BALB C; Mutation; Oxidative Stress; Papilloma; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Salmonella typhimurium; Skin Neoplasms; Sodium Fluoride; Solvents; Superoxide Dismutase; Time Factors | 2016 |
Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biopsy, Needle; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Disease Models, Animal; DNA Methylation; Down-Regulation; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Retinoic Acid; Skin Neoplasms; Tissue Polypeptide Antigen; Transfection | 2016 |
Studying skin tumourigenesis and progression in immunocompetent hairless SKH1-hr mice using chronic 7,12-dimethylbenz(a)anthracene topical applications to develop a useful experimental skin cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Disease Progression; Female; Mice; Mice, Hairless; Skin Neoplasms | 2017 |
Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cells, Cultured; Epidermis; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Skin Neoplasms; Tumor Suppressor Protein p53 | 2016 |
Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Differentiation; Cell Proliferation; Codon, Nonsense; Disease Models, Animal; Down-Regulation; Epidermal Cells; Epidermis; Exons; Female; Gain of Function Mutation; Gene Deletion; Hair Follicle; Heterozygote; Immunohistochemistry; Integrases; Keratinocytes; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Catalase; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Reactive Oxygen Species; Silybin; Silymarin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2016 |
Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Female; Male; Mice; Mice, Hairless; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Administration of resveratrol enhances cell-cycle arrest followed by apoptosis in DMBA-induced skin carcinogenesis in male Wistar rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Cell Cycle Checkpoints; Male; Rats; Rats, Wistar; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2016 |
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Lymph Nodes; Lymphangiogenesis; Lymphatic Metastasis; Lymphatic Vessels; Lymphocyte Count; Macrophages; Mast Cells; Mice; Mice, Knockout; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor D | 2016 |
Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Mass Index; Carcinogenesis; Carcinogens; Connexins; Crosses, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Predisposition to Disease; Humans; Inflammation; Lipid Metabolism; Male; Mice; Mice, Inbred Strains; Quantitative Trait Loci; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Animals; Cell Movement; Chemokine CXCL10; Cytotoxicity, Immunologic; Female; Humans; Interferon-gamma; Mice; Mice, Inbred C57BL; Receptors, Antigen, T-Cell, gamma-delta; Receptors, CXCR3; Sirolimus; Skin Neoplasms; T-Lymphocyte Subsets; TOR Serine-Threonine Kinases | 2016 |
Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bile Duct Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Hyperplasia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphoproteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2017 |
Suppression of skin tumorigenesis in CD109-deficient mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; Genes, ras; Genetic Predisposition to Disease; Keratinocytes; Mice, Knockout; Mutation; Neoplasm Proteins; NF-E2-Related Factor 2; Papilloma; Phenotype; Phosphorylation; Signal Transduction; Skin Neoplasms; Smad2 Protein; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta1 | 2016 |
Inhibition of Dimethylbenz(a)anthracene (DMBA) - Croton Oil-Induced Mouse Skin Tumorigenesis by Gmelina arborea with Potential Anti-Inflammatory Activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Carcinogenesis; Croton Oil; Lamiaceae; Male; Mice; Papilloma; Plant Bark; Plant Extracts; Skin Neoplasms | 2016 |
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cyclin D1; Daucus carota; G1 Phase; Humans; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Protective Agents; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2017 |
TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Analysis of Variance; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal; Epidermal Cells; Epidermis; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Keratinocytes; Keratosis, Actinic; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 7; Random Allocation; Signal Transduction; Skin Neoplasms; TNF Receptor-Associated Factor 1; Ultraviolet Rays; Up-Regulation | 2017 |
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aged, 80 and over; Amino Acid Oxidoreductases; Animals; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Carcinoma, Squamous Cell; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Laryngeal Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Mice; Middle Aged; Oligonucleotide Array Sequence Analysis; Organ Culture Techniques; Prognosis; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Skin Neoplasms; Snail Family Transcription Factors; Survival Rate; Tissue Array Analysis; Transcription Factors | 2008 |
Tumor suppression by p53 in the absence of Atm.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Loss of Heterozygosity; Mice; Protein Serine-Threonine Kinases; Signal Transduction; Skin Neoplasms; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Epidermis; Keratinocytes; Mice; Mice, Transgenic; Mutation; Skin Neoplasms | 2008 |
Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Carcinogens; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Female; Mice; Mice, Hairless; Oxidative Stress; Pyridoxal Phosphate; Pyridoxine; Skin; Skin Neoplasms; Thiobarbituric Acid Reactive Substances; Ultraviolet Rays; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex | 2008 |
Chemopreventive potential of an Indian medicinal plant (Tinospora cordifolia) on skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; Croton Oil; Disease Models, Animal; Glutathione; India; Male; Medicine, Ayurvedic; Mice; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Thiobarbituric Acid Reactive Substances; Tinospora; Tumor Burden | 2008 |
Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine: a novel candidate in photodynamic therapy for skin cancer models in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Caspase 3; Cyclobutanes; Glucuronidase; Hexokinase; Kidney; L-Lactate Dehydrogenase; Liver; Male; Mice; N-Acetylneuraminic Acid; Neoplasms, Experimental; Peroxidase; Phenols; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Thiosulfate Sulfurtransferase | 2008 |
Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cyclooxygenase 2 Inhibitors; Edema; Female; Hyperplasia; I-kappa B Kinase; I-kappa B Proteins; MAP Kinase Signaling System; Mice; Mice, Inbred SENCAR; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Ornithine Decarboxylase Inhibitors; Phosphorylation; Pregnenediones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinogens; Caspases; Cytochromes c; Cytosol; Down-Regulation; Enzyme Activation; Female; Inhibitor of Apoptosis Proteins; Mice; Microtubule-Associated Proteins; Mitochondria; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Repressor Proteins; Resveratrol; Signal Transduction; Skin Neoplasms; Stilbenes; Survivin; Tumor Suppressor Protein p53 | 2009 |
Protective effect of ferulic acid on 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Antineoplastic Agents; Antioxidants; Carcinogens; Carcinoma, Squamous Cell; Coumaric Acids; Lipid Peroxidation; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Mice; Skin Neoplasms | 2009 |
Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinogens; Cytosol; Foeniculum; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Mice; Microsomes, Liver; Papilloma; Plant Extracts; Skin Neoplasms; Stomach Neoplasms; Xenobiotics | 2008 |
Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Diglycerides; Fatty Acids; Female; Fluocinolone Acetonide; Linoleic Acid; Mice; Oils; Oleic Acid; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; DNA Primers; Genes, Tumor Suppressor; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Polymerase Chain Reaction; Promyelocytic Leukemia Protein; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Proteins | 2009 |
Aryl hydrocarbon receptor polymorphism modulates DMBA-induced inflammation and carcinogenesis in phenotypically selected mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytochrome P-450 CYP1A1; DNA Primers; Inflammation; Interferon-gamma; Interleukin-18; Interleukins; Mice; Neoplasms, Experimental; Phenotype; Polymorphism, Genetic; Receptors, Aryl Hydrocarbon; Skin Neoplasms; Up-Regulation | 2009 |
Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carrier Proteins; Female; Mice; Phosphotransferases (Alcohol Group Acceptor); Sirolimus; Skin Neoplasms; TOR Serine-Threonine Kinases | 2008 |
Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Benz(a)Anthracenes; Biomarkers; Body Weight; Carcinogens; Caspase 3; Cyclooxygenase 2; Female; Garlic; Humans; Lipid Peroxidation; Mice; Papilloma; Plant Extracts; Skin; Skin Neoplasms; Tumor Suppressor Protein p53 | 2009 |
Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Esophageal Neoplasms; Female; Flavonoids; India; Male; Mice; Mice, Inbred Strains; Phenols; Plant Extracts; Polyphenols; Seeds; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2008 |
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Drug Eruptions; Enzyme Activation; Female; Hair Follicle; HeLa Cells; Humans; Keratinocytes; Ligands; Male; Mice; Neutrophils; Protein Kinase C-alpha; Receptors, Interleukin-8B; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Female; Immunity, Cellular; Mice; Mice, Inbred C3H; Mice, Knockout; Neovascularization, Pathologic; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Stilbenes; Toll-Like Receptor 4 | 2009 |
Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cyclin D1; Cyclooxygenase 2; Dinoprostone; Female; Grape Seed Extract; Inflammation; Mice; Papilloma; Plant Extracts; Proanthocyanidins; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Drug Screening Assays, Antitumor; Edema; Extracellular Signal-Regulated MAP Kinases; Female; Hyperplasia; Inflammation; Mice; Monoterpenes; Oxidative Stress; ras Proteins; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Inflammation; Interferon gamma Receptor; Interferon-gamma; Interleukin-17; Mice; Papilloma; Phosphorylation; Receptors, Interferon; Skin Neoplasms; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2009 |
Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle Proteins; Disease Progression; Epithelial Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Selenium-Binding Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Carcinogens; Cell Proliferation; Cells, Cultured; Female; Immunoenzyme Techniques; Integrases; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Radiation-Induced; Skin Neoplasms; Ultraviolet Rays | 2009 |
Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crocus; Female; Mice; Oxidative Stress; Papilloma; Plant Extracts; Skin Neoplasms | 2010 |
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Bromelains; Cyclooxygenase 2 Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Mice; Mitochondria; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2009 |
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Calcium; Caspase 3; Caspase 9; Caspase Inhibitors; Cells, Cultured; Dose-Response Relationship, Drug; Female; Immunohistochemistry; In Situ Nick-End Labeling; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Papilloma; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate | 2009 |
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Genotype; Hyperplasia; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Protein v-akt; Papilloma; Phosphorylation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Caspase 3; Cell Cycle; Chromosome Aberrations; DNA Damage; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Hymecromone; Male; Mice; Micronucleus Tests; Signal Transduction; Skin Neoplasms; Sperm Head | 2009 |
Photodynamic therapy using a novel photosensitizer, EC036, is more effective compared with ATX-S10(Na) photodynamic therapy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Female; Lasers, Semiconductor; Mice; Mice, Hairless; Ointments; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Immunohistochemistry; MAP Kinase Kinase Kinases; Mice; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 2009 |
Inhibition of CREB function in mouse epidermis reduces papilloma formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Epidermis; Female; Genes, ras; In Situ Nick-End Labeling; Keratinocytes; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Air Pollutants; Animals; Benz(a)Anthracenes; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; DNA Damage; Epidermis; Female; Mice; Skin; Skin Neoplasms; Vehicle Emissions | 2009 |
Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coproporphyrinogen Oxidase; Dose-Response Relationship, Drug; Ferrochelatase; Filaggrin Proteins; Humans; Keratinocytes; Light; Methotrexate; Mice; Mice, Nude; Neoplasms, Experimental; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Xenograft Model Antitumor Assays | 2009 |
Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Chemoprevention; Cyclooxygenase 2; Disease Models, Animal; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Farnesol; Inflammation; Mice; Ornithine Decarboxylase; Oxidative Stress; ras Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Blood Vessels; Carcinogens; Cell Transformation, Neoplastic; Female; Genotype; Immunohistochemistry; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neoplasms, Experimental; NIH 3T3 Cells; Resveratrol; Sirtuin 1; Sirtuins; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Kaplan-Meier Estimate; Mice; Mice, Inbred Strains; Papilloma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Catechin; Female; Hippophae; Inflammation; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Increased skin carcinogenesis in caspase-activated DNase knockout mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Conserved Sequence; Crosses, Genetic; Deoxyribonucleases; DNA; DNA Fragmentation; DNA Primers; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neoplasm Staging; Nucleosomes; Skin Neoplasms | 2009 |
[Dimethylarsinous acid-promoted skin tumorigenesis through the induction of oxidative stress in mice].
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cacodylic Acid; Carcinogens; Deoxyguanosine; Female; Mice; Mice, Hairless; Oxidative Stress; Skin Neoplasms | 2009 |
Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspases; Cytochromes c; Enzyme Activation; Flavonoids; Male; Mice; Mitochondria; Models, Biological; Phenols; Phytotherapy; Poly(ADP-ribose) Polymerases; Polyphenols; Signal Transduction; Skin; Skin Neoplasms; Tea; Tumor Suppressor Protein p53 | 2009 |
Prevention of skin cancer by green tea: past, present and future.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Flavonoids; Mice; Models, Biological; Phenols; Phytotherapy; Polyphenols; Skin; Skin Neoplasms; Tea | 2009 |
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Gene Deletion; Genes, Tumor Suppressor; Homeodomain Proteins; Mice; Mice, Knockout; Receptor, Notch1; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate | 2009 |
Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Carcinogens; Coumarins; Female; Ferula; Lactones; Mice; Mice, Inbred ICR; Monoterpenes; Papilloma; Phytotherapy; Plant Extracts; Plant Roots; Sesquiterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Chemoprevention of skin cancer by the flavonoid fraction of Saraca asoka.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Croton Oil; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Fabaceae; Flavonoids; Male; Mice; Phytotherapy; Plant Extracts; Skin; Skin Neoplasms | 2010 |
RIP4 regulates epidermal differentiation and cutaneous inflammation.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Differentiation; Dermatitis, Contact; Epidermis; Female; Humans; I-kappa B Kinase; Keratin-14; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor, Type I; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Apoptosis; Carcinogens; Carcinoma; Cells, Cultured; Embryo, Mammalian; Exodeoxyribonucleases; Female; Genetic Predisposition to Disease; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Skin Neoplasms; Tissue Distribution | 2009 |
Preformulation, formulation, and in vivo efficacy of topically applied apomine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Buffers; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Diphosphonates; Drug Stability; Ethanol; Hydrogen-Ion Concentration; Kinetics; Melanoma, Experimental; Mice; Ointments; Osmolar Concentration; ras Proteins; Skin Neoplasms; Solubility; Solvents; Technology, Pharmaceutical; Temperature | 2009 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile Acids and Salts; Carcinogens; Chenodeoxycholic Acid; Disease Models, Animal; Edema; Female; Indomethacin; Inflammation; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2009 |
Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Antineoplastic Agents; Benzodioxoles; Cricetinae; Male; Mouth Mucosa; Piperidines; Polyunsaturated Alkamides; Skin Neoplasms | 2009 |
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Transformation, Neoplastic; Genes, ras; Keratinocytes; Mice; Mice, Transgenic; Mifepristone; Mutation; Skin Neoplasms; STAT3 Transcription Factor; Stem Cells | 2009 |
A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Aurora Kinase A; Aurora Kinases; Carcinoma, Squamous Cell; Cell Death; Cell Transformation, Neoplastic; Genomic Instability; Humans; Keratinocytes; Mice; Mice, Transgenic; Papilloma; Protein Serine-Threonine Kinases; Skin Neoplasms; Spindle Apparatus | 2009 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Female; Keratinocytes; Keratins; Keratoacanthoma; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; PPAR delta; PPAR-beta; RNA, Messenger; Skin Neoplasms; Sulfonamides; Thiazoles; Time Factors | 2010 |
IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cyclin D1; Cyclooxygenase 2; Cytokines; Female; Inflammation; Interleukin-12 Subunit p40; Interleukin-6; Mice; Mice, Knockout; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Skin tumor promotion by argemone oil/alkaloid in mice: evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Carcinogens; Cell Count; Cell Nucleus; Cell Proliferation; Cyclooxygenase 2; Cytosol; DNA; Electrophoretic Mobility Shift Assay; Female; Isoquinolines; Keratinocytes; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Ornithine Decarboxylase; Plant Extracts; Plant Oils; Seeds; Skin; Skin Neoplasms | 2010 |
Anticancer activity of an Indian medicinal plant, Alstonia scholaris, on skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alstonia; Animals; Catalase; Chemoprevention; Croton Oil; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Papilloma; Plant Bark; Plant Extracts; Skin; Skin Neoplasms; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2009 |
Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amphiregulin; Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; EGF Family of Proteins; Forkhead Transcription Factors; Gene Expression Profiling; Glycoproteins; Hepatitis A Virus Cellular Receptor 2; Intercellular Signaling Peptides and Proteins; Interleukin-10; Interleukin-17; Mice; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Virus; Skin Neoplasms | 2010 |
Chemomodulatory effect of Trachyspermum ammi on murine skin and forestomach papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apiaceae; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Female; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Papilloma; Seeds; Skin Neoplasms; Stomach Neoplasms | 2010 |
Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Infective Agents; Apoptosis; Blotting, Western; Carcinogens; Cell Proliferation; Eugenol; Glutathione; Immunoenzyme Techniques; Inflammation; Lipid Peroxidation; Male; Mice; Ornithine Decarboxylase; Oxidative Stress; Skin Neoplasms; Tumor Cells, Cultured | 2010 |
Studies on glyphosate-induced carcinogenicity in mouse skin: a proteomic approach.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Glycine; Glyphosate; Herbicides; Mice; Proteomics; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2010 |
Evaluation of anticarcinogenic and antimutagenic potential of Bauhinia variegata extract in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Antineoplastic Agents; Bauhinia; Carcinogens; Chromosome Aberrations; Croton Oil; Cyclophosphamide; Female; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Micronuclei, Chromosome-Defective; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Xenograft Model Antitumor Assays | 2009 |
Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Cyclooxygenase 2; Electrophoretic Mobility Shift Assay; Epidermis; Female; Genes, ras; Luciferases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteopontin; Papilloma; Parathyroid Hormone; Phosphates; Phosphorus, Dietary; Proto-Oncogene Proteins c-fos; Skin Neoplasms; Transcription Factor AP-1; Transfection | 2010 |
The effect of c-myc on stem cell fate influences skin tumor phenotype.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma, Sebaceous; Animals; Carcinogens; Cell Differentiation; Cell Lineage; Crosses, Genetic; Female; Heterozygote; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Mice, Transgenic; Multipotent Stem Cells; Papilloma; Phenotype; Proto-Oncogene Proteins c-myc; Sebaceous Gland Neoplasms; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Transgenes | 2010 |
Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Progression; Female; Fluorodeoxyglucose F18; Glucose; Mice; Papilloma; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tomography, X-Ray Computed | 2010 |
Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; Drug Interactions; Enzyme Activation; Enzyme Induction; Female; Humans; MAP Kinase Kinase 4; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Chemoprevention; Croton Oil; Male; Mice; Papilloma; Phyllanthus; Phytotherapy; Plant Extracts; Skin Neoplasms | 2009 |
Chemopreventive activities of etodolac and oxyphenbutazone against mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Etodolac; Mice; Oxyphenbutazone; Skin Neoplasms | 2010 |
Genetic heterogeneity of inflammatory response and skin tumorigenesis in phenotypically selected mouse lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Genetic Drift; Genetic Heterogeneity; Genetic Predisposition to Disease; Genome-Wide Association Study; Inflammation; Mice; Neutrophil Infiltration; Papilloma; Phenotype; Polymorphism, Single Nucleotide; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Antigens, Surface; Carcinoma, Squamous Cell; Cell Growth Processes; Female; Gene Knockdown Techniques; Humans; Keratinocytes; Membrane Glycoproteins; Mice; Orexin Receptors; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Keratinocytes; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Neuropeptides; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
A Bayesian statistical analysis of mouse dermal tumor promotion assay data for evaluating cigarette smoke condensate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bayes Theorem; Carcinogenicity Tests; Carcinogens; Female; Mice; Mice, Inbred SENCAR; Models, Biological; Nicotiana; Skin Neoplasms; Tobacco Smoke Pollution | 2010 |
Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Anti-Inflammatory Agents; Antigens, Viral; Antineoplastic Agents, Phytogenic; Carrageenan; Cell Line, Tumor; Cinnamates; Dose-Response Relationship, Drug; Edema; Female; Hindlimb; Mice; Mice, Inbred ICR; Sapotaceae; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes | 2010 |
Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Transformation, Neoplastic; Croton Oil; Down-Regulation; Eugenol; Female; Genes, myc; Genes, p53; Genes, ras; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Up-Regulation | 2010 |
Evaluation of diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a two-stage mouse skin carcinogenesis assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; Diuron; Female; Herbicides; Mice; Pyridines; Skin; Skin Neoplasms; Solvents | 2010 |
Chemopreventive action of Syzygium cumini on DMBA-induced skin papillomagenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Croton Oil; Disease Models, Animal; Male; Mice; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Syzygium | 2010 |
The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Female; Genes, ras; Inbreeding; Male; MAP Kinase Kinase 4; Mice; Skin; Skin Neoplasms | 2010 |
Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Caspase 3; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinases; Papilloma; Phytotherapy; Scopoletin; Signal Transduction; Skin Neoplasms; Tissue Inhibitor of Metalloproteinase-2 | 2010 |
Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Bone Marrow; Bone Marrow Transplantation; Carcinogens; Drug Synergism; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-1beta; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Escape; Tumor Suppressor Proteins; U937 Cells; Whole-Body Irradiation | 2010 |
Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Cell Line; Cell Line, Tumor; Diagnosis, Differential; DNA Methylation; Egg Proteins; Histones; Humans; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Nevus; Skin Neoplasms | 2010 |
Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocarcinogenesis; Cyclooxygenase 2; Drug Synergism; Enzyme Activation; ErbB Receptors; Female; Humans; Male; Mice; Mice, Knockout; Signal Transduction; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2010 |
Cooperativity of Cdk4R24C and Ras in melanoma development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Amino Acid Substitution; Animals; Cyclin-Dependent Kinase 4; Disease Susceptibility; Germ-Line Mutation; Melanoma; Mice; Mutation; Oncogene Protein p21(ras); Skin Neoplasms; Tumor Suppressor Protein p53 | 2010 |
Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azadirachta; Carcinoma; Disease Models, Animal; Male; Mice; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Antineoplastic Agents; Carcinogens; Catalase; Glutathione; Glutathione Reductase; Liliaceae; Lipid Peroxidation; Male; Mice; Micronucleus Tests; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Superoxide Dismutase | 2010 |
Chemopreventive and anticarcinogenic effects of Momordica charantia extract.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Bone Marrow Cells; Carcinogens; Chromosome Aberrations; Croton Oil; Female; Fruit; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Momordica charantia; Papilloma; Phytotherapy; Plant Extracts; Plant Leaves; Skin Neoplasms; Survival Rate | 2010 |
p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Clone Cells; Disease Models, Animal; Disease Progression; Humans; Imidazoles; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Nevus; Pigmentation; Piperazines; Proto-Oncogene Proteins; Skin Neoplasms; Staining and Labeling; Survival Analysis; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2010 |
Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Antineoplastic Agents, Phytogenic; Croton Oil; DNA Adducts; Male; Mice; Papilloma; Plant Extracts; Protein Kinase C; Skin Neoplasms | 2010 |
Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cattle; Cell Differentiation; Chlorocebus aethiops; COS Cells; Disease Susceptibility; Epidermal Cells; Epidermis; Female; Humans; Immunoenzyme Techniques; Keratin-5; Keratinocytes; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Sp2 Transcription Factor; Wounds and Injuries | 2010 |
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Proliferation; Gene Deletion; Integrases; Keratinocytes; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Papilloma; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Skin; Skin Neoplasms; Up-Regulation | 2010 |
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Embryo, Mammalian; Fibroblasts; Histones; Mice; Mice, Inbred C57BL; Mice, Knockout; Octamer Transcription Factor-3; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Effects of low level microwave radiation on carcinogenesis in Swiss Albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Ehrlich Tumor; Cell Proliferation; Hyperplasia; Male; Mice; Microwaves; Neoplasms, Radiation-Induced; Skin Neoplasms; Time Factors; Tumor Burden | 2011 |
Lack of skin carcinogenicity of topically applied titanium dioxide nanoparticles in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Body Weight; Carcinogenicity Tests; Metal Nanoparticles; Mice; Mice, Inbred ICR; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Titanium | 2011 |
Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; A Kinase Anchor Proteins; Animals; Cell Cycle Proteins; Disease Progression; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2011 |
Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Catalase; Cell Transformation, Neoplastic; Chemoprevention; Croton Oil; Glutathione; Herbal Medicine; Lipid Peroxidation; Liver; Male; Mice; Papilloma; Plant Extracts; Seeds; Skin; Skin Neoplasms; Superoxide Dismutase; Syzygium | 2011 |
Chemomodulatory effects of Aegle marmelos against DMBA-induced skin tumorigenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aegle; Animals; Antineoplastic Agents; Apoptosis; Cell Transformation, Neoplastic; Chemoprevention; Croton Oil; Medicine, Ayurvedic; Mice; Phytotherapy; Plant Extracts; Plant Preparations; Skin; Skin Neoplasms; Tumor Burden | 2010 |
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Binding Sites; Carcinogens; Clathrin; Drug Resistance, Neoplasm; Endocytosis; Female; Glutathione; GTPase-Activating Proteins; Humans; Male; Mice; Mice, Knockout; Protein Kinase C-alpha; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Suppressor Protein p53 | 2011 |
FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Chemokine CCL2; Chronic Disease; Fibroblasts; Humans; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Disease Progression; Epidermis; Female; Humans; Mice; Mice, Hairless; Mice, Transgenic; Receptors, Prostaglandin E, EP1 Subtype; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Up-Regulation | 2011 |
Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Skin Neoplasms | 2011 |
Chemomodulatory potential of Asparagus adscendens against murine skin and forestomach papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Asparagus Plant; Carcinogens; Catalase; Female; Glutathione; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Lipid Peroxidation; Mice; Papilloma; Plant Extracts; Skin Neoplasms; Stomach Neoplasms; Superoxide Dismutase | 2011 |
Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; ErbB Receptors; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamides; Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; ErbB Receptors; Female; Humans; Keratinocytes; Male; Mice; Mice, Hairless; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; TRPV Cation Channels | 2011 |
Inhibitory potency of tacrolimus ointment on skin tumor induction in a mouse model of an initiation-promotion skin tumor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Female; Immunosuppressive Agents; Mice; Mice, Inbred ICR; Ointments; Skin; Skin Neoplasms; Tacrolimus | 2011 |
Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemokine CCL2; Chemokine CXCL2; Cyclooxygenase 2; Female; Inflammation; Mice; Oligodeoxyribonucleotides; Ornithine Decarboxylase; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Re-assessing K15 as an epidermal stem cell marker.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Cell Differentiation; Embryo, Mammalian; Embryonic Development; Epidermis; Gene Expression Regulation, Neoplastic; Homeostasis; Keratin-15; Mice; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Appetite; Arcuate Nucleus of Hypothalamus; Caloric Restriction; Female; Hunger; Male; Mice; Mice, Knockout; Neoplasms, Experimental; Neurons; Neuropeptide Y; Papilloma; RNA, Messenger; Skin Neoplasms; Sodium Glutamate; Tetradecanoylphorbol Acetate | 2011 |
Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NF-κB and reduced cell proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Apoptosis; Beverages; Cell Proliferation; Drug Evaluation, Preclinical; Drug Synergism; Fruit; I-kappa B Kinase; I-kappa B Proteins; Lythraceae; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Plant Extracts; Skin Neoplasms; Sulfides | 2011 |
CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Disease Progression; Epidermal Cells; Epidermis; Humans; Hyperplasia; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Lymphatic Metastasis; Mice; Mice, Transgenic; Mutation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitination | 2011 |
Potential O-acyl-substituted (-)-Epicatechin gallate prodrugs as inhibitors of DMBA/TPA-induced squamous cell carcinoma of skin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Catechin; Female; Humans; Hydrolysis; Mice; Prodrugs; Skin; Skin Neoplasms; Solubility; Tea; Tetradecanoylphorbol Acetate | 2011 |
Chemoprevention by Triticum Aestivum of mouse skin carcinogenesis induced by DMBA and croton oil - association with oxidative status.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Catalase; Chemoprevention; Croton Oil; Glutathione; Lipid Peroxidation; Male; Mice; Papilloma; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Superoxide Dismutase; Triticum | 2011 |
Azadirachta indica exerts chemopreventive action against murine skin cancer: studies on histopathological, ultrastructural changes and modulation of NF-kappaB, AP-1, and STAT1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Azadirachta; Male; Mice; NF-kappa B; Plant Extracts; RNA, Messenger; Skin Neoplasms; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
Ambient oxygen promotes tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Carcinogens; DNA Primers; Female; Genomic Instability; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasms, Experimental; Oxygen; Skin Neoplasms | 2011 |
Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Ascorbic Acid; Glutathione; Lipid Peroxidation; Male; Mice; Oxidative Stress; Papilloma; Phyllanthus; Phytotherapy; Plant Extracts; Skin Neoplasms | 2011 |
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Flavanones; Genistein; Herpesvirus 4, Human; Hesperidin; Isoflavones; Mice; Oleanolic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia Crispa root hexane extract.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Ardisia; Carcinogens; Croton Oil; Hexanes; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Survival Rate | 2011 |
Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Epidermal Cells; Epidermis; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Knockout; MicroRNAs; ras Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Asphalt fume dermal carcinogenicity potential: II. Initiation-promotion assay of Type III built-up roofing asphalt.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Air Pollutants, Occupational; Animals; Body Weight; Carcinogens; Hydrocarbons; Male; Mice; Occupational Exposure; Skin; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adoptive Transfer; Animals; B-Lymphocytes; Carcinogens; Carcinoma, Squamous Cell; Immunohistochemistry; Mice; Mice, Knockout; Skin Neoplasms; Tumor Necrosis Factor-alpha | 2011 |
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Blotting, Western; Carcinogens; Humans; Hyperplasia; Mice; Neoplasm Staging; Papilloma; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2011 |
CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Epidermis; Humans; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Mutant Strains; Receptors, CXCR3; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2011 |
The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Disease Progression; Female; Immunohistochemistry; Mice; Mice, Transgenic; Receptors, Prostaglandin E, EP1 Subtype; Skin Neoplasms | 2012 |
Chemoprevention of two-stage skin cancer in vivo by Saraca asoca.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catalase; Chemoprevention; Croton Oil; Disease Models, Animal; Fabaceae; Flavonoids; Flowers; Glutathione; Lipid Peroxidation; Male; Medicine, Ayurvedic; Mice; Plant Extracts; Proteins; Skin Neoplasms; Time Factors | 2012 |
Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Carcinogens; Curcumin; Dermatitis; Ear, External; Edema; Female; Ketones; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; Chemoprevention; Daucus carota; Flowers; Mice; Mice, Inbred BALB C; Oils; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Tumor Burden | 2011 |
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alphapapillomavirus; Animals; Carcinogens; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Humans; Keratinocytes; Keratosis, Actinic; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Papillomavirus Infections; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2011 |
Inhibitory effects of interferon-gamma plasmid DNA on DMBA-TPA induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Caspase 3; Cell Proliferation; Female; Genetic Therapy; Interferon-gamma; Mice; Mice, Inbred BALB C; Plasmids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcitriol; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Epidermis; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Calcitriol; Signal Transduction; Skin Neoplasms; Ultraviolet Rays | 2011 |
Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Drug Synergism; Genes, ras; Green Fluorescent Proteins; Humans; Long Interspersed Nucleotide Elements; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Mutagenesis, Insertional; Neoplasm Proteins; Receptors, Aryl Hydrocarbon; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2011 |
Amelioration of chemical-induced skin carcinogenesis by Aegle marmelos, an Indian medicinal plant, fruit extract.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Aegle; Animals; Antioxidants; Disease Models, Animal; India; Lipid Peroxidation; Liver; Male; Mice; Oxidative Stress; Papilloma; Plant Extracts; Skin Neoplasms; Tumor Burden | 2012 |
Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Female; Heme Oxygenase-1; Mice; Mice, Inbred Strains; Mice, Knockout; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Protein Stability; Remission Induction; Resveratrol; Skin Neoplasms; Stilbenes; Tea; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2011 |
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Gene Silencing; Homeostasis; Keratinocytes; Mice; Mice, Mutant Strains; Phosphoproteins; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2011 |
Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Dedifferentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Human epithelial carcinoma cytotoxicity and inhibition of DMBA/TPA induced squamous cell carcinoma in Balb/c mice by Acacia catechu heartwood.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione; Humans; Lipid Peroxidation; Liver; Mice; Mice, Inbred BALB C; Plant Preparations; Random Allocation; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2011 |
Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Disease Progression; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Reporter; Genes, Synthetic; Humans; Mice; Mice, Transgenic; Neoplasm Proteins; Papilloma; Promoter Regions, Genetic; Recombinant Fusion Proteins; Skin Neoplasms; Sp1 Transcription Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Analysis of Variance; Animals; Anticarcinogenic Agents; Basidiomycota; Croton Oil; Female; Inflammation; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Papilloma; Plant Extracts; Skin Neoplasms | 2011 |
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Movement; Cell Transformation, Neoplastic; Cytoskeleton; Disease Progression; Endothelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Neovascularization, Pathologic; Papilloma; Phorbols; Protein Serine-Threonine Kinases; Skin Neoplasms; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Chemomodulatory potential of Glycine max against murine skin and cervical papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Catalase; Cell Transformation, Neoplastic; Chemoprevention; Female; Glutathione Transferase; Glycine max; Lactoylglutathione Lyase; Methylcholanthrene; Mice; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Papilloma; Plant Extracts; Skin Neoplasms; Superoxide Dismutase; Uterine Cervical Neoplasms | 2011 |
Chemically induced skin carcinogenesis in mice and its prevention by Aegle marmelos (an Indian medicinal plant) fruit extract.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Aegle; Animals; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Male; Mice; Phytotherapy; Plant Extracts; Skin Neoplasms | 2011 |
Carcinogen treatment in mouse selectively expressing activated N-Ras Q61K in melanocytes recapitulates metastatic cutaneous melanoma development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Substitution; Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Genes, ras; Humans; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Skin Neoplasms | 2012 |
Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-κB signalling pathways.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Cyclooxygenase 2; Elettaria; Female; Metabolic Detoxication, Phase II; Mice; Neoplasm Proteins; NF-E2-Related Factor 2; NF-kappa B; Papilloma; Seeds; Signal Transduction; Skin; Skin Neoplasms; Spices; Tumor Burden | 2012 |
Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Dioxoles; Female; Humans; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1; Cyclin D2; Cyclin D3; Gene Expression Regulation; Mice; Mice, Transgenic; Oncogene Protein p21(ras); Papilloma; Skin; Skin Neoplasms; Tumor Burden | 2012 |
Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Damage; Genes, ras; Humans; Keratinocytes; Langerhans Cells; Mice; Mice, Transgenic; Skin Neoplasms; T-Lymphocytes | 2012 |
Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosylmethionine Decarboxylase; Animals; Colon; Disease Models, Animal; Epidermis; Gene Expression Regulation, Enzymologic; Genes, APC; Intestinal Neoplasms; Mice; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Spermidine; Spermine; Spermine Synthase; Tetradecanoylphorbol Acetate | 2012 |
Separation of initiating and promoting effects of the skin carcinogen 7-bromomethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Survival Rate | 1980 |
Effects of dose and duration of treatment with the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate on mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Cell Transformation, Neoplastic; Ear Neoplasms; ErbB Receptors; Feedback, Physiological; Female; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neoplasm Proteins; Point Mutation; Real-Time Polymerase Chain Reaction; Skin Neoplasms | 2012 |
D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Catalase; Cyclohexenes; Cyclooxygenase 2; Female; Glutathione; Inflammation; Limonene; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; raf Kinases; ras Proteins; Signal Transduction; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 2012 |
Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angelica; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Apoptosis; Aspergillus; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Chalcones; Humans; Mice; Molecular Structure; Prenylation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2012 |
Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Glycosides; Humans; Mice; Molecular Structure; Momordica charantia; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes; Tumor Cells, Cultured | 2012 |
Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Transformation, Viral; Disease Models, Animal; Disease Progression; Gene Expression; Genes, ras; Keratin-14; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mutation; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Viral Matrix Proteins | 2012 |
Chemopreventive effects of cardamom (Elettaria cardamomum L.) on chemically induced skin carcinogenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Croton Oil; Elettaria; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Papilloma; Phytotherapy; Plant Preparations; Skin; Skin Neoplasms | 2012 |
A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, ras; Hair Follicle; Humans; Integrases; Keratin-15; Keratinocytes; Laser Capture Microdissection; Mice; Mice, Transgenic; Mutation; Papilloma; Skin; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2013 |
Anti-tumor activity of rosmarinic acid in 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Antioxidants; Carcinogens; Carcinoma, Squamous Cell; Caspase 3; Caspase 9; Cinnamates; Depsides; Drug Screening Assays, Antitumor; Humans; Mice; Proto-Oncogene Proteins c-bcl-2; Rosmarinic Acid; Skin Neoplasms; Thiobarbituric Acid Reactive Substances; Tumor Suppressor Protein p53 | 2012 |
JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Carcinogens; Carrier Proteins; Cell Proliferation; Cells, Cultured; DNA Damage; ets-Domain Protein Elk-1; Heat-Shock Proteins; Immunohistochemistry; MAP Kinase Signaling System; Membrane Transport Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Papilloma; Phosphorylation; Proliferating Cell Nuclear Antigen; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aminolevulinic Acid; Animals; Disease Models, Animal; Female; Mice; Mice, Hairless; Ointments; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2012 |
Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Female; Genes, ras; Humans; Male; Mice; Mice, Transgenic; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Silicones; Skin Absorption; Skin Neoplasms; Titanium | 2012 |
Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Adhesion; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Female; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; RNA Interference; RNA, Small Interfering; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate | 2012 |
Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p21; Mice; Mice, Transgenic; Neoplasms, Experimental; Nuclear Proteins; Protein Inhibitors of Activated STAT; Protein Structure, Tertiary; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ubiquitin-Protein Ligases | 2012 |
Inotilone suppresses phorbol ester-induced inflammation and tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Cyclooxygenase 2; Dermatitis; Enzyme Activation; Female; Furans; Inflammation Mediators; Macrolides; Mice; Mice, Inbred ICR; NF-kappa B; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Tamoxifen-loaded novel liposomal formulations: evaluation of anticancer activity on DMBA-TPA induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents, Hormonal; Cocarcinogenesis; Drug Compounding; Drug Delivery Systems; Female; Liposomes; Mice; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate; Treatment Outcome | 2012 |
Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Edema; Female; Humulus; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Phloroglucinol; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alpinia; Animals; Benzyl Alcohols; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Fluocinolone Acetonide; Humans; Mice; Mice, Transgenic; NF-kappa B; Plant Extracts; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Zingiber officinale | 2012 |
Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins; Binding, Competitive; Cell Transformation, Neoplastic; Clone Cells; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cytoprotection; Enzyme Stability; ErbB Receptors; Female; Humans; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Molecular Sequence Data; Nuclear Proteins; Protein Binding; Proteolysis; Signal Transduction; Skin Neoplasms; Transcriptional Activation | 2012 |
Anti-tumor-promoting activities of agaro-oligosaccharides on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Antineoplastic Agents; Carcinogens; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Edema; Humans; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitrites; Oligosaccharides; Prostaglandin-E Synthases; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Atorvastatin; Cell Proliferation; Croton Oil; Epidermal Cells; Epidermis; Female; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Neovascularization, Pathologic; Pyrroles; Rats; Rats, Wistar; Skin Neoplasms | 2012 |
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Integrin alpha6beta4; Mice; Mice, Knockout; Phosphorylation; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tetraspanin 24; Tumor Cells, Cultured | 2013 |
Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cyclooxygenase 2; Down-Regulation; Female; Inflammation; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Resveratrol; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2012 |
Independent genetic control of early and late stages of chemically induced skin tumors in a cross of a Japanese wild-derived inbred mouse strain, MSM/Ms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Crosses, Genetic; Female; Genetic Linkage; Japan; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2012 |
PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Mice; Mice, Knockout; Protein Kinase C-alpha; Skin Neoplasms | 2012 |
Progression of mouse skin carcinogenesis is associated with increased ERα levels and is repressed by a dominant negative form of ERα.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Cytoskeleton; Estrogen Receptor alpha; Estrogen Receptor beta; Genes, Dominant; Mice; Neoplasm Proteins; Skin Neoplasms; Transfection | 2012 |
Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cell Line; Cell Proliferation; Fluorouracil; Humans; Imidazoles; Indoles; Melanoma; Mice; Oximes; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Vemurafenib | 2013 |
Energy balance modulates mouse skin tumor promotion through altered IGF-1R and EGFR crosstalk.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Caloric Restriction; Carcinogens; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Diet; Energy Metabolism; ErbB Receptors; Female; Insulin-Like Growth Factor I; Keratinocytes; Mice; Mice, Inbred ICR; Obesity; Papilloma; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin Neoplasms; TOR Serine-Threonine Kinases | 2012 |
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Transformation, Neoplastic; ErbB Receptors; Genes, ras; I-kappa B Proteins; Inflammation; Interleukin-1alpha; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myeloid Differentiation Factor 88; NF-kappa B; Phosphorylation; Receptors, Interleukin-1; Signal Transduction; Skin Neoplasms | 2012 |
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Animals, Inbred Strains; Azoxymethane; Cell Transformation, Neoplastic; Chemokines, CXC; Colitis; Colonic Neoplasms; Dermatitis, Contact; Dextran Sulfate; Gene Expression; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Papilloma; Peroxidase; Precancerous Conditions; Receptors, Interleukin-8B; Skin Neoplasms; Statistics, Nonparametric; Tetradecanoylphorbol Acetate; Tumor Burden | 2012 |
Chemopreventive potential of Annona muricata L leaves on chemically-induced skin papillomagenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Annona; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Croton Oil; Male; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Plant Extracts; Plant Leaves; Skin Neoplasms | 2012 |
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Epistasis, Genetic; Female; Genes, ras; Lung; Lung Neoplasms; Male; Mice; Mice, Knockout; Models, Genetic; Mutation; ras Proteins; Skin; Skin Neoplasms; Urethane | 2013 |
Chemopreventive potential of geraniol in 7,12-dimethylbenz(a) anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyclic Monoterpenes; Animals; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Male; Mice; Skin Neoplasms; Terpenes | 2012 |
Azadirachta indica acts as a pro-oxidant and modulates cell cycle associated proteins during DMBA/TPA induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Azadirachta; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression; Lipid Peroxidation; Male; Mice; Plant Extracts; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2013 |
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Caspase 1; Cell Proliferation; Cell Transformation, Neoplastic; Cytokines; Cytoskeletal Proteins; Down-Regulation; Epithelium; Humans; Inflammasomes; Inflammation; Keratinocytes; Mice; Mice, Knockout; Myeloid Cells; Neoplasms, Squamous Cell; Organ Specificity; Receptors, Interleukin-1; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Microenvironment; Tumor Suppressor Protein p53 | 2012 |
Spatiotemporal assessments of dermal hyperemia enable accurate prediction of experimental cutaneous carcinogenesis as well as chemopreventive activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Carcinogens; Celecoxib; Cell Transformation, Neoplastic; Female; Hyperemia; Inflammation; Mice; Optical Imaging; Pyrazoles; Skin; Skin Neoplasms; Sulfonamides; Ultraviolet Rays | 2013 |
Baicalein inhibits DMBA/TPA-induced skin tumorigenesis in mice by modulating proliferation, apoptosis, and inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Female; Flavanones; Hyperplasia; Inflammation; Mice; Mice, Inbred C57BL; Plant Extracts; Scutellaria baicalensis; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin D1; Cyclooxygenase 2; Enzyme Activation; Epidermis; ErbB Receptors; Female; Gene Knockdown Techniques; Hyperplasia; Keratinocytes; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Ochratoxins; Ornithine Decarboxylase; Phosphorylation; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Skin Neoplasms; Transcription Factor AP-1; Transcriptional Activation | 2013 |
Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Fetal Development; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Keratin-14; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Patched Receptors; Patched-1 Receptor; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Transgenes | 2013 |
Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Papillomaviridae; Skin; Skin Neoplasms | 2013 |
Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Lineage; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Epidermis; Hair Follicle; Integrin alpha3; Keratin-15; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Staining and Labeling | 2012 |
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Aneuploidy; Animals; Cell Count; Cell Cycle Proteins; Cells, Cultured; Chromosomal Instability; Female; Gene Expression; Life Expectancy; Lung Neoplasms; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Phenotype; Protein Serine-Threonine Kinases; Skin Neoplasms; Stem Cells | 2013 |
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Antigens, CD34; Catechin; CCAAT-Enhancer-Binding Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitotic Index; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2013 |
Chemopreventive effect of Ardisia crispa hexane fraction on the peri-initiation phase of mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ardisia; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Croton Oil; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Plant Extracts; Skin Neoplasms | 2013 |
Protective effect of tenuazonic acid against dimethyl benz(a)antracene-induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Carcinogens; Drug Screening Assays, Antitumor; Female; Mice; Skin Neoplasms; Structure-Activity Relationship; Tenuazonic Acid | 2002 |
In vivo pharmacokinetics of 8-aminolevulinic acid-induced protoporphyrin IX during pre- and post-photodynamic therapy in 7,12-dimethylbenz(a)nthracene-treated skin carcinogenesis in Swiss mice: a comparison by three-compartment model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Female; Mice; Models, Biological; Photochemotherapy; Protoporphyrins; Skin Neoplasms | 2002 |
The effect of beta-carotene on lung and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carcinogens; Dose-Response Relationship, Drug; Ferrets; Lung Neoplasms; Mice; Nicotiana; Papilloma; Precancerous Conditions; Skin Neoplasms; Smoke; Tetradecanoylphorbol Acetate | 2002 |
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Artemia; Benzodioxoles; Biphenyl Compounds; Cocarcinogenesis; Female; Free Radical Scavengers; Herpesvirus 4, Human; Lethal Dose 50; Mice; Mice, Inbred ICR; Phenols; Picrates; Plant Oils; Resveratrol; Sesame Oil; Skin Neoplasms; Stilbenes; Sunflower Oil; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 2002 |
Carcinogenic and cocarcinogenic potential of cypermethrin on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Insecticides; Male; Mice; Pyrethrins; Skin Neoplasms | 2002 |
Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 12-Lipoxygenase; Carcinogens; Down-Regulation; Female; Gene Expression; Isoenzymes; Linoleic Acids; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Papilloma; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2002 |
Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Ear; Edema; Female; Mice; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Plants, Medicinal; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cocarcinogenesis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Gene Expression; Isoenzymes; Mice; Mice, Transgenic; Papilloma; Phenotype; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 2002 |
Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Male; Maximum Tolerated Dose; Mice; Phytotherapy; Plant Extracts; Plant Roots; Reactive Oxygen Species; Skin Neoplasms; Withania | 2002 |
Modulating effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on skin carcinogenesis initiated by the weak inducer 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Buffers; Carcinogens; Cytosol; DNA; Environmental Pollutants; Enzyme Induction; Mice; Mice, Inbred C57BL; Microsomes; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Skin; Skin Neoplasms | 1994 |
Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Anticarcinogenic Agents; DNA Adducts; Female; Furocoumarins; Mice; Mice, Inbred SENCAR; Phytotherapy; Skin Neoplasms | 2002 |
Inhibition by ajoene of skin-tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Disulfides; Garlic; Male; Mice; Mice, Inbred ICR; Plant Extracts; Skin Neoplasms; Solvents; Sulfoxides; Tetradecanoylphorbol Acetate | 2002 |
Progressive iron overload enhances chemically mediated tumor promotion in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benzoyl Peroxide; Carcinogens; Catalase; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Enzyme Repression; Glutathione; Iron; Iron Overload; Lipid Peroxidation; Mice; Ornithine Decarboxylase; Oxidative Stress; Papilloma; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Bromodeoxyuridine; Carcinogens; Cell Division; Homozygote; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phenotype; Receptors, Calcitriol; Sex Factors; Skin; Skin Neoplasms; Time Factors | 2002 |
A 60 Hz magnetic field does not affect the incidence of squamous cell carcinomas in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Back; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Drug Tolerance; Electricity; Electromagnetic Fields; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Radiation Tolerance; Reference Values; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Hydroxylamines; Indoles; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Phenobarbital; Plant Extracts; Plant Roots; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2003 |
Circadian rhythm of tumor promotion in the two-stage model of mouse tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Circadian Rhythm; Disease Models, Animal; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Female; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neoplasm Proteins; Papilloma; Skin; Skin Neoplasms; Survivin; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2003 |
Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Capsaicin; Capsicum; Carcinogens; Cell Line; Chemoprevention; Flow Cytometry; Humans; Jurkat Cells; Membrane Potentials; Mice; Papilloma; Reactive Oxygen Species; Receptors, Drug; Skin Neoplasms; Tumor Cells, Cultured | 2003 |
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Survival; Cimicifuga; Female; Herpesvirus 4, Human; Lanosterol; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms | 2003 |
Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 Mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Female; Hyperplasia; Interleukin-1; Mice; Mice, Inbred Strains; Pentachlorophenol; Proliferating Cell Nuclear Antigen; Skin; Skin Neoplasms; Tumor Necrosis Factor-alpha | 2003 |
Skin tumor promotion by Vitamin E in mice: amplification by ionizing radiation and Vitamin C.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antioxidants; Ascorbic Acid; Beta Particles; Carcinogens; Cocarcinogenesis; Female; Free Radical Scavengers; Mice; Mice, Inbred SENCAR; Oxidation-Reduction; Radiation, Ionizing; Skin; Skin Neoplasms; Vitamin E | 2003 |
Comparative potencies of nutraceuticals in chemically induced skin tumor prevention.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Beta vulgaris; Croton Oil; Cucumis sativus; Curcuma; Incidence; Mice; Plant Extracts; Random Allocation; Skin Neoplasms; Spinacia oleracea | 2002 |
Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Apoptosis; Disease Models, Animal; DNA Fragmentation; Flow Cytometry; In Situ Nick-End Labeling; Mice; Skin Neoplasms; Sulfides | 2002 |
Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Multiple; Animals; Carcinogens; Carcinoma, Squamous Cell; Epidermis; Fibrosarcoma; Genetic Predisposition to Disease; Genotype; Group II Phospholipases A2; Humans; Keratins; Mice; Mice, Transgenic; Neoplasms, Basal Cell; Papilloma; Phenotype; Phospholipases A; Promoter Regions, Genetic; Recombinant Fusion Proteins; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate; Transgenes; Vibrissae | 2003 |
Calcium glucarate prevents tumor formation in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; DNA; Enzyme Inhibitors; Female; Glucaric Acid; Mice; Skin Neoplasms; Thymidine; Transglutaminases | 2003 |
An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies, Monoclonal; Carcinogens; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Immunity, Innate; Keratinocytes; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Staging; Papilloma; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2003 |
Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Hyperplasia; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2003 |
IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epidermis; Female; Humans; Immunity, Innate; Interleukin-1; Keratin-14; Keratins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nuclear Proteins; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2003 |
The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; Disease Susceptibility; DNA; DNA Primers; Epidermal Cells; Epidermis; Epithelial Cells; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Mice; Mice, Knockout; Mice, Transgenic; Nasopharyngeal Neoplasms; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Viral Matrix Proteins | 2003 |
Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Female; Genes, ras; Metallothionein; Mice; Mice, Inbred C57BL; Mutation; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Toxicological evaluation of honey as an ingredient added to cigarette tobacco.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Inhalation; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Honey; In Vitro Techniques; Male; Mutagenicity Tests; Nicotiana; Organ Size; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Sister Chromatid Exchange; Skin Neoplasms; Smoke; Smoking; Tetradecanoylphorbol Acetate | 2003 |
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; Codon; Female; Genes, ras; Mice; Mutation; Nitric Oxide; Nitro Compounds; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Progressive alterations in global and GC-rich DNA methylation during tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Cytosine; DNA Methylation; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Guanosine; Mice; Mice, Inbred SENCAR; Polymerase Chain Reaction; Recovery of Function; Skin Neoplasms; Smoke; Tars | 2003 |
Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cells, Cultured; Cocarcinogenesis; Female; Lymphocytes; Mice; Mice, Inbred ICR; Momordica; Peroxynitrous Acid; Skin Neoplasms; Sweetening Agents; Tetradecanoylphorbol Acetate; Triterpenes | 2003 |
Suppression of DMBA-induced mouse skin tumor development by inositol hexaphosphate and its mode of action.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cell Division; DNA; Dose-Response Relationship, Drug; Epidermis; Female; Mice; Phytic Acid; Skin Neoplasms; Thymidine Kinase; Transglutaminases | 2003 |
Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; CSK Tyrosine-Protein Kinase; Female; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasm Metastasis; Protein-Tyrosine Kinases; Skin; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2003 |
The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Hematopoietic Stem Cells; Liver; Mice; Mice, Knockout; Neoplasm Staging; Papilloma; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Carcinoma; Cells, Cultured; Endoglin; Epidermal Cells; Epidermis; Humans; Keratinocytes; Mice; Mice, Mutant Strains; Neoplasms, Experimental; Papilloma; Receptors, Cell Surface; Reference Values; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1 | 2003 |
Effects of thyroxine and thiouracil on induction of skin tumors in mice by 9,10-dimethyl-1,2-benzanthracene and croton oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benz(a)Anthracenes; Carcinogens; Croton Oil; Mice; Skin Neoplasms; Thiouracil; Thyroxine | 1958 |
[Value of the rabbit in study of experimental reaction to 9-10-dimethyl-1-2-benzanthracene in induction of skin cancer].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benz(a)Anthracenes; Neoplasms, Experimental; Rabbits; Skin Neoplasms | 1958 |
[Effect of ultraviolet rays on 9,10-dimethyl-1,2-benzanthracene- & 3,4-benzopyrene-induced skin carcinogenesis in the rat].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogenesis; Neoplasms, Experimental; Rats; Skin Neoplasms; Ultraviolet Rays | 1959 |
Effects of zephirol, sodium dodecylsufate, sodium taurocholate, and tween 81 as solvents for 9,10-dimethyl-1,2-benzanthracene, on skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Ammonium Compounds; Animals; Anti-Infective Agents, Local; Benz(a)Anthracenes; Carcinogenesis; Mice; Neoplasms, Experimental; Polysorbates; Quaternary Ammonium Compounds; Skin Neoplasms; Sodium; Solvents; Surface-Active Agents; Taurocholic Acid | 1960 |
A comparison of the initiating and promoting actions of 9,10-dimethyl-1,2-benzanthracene and 1,2,5,6-di-benzanthracene in skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Neoplasms, Experimental; Skin Neoplasms | 1960 |
A study of skin carcinogenesis in the mouse with single applications of 9,10-dimethyl-1,2-benzanthracene at different dosages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Mice; Neoplasms, Experimental; Skin Neoplasms | 1960 |
Localization of radioactivity in mouse skin following one application of C14-labelled 9,10-dimethyl-1,2-benzanthracene (an autoradiographic study).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Mice; Neoplasms, Experimental; Radioactivity; Skin Neoplasms | 1960 |
[Changes in the connective tissue of the skin of the rabbit ear in the process of carcinogenesis by 9,10-dimethyl-1,2-benzanthracene].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Connective Tissue; DNA; DNA, Neoplasm; Neoplasms; Rabbits; RNA; RNA, Neoplasm; Skin; Skin Neoplasms | 1963 |
The fine structure of the basement membrane in epidermal tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basement Membrane; Benz(a)Anthracenes; Croton Oil; Female; Mice; Neoplasms, Experimental; Skin Neoplasms | 1962 |
Hair cycle and chemically induced epidermal carcinogenesis in mice receiving tri-iodothyronine. I. Findings after single application of 9,10-dimethyl-1,2-benzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Epidermis; Hair; Mice; Neoplasms; Neoplasms, Experimental; Skin Neoplasms; Triiodothyronine | 1963 |
[Influence of the hair cycle on cutaneous cancerogenesis by 9,10-dimethyl-1, 2-benzanthracene (DMBA) in the mouse].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Benz(a)Anthracenes; Hair; Mice; Neoplasms, Experimental; Skin Neoplasms | 1962 |
A STOCHASTIC MODEL OF CARCINOGENESIS COMPARED WITH MOUSE SKIN TUMOUR ENHANCEMENT AFTER GASTRIC INSTILLATION OF 9,10-DIMETHYL-1,2-BENZANTHRACENE WITH SUBSEQUENT LOCAL CONTINUOUS EXPOSURE TO 'TWEEN 40'.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Mice; Neoplasms; Polysorbates; Research; Skin Neoplasms; Stomach; Surface-Active Agents | 1963 |
MELANOMAS OF THE SKIN OF GUINEA PIGS FOLLOWING THE APPLICATION OF A SOLUTION OF 9,10-DIMETHYL-1,2-BENZANTHRACENE IN BENZENE.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benz(a)Anthracenes; Benzene; Guinea Pigs; Melanoma; Neoplasms; Neoplasms, Experimental; Research; Skin Neoplasms; Toxicology | 1963 |
ACID MUCOPOLYSACCHARIDES OF THE DERMIS GROUND SUBSTANCE DURING SKIN TREATMENT WITH 9,10-DIMETHYL-1,2-BENZANTHRACENE AND WITH CROTON OIL.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Croton Oil; Dermis; Glycosaminoglycans; Hexosamines; Neoplasms; Neoplasms, Experimental; Pharmacology; Rabbits; Research; Skin; Skin Neoplasms | 1963 |
[REACTION OF THE EPIDERMIS TO THE PRIMARY AND SECONDARY ACTION OF 9,10-DIMETHYL-1,2-BENZANTHRACENE ON THE SKIN OF MICE].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Benz(a)Anthracenes; Epidermis; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Skin Neoplasms; Toxicology | 1964 |
[TUMORS OF THE SKIN IN RATS INDUCED BY 9,10-DIMETHYL-1,2-BENZANTHRACENE].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benz(a)Anthracenes; Carcinoma; Carcinoma, Basal Cell; Cysts; Keratoacanthoma; Lung Neoplasms; Lymphatic Metastasis; Neoplasm Metastasis; Neoplasms, Experimental; Papilloma; Pathology; Rats; Research; Skin Neoplasms | 1964 |
RESISTANCE AGAINST CARCINOMAS OF THE SKIN INDUCED BY DIMETHYLBENZANTHRACENE (DMBA) IN MICE OF THE STRAIN XVII BLN.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benz(a)Anthracenes; Mice; Neoplasms; Neoplasms, Experimental; Research; Skin Neoplasms; Toxicology | 1964 |
PROTEIN BINDING DURING MOUSE SKIN CARCINOGENESIS BY 9,10-DIMETHYL-1,2-BENZANTHRACENE. THE EFFECT OF COPPER ACETATE AND THE NON-RANDOM DISTRIBUTION OF INDUCTION TIMES AMONG MICE GIVEN IDENTICAL TREATMENT.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Acetone; Animals; Benz(a)Anthracenes; Carcinogenesis; Carcinogens; Copper; Mice; Neoplasms; Neoplasms, Experimental; Oils; Pathology; Pharmacology; Protein Binding; Proteins; Research; Skin Neoplasms; Toxicology | 1964 |
EXPERIMENTALLY-INDUCED NEOPLASMS IN THE SKIN OF MICE. I. SINGLE-DOSE EFFECTS OF DMBA IN HAIRED, HAIRLESS, AND RHINO MICE.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Chromatophores; Genetics; Hair; Histocytochemistry; Methylcholanthrene; Mice; Neoplasms; Neoplasms, Experimental; Pigmentation Disorders; Research; Skin Neoplasms; Toxicology | 1965 |
[Effect of 9,10-dimethyl-1,2-benzanthracene on the skin in rabbits].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Lagomorpha; Rabbits; Skin; Skin Neoplasms | 1952 |
Induction of skin tumors in strain DBA mice following intermittent treatment with 9,10-dimethyl-1,2-benzanthracene and croton oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Croton Oil; Mice; Mice, Inbred DBA; Neoplasms, Experimental; Skin Neoplasms | 1955 |
Skin tumours in the rat produced by 9,10-dimethyl-1,2-benzanthracene and methylcholanthrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cysts; Methylcholanthrene; Neoplasms, Experimental; Papilloma; Rats; Skin Neoplasms | 1962 |
Absence of tumor promoting activity of Euphorbia milii latex on the mouse back skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Euphorbia; Female; Latex; Male; Mice; Mice, Inbred DBA; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Female; Lythraceae; Mice; Mice, Inbred Strains; Plant Oils; Random Allocation; Seeds; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Carcinogens; Carcinoma, Squamous Cell; CD4 Lymphocyte Count; Cell Transformation, Neoplastic; Female; Immunosuppressive Agents; Lymph Nodes; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tacrolimus | 2003 |
Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Antipsychotic Agents; Carcinogenicity Tests; Carcinogens; Cell Survival; Disease Models, Animal; Female; Mice; Mice, Inbred ICR; Molecular Structure; Oxazines; Peroxynitrous Acid; Phenothiazines; Phorbol Esters; Skin Neoplasms; Structure-Activity Relationship; Time Factors; Virus Activation | 2004 |
Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene Derivatives; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; Disease Progression; Female; Free Radicals; Hydrogen Peroxide; Iron; Iron Overload; Iron-Dextran Complex; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Cinnamates; Depsides; DNA Primers; Male; Mice; Mice, Inbred BALB C; Perilla frutescens; Phytotherapy; Polymerase Chain Reaction; RNA, Messenger; Rosmarinic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
E6 and E7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Carcinogens; Cell Line, Tumor; Chromosome Mapping; Chromosomes; DNA Primers; Genes, p53; Genes, ras; Genes, Retinoblastoma; Karyotyping; Mice; Mice, Transgenic; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Repressor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antigens, Viral; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred ICR; Otitis; Papilloma; Perilla frutescens; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2004 |
DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Caspase 3; Caspases; Cell Survival; Cell Transformation, Neoplastic; DNA-Binding Proteins; Fibroblasts; Gene Deletion; Mice; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2004 |
On the mechanism of experimental carcinogenesis. II. The effect of different concentrations of 9,10-dimethyl-1,2-benzanthracene on skin-carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogenesis; Mice; Papilloma; Skin Neoplasms | 1951 |
Topical application of dimethylbenz[a]anthracene results in the generation of multiple melanocytic nevi in C3H/HeN mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Carcinogenicity Tests; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C3H; Nevus, Pigmented; Phorbol Esters; Skin; Skin Neoplasms | 2004 |
A responsive, sensitive, and reproducible dermal tumor promotion assay for the comparative evaluation of cigarette smoke condensates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred SENCAR; Nicotiana; Reference Standards; Skin; Skin Neoplasms; Smoke; Survival Analysis | 2004 |
Comparative study of smoke condensates from 1R4F cigarettes that burn tobacco versus ECLIPSE cigarettes that primarily heat tobacco in the SENCAR mouse dermal tumor promotion assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Biological Assay; Carcinogens; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Mice; Mice, Inbred SENCAR; Mutagenicity Tests; Mutagens; Nicotiana; Skin; Skin Neoplasms; Smoke | 2004 |
Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Cocarcinogenesis; DNA Primers; Drug Resistance, Neoplasm; Female; Genes, ras; Genetic Predisposition to Disease; Male; Mice; Mutation; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Chemomodulatory efficacy of basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Catalase; Glutathione Reductase; Kidney; Lipid Peroxidation; Liver; Lung; Mice; Ocimum basilicum; Phytotherapy; Plant Extracts; Plant Leaves; Skin Neoplasms; Stomach; Stomach Neoplasms; Superoxide Dismutase | 2004 |
PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Susceptibility; DNA Primers; Female; Heterozygote; Humans; Mammary Neoplasms, Experimental; Mice; Ovarian Neoplasms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Survival Rate; Transcription Factors; Zinc Fingers | 2004 |
Study on prevention of two-stage skin carcinogenesis by Hibiscus rosa sinensis extract and the role of its chemical constituent, gentisic acid, in the inhibition of tumour promotion response and oxidative stress in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Croton Oil; Dose-Response Relationship, Drug; Female; Gentisates; Glutathione; Hibiscus; Hydrogen Peroxide; Lipid Peroxidation; Malondialdehyde; Mice; Ornithine Decarboxylase; Oxidative Stress; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Binding Sites; Carcinogens; Cell Division; Disease Progression; Enzyme Activation; Epidermis; Epithelium; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Mitosis; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; DNA-Binding Proteins; Female; Genes, ras; Incidence; Mice; Mice, Transgenic; Muridae; Mutation; Nuclear Proteins; Papillomaviridae; Skin Neoplasms; Transgenes; Viral Proteins | 2004 |
Modulation of antioxidant potential in liver of mice by kernel oil of cashew nut (Anacardium occidentale) and its lack of tumour promoting ability in DMBA induced skin papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Anacardium; Animals; Antioxidants; Carcinogens; Catalase; Female; Glutathione; Glutathione Transferase; Lactoylglutathione Lyase; Liver; Mice; Microsomes, Liver; Nuts; Papilloma; Plant Oils; Skin Neoplasms; Superoxide Dismutase | 2004 |
Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Azadirachta; Benzo(a)pyrene; Disease Models, Animal; Dose-Response Relationship, Drug; Lipid Peroxidation; Liver; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Skin Neoplasms; Stomach Neoplasms | 2004 |
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Progression; Epidermis; Genetic Predisposition to Disease; Humans; Infant, Newborn; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred SENCAR; Mice, Nude; Oncogene Proteins, Viral; Papilloma; Papillomaviridae; Papillomavirus E7 Proteins; Repressor Proteins; Skin Neoplasms; Species Specificity | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepatocellular; Carrageenan; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Edema; Female; Hindlimb; Humans; Hydroquinones; Indomethacin; Inflammation; Isoenzymes; Liver Neoplasms; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenylbutazone; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tyrphostins | 2004 |
In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Nucleus; Cytoplasm; DNA, Complementary; Female; Humans; Immunohistochemistry; Keratinocytes; Kinetics; Mice; Mice, Transgenic; Microscopy, Electron; Mitochondria; Oxygen; Signal Transduction; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; DNA-Binding Proteins; Histological Techniques; Immunohistochemistry; Mice; Mice, Transgenic; Papilloma; Signal Transduction; Skin Neoplasms; Smad2 Protein; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 2004 |
Increased skin carcinogenesis in a keratinocyte directed thioredoxin-1 transgenic mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Humans; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioredoxins; Ultraviolet Rays | 2004 |
Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allelic Imbalance; Animals; Carcinogens; Carcinoma, Basal Cell; Female; Genetic Predisposition to Disease; Inbreeding; Intracellular Signaling Peptides and Proteins; Loss of Heterozygosity; Male; Membrane Proteins; Mice; Neoplasms, Radiation-Induced; Patched Receptors; Patched-1 Receptor; Proteins; Receptors, Cell Surface; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Division; India; Male; Medicine, Traditional; Mice; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Swertia | 2004 |
XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dermatitis; DNA Damage; DNA-Binding Proteins; Epidermis; Immunity, Innate; In Situ Nick-End Labeling; Langerhans Cells; Melanins; Melanocytes; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Pyrimidine Dimers; Skin Neoplasms; Stem Cell Factor; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 2004 |
Experimental study to test the potential tumor promotion effect of a tooth bleaching agent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbamide Peroxide; Carcinogens; Cricetinae; Disease Models, Animal; Drug Combinations; Female; Hyperplasia; Male; Mesocricetus; Mice; Mice, Inbred SENCAR; Mouth Mucosa; Mouth Neoplasms; Oxidants; Peroxides; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tooth Bleaching; Urea | 2001 |
Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; alpha-2-HS-Glycoprotein; Animals; Apoptosis; Blood Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Mice; Mice, Inbred C57BL; Mutation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Male; Mice; Nyctaginaceae; Papilloma; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Skin Neoplasms | 2003 |
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Progression; Genes, ras; Heterozygote; Homozygote; Loss of Heterozygosity; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Papilloma; Protein Tyrosine Phosphatases; PTEN Phosphohydrolase; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2004 |
Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Apoptosis; Carcinogens; DNA Damage; Genes, Tumor Suppressor; Germ-Line Mutation; Keratinocytes; Mice; Mice, Knockout; Papilloma; Phosphoric Monoester Hydrolases; PTEN Phosphohydrolase; Skin Neoplasms; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2004 |
[Chemopreventive effect of resveratrol to cancer].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Croton Oil; Ear Diseases; Edema; Epithelial Cells; Female; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagenicity Tests; Ornithine Decarboxylase; Papilloma; Resveratrol; Salmonella typhimurium; Skin Neoplasms; Stilbenes | 2004 |
Chemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chemoprevention; Croton Oil; Female; Mice; Papilloma; Phyllanthus; Phytotherapy; Plant Extracts; Skin Neoplasms | 2003 |
Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Boraginaceae; Carcinogens; Catalase; Cell Division; Croton Oil; DNA; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Malondialdehyde; Mice; Ornithine Decarboxylase; Oxidative Stress; Phytotherapy; Plant Extracts; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2004 |
Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Croton Oil; Dermatologic Agents; Female; Lipid Peroxidation; Mice; Organoselenium Compounds; Papilloma; Skin Neoplasms | 2004 |
Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthocyanins; Carcinogens; Cyclooxygenase 2; Edema; Epidermis; Female; Fruit; Hydrolyzable Tannins; Hyperplasia; I-kappa B Kinase; Isoenzymes; Lythraceae; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Ornithine Decarboxylase; Phosphorylation; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Signal Transduction; Skin Neoplasms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate | 2005 |
Modulatory effect of Morus indica against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Antioxidants; Aryl Hydrocarbon Hydroxylases; Carcinogens; Croton Oil; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA Damage; Enzyme Inhibitors; Female; Lipid Peroxidation; Male; Mice; Morus; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Immunohistochemistry; Mice; Mutation; Skin Neoplasms; Sulfides; Tumor Suppressor Protein p53 | 2004 |
Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activating Transcription Factor 2; Activating Transcription Factor 3; Animals; Carcinogens; Carcinoma; Cell Cycle; Cell Growth Processes; Cyclic AMP Response Element-Binding Protein; Cyclin A; Cyclin D1; Disease Progression; Genes, jun; Mice; Mice, Inbred BALB C; Mice, SCID; Phosphorylation; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Transcription Factor AP-1; Transcription Factors; Transfection; Up-Regulation | 2004 |
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; DNA Primers; Flow Cytometry; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Deletion; Genotype; Hydroxytestosterones; Immunohistochemistry; Integrases; Keratin-14; Keratinocytes; Keratins; Mice; Mice, Transgenic; Neoplasm Metastasis; Protein-Tyrosine Kinases; Receptors, Estrogen; Skin Neoplasms; Tamoxifen | 2004 |
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Mice; Mice, Inbred C57BL; Mutation; Phosphoinositide Phospholipase C; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2004 |
Polyamines modulate carcinogen-induced mutagenesis in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Methylnitronitrosoguanidine; Mice; Mice, Transgenic; Mutagenesis; Mutation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Skin Neoplasms | 2005 |
Anticancer and radioprotective potentials of Mentha piperita.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Catalase; Cell Division; Croton Oil; Disease Models, Animal; Glutathione Reductase; Glutathione Transferase; HeLa Cells; Humans; Lipid Peroxidation; Liver; Mentha piperita; Mice; Phytotherapy; Plant Leaves; Radiation-Protective Agents; Skin Neoplasms; Superoxide Dismutase | 2004 |
Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem bark of Glochidion zeylanicum and Phyllanthus flexuosus.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Female; Herpesvirus 4, Human; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Papilloma; Phyllanthus; Phytotherapy; Plant Bark; Plant Extracts; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Triterpenes | 2004 |
Antitumor-promoting activity of coumarins from citrus plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Citrus; Coumarins; Inhibitory Concentration 50; Mice; Phytotherapy; Skin Neoplasms | 2005 |
Haploinsufficiency for odc modifies mouse skin tumor susceptibility.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biogenic Polyamines; Carcinogens; Cocarcinogenesis; Enzyme Induction; Female; Genetic Predisposition to Disease; Haploidy; Male; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Catalase; DNA-Binding Proteins; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hippophae; Interferon Regulatory Factor-1; Liver; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Papilloma; Phosphoproteins; Phytotherapy; Plant Extracts; Skin Neoplasms; Stomach Neoplasms; Superoxide Dismutase | 2005 |
Chfr is required for tumor suppression and Aurora A regulation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aurora Kinase A; Aurora Kinases; Carcinogens; Cell Cycle Proteins; Chromosomal Instability; Embryo, Mammalian; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Gene Targeting; Genes, Tumor Suppressor; Heterozygote; Homozygote; Male; Mice; Mice, Knockout; Mitosis; Neoplasm Proteins; Poly-ADP-Ribose Binding Proteins; Protein Kinases; Protein Serine-Threonine Kinases; Skin Neoplasms; Ubiquitin; Ubiquitin-Protein Ligases; Xenopus Proteins | 2005 |
Evaluation of chemopreventive action and antimutagenic effect of the standardized Panax ginseng extract, EFLA400, in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Bone Marrow Cells; Chromosome Aberrations; Croton Oil; Ginsenosides; Male; Mice; Micronuclei, Chromosome-Defective; Panax; Papilloma; Phytotherapy; Skin Neoplasms | 2005 |
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Green Fluorescent Proteins; Immunoprecipitation; In Situ Hybridization; Lymphangiogenesis; Lymphatic Metastasis; Mice; Mice, Transgenic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Vascular Endothelial Growth Factor A | 2005 |
The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Chromans; Diet; Female; Keratinocytes; Ligands; Mice; PPAR gamma; RNA, Messenger; Rosiglitazone; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiazolidinediones; Troglitazone; Ultraviolet Rays | 2005 |
Mouse skin tumor promotion by sodium arsenate is associated with enhanced PCNA expression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arsenates; Cell Proliferation; Immunohistochemistry; Male; Mice; Mice, Hairless; Proliferating Cell Nuclear Antigen; Skin Neoplasms | 2005 |
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Growth Processes; Cell Transformation, Neoplastic; Chromosome Mapping; DNA Damage; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Fibroblasts; Gene Expression Profiling; Genes, Tumor Suppressor; Immediate-Early Proteins; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation | 2005 |
Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Female; Male; Melanins; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Pinus; Plant Bark; Skin Neoplasms; Time Factors; Ultraviolet Rays | 2006 |
Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carcinogens; Caspase 3; Caspases; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; DNA, Antisense; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Papilloma; Phosphoproteins; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Communication; Cell Differentiation; Disease Progression; Extracellular Matrix; Fibroblasts; Mice; Models, Biological; Skin Neoplasms; Stromal Cells | 2005 |
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cadherins; Carcinoma, Squamous Cell; Female; Incidence; Keratoacanthoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2005 |
Mice lacking the p53/p63 target gene Perp are resistant to papilloma development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Adhesion; Cell Differentiation; Cell Growth Processes; Female; Gene Silencing; Genes, p53; Genetic Predisposition to Disease; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Phosphoproteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2005 |
Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Diterpenes; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methylnitronitrosoguanidine; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cytokines; DNA; Female; Hyperplasia; Keratinocytes; Mice; Protein Kinase C; Protein Kinase C-alpha; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Apoptosis; Carcinogens; Cells, Cultured; DNA Damage; Embryo, Mammalian; Epithelial Cells; Fibroblasts; G1 Phase; Intestinal Mucosa; Intestine, Small; Mice; Mice, Knockout; Molecular Sequence Data; Mutation; Papilloma; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Skin Neoplasms; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2005 |
Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Cyclooxygenase 2; Disease Progression; Drug Interactions; Female; Immunologic Factors; Keratinocytes; Mice; Papilloma; Prostaglandin D2; Skin Neoplasms | 2006 |
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Line, Tumor; Disease Susceptibility; Down-Regulation; Female; Immunologic Surveillance; Killer Cells, Natural; Ligands; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NK Cell Lectin-Like Receptor Subfamily K; Papilloma; Receptors, Immunologic; Receptors, Natural Killer Cell; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Burden | 2005 |
Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Viral; DNA; Human papillomavirus 16; Humans; Membrane Proteins; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Protein Structure, Tertiary; Repressor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Chemopreventive effects of various concentrations of alpha-santalol on skin cancer development in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Papilloma; Phorbol Esters; Polycyclic Sesquiterpenes; Sesquiterpenes; Skin Neoplasms | 2005 |
Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Female; Integrases; Keratin-15; Keratin-5; Keratinocytes; Keratins; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Cyclic AMP; Dinoprostone; Drug Eruptions; Female; Hyperplasia; Keratinocytes; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Autofluorescence characterization for the early diagnosis of neoplastic changes in DMBA/TPA-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; Early Diagnosis; Female; Immunohistochemistry; Linear Models; Mice; Multivariate Analysis; Probability; Sensitivity and Specificity; Skin Neoplasms; Spectrometry, Fluorescence | 2005 |
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Death; Cell Differentiation; Cell Proliferation; Chemotaxis, Leukocyte; Cocarcinogenesis; Disease Models, Animal; Epidermis; Female; Hair Follicle; Hyperplasia; Keratin-10; Keratinocytes; Keratins; Mice; Mice, Transgenic; Neutrophils; Phenotype; Precancerous Conditions; Protein Kinase C-epsilon; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Caspase 3; Caspases; Cell Proliferation; Chemoprevention; Croton Oil; Dermatologic Agents; Female; Mice; Organoselenium Compounds; Papilloma; Skin Neoplasms | 2005 |
Unexpected roles for pRb in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; E2F Transcription Factors; Mice; Papilloma; Phosphorylation; Retinoblastoma Protein; Signal Transduction; Skin Neoplasms; Tumor Suppressor Protein p53 | 2005 |
Inhibitory effects of Azadirachta indica on DMBA-induced skin carcinogenesis in Balb/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Antioxidants; Azadirachta; Carcinogens; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Plant Leaves; Skin Neoplasms; Superoxide Dismutase | 2006 |
Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Carcinogens; Cell Membrane; Cyclin-Dependent Kinase Inhibitor p21; Garlic; Gene Expression Regulation, Neoplastic; Male; Mice; Mutation; Oncogene Protein p21(ras); Signal Transduction; Skin; Skin Neoplasms; Sulfides | 2006 |
Overexpression of extracellular superoxide dismutase (EC-SOD) in mouse skin plays a protective role in DMBA/TPA-induced tumor formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; DNA Damage; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reactive Oxygen Species; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2005 |
Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p16; Melanoma, Experimental; Mice; Mice, Knockout; Neoplasms, Radiation-Induced; Nevus; Sarcoma; Skin Neoplasms; Tumor Suppressor Protein p14ARF; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein | 2006 |
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Cocarcinogenesis; Keratinocytes; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Glucosides; In Situ Nick-End Labeling; Iridoids; Male; Medicine, Traditional; Membrane Proteins; Mice; Phytotherapy; Plant Extracts; Skin Neoplasms; Swertia; Up-Regulation | 2006 |
Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Minichromosome Maintenance Complex Component 7; Mutation; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azadirachta; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Enzymes; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Leaves; Random Allocation; Skin Neoplasms | 2006 |
Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Phone; Dose-Response Relationship, Radiation; Electromagnetic Fields; Male; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Female; Filaggrin Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Altered methylation in gene-specific and GC-rich regions of DNA is progressive and nonrandom during promotion of skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; CpG Islands; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; Mice, Inbred SENCAR; Nicotiana; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Smoke | 2006 |
Ras mutation promotes p53 activation and apoptosis of skin keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Enzyme Inhibitors; Genes, ras; Keratinocytes; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; NADPH Oxidases; Onium Compounds; Protein Transport; rac1 GTP-Binding Protein; Reactive Oxygen Species; RNA, Small Interfering; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2006 |
Evaluation of chemopreventive action of Ginsenoside Rp1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Catalase; Cytochrome P-450 Enzyme System; Cytochromes b5; Ginsenosides; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Papilloma; Random Allocation; Skin; Skin Neoplasms; Superoxide Dismutase | 2006 |
Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Blotting, Western; Carcinogenicity Tests; Carcinogens; Cell Culture Techniques; Cells, Cultured; Chlorocebus aethiops; COS Cells; Eosine Yellowish-(YS); Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Hematoxylin; Histocytochemistry; Hydroquinones; Keratinocytes; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; NF-E2-Related Factor 2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2006 |
Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Drugs, Chinese Herbal; Female; Mice; Mice, Hairless; Models, Chemical; Neoplasms, Radiation-Induced; Ornithine Decarboxylase; Polycyclic Sesquiterpenes; Sesquiterpenes; Skin Neoplasms; Ultraviolet Rays | 2006 |
The Rac activator Tiam1 and Ras-induced oncogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Separation; Down-Regulation; Guanine Nucleotide Exchange Factors; Keratinocytes; Mice; Mice, Knockout; NIH 3T3 Cells; ras Proteins; Skin Neoplasms; T-Lymphoma Invasion and Metastasis-inducing Protein 1 | 2006 |
Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Carcinogens; DNA Mutational Analysis; Genes, ras; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Squamous Cell; Oncogene Protein p21(ras); Point Mutation; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Mas; Pyridines; Skin Neoplasms; Species Specificity | 2006 |
Dermatological effects of chronic exposure to 7,12-dimethylbenz[A]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Analysis of Variance; Animals; Cocarcinogenesis; Female; Methylnitronitrosoguanidine; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Swine; Ultraviolet Rays | 2006 |
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Enzyme Activation; Ephrin-A1; Female; Genetic Predisposition to Disease; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptor, EphA2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Papilloma development is delayed in osteopontin-null mice: implicating an antiapoptosis role for osteopontin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Epidermis; Female; Male; Mice; Osteopontin; Papilloma; Sialoglycoproteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-myc; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Disease Susceptibility; DNA, Neoplasm; Isothiocyanates; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2 Transcription Factor; Polymerase Chain Reaction; Skin Neoplasms; Sulfoxides; Thiocyanates | 2006 |
Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Croton Oil; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Phytotherapy; Plant Extracts; Plant Leaves; Rosmarinus; Skin Neoplasms; Tumor Burden | 2006 |
Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Line; Cocarcinogenesis; Cyclooxygenase 2; Female; Flavones; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
DBA/2 mouse skin is unresponsive to dermal tumor promotion by cigarette smoke condensate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mice, Inbred SENCAR; Nicotiana; Polycyclic Aromatic Hydrocarbons; Skin Neoplasms; Smoke | 2006 |
Non-invasive imaging of carcinogen-induced early neoplasia using ultrahigh-resolution optical coherence tomography.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Diagnostic Imaging; Feasibility Studies; Humans; Mice; Models, Biological; Neoplasm Staging; Signal Processing, Computer-Assisted; Skin; Skin Neoplasms; Time Factors; Tomography, Optical Coherence | 2006 |
Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Female; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; Papilloma; Pentacyclic Triterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes | 2007 |
Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene Derivatives; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2007 |
Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Chromosomal Instability; Disease Models, Animal; DNA Damage; Keratin-15; Keratin-5; Keratinocytes; Mice; Recombination, Genetic; Skin; Skin Neoplasms; Specific Pathogen-Free Organisms; Telomerase; Telomere; Telomeric Repeat Binding Protein 2; Ultraviolet Rays | 2007 |
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Epidermis; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Transgenic; Nevus, Pigmented; Papilloma; PPAR gamma; Retinoid X Receptor alpha; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Caspase 3; Caspase 8; Caspase 9; Cell Proliferation; Cyclooxygenase 2; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CCAAT-Enhancer-Binding Proteins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; NF-kappa B; Oncogene Proteins, Viral; Osteopontin; Papillomavirus E7 Proteins; Peptide Fragments; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2007 |
The ends of a conundrum?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Binding Sites; Carcinogens; Cell Proliferation; Cells, Cultured; Disease Susceptibility; Epidermal Cells; Intermediate Filaments; Keratin-10; Keratin-14; Keratin-5; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Protein Binding; Protein Structure, Tertiary; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Codon; Crosses, Genetic; DNA Helicases; Female; Genes, ras; Male; Mice; Mice, Inbred C57BL; Minichromosome Maintenance Complex Component 4; Papilloma; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cellular Senescence; Embryo, Mammalian; Fibroblasts; Mice; Papilloma; Skin Neoplasms; Telomere; Tumor Suppressor Protein p53 | 2007 |
Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma, Sebaceous; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Female; Genes, ras; Lymphoid Enhancer-Binding Factor 1; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mutation; Sebaceous Gland Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2007 |
CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD34; Cell Cycle; Cell Movement; Female; Hair Follicle; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2007 |
DMBA/TPA-induced tumor formation is aggravated in human papillomavirus type 16 E6/E7 transgenic mouse skin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Deoxyguanosine; Dermis; DNA Damage; Epidermis; Gene Expression; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Repressor Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female; Gene Expression Profiling; Immunity, Cellular; Immunophenotyping; Mice; Mice, Inbred SENCAR; Oligonucleotide Array Sequence Analysis; Papilloma; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Dermatologic Agents; Drug Resistance, Neoplasm; Female; Humans; Interleukin-1alpha; Mice; Mice, Transgenic; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Mapping; Crosses, Genetic; Drug Resistance; Female; Genes, Dominant; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Male; Mice; Mice, Inbred Strains; Neoplasms, Second Primary; Papilloma; Quantitative Trait Loci; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Codon; Disease Progression; DNA; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Paraffin; Phenotype; ras Proteins; Skin Neoplasms | 2007 |
Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Glutathione; Glutathione S-Transferase pi; HSP70 Heat-Shock Proteins; Interleukin-1beta; Lipid Peroxidation; Methylcholanthrene; Mice; Ocimum; Ornithine Decarboxylase; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Animals; Base Sequence; Disease Susceptibility; DNA Primers; Immunohistochemistry; Mice; Mice, Inbred C57BL; Skin Neoplasms | 2007 |
Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, ras; Humans; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2007 |
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Fruit; Glycosides; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Momordica charantia; Nitric Oxide Donors; Peroxynitrous Acid; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2007 |
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Epidermis; Keratinocytes; Mice; Mice, Transgenic; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2008 |
Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Caspases; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glucaric Acid; Mice; Peptide Hydrolases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Skin; Skin Neoplasms; Tumor Suppressor Protein p53 | 2007 |
In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Cell Differentiation; Disease Models, Animal; Female; Keratolytic Agents; Mice; Papilloma; Pregnancy; Prenatal Exposure Delayed Effects; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 2007 |
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; DNA-Binding Proteins; Fibroblasts; Gene Expression Regulation, Neoplastic; Genotype; Glucose; Heat Shock Transcription Factors; Humans; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; Phenotype; Protein Biosynthesis; Proto-Oncogene Proteins c-sis; ras Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factors; Transduction, Genetic; Tumor Suppressor Protein p53 | 2007 |
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Bromelains; Cyclooxygenase 2; Female; MAP Kinase Signaling System; Mice; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2008 |
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma; Cocarcinogenesis; Female; Genes, ras; Genetic Predisposition to Disease; I-kappa B Kinase; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Neovascularization, Pathologic; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2007 |
Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Claudin-1; Disease Progression; Epidermis; Gene Expression; Membrane Proteins; Mice; Models, Animal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tight Junctions; Time Factors | 2007 |
RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Progression; Epidermis; Female; Guanine Nucleotide Exchange Factors; Keratinocytes; Male; Mice; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Chemotherapeutic/chemopreventive role of retinoids in chemically induced skin carcinogenesis in albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Diterpenes; Isotretinoin; Mice; Precancerous Conditions; Retinyl Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 2007 |
Chemopreventive potential of Aloe vera against 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Body Weight; Catalase; Chemoprevention; Croton Oil; DNA; Glutathione; Lipid Peroxides; Male; Mice; Papilloma; Phytotherapy; Plant Extracts; Plant Leaves; Proteins; Skin; Skin Neoplasms | 2007 |
p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; B-Lymphocytes; Carcinoma, Squamous Cell; Cell Proliferation; Chemotaxis, Leukocyte; Cyclin-Dependent Kinase Inhibitor p16; Lymph Nodes; Lymphangiogenesis; Lymphatic Metastasis; Macrophages; Mice; Mice, Transgenic; Neovascularization, Pathologic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2008 |
Imiquimod treatment of papilloma virus and DMBA /TPA-induced cutaneous skin cancer in Mastomys coucha: an unique animal model system useful for preclinical studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoquinolines; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Imiquimod; Murinae; Papilloma; Papillomavirus Infections; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2007 |
The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Keratin-6; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Sarcoma Viruses, Murine; Skin Neoplasms; Spleen; Transfection | 2008 |
Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Endostatins; Female; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Lymphatic Metastasis; Male; Mice; Mice, Transgenic; Neovascularization, Pathologic; Skin Neoplasms | 2007 |
Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinoma, Squamous Cell; Female; Genes, ras; Mice; Mice, Transgenic; Mutation; Papilloma; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Genetic Predisposition to Disease; HMGA Proteins; Keratinocytes; Mice; Mice, Knockout; Papilloma; Proto-Oncogene Proteins c-fos; rab GTP-Binding Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; AMP-Activated Protein Kinases; Animals; Carcinogens; Cell Transformation, Neoplastic; Epidermis; Lung Neoplasms; Mice; Mice, Mutant Strains; Neoplasms, Squamous Cell; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Skin Neoplasms; Tumor Suppressor Protein p53 | 2008 |
Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cytoprotection; Dermatitis, Contact; Female; Genetic Predisposition to Disease; Interleukin-12; Interleukin-23; Mice; Mice, Inbred C3H; Mice, Knockout; Neovascularization, Pathologic; Skin Neoplasms; Toll-Like Receptor 4 | 2008 |
RETRACTED: Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Carcinogens; Chemoprevention; Cytochromes c; Disease Models, Animal; In Situ Nick-End Labeling; Male; Mice; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Resveratrol; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2008 |
Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Amino Acids; Animals; Arginine; Ascorbic Acid; Camellia sinensis; Carcinogens; Copper; Diet; Female; Keratoacanthoma; Lysine; Manganese; Mice; Mice, Inbred SENCAR; Papilloma; Plant Extracts; Proline; Selenium; Skin; Skin Neoplasms | 2008 |
RAGE signaling sustains inflammation and promotes tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Gene Expression Regulation, Neoplastic; Inflammation; Macrophage Inflammatory Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor for Advanced Glycation End Products; Receptors, Immunologic; S100 Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Artemisia; Camphanes; Camphor; Carcinogenicity Tests; Carcinogens; Chloroform; Coumarins; Disease Models, Animal; Female; Gas Chromatography-Mass Spectrometry; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Random Allocation; Sesquiterpenes; Skin Neoplasms | 2008 |
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activating Transcription Factor 2; Animals; Apoptosis; beta Catenin; Carcinogens; Cell Proliferation; Cyclin D1; DNA; Epidermis; Keratinocytes; Mice; Mice, Knockout; Papilloma; Presenilin-1; Proto-Oncogene Proteins c-myb; Receptor, Notch1; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Array Analysis; Tumor Suppressor Proteins | 2008 |
Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; CHO Cells; Cocarcinogenesis; Consumer Product Safety; Cricetinae; Cricetulus; Female; Inhalation Exposure; Male; Mutagens; Nicotiana; Organ Size; Organ Specificity; Phosphates; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Sister Chromatid Exchange; Skin Neoplasms; Tars; Tobacco Industry; Toxicity Tests; Urea | 2008 |
Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Differentiation; DNA Replication; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, Reporter; Keratinocytes; Membrane Glycoproteins; Mice; Neoplasm Proteins; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Skin Neoplasms; Transforming Growth Factor beta1 | 2008 |
Cancer chemoprotective effects of Curcuma xanthorrhiza.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Curcuma; Dose-Response Relationship, Drug; Ear; Edema; Female; Humans; Methanol; Mice; Mice, Inbred ICR; Mutagenesis; Phytotherapy; Plant Extracts; Salmonella typhimurium; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Epidermis; Female; Flavonoids; Inflammation Mediators; MAP Kinase Signaling System; Mice; Ornithine Decarboxylase; Phenols; Polymers; Polyphenols; Precancerous Conditions; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Protein p53 | 2008 |
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Blotting, Western; Cell Line, Transformed; Cell Line, Tumor; Chalcones; Cocarcinogenesis; Female; Flowers; Helichrysum; Mice; Mice, Inbred SENCAR; p38 Mitogen-Activated Protein Kinases; Papilloma; Phorbol Esters; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Uzbekistan | 2008 |
Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alpinia; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Carcinogens; Diarylheptanoids; Female; Inflammation; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Plant Extracts; Rhizome; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Cancer chemopreventive activity of "rosin" constituents of Pinus spez. and their derivatives in two-stage mouse skin carcinogenesis test.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carboxylic Acids; Carcinogenicity Tests; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred ICR; Papilloma; Phenanthrenes; Pinus; Resins, Plant; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Chemopreventive activity of lantadenes on two-stage carcinogenesis model in Swiss albino mice: AP-1 (c-jun), NFkappaB (p65) and P53 expression by ELISA and immunohistochemical localization.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Cytoprotection; Enzyme-Linked Immunosorbent Assay; Esters; Female; Immunohistochemistry; Mice; NF-kappa B; Oleanolic Acid; Papilloma; Skin Neoplasms; Tissue Distribution; Transcription Factor AP-1; Tumor Suppressor Protein p53 | 2008 |
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Immunohistochemistry; Mice; Mice, Transgenic; Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tamoxifen; Tetradecanoylphorbol Acetate | 2008 |
Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Carcinogens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dendritic Cells; Dermatitis, Contact; Female; Gene Expression Regulation, Neoplastic; Interferon-gamma; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Skin Neoplasms | 2008 |
Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Dioxoles; Drug Synergism; Female; Food, Formulated; Lignans; Liver; Mice; Mice, Hairless; Palm Oil; Papilloma; Plant Oils; Skin; Skin Neoplasms; Sunburn; Thiobarbituric Acid Reactive Substances; Tocotrienols; Ultraviolet Rays; Vitamin E | 2008 |
Effects of oral administration of ciclosporin A on skin carcinogenesis: a study using the two-stage carcinogenesis protocol in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Cyclosporine; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Mice; Mice, Hairless; Neoplasm Staging; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Preclinical evaluation of acid products for treatment of solid experimental skin tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Evaluation, Preclinical; Female; Mice; Mice, Nude; Neoplasms, Experimental; Nitrates; Nitric Acid; Sarcoma; Skin Neoplasms; T-Lymphocytes | 1984 |
Chemical carcinogenesis by the two-stage protocol in the skin Mastomys natalensis (Muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Keratoacanthoma; Male; Muridae; Neoplasms, Experimental; Phorbols; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Hairless mouse skin in two-stage chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Drug Resistance; Female; Hyperplasia; Male; Mice; Mice, Hairless; Neoplasm Regression, Spontaneous; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Comparison of the effects of 3-isobutyl-1-methylxanthine and adenosine cyclic 3':5'-monophosphate on the induction of skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.
Topics: 1-Methyl-3-isobutylxanthine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cyclic AMP; DNA; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Polyamines; Protein Biosynthesis; RNA; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1982 |
Simultaneous appearance of keratin modifications and gamma-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyltransferases; Animals; Carcinoma, Squamous Cell; Female; Histocytochemistry; Keratins; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1983 |
Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Calcium; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Drug Resistance; Keratins; Methylnitronitrosoguanidine; Mice; Microscopy, Electron, Scanning; Skin; Skin Neoplasms; Skin Physiological Phenomena | 1983 |
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Diethylnitrosamine; Drug Interactions; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Proliferation of mast cells in normal and DMBA-treated mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autoradiography; Benz(a)Anthracenes; Cell Division; DNA; Mast Cells; Mice; Skin; Skin Neoplasms; Staining and Labeling; Thymidine; Time Factors; Tritium | 1984 |
[Antitumor effects of aromatic retinoids (Ro 10-1670, Ro 10-9359) on the chemically-induced epithelial tumors].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acitretin; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cricetinae; Etretinate; Mesocricetus; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tretinoin | 1982 |
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenes; Animals; Benz(a)Anthracenes; Dehydroepiandrosterone; Drug Administration Schedule; Drug Antagonism; Estradiol; Female; Mice; Papilloma; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterus | 1984 |
Comparison of the tumor-initiating activity of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene in female SENCAR and CS-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Neoplasms, Experimental; Oxidation-Reduction; Skin; Skin Neoplasms; Species Specificity | 1980 |
Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; DNA; Drug Interactions; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Skin Neoplasms | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; Injections, Intraperitoneal; Methylcholanthrene; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Relationship of benign papillomas to cancer induction in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Dose-Response Relationship, Drug; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Initiation/promotion studies with coal-derived liquids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Coal; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms | 1983 |
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; Chlorogenic Acid; Cinnamates; Coumaric Acids; Ellagic Acid; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Line; Cricetinae; Cricetulus; Female; Lung; Mice; Mice, Inbred Strains; Mutagenicity Tests; Mutagens; Mutation; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Nature of the epidermal hyperplasia produced by mezerein, a weak tumor promoter, in initiated skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Evidence for a new model of tumor progression from carcinogenesis and tumor promotion studies with 7-bromomethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Cocarcinogenesis; Female; Mice; Models, Biological; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Time Factors | 1983 |
Skin painting studies in Syrian hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Dose-Response Relationship, Drug; Female; Male; Melanoma; Mesocricetus; Neoplasms, Experimental; Nicotiana; Papilloma; Plants, Toxic; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 7-bromomethylbenz[a]anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Dexamethasone; Drug Interactions; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1983 |
Nevi and melanoma induced by chemical carcinogens in laboratory animals: similarities and differences with human lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Fishes; Gerbillinae; Guinea Pigs; Humans; Melanoma; Mice; Microscopy, Electron; Neoplasms, Experimental; Nevus, Pigmented; Skin Neoplasms; Urethane | 1983 |
On the persistence of tumor initiation in two-stage carcinogenesis on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Cell Transformation, Neoplastic; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Transplacental skin tumor initiation of Ha/ICR mice at different fetal ages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Guinea pig cutaneous nevi transplanted to athymic nude mice: a potential model for benign and malignant melanocytic lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Guinea Pigs; Male; Melanocytes; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nevus, Pigmented; Skin Neoplasms; Transplantation, Heterologous | 1983 |
Tumor initiating activity of 9- and 10-fluoro-7,12-dimethylbenz[a]-anthracene (DMBA) and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on tumor initiation by monofluoro derivatives of DMBA in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Dioxins; Drug Interactions; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Polychlorinated Dibenzodioxins; Skin Neoplasms; Structure-Activity Relationship | 1983 |
Incidence and type of tumors induced by DMBA carcinogenesis in H-2 congenic strains on a B10 background.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Disease Susceptibility; Female; H-2 Antigens; Killer Cells, Natural; Lymphoma; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms | 1983 |
Retinoids in skin cancer and hyperproliferative skin disease.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benzoates; Cell Differentiation; Cell Division; Guinea Pigs; Humans; Hyperplasia; In Vitro Techniques; Isotretinoin; Neoplasms, Experimental; Rabbits; Retinoids; Skin; Skin Neoplasms; Tretinoin; Vitamin A | 1983 |
Sequential histological changes and mast cell response in skin during chemically-induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cell Division; Mast Cells; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms | 1983 |
Skin carcinogenesis tests in mice of derivatives of 7,12-dimethylbenz[a]anthracene substituted in the 'A' ring.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Female; Mice; Mutagenicity Tests; Skin Neoplasms; Structure-Activity Relationship | 1983 |
The development of retinoids in experimental and clinical oncology and dermatology.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemical Phenomena; Chemistry; Mice; Papilloma; Retinoids; Skin Diseases; Skin Neoplasms | 1983 |
The reduction of tumor initiating activity and cell mediated mutagenicity of dimethylbenz[a]anthracene by a copper coordination compound.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Biotransformation; Cocarcinogenesis; Cricetinae; Female; Mice; Salicylates; Skin Neoplasms | 1984 |
Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(alpha)anthracene. Influence of dose and frequency on tumour response and its histological type.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benz(a)Anthracenes; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Papilloma; Rats; Rats, Inbred Strains; Skin Neoplasms; Time Factors | 1983 |
The effect of steric strain in the bay-region of polycyclic aromatic hydrocarbons: tumorigenicity of alkyl-substituted benz[a]anthracenes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Female; Methylcholanthrene; Mice; Skin Neoplasms; Structure-Activity Relationship | 1983 |
Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benz(a)Anthracenes; Carcinogens; Drug Antagonism; Female; Fibroblasts; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phospholipids; Skin Neoplasms; Sulfonamides; Trifluoperazine | 1984 |
Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cricetinae; Drug Synergism; Female; Male; Neoplasms; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Tumor-producing activity of dithranol (anthralin) and two of its 10-acyl analogs in the dorsal skin of female NMRI mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthracenes; Anthralin; Body Weight; Carcinogens; Female; Leukemia, Experimental; Mammary Neoplasms, Experimental; Mast-Cell Sarcoma; Mice; Skin Neoplasms | 1984 |
Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benz(a)Anthracenes; Body Weight; Carcinogens; Drug Interactions; Female; Flavonoids; Lyngbya Toxins; Mice; Papilloma; Quercetin; Skin; Skin Neoplasms; Time Factors | 1984 |
Intraclonal conversion from papilloma to carcinoma in the skin of Pgk-1a/Pgk-1b mice treated by a complete carcinogenesis process or by an initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Male; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity | 1984 |
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Dermotoxins; Lyngbya Toxins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Histochemical AMD electron microscopic studies of intercellular matrices of papilloma induced by painting DMBA on the skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Glycosaminoglycans; Histocytochemistry; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1984 |
Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; DNA Replication; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA; Female; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Glycyrrhetinic Acid; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phospholipids; Skin Neoplasms | 1984 |
Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Bromates; Chlorides; Female; Hydrogen Peroxide; Mice; Oxidation-Reduction; Skin Neoplasms; Sodium Hypochlorite; Tetradecanoylphorbol Acetate | 1984 |
[Comparison of the effect of different carcinogens on the skin of rats].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Diazonium Compounds; Female; Keratoacanthoma; Male; Methylnitronitrosoguanidine; Methylnitrosourea; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Papilloma; Rats; Skin Neoplasms | 1984 |
Antitumor activity of vitamin A and its derivatives.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Vitamin A | 1984 |
Stages of tumour promotion in skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Aging; Animals; Animals, Newborn; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Hyperplasia; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wounds and Injuries | 1984 |
On the role of tumour promotion in chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dexamethasone; DNA Replication; Hyperplasia; Indomethacin; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Tumor promoting and skin irritant diterpene esters of Euphorbia virgata latex.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Drug Eruptions; Female; Irritants; Latex; Magnoliopsida; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1981 |
Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Characteristics of neoplastic progression and tumor behavior in skin carcinogenesis by different methods: an experimental study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Keratoacanthoma; Mice; Neoplasms, Experimental; Papilloma; Precancerous Conditions; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with or without promotion from croton oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Croton Oil; Disease Models, Animal; Keratoacanthoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Rabbits; Skin; Skin Neoplasms; Species Specificity; Swine; Time Factors | 1980 |
Tumour initiation in mouse skin by 7,12-dimethylbenz[a]anthracene: irrelevance of systemic activation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Oxygenases; Skin; Skin Neoplasms | 1980 |
Time-dependent inhibition by 2,3,7,8-tetrachlorodibenzo-p-dioxin of skin tumorigenesis with polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Dioxins; Epidermis; Female; Methylcholanthrene; Mice; Neoplasms, Experimental; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Skin Neoplasms; Structure-Activity Relationship | 1980 |
Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diterpenes; Epidermal Cells; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1980 |
Ultrastructural observations on DMBA-induced dermal hyperpigmentation and blue nevus-like tumors in the Mongolian gerbil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Gerbillinae; Male; Melanocytes; Nevus, Pigmented; Pigmentation Disorders; Skin Neoplasms | 1980 |
Metabolism of 7,12-dimethylbenzanthracene (DMBA) by mouse skin keratinocytes, fibroblasts, and carcinoma cells in culture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cells, Cultured; Fibroblasts; Kinetics; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms; Temperature; Time Factors | 1980 |
9-Hydroxyellipticine: inhibitory effect on skin carcinogenesis induced in Swiss mice by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benz(a)Anthracenes; Ellipticines; Male; Mice; Neoplasms, Experimental; Skin Neoplasms; Time Factors | 1980 |
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chemical Phenomena; Chemistry; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1980 |
Haematoporphyrin diacetate: a probe to distinguish malignant from normal tissue by selective fluorescence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Chromatography, Thin Layer; Fluorescent Dyes; Hematoporphyrins; Liver Neoplasms, Experimental; Male; Mice; Neoplasms, Experimental; Rats; Skin Neoplasms | 1980 |
Adnexal participation in formation of cutaneous tumors following topical application of 9,10-dimethyl-benzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Administration, Topical; Animals; Benz(a)Anthracenes; Female; Hair; Mice; Microscopy, Electron; Neoplasms, Experimental; Skin Neoplasms | 1980 |
Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hyperplasia; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms | 1980 |
Skin melanoma induced by 7,12-dimethylbenzanthracene in albino guinea pigs and its similarities to skin melanoma of humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Disease Models, Animal; Guinea Pigs; Humans; Male; Melanoma; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Skin Neoplasms | 1980 |
Carcinogenicity and mutagenicity of the 3,4-dihydrodiols and other metabolites of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Female; Mice; Microsomes; Mutagens; Neoplasms, Experimental; Neoplasms, Multiple Primary; Papilloma; Salmonella typhimurium; Skin Neoplasms; Toxicology | 1980 |
Protection of mice against 7,12-dimethylbenz(a)anthracene-induced skin tumors by immunization with a fluorinated analog of the carcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Benz(a)Anthracenes; Cocarcinogenesis; Immunization; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Benz(a)Anthracenes; Carcinoma, Squamous Cell; Cocarcinogenesis; Dose-Response Relationship, Drug; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms | 1981 |
[Effect of the joint action of retinol palmitate and BCG vaccine on the occurrence of skin tumors induced by DMBA].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; BCG Vaccine; Benz(a)Anthracenes; Diterpenes; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Mice; Neoplasms, Experimental; Palmitates; Retinyl Esters; Skin Neoplasms; Vitamin A | 1981 |
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Fetus; Gestational Age; Mice; Phorbols; Pregnancy; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Multistage chemical carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Cocarcinogenesis; Diterpenes; DNA; Epidermis; Mice; Neoplasms, Experimental; Phorbol Esters; Polyamines; Skin Neoplasms; Terpenes | 1980 |
Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoquinolines; Animals; Cricetinae; Eye Neoplasms; Iodine Radioisotopes; Male; Melanoma; Mesocricetus; Methyltyrosines; Neoplasm Transplantation; Neoplasms, Experimental; Radionuclide Imaging; Skin Neoplasms; Tissue Distribution | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. III. Linear extrapolation from high doses may underestimate low-dose tumour risks.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Risk; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Epidermis; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Carcinogens; Cocarcinogenesis; Dermotoxins; Enzyme Induction; Female; Irritants; Lyngbya Toxins; Marine Toxins; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin Neoplasms; Structure-Activity Relationship | 1981 |
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Cocarcinogenesis; Free Radicals; Mice; Neoplasms, Experimental; Peroxides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Influence of the rate of 7,12-dimethylbenz[a]anthracene metabolic activation, in vivo, on its binding to epidermal DNA and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Biotransformation; DNA; Kinetics; Male; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms | 1981 |
Tumor promotion by foreign bodies (IUD).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Foreign Bodies; Injections, Intraperitoneal; Intrauterine Devices; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1981 |
Sensitivity to two-stage carcinogenesis of SENCAR mouse skin grafted to nude mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Skin Transplantation; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
Antitumor activity of beta-carotene, canthaxanthin and phytoene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Canthaxanthin; Carcinoma, Squamous Cell; Carotenoids; Croton Oil; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Papilloma; Skin Neoplasms; Ultraviolet Rays | 1982 |
Skin tumor promotion by phorbol esters is a two-stage process.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Diterpenes; Female; Mice; Mitogens; Neoplasms, Experimental; Phorbol Esters; Phorbols; Prostaglandins; Skin Neoplasms; Structure-Activity Relationship; Terpenes | 1981 |
Is the initiation-promotion regimen in mouse skin relevant to complete carcinogenesis?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1982 |
Epidermal tumor promotion by regeneration.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Division; Epidermis; Female; Hyperplasia; Mice; Neoplasms, Experimental; Regeneration; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
The differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; Carcinogens; Cocarcinogenesis; Enzyme Induction; Flavonoids; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1982 |
Diterpene ester-mediated two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cricetinae; Female; Guinea Pigs; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Milk; Neoplasms, Experimental; Phorbols; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vaginal Neoplasms | 1982 |
Two-stage skin carcinogenesis in sensitive and resistant mouse strains.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Species Specificity; Time Factors | 1982 |
Epidermal-dermal junction during experimental skin carcinogenesis and cocarcinogenesis as revealed by scanning electron microscopy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Arotinoids. A new class of retinoids with activities in oncology and dermatology.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benzoates; Carcinoma; Dose-Response Relationship, Drug; Mice; Neoplasms, Experimental; Papilloma; Retinoids; Skin Neoplasms | 1981 |
Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetra-decanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Hyperplasia; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Phorbols; Rats; Rats, Inbred F344; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Female; Hydrocarbons, Fluorinated; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Tumor-initiating activity of 4-fluoro-7,12-dimethylbenz[a]anthracene and 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Biotransformation; Carcinogens; Female; Mice; Mice, Inbred Strains; Mutagens; Neoplasms, Experimental; Skin Neoplasms; Structure-Activity Relationship | 1982 |
7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Diazonium Compounds; Male; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Tumor initiation by 7,12-dimethylbenz[a]anthracene in dermal melanocytes of hamster: inhibition through 7,8-benzoflavone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; Cricetinae; Female; Flavonoids; Melanocytes; Mesocricetus; Neoplasms, Experimental; Skin Neoplasms; Time Factors | 1982 |
Skin carcinogenesis and promoter binding characteristics in different mouse strains.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Croton Oil; Female; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Phenobarbital; Rodentia; Skin Neoplasms; Species Specificity; Time Factors | 1982 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Stimulation of fibronectin production by retinoic acid in mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromatography, Affinity; Female; Fibronectins; Fucose; Leucine; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Carcinogens; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Streptomyces; Tetradecanoylphorbol Acetate | 1982 |
Effect of crocetin on experimental skin tumors in hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carotenoids; Croton Oil; Female; Mice; Mice, Hairless; Neoplasms, Experimental; Skin Neoplasms; Ultraviolet Rays; Vitamin A | 1982 |
Ascorbic acid and its effect on the skin of Bufo regularis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ascorbic Acid; Bufonidae; Female; Male; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1982 |
DMBA-induced tumors and their prevention by aromatic retinoid (Ro 10-9359).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Esophagus; Etretinate; Intubation; Keratoacanthoma; Microscopy, Electron; Neoplasms, Experimental; Rabbits; Skin; Skin Diseases; Skin Neoplasms; Tretinoin | 1982 |
Alkane-6,8-diol: inhibitor of tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Fatty Alcohols; Female; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Cell Differentiation; Female; Filaggrin Proteins; Immunohistochemistry; Intermediate Filament Proteins; Keratins; Membrane Proteins; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms | 1994 |
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Cocarcinogenesis; Codon; Cytosine; DNA, Neoplasm; Exons; Female; Genes, ras; Mice; Mice, Inbred SENCAR; Mice, Nude; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Papilloma; Polymerase Chain Reaction; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Differential expression of the H-ras mutated and normal alleles in rabbit DMBA-induced keratoacanthomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Gene Expression; Genes, ras; Keratoacanthoma; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Rabbits; RNA-Directed DNA Polymerase; Skin Neoplasms | 1995 |
Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Compartmentation; Epidermis; In Situ Hybridization; Keratins; Mice; Papilloma; Receptors, Retinoic Acid; Retinoid X Receptors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 1995 |
Anti-tumor-promoting activities of euglobals from Eucalyptus plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Burkitt Lymphoma; Cell Cycle; Cocarcinogenesis; Drug Screening Assays, Antitumor; Eucalyptus; Female; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Structure-Activity Relationship; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Base Sequence; Carcinogens; Cell Division; Drug Interactions; Ear, External; Edema; Female; Fluocinolone Acetonide; Genes, ras; Genotype; Mice; Mice, Inbred Strains; Mirex; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1995 |
7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; DNA; DNA Damage; Female; Guanine; Hydrogen Peroxide; Mice; Mice, Inbred SENCAR; Neutrophils; Oxidation-Reduction; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1995 |
Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acanthosis Nigricans; Animals; Carcinogenicity Tests; Collagenases; Disease Susceptibility; Epidermis; Haptoglobins; Humans; Hyperplasia; Keratosis; Mice; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
12-Lipoxygenase isoenzymes in mouse skin tumor development.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Arachidonate 12-Lipoxygenase; Base Sequence; Blood Platelets; Cloning, Molecular; Cytosol; DNA, Complementary; Epidermis; Female; Gene Expression Regulation, Neoplastic; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukocytes; Mice; Molecular Sequence Data; RNA, Neoplasm; Skin Neoplasms; Stereoisomerism; Tetradecanoylphorbol Acetate | 1995 |
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Differentiation; Cells, Cultured; Female; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Organ Culture Techniques; Ornithine Decarboxylase; Precancerous Conditions; Protein Kinase C; RNA, Messenger; Rotenone; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cholesterol Esters; Enzyme Activation; Enzyme Induction; Female; Hyperplasia; Isoenzymes; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Second Messenger Systems; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cell Line; Cell Transformation, Neoplastic; Coumaric Acids; Curcumin; Diarylheptanoids; Dose-Response Relationship, Drug; Enzyme Induction; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Studies on the tumor initiation/promotion potential of six middle distillates (MDs) in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Carcinogenicity Tests; Carcinogens; Male; Mice; Mice, Inbred ICR; Mutagenesis; Mutagens; Petroleum; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2'-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[alpha]anthracene.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Replication; Immunohistochemistry; Kinetics; Male; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Time Factors | 1995 |
A 60-Hz magnetic field increases the incidence of squamous cell carcinomas in mice previously exposed to chemical carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Disease Progression; Free Radicals; Magnetics; Mice; Mice, Inbred SENCAR; Papilloma; Skin; Skin Neoplasms | 1995 |
Sapintoxin D is a weak tumour promoter in Sencar mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Mice, Inbred SENCAR; Microscopy, Fluorescence; Papilloma; Phorbol Esters; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Composition; Base Sequence; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Female; Fibrosarcoma; Genes, p53; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Cell-type-specific ras mutations but no microsatellite instability in chemically induced mouse skin tumors and transformed 3T3 cells.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma; Cell Transformation, Neoplastic; DNA Primers; DNA, Neoplasm; DNA, Satellite; Female; Fibrosarcoma; Genes, ras; Genetic Markers; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Papilloma; Point Mutation; Repetitive Sequences, Nucleic Acid; Skin Neoplasms | 1995 |
Antioxidant enzymes are elevated in dimethylbenz[a]anthracene-induced neoplastic murine keratinocytes containing an active rasHa oncogene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Catalase; Cell Survival; Gene Expression Regulation, Neoplastic; Genes, ras; Glutathione Transferase; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Nude; Oxidative Stress; Skin Neoplasms; Superoxide Dismutase; Trypan Blue; Tumor Cells, Cultured; Ultraviolet Rays | 1995 |
High dietary retinoic acid inhibits tumor promotion and malignant conversion in a two-stage skin carcinogenesis protocol using 7,12-dimethylbenz[a]anthracene as the initiator and mezerein as the tumor promoter in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Diet; Diterpenes; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Terpenes; Tretinoin | 1995 |
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; Cloning, Molecular; DNA Repair; DNA-Binding Proteins; Female; Gene Deletion; Gene Targeting; Incidence; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms, Radiation-Induced; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 1995 |
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cells, Cultured; DNA Repair; DNA-Binding Proteins; Eye Neoplasms; Gene Deletion; Gene Targeting; Genetic Predisposition to Disease; Humans; Mice; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Radiation Tolerance; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 1995 |
Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Transformation, Neoplastic; Genes, ras; Keratinocytes; Keratins; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Skin Neoplasms; Up-Regulation | 1993 |
Cytogenetic damage and tumor incidence in mouse skin after single, topical applications of 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aneuploidy; Animals; Cells, Cultured; Chromosome Aberrations; Keratinocytes; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Skin Neoplasms | 1993 |
Anti-tumor-promoting action of FK506, a potent immunosuppressive agent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dermatitis, Contact; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phosphorylation; Skin Neoplasms; Tacrolimus; Tetradecanoylphorbol Acetate | 1993 |
Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Cheek; Cricetinae; DNA, Neoplasm; Genes, ras; Immunoenzyme Techniques; Keratins; Male; Mesocricetus; Molecular Sequence Data; Papilloma; Point Mutation; Polymerase Chain Reaction; Sequence Analysis, DNA; Skin Neoplasms; Species Specificity | 1993 |
Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fetus; Genes, ras; Male; Mice; Mutation; Neoplasms, Radiation-Induced; Papilloma; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Whole-Body Irradiation; X-Rays | 1993 |
Role of ornithine decarboxylase in epidermal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Line; Cells, Cultured; Fibroblasts; Genetic Vectors; Keratinocytes; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Papilloma; Polyamines; Recombinant Proteins; Retroviridae; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Membrane; Enzyme Activation; Female; Isoenzymes; Lovastatin; Mice; Mice, Inbred SENCAR; Papilloma; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Skin; Skin Neoplasms | 1995 |
Evidence that in situ generated reactive oxygen species act as a potent stage I tumor promoter in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Mice; Peroxidase; Photosensitizing Agents; Radionuclide Imaging; Reactive Oxygen Species; Skin; Skin Neoplasms | 1995 |
Inhibitors of skin-tumor promotion. XIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation and on two-stage carcinogenesis of mouse skin tumors. (2).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Transformed; Female; Herpesvirus 4, Human; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Papilloma; Phloroglucinol; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1995 |
Chemopreventive action of Liv. 52 on DMBA-induced papillomagenesis in skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Combinations; Male; Mice; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms | 1994 |
Carcinoma formation in NMRI mouse skin painting studies is a process suggesting greater than two stages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogenicity Tests; Disease Models, Animal; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Malignant progression of papillomas induced by the initiation--promotion protocol in NMRI mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Disease Models, Animal; Disease Progression; Female; Mice; Mice, Inbred Strains; Models, Statistical; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Chemopreventive action by an extract from Ocimum sanctum on mouse skin papillomagenesis and its enhancement of skin glutathione S-transferase activity and acid soluble sulfydryl level.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents, Phytogenic; Glutathione; Glutathione Transferase; Male; Mice; Papilloma; Plant Extracts; Plants, Medicinal; Skin; Skin Neoplasms; Sulfhydryl Compounds | 1994 |
Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Female; Indoles; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Skin Neoplasms; Thiocarbamates | 1995 |
Effects of methoxychlor on skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Enzyme Induction; Epidermis; Female; Methoxychlor; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Suppression by kampo medicine, sho-saiko-to, on papillomas induced by 7,12-dimethylbenz(a)anthracene in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drugs, Chinese Herbal; Male; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Succinate Dehydrogenase | 1994 |
Antioxidant and antipromotional effects of the soybean isoflavone genistein.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Cell Differentiation; Female; Flavonoids; Gene Expression; Genistein; Glycine max; Humans; Hydrogen Peroxide; Intestine, Small; Isoflavones; Mice; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Xanthine Oxidase | 1995 |
Lack of initiation and promotion potential of deoxynivalenol for skin tumorigenesis in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Body Weight; Carcinoma, Squamous Cell; Data Interpretation, Statistical; Female; Hyperplasia; Mice; Organ Size; Papilloma; Random Allocation; Skin; Skin Neoplasms; Spleen; Tetradecanoylphorbol Acetate; Trichothecenes | 1995 |
Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Aberrations; Chromosome Deletion; Genes, ras; Methylnitronitrosoguanidine; Mice; Mutation; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trisomy | 1994 |
Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Coumaric Acids; Female; Mice; Mice, Inbred ICR; Plants, Medicinal; Polymers; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Augmented expression of cytokines in mouse epidermal tumor cells and its possible involvement in the induction of hematopoietic alterations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Cell Line; Cytokines; Female; Gene Expression; Hematopoietic Stem Cells; Keratinocytes; Mice; Mice, Inbred C57BL; RNA, Messenger; Skin Neoplasms; Spleen; Tumor Cells, Cultured | 1994 |
A course of very small doses of DMBA, each of them allegedly with no promoting potency, acts with clear synergistic effect as a strong promoter of DMBA-initiated mouse skin carcinogenesis. A comparison of the tumorigenic and carcinogenic effects of DMBA (
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma; Drug Synergism; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1994 |
Nucleolar organizer regions as a marker of incipient transformation in a model of experimental carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female; Keratoacanthoma; Mice; Mice, Inbred SENCAR; Nucleolus Organizer Region; Papilloma; Silver Staining; Skin Neoplasms | 1994 |
Lack of transforming growth factor-beta 1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Gene Deletion; Genes, p53; Immunohistochemistry; Keratinocytes; Mice; Mice, Mutant Strains; Papilloma; Prognosis; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Transforming Growth Factor beta | 1994 |
Consumption of reduced-energy/low-fat diet or constant-energy/high-fat diet during mezerein treatment inhibited mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diet, Fat-Restricted; Dietary Carbohydrates; Dietary Fats; Diterpenes; Energy Intake; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred SENCAR; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1994 |
Genetics of chemical carcinogenesis--II. Papilloma induction and malignant conversion in susceptible (Car-s) and resistant (Car-R) lines of mice produced by bidirectional selective breeding and in their (Car-S X Car-R) F1 hybrids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hybridization, Genetic; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Cytogenetic analysis of malignant skin tumors induced in chemically treated TG-AC transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene; Carcinoma, Squamous Cell; Female; Gene Expression; Genes, ras; Karyotyping; Male; Mice; Mice, Transgenic; Neoplasm Transplantation; Papilloma; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Drug Screening Assays, Antitumor; Female; Mice; Mice, Hairless; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Plant Extracts; Skin Neoplasms; Tea; Ultraviolet Rays | 1994 |
The use of cell proliferation data in modeling of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cocarcinogenesis; Kinetics; Likelihood Functions; Mice; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Minimal role of enhanced cell proliferation in skin tumor promotion by mirex: a nonphorbol ester-type promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Drug Synergism; Female; Hyperplasia; Mice; Mirex; Rats; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Inflammation; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1994 |
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; Mice, Transgenic; Models, Genetic; Molecular Sequence Data; Mutation; Skin; Skin Neoplasms; Transforming Growth Factor alpha | 1994 |
Tumour-promoting activity of ninhydrin on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Diterpenes; Female; Mice; Ninhydrin; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
Comparison of 7,12-dimethylbenz(a)anthracene-DNA adduction in the epidermis of two lines of mice selected for resistance (CAR-R) or susceptibility (CAR-S) to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; DNA; DNA Adducts; Drug Resistance; Epidermis; Female; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
The absence of a synergistic protective effect of beta-carotene and vitamin E on skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Diet; Drug Synergism; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Vitamin E | 1993 |
beta-Carotene inhibition of chemically induced toxicity in vivo and in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animal Feed; Animals; beta Carotene; Carotenoids; Cell Line; Diet; Fibroblasts; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Effect of excess dietary retinoic acid on skin papilloma and carcinoma formation induced by a complete carcinogenesis protocol in female Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Diet; Female; Mice; Papilloma; Skin Neoplasms; Tretinoin | 1994 |
The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Body Weight; Carotenoids; Female; Food, Fortified; Mice; Mice, Hairless; Prospective Studies; Skin Neoplasms; Trace Elements; Vitamin E | 1994 |
Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies; Base Sequence; Chemotactic Factors; Female; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrogen Peroxide; Immunochemistry; Mice; Molecular Sequence Data; Neutrophils; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcinogenic Agents; Arachidonate Lipoxygenases; Benzo(a)pyrene; Female; Indomethacin; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Piperidines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
[Anti-tumor promoting activities of kampo prescriptions. II. Inhibitory effects of souseiryu-to on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Cell Cycle; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Skin-tumour-promoting activity of processed bidi tobacco in hairless S/RV Cri-ba mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cocarcinogenesis; Female; Mice; Mice, Mutant Strains; Nicotiana; Occupational Exposure; Papilloma; Plant Extracts; Plants, Toxic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Protection against malignant conversion of chemically induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinoma, Squamous Cell; Female; Mice; Nitroquinolines; Papilloma; Plant Extracts; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1993 |
Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Benzo(a)pyrene; Codon; DNA, Neoplasm; Epidermis; Female; Genes, ras; Isoenzymes; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Papilloma; Point Mutation; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Aberrations; Drug Administration Schedule; Drug Interactions; Karyotyping; Male; Methyl Methanesulfonate; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Cell; Drug Resistance; Female; Genetic Predisposition to Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1993 |
The reverse experiment in two-stage skin carcinogenesis. It cannot be genuinely performed, but when approximated, it is not innocuous.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Cycle; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Glutathione; Male; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Digitoxin; Female; Glycerol; Lung Neoplasms; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Amino Acid Sequence; Animals; Carcinogens; Mice; Mice, Hairless; Mitosis; Molecular Sequence Data; Oligopeptides; Papilloma; Pyrrolidonecarboxylic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Clone Cells; Decanoic Acids; Diglycerides; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Papilloma; Second Messenger Systems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymine | 1993 |
Mouse skin papilloma formation by chronic dermal application of 7,12-dimethylbenz[a]anthracene is not reduced by diet restriction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Body Weight; Diet, Reducing; Dietary Carbohydrates; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Time Factors | 1994 |
Transforming growth factor-beta 1 expression in Syrian hamster cheek pouch carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cheek; Cricetinae; Disease Models, Animal; Extracellular Space; Immunohistochemistry; Intracellular Fluid; Male; Mesocricetus; Mouth Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Skin Neoplasms; Transforming Growth Factor beta | 1994 |
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abietanes; Animals; Anticarcinogenic Agents; Antioxidants; Arachidonic Acid; Benzo(a)pyrene; Dermatitis, Contact; DNA; Drug Interactions; Enzyme Induction; Epidermis; Female; Hyperplasia; Magnoliopsida; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phenanthrenes; Plant Extracts; Skin; Skin Neoplasms; Spices; Tetradecanoylphorbol Acetate; Triterpenes; Tritium; Ursolic Acid | 1994 |
Intermittent 50 Hz magnetic field and skin tumor promotion in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Hyperplasia; Magnetics; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Exceptional tumor-initiating activity of 4-fluorobenzo[j]-fluoranthene on mouse skin: comparison with benzo[j]-fluoranthene, 10-fluoro-benzo[j]fluoranthene, benzo[a]pyrene, dibenzo[a,l]pyrene and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Female; Fluorenes; Mice; Skin Neoplasms | 1993 |
DNA adducts, cell proliferation and papilloma latency time in mouse skin after repeated dermal application of DMBA and TPA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Cell Division; DNA Damage; Female; Mice; Papilloma; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cyclohexanols; Diterpenes; Ethers, Cyclic; Female; Mevalonic Acid; Mice; Okadaic Acid; Protein Prenylation; Skin Neoplasms; Tumor Necrosis Factor-alpha | 1993 |
Caraway oil inhibits skin tumors in female BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Mice; Mice, Inbred BALB C; Oils, Volatile; Plant Oils; Skin Neoplasms | 1993 |
Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Drug Screening Assays, Antitumor; Flow Cytometry; Hexanes; Methanol; Mice; Plant Extracts; Rotenone; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Air Pollutants; Animals; Cocarcinogenesis; Female; Fluorenes; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Southern; Carcinoma; DNA; Genes, p53; Genes, ras; Genotype; Heterozygote; Humans; Male; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Inhibitory effects of 3'-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Chalcone; Chalcones; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mice; Neoplasm Proteins; Neoplasms; Papilloma; Phosphorylation; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Bridged Bicyclo Compounds; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Biomarkers, Tumor; Diterpenes; Female; Immunohistochemistry; Integrin alpha6beta4; Kinetics; Mice; Mice, Inbred Strains; Papilloma; Risk Factors; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Further studies on the influence of initiation dose on papilloma growth and progression during two-stage carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinoma, Squamous Cell; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: possible involvement of hair follicle stem cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Susceptibility; Hair; Mice; Mice, Inbred Strains; Skin Neoplasms; Stem Cells | 1993 |
Inhibition of skin tumor promotion by restriction of fat and carbohydrate calories in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Cocarcinogenesis; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Intake; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Genes, Tumor Suppressor; Heterozygote; Immunohistochemistry; Mice; Mutation; Neoplasms, Experimental; Papilloma; Point Mutation; Polymerase Chain Reaction; Skin Neoplasms; Tumor Suppressor Protein p53 | 1993 |
C57BL/6 mice are resistant to tumor promotion by full thickness skin wounding.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Papilloma; Skin; Skin Neoplasms; Wounds, Penetrating | 1993 |
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Drug Synergism; Enzyme Induction; Ethers, Cyclic; Female; Lyngbya Toxins; Mice; Okadaic Acid; Ornithine Decarboxylase; Phosphorylation; Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
12-O-tetradecanoylphorbol-13-acetate-mediated systemic co-promotion in the murine skin multistage carcinogenesis protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Diet; Female; Mice; Papilloma; Skin Neoplasms; Tretinoin | 1993 |
A study on skin tumour formation in mice with 50 Hz magnetic field exposure.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Electromagnetic Fields; Female; Hyperplasia; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Vitamin E is a complete tumor promoter in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma; Cocarcinogenesis; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Vitamin E | 1993 |
Differential effects of dietary beta-carotene on papilloma and carcinoma formation induced by an initiation-promotion protocol in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carcinoma; Carotenoids; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Incidence; Male; Mice; Neoplasms, Multiple Primary; Papilloma; Pregnancy; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Effect of asoka on the intracellular glutathione levels and skin tumour promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catechin; Croton Oil; Drug Screening Assays, Antitumor; Fibrosarcoma; Glutathione Reductase; Glutathione Transferase; Male; Methylcholanthrene; Mice; Papilloma; Sarcoma 180; Skin Neoplasms | 1993 |
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Papilloma; Phorbol Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Sebaceous Gland Neoplasms; Skin Neoplasms; Time Factors | 1993 |
Characterization of skin tumor promotion by mirex: structure-activity relationships, sexual dimorphism and presence of Ha-ras mutation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cocarcinogenesis; DNA Mutational Analysis; Female; Genes, ras; Liver; Male; Mice; Mirex; Mutation; Organ Size; Papilloma; Sex Characteristics; Skin Neoplasms; Structure-Activity Relationship | 1993 |
Inhibition of benzoyl peroxide-induced tumor promotion and progression by copper(II)(3,5-diisopropylsalicylate)2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benzoyl Peroxide; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Incidence; Keratoacanthoma; Mice; Papilloma; Salicylates; Skin Neoplasms | 1993 |
The effects of calcium antagonists on anthrone skin tumor promotion and promoter-related effects in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Calcium; Calcium Channel Blockers; Carcinogens; Edema; Enzyme Induction; Female; Gallic Acid; Hyperplasia; Mice; Mice, Inbred SENCAR; Ornithine Decarboxylase Inhibitors; Papilloma; Reactive Oxygen Species; Skin; Skin Neoplasms; Statistics, Nonparametric; Verapamil | 1995 |
Modulatory influence of arecanut on the mouse hepatic xenobiotic detoxication system and skin papillomagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Areca; Carcinogens; Cytochrome P-450 Enzyme System; Cytochromes b5; Diet; Female; Inactivation, Metabolic; Lipid Peroxidation; Liver; Male; Malondialdehyde; Mice; Papilloma; Plants, Medicinal; Skin Neoplasms; Sulfhydryl Compounds; Xenobiotics | 1995 |
Connexin expression in epidermal cell lines from SENCAR mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Carcinogens; Cell Communication; Cell Division; Connexin 43; Connexins; Gap Junctions; Isoquinolines; Keratinocytes; Mice; Mice, Inbred SENCAR; Mice, Nude; Neoplasm Transplantation; Phenotype; Skin Neoplasms; Tumor Cells, Cultured | 1996 |
Antitumour activity of protein A in a mouse skin model of two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Anticarcinogenic Agents; Carcinogens; Female; Mice; Skin Neoplasms; Staphylococcal Protein A; Staphylococcus aureus; Survival Analysis; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
The preventive and therapeutic potential of the squalene-containing compound, Roidex, on tumor promotion and regression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Carcinogens; Drug Combinations; Drug Screening Assays, Antitumor; Female; Mice; Mineral Oil; Neoplasms, Experimental; Plants, Medicinal; Remission Induction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A; Vitamin E | 1996 |
Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Caffeic Acids; Carcinogens; DNA; DNA Damage; Female; HeLa Cells; Humans; Mice; Oxidative Stress; Papilloma; Phenylethyl Alcohol; Protein Biosynthesis; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Dose-time response in mouse skin tumor induction by 7, 12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; DNA Adducts; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Random Allocation; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Carcinogenesis in human skin grafted to SCID mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Neoplasm; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Humans; Keratins; Ki-67 Antigen; Mice; Mice, SCID; Neoplasm Proteins; Nuclear Proteins; Papilloma; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Ultraviolet Rays | 1996 |
Camptothecin post-treatments inhibit the biochemical events linked to the tumor-promoting component of carcinogenesis in mouse epidermis in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Camptothecin; DNA; DNA Adducts; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Mice; Ornithine Decarboxylase; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors | 1996 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobacterium Phormidium tenue.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Carbohydrate Sequence; Carcinogenicity Tests; Carcinogens; Cyanobacteria; Female; Galactolipids; Glycolipids; Mice; Mice, Inbred ICR; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Diterpenes; DNA Replication; Female; Mice; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors | 1996 |
Regression and progression characteristics of papillomas induced by chrysarobin in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; Female; Free Radicals; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Expression of Mad, an antagonist of Myc oncoprotein function, in differentiating keratinocytes during tumorigenesis of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogens; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Differentiation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epidermal Cells; Epidermis; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization; Keratinocytes; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Probes; Skin; Skin Neoplasms | 1996 |
The field bean protease inhibitor can effectively suppress 7,12-dimethylbenz[a]anthracene-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Fabaceae; Female; Mice; Plants, Medicinal; Protease Inhibitors; Skin Neoplasms | 1996 |
Lack of tumor promoting effects of KCB-1, a recombinant human basic fibroblast growth factor, on two-stage skin carcinogenesis in female CD-1 (ICR) mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Body Weight; Bromodeoxyuridine; Cell Nucleus; Cocarcinogenesis; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Hematopoiesis; Immunohistochemistry; Incidence; Mice; Mice, Inbred ICR; Papilloma; Recombinant Proteins; Skin Neoplasms | 1996 |
[Inhibition of ornithine decarboxylase activity and epidermal papilloma in mice by beta-carotene].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Female; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Modulatory influence of chlorophyllin on the mouse skin papillomagenesis and xenobiotic detoxication system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyllides; Croton Oil; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Glutathione Transferase; Inactivation, Metabolic; Liver; Male; Mice; Papilloma; Skin; Skin Neoplasms; Time Factors; Xenobiotics | 1996 |
Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Female; Gene Expression Regulation, Neoplastic; Inflammation Mediators; Interleukin-1; Mice; Papilloma; Pentoxifylline; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1996 |
Dietary retinoic acid inhibits mouse skin carcinogenesis irrespective of age at initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Antineoplastic Agents; Carcinogens; Diet; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1996 |
Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: possible role of in situ-generated reactive oxygen species.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dihematoporphyrin Ether; Drug Synergism; Mice; Papilloma; Photosensitizing Agents; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; DNA Primers; Enzyme Induction; Female; Keratinocytes; Mice; Mice, Inbred Strains; Models, Biological; Nitric Oxide Synthase; Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1996 |
Suppression of mouse skin papilloma by canthaxanthin and beta-carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Canthaxanthin; Female; Gene Expression; Mice; Papilloma; Proto-Oncogene Proteins c-myc; Receptors, Retinoic Acid; RNA, Messenger; Skin Neoplasms; Tretinoin | 1996 |
Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cells, Cultured; Female; Gene Expression Regulation, Neoplastic; Insulin-Like Growth Factor I; Keratinocytes; Mice; Papilloma; Polymerase Chain Reaction; Receptor, IGF Type 1; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Skin Neoplasms | 1996 |
Influence of vehicle, distant topical delivery, and biotransformation on the chemopreventive activity of apigenin, a plant flavonoid, in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Topical; Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Chamomile; Dimethyl Sulfoxide; Drug Interactions; Enzyme Induction; Female; Flavonoids; Mice; Mice, Inbred SENCAR; Oils, Volatile; Ornithine Decarboxylase; Pharmaceutical Vehicles; Plants, Medicinal; Propylene Glycol; Propylene Glycols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Epidermis; Female; Gene Expression Regulation, Enzymologic; Lipoxygenase Inhibitors; Mice; Piperidines; RNA, Messenger; Skin Neoplasms | 1996 |
Genetics of chemical carcinogenesis--III. Tissue-specificity of the genes controlling susceptibility and resistance to skin carcinogenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Disease Susceptibility; Female; Immunity, Innate; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Organ Specificity; Sensitivity and Specificity; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1996 |
Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyll; Drug Screening Assays, Antitumor; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Characterization of mutant HA-ras gene expression in transformed murine keratinocyte lines grown under in vitro and in vivo conditions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Communication; Cell Division; Cell Line, Transformed; Gene Expression; Genes, ras; Keratinocytes; Mice; Mice, Nude; Mutation; Papilloma; Skin Neoplasms; Tumor Cells, Cultured | 1996 |
Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Codon; Female; Genes, ras; Mice; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Transplacental mutagenicity of cisplatin: H-ras codon 12 and 13 mutations in skin tumors of SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Cisplatin; Codon; Female; Fetus; Genes, ras; Mice; Mutagens; Mutation; Pregnancy; Skin Neoplasms | 1996 |
Mutagenic, carcinogenic and cocarcinogenic activity of cashewnut shell liquid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Anacardic Acids; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Female; Mice; Mutagenicity Tests; Neoplasms, Experimental; Plant Extracts; Plants, Toxic; Resorcinols; Salicylates; Salmonella typhimurium; Skin Neoplasms | 1997 |
Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Curcumin; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Mice; Neoplasms, Experimental; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Effect of Sobatum on tumour development and chemically induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Ehrlich Tumor; Lymphoma; Male; Mice; Neoplasms, Experimental; Papilloma; Plant Extracts; Skin Neoplasms | 1997 |
Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Squamous Cell; Catechin; Cocarcinogenesis; Disease Progression; Diterpenes; Flavonoids; Mice; Mice, Inbred SENCAR; Papilloma; Phenols; Plant Extracts; Polymers; Skin Neoplasms; Tea; Terpenes | 1997 |
Susceptibility of 129/SvEv mice in two-stage carcinogenesis protocols to 12-O-tetradecanoylphorbol-13-acetate promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Dermatitis, Contact; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Synergism; Epidermis; Hyperplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Neutrophils; Papilloma; Peroxidase; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1997 |
The effect of 60-Hz magnetic fields on co-promotion of chemically induced skin tumors on SENCAR mice: a discussion of three studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Electromagnetic Fields; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Effect of spray-dried yogurt and lactic acid bacteria on the initiation and promotion stages of chemically induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bifidobacterium; Body Weight; Carcinogens; Carcinoma; Eating; Energy Intake; Female; Lactobacillus acidophilus; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Yogurt | 1997 |
Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Capsaicin; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Protective effects of silymarin against photocarcinogenesis in a mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Catalase; Disease Models, Animal; Epidermis; Female; Gene Expression Regulation, Neoplastic; Mice; Mice, Hairless; Ornithine Decarboxylase; Prostaglandin-Endoperoxide Synthases; Silymarin; Skin Neoplasms; Sunburn; Ultraviolet Rays | 1997 |
Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; DNA; Female; Glutathione Peroxidase; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Papilloma; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1997 |
Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle; Cyclin D1; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Mice; Oncogene Proteins; Papilloma; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Enhanced sensitivity to tumor growth and development in multistage skin carcinogenesis by transforming growth factor-alpha-induced epidermal growth factor receptor activation but not p53 inactivation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cloning, Molecular; ErbB Receptors; Exons; Genes, p53; Humans; Mice; Mice, Transgenic; Papilloma; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Recombinant Proteins; Skin; Skin Neoplasms; Transforming Growth Factor alpha | 1997 |
Altered glucocorticoid receptor expression and function during mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Fluocinolone Acetonide; Hyperplasia; Keratinocytes; Mice; Mice, Inbred Strains; Papilloma; Receptors, Glucocorticoid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 1997 |
Nitric oxide synthase and skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Deoxyadenosines; Epidermis; Female; Mice; Nitric Oxide Synthase; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1997 |
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Female; Fluocinolone Acetonide; Luciferases; Male; Mice; Mice, Transgenic; Papilloma; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Retinoids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Tretinoin | 1997 |
Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Animals, Newborn; Benzo(a)pyrene; Hair Follicle; Immunohistochemistry; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Putrescine; Skin; Skin Neoplasms; Spermidine; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Chemical carcinogens and antigens contribute to cutaneous tumor promotion by depleting epidermal Langerhans cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens; Carcinogens; Carcinoma, Squamous Cell; Female; Langerhans Cells; Mice; Mice, Inbred BALB C; Papilloma; Picryl Chloride; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Inhibitory effect of dietary curcumin on skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Curcumin; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Female; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Phenobarbital; Plants, Medicinal; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Line; Citrus; Coumarins; Female; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mice; Mice, Inbred ICR; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Umbelliferones | 1997 |
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogens; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms, Experimental; Ornithine Decarboxylase Inhibitors; Rats; Rats, Sprague-Dawley; Skin Neoplasms | 1997 |
Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antimetabolites, Antineoplastic; Carcinogens; Cell Division; Epidermis; Female; Fluorouracil; Hair Follicle; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Coumarins; DNA Adducts; Dose-Response Relationship, Drug; Epidermis; Furocoumarins; Mice; Mice, Inbred SENCAR; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Umbelliferones | 1997 |
Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cimetidine; Cyclic AMP; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Hydrolysis; Mast Cells; Mice; Phosphatidylinositols; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2; Second Messenger Systems; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Delays in malignant tumor development in transgenic mice by forced epidermal keratin 10 expression in mouse skin carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cattle; Cell Division; Cocarcinogenesis; Gene Expression; Humans; Keratin-10; Keratins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Skin; Skin Neoplasms; Skin Physiological Phenomena; Transgenes | 1997 |
Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Fluorescence; Skin; Skin Neoplasms; Stromal Cells | 1997 |
Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Blotting, Southern; Carcinogens; Cocarcinogenesis; DNA, Viral; Hybridization, Genetic; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mutation; Papillomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Transplantation analyses of the immunogenicity of epidermal tumors generated in murine skin two-stage carcinogenesis protocols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Female; Graft Rejection; Mice; Mice, Inbred SENCAR; Mice, Nude; Neoplasm Transplantation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Cocarcinogenesis; Female; Genes, ras; Genotype; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred BALB C; Mirex; Mutation; Nitrosourea Compounds; Papilloma; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Changes in protein expression during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Carcinogens; Connexin 26; Connexins; Cyclin D1; Cyclins; Epidermal Growth Factor; Female; gamma-Glutamyltransferase; Heparin-binding EGF-like Growth Factor; Integrin alpha6beta4; Integrins; Intercellular Signaling Peptides and Proteins; Keratins; Mice; Mice, Inbred SENCAR; Neoplasm Proteins; Oncogene Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Disease Susceptibility; Diterpenes; Female; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred SENCAR; Papilloma; Phenotype; Sensitivity and Specificity; Skin Neoplasms; Terpenes; Urethane | 1997 |
Evidence that initiated keratinocytes clonally expand into multiple existing hair follicles during papilloma histogenesis in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Clone Cells; Female; Hair Diseases; Hair Follicle; Keratinocytes; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Chemopreventive effects of sandalwood oil on skin papillomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemoprevention; Chi-Square Distribution; Coumarins; Disease Models, Animal; Incidence; Mice; Mice, Inbred Strains; Odds Ratio; Ornithine Decarboxylase; Papilloma; Plant Oils; Reference Values; Sesquiterpenes; Skin Neoplasms; Survival Rate | 1997 |
Inhibitory effect of black tea on the growth of established skin tumors in mice: effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Bromodeoxyuridine; Carcinoma, Squamous Cell; DNA; Female; Keratoacanthoma; Mice; Mitosis; Papilloma; Skin Neoplasms; Tea; Ultraviolet Rays | 1997 |
UVB induction of epithelial tumors in human skin using a RAG-1 mouse xenograft model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; DNA-Binding Proteins; Homeodomain Proteins; Humans; Mice; Mice, SCID; Neoplasms, Radiation-Induced; Skin Neoplasms; Skin Transplantation; Transplantation, Heterologous; Ultraviolet Rays | 1997 |
Telomerase and cell proliferation in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Mice; Mice, Inbred Strains; Mitotic Index; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Telomerase; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Mathematical modeling of skin papilloma data in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Mice; Mice, Inbred SENCAR; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Differential effects of butyric acid on mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Butyrates; Butyric Acid; Carcinogens; Female; Histamine Antagonists; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Areca; Cocarcinogenesis; Esophageal Neoplasms; Female; Male; Mice; Mice, Hairless; Mice, Inbred ICR; Plants, Medicinal; Powders; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Biomarkers, Tumor; Carcinogens; Cyclin D1; Disease Susceptibility; Female; Immunohistochemistry; Integrin alpha6beta4; Integrins; Mice; Mice, Inbred Strains; Papilloma; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta | 1998 |
Response differences among mouse strains in DNA damage and skin carcinogenicity of 7,12-dimethylbenz[a]anthracene are due to inducible aryl hydrocarbon hydroxylase activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; DNA Damage; Electrophoresis; Enzyme Induction; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Skin Neoplasms; Species Specificity | 1998 |
Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Division; DNA Fragmentation; Gene Expression Regulation, Developmental; Genes, bcl-2; Humans; Keratinocytes; Keratins; Mice; Mice, Transgenic; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1998 |
Beta2 integrin/ICAM-1 adhesion molecule interactions in cutaneous inflammation and tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; CD18 Antigens; Cell Division; Dermatitis; Disease Models, Animal; Female; Immunohistochemistry; Intercellular Adhesion Molecule-1; Leukocytes; Mice; Peroxidase; Protein Binding; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Cancer chemopreventive and therapeutic activities of red ginseng.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cell Division; Croton Oil; Cysteine; Female; Ferrous Compounds; Lipid Peroxidation; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Neoplasms, Experimental; Panax; Papilloma; Plant Extracts; Plants, Medicinal; Rats; Skin Neoplasms; T-Lymphocytes | 1998 |
Dietary fat and energy modulation of biochemical events in tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytosol; Dietary Carbohydrates; Dietary Fats; Diglycerides; Energy Metabolism; Isoenzymes; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cloning, Molecular; Cytosol; Female; Genes; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Mice; Mice, Knockout; Multigene Family; Neoplasms, Experimental; RNA, Messenger; Sequence Deletion; Skin Neoplasms; Tissue Distribution | 1998 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine | 1998 |
Effect of iron overload on the benzoyl peroxide-mediated tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Female; Iron; Iron Overload; Keratolytic Agents; Mice; Papilloma; Skin Neoplasms | 1998 |
UVB induces atypical melanocytic lesions and melanoma in human skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; DNA, Neoplasm; Humans; Hyperplasia; In Situ Hybridization; Infant, Newborn; Male; Melanocytes; Melanoma; Mice; Mice, Knockout; Mice, SCID; Neoplasms, Radiation-Induced; Severe Combined Immunodeficiency; Skin; Skin Neoplasms; Skin Transplantation; Transplantation, Heterologous; Ultraviolet Rays | 1998 |
Altered gene expression in a clonal epidermal cell model of carcinogenesis identified by RNA differential display.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Clone Cells; Cloning, Molecular; Epidermal Cells; Epidermis; Gene Expression; Mice; Models, Biological; Molecular Sequence Data; RNA; Sequence Homology, Nucleic Acid; Skin Neoplasms | 1998 |
A Bcl-xL transgene promotes malignant conversion of chemically initiated skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Transformation, Neoplastic; Disease Progression; Mice; Mice, Transgenic; Papilloma; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Transgenes | 1998 |
MOCA and some proposed substitutes (Cyanacure, Conacure, Polacure 740M and Ethacure 300) as two-stage skin carcinogens in HRA/Skh hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aniline Compounds; Animals; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Hairless; Papilloma; Skin Neoplasms | 1998 |
Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amphiregulin; Animals; Betacellulin; Carcinogens; Carcinoma, Squamous Cell; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Mice; Mice, Inbred SENCAR; Papilloma; RNA, Messenger; Skin; Skin Neoplasms; Transforming Growth Factor alpha; Up-Regulation | 1998 |
Papillomas at high risk for malignant progression arising both early and late during two-stage carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Progression; Female; Mice; Papilloma; Risk Factors; Skin Neoplasms | 1998 |
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Centrosome; Disease Susceptibility; Epidermis; Female; Gene Amplification; Humans; Keratins; Male; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Papilloma; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes; Tumor Suppressor Protein p53 | 1998 |
Skin tumor development and keratin expression in different experimental models. Relation to inducing agent and target tissue structure.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Keratins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Skin Neoplasms | 1998 |
Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; DNA Primers; Genes, ras; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Ornithine Decarboxylase; Papilloma; Skin Neoplasms | 1998 |
Cancer chemopreventive activity of synthetic colorants used in foods, pharmaceuticals and cosmetic preparations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Line; Coloring Agents; Cosmetics; Female; Food Analysis; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Skin Neoplasms | 1998 |
Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Catechols; Curcumin; Epidermis; Fatty Alcohols; Female; Inflammation; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Potent suppressive activity of pheophytin a and b from the non-polyphenolic fraction of green tea (Camellia sinensis) against tumor promotion in mouse skin.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Edema; Female; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Ornithine Decarboxylase; Pheophytins; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1998 |
Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; HL-60 Cells; Humans; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Zingiberales | 1998 |
Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Eflornithine; Genes, ras; Keratoacanthoma; Mice; Mice, Transgenic; Ornithine Decarboxylase; Papilloma; Proliferating Cell Nuclear Antigen; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; DNA Adducts; Down-Regulation; Drug Screening Assays, Antitumor; Female; Genistein; Hydrogen Peroxide; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Peroxidase; Protein-Tyrosine Kinases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dose-Response Relationship, Drug; Metallothionein; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Proliferating Cell Nuclear Antigen; Skin Neoplasms | 1998 |
Potent suppressive activity of chlorophyll a and b from green tea (Camellia sinensis) against tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chlorophyll; Chlorophyll A; Edema; Mice; Mice, Inbred BALB C; Pigments, Biological; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1998 |
Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Female; Hyperplasia; Mice; Mice, Inbred SENCAR; Neoplasm Regression, Spontaneous; Neoplasm Staging; Papilloma; Precancerous Conditions; Sebaceous Glands; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Influence of diet restriction and tumor promoter dose on cell proliferation, oxidative DNA damage and rate of papilloma appearance in the mouse skin after initiation with DMBA and promotion with TPA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; Cell Division; Deoxyguanosine; Diet; DNA; DNA Damage; Immunohistochemistry; Male; Mice; Oxidative Stress; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Diterpenes; Euphorbiaceae; Female; Humans; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1998 |
Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents; Carcinogens; Drug Antagonism; Female; Hesperidin; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Dermatitis, Contact; Female; Hypolipidemic Agents; Mice; Mice, Inbred ICR; Oryza; Phenylpropionates; Phytosterols; Plant Extracts; Skin; Skin Neoplasms; Sterols; Tetradecanoylphorbol Acetate; Triterpenes | 1998 |
Ultraviolet B-induced squamous epithelial and melanocytic cell changes in a xenograft model of cancer development in human skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Antigens, Nuclear; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Disease Models, Animal; Epithelial Cells; Homeodomain Proteins; Humans; Male; Melanocytes; Mice; Neoplasms, Radiation-Induced; Nuclear Proteins; Precancerous Conditions; Skin; Skin Neoplasms; Skin Transplantation; Time Factors; Transplantation, Heterologous; Tumor Suppressor Protein p53; Ultraviolet Rays | 1998 |
Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Centrosome; Disease Progression; Endothelial Growth Factors; Genes, p53; Humans; Lymphokines; Mice; Mice, Knockout; Neovascularization, Pathologic; Papilloma; Phenotype; Point Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thrombospondin 1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
p53 expression in skin carcinogenesis and its relationship to cell proliferation and tumour growth.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Female; Immunohistochemistry; Mice; Neoplasms, Radiation-Induced; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 1998 |
Antitumour activity of diallyl sulfide on polycyclic aromatic hydrocarbon-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Benzo(a)pyrene; Female; Mice; Skin Neoplasms; Sulfides; Time Factors | 1998 |
Carcinogenicity and co-carcinogenicity studies on propoxur in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Drug Interactions; Female; Insecticides; Male; Mice; Propoxur; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Angiogenesis is an early event in the development of chemically induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Mice; Mice, Inbred SENCAR; Neovascularization, Pathologic; Papilloma; Skin Neoplasms | 1998 |
Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Caffeic Acids; Carcinogens; Coumaric Acids; Diglycerides; Diterpenes; Ellagic Acid; Flavonoids; Glycerol; Hydrolyzable Tannins; Macrophages; Male; Mice; Phenols; Polymers; Polyphenols; Skin Neoplasms; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1998 |
MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers; Carcinogens; DNA; Epidermis; Gene Expression; Mice; Mice, Knockout; Mice, Transgenic; Nuclear Proteins; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rabbits; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Augmentation of 12-O-tetradecanoyl 13-phorbol acetate-mediated tumor promoting response by the porphyrin photosensitization of 7,12-dimethyl benz[a]anthracene-initiated murine skin: role of in situ generated reactive oxygen species.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Mice; Papilloma; Photosensitivity Disorders; Photosensitizing Agents; Porphyrins; Reactive Oxygen Species; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Spectrofluorimetric detection of DMBA-induced mouse skin carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Erythrocyte Membrane; Erythrocytes; Fluorescence; Male; Mice; Skin Neoplasms; Spectrometry, Fluorescence | 1999 |
Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthocyanins; Carcinogens; Drug Screening Assays, Antitumor; Eflornithine; Enzyme Inhibitors; Female; Flavonoids; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peroxidase; Phenols; Polymers; Proanthocyanidins; Rosales; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Differentiation; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Progression; Epidermis; Gene Deletion; Genes, p53; Genotype; Hyperplasia; Mice; Mice, Knockout; Mitotic Index; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Altered expression of interleukin-1 receptor antagonist in different stages of mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Polarity; Cytoplasm; Disease Progression; Epidermis; Gene Expression Regulation, Neoplastic; Hyperplasia; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Keratinocytes; Mice; Mice, Inbred SENCAR; Neoplasm Proteins; Papilloma; Precancerous Conditions; RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1999 |
Chemopreventive action by an extract from Brassica compestris (var Sarason) on 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Brassica; Carcinogens; Male; Mice; Papilloma; Skin Neoplasms | 1999 |
Low antibody responsiveness is found to be associated with resistance to chemical skin tumorigenesis in several lines of Biozzi mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Carcinogenicity Tests; Carcinogens; Disease Susceptibility; Mice; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1999 |
Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Catalase; Glutathione; Liver; Male; Malondialdehyde; Mice; Podophyllotoxin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1999 |
The role of dermal irritation in the skin tumor promoting activity of petroleum middle distillates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dose-Response Relationship, Drug; Hydrocarbons; Irritants; Male; Mice; Mutagenicity Tests; Mutagens; Petroleum; Skin Neoplasms | 1999 |
Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Female; Indoles; Male; Mice; Skin; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate | 1998 |
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Female; Immunity, Innate; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neoplasm Invasiveness; Neoplasm Staging; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Potent suppressive effect of a Japanese edible seaweed, Enteromorpha prolifera (Sujiao-nori) on initiation and promotion phases of chemically induced mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Pheophytins; Plant Extracts; Seaweed; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Dose-Response Relationship, Drug; Epidermis; Female; Herpesvirus 4, Human; HL-60 Cells; Humans; Hydrogen Peroxide; Intracellular Fluid; Mice; Mice, Inbred ICR; Oxidative Stress; Pyrans; Skin Neoplasms; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 1999 |
Anti-carcinogenic activity of Taraxacum plant. I.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carboxylic Acids; Female; Fumonisins; Humans; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Cockayne Syndrome; Disease Models, Animal; DNA Helicases; DNA Repair; DNA-Binding Proteins; Fibroblasts; Gene Targeting; Genetic Predisposition to Disease; Growth Disorders; Hair Diseases; Humans; Hyperplasia; Ichthyosis; Mice; Mice, Inbred C57BL; Neoplastic Syndromes, Hereditary; Point Mutation; Proteins; Radiation Tolerance; Skin; Skin Neoplasms; Transcription Factor TFIIH; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group D Protein | 1999 |
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Skin Neoplasms | 1999 |
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Drug Screening Assays, Antitumor; Flavonoids; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Papilloma; Phenols; Plant Extracts; Plants, Medicinal; Polymers; Polyphenols; Rosales; Skin Neoplasms; Specific Pathogen-Free Organisms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 1999 |
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Genes, ras; Genes, Tumor Suppressor; Intestinal Neoplasms; Keratinocytes; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mutation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 1999 |
Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Biflavonoids; Catechin; Cocarcinogenesis; Epidermis; Female; Flavonoids; Lipid Peroxidation; Mice; Mice, Inbred SENCAR; Microsomes; Molecular Structure; Phenols; Plant Extracts; Polymers; Proanthocyanidins; Rosales; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E | 1999 |
Induction of melanoma in TPras transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albinism; Animals; Carcinoma; Gene Expression Regulation; Genes, ras; Genetic Predisposition to Disease; Hair Color; Hyperplasia; Melanocytes; Melanoma; Mice; Mice, SCID; Mice, Transgenic; Monophenol Monooxygenase; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1999 |
Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcimycin; Calcium; Carcinogens; Cocarcinogenesis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Induction; Epidermis; Female; Fluocinolone Acetonide; Gene Expression Regulation; Glutaredoxins; Glutathione; Ionophores; Mice; Oxidation-Reduction; Oxidoreductases; Phorbol Esters; Protein Kinase C; Proteins; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Thioredoxin-Disulfide Reductase; Thioredoxins; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1999 |
A multihit, multistage model of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA Mutational Analysis; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes; Keratins; Mice; Models, Biological; Neoplasm Proteins; Papilloma; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Modulatory potential of clocimum oil on mouse skin papillomagenesis and the xenobiotic detoxication system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemoprevention; Disease Progression; Inactivation, Metabolic; Male; Mice; Ocimum; Ocimum basilicum; Papilloma; Plant Oils; Skin Neoplasms; Xenobiotics | 1999 |
Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cell Line, Transformed; Female; Genes, ras; Interleukin-1; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Okadaic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Necrosis Factor-alpha | 1999 |
Skin tumorigenesis by initiators and promoters of different chemical structures in lines of mice selectively bred for resistance (Car-r) or susceptibility (Car-s) to two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Protection against 12-O-tetradecanoylphorbol-13-acetate induced skin-hyperplasia and tumor promotion, in a two-stage carcinogenesis mouse model, by the 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-[2,3-b]quinoxaline analogue of ellipticine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzoyl Peroxide; Carcinogens; Dermatitis, Contact; Female; Hyperplasia; Indoles; Mice; Mice, Inbred SENCAR; Precancerous Conditions; Quinoxalines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Chemoprevention; Chlorophyllides; Female; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Sandalwood oil prevent skin tumour development in CD1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; Chi-Square Distribution; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Plant Oils; Reference Values; Sesquiterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Anti-carcinogenic activity of the roots of Panax notoginseng. II.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Drug Screening Assays, Antitumor; Female; Mice; Panax; Papilloma; Plant Extracts; Plant Roots; Plants, Medicinal; Skin Neoplasms | 1999 |
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Humans; Isoenzymes; Keratin-14; Keratins; Keratosis; Male; Mice; Mice, Transgenic; Neoplasm Proteins; Papilloma; Protein Kinase C; Protein Kinase C-delta; Sex Factors; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; B-Cell Lymphoma 3 Protein; Carcinogens; Epidermis; Female; Gene Expression Regulation, Neoplastic; I-kappa B Proteins; Mice; Mice, Inbred SENCAR; NF-kappa B; NF-kappa B p50 Subunit; Proto-Oncogene Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription Factors | 1999 |
Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Biological Assay; Body Weight; Carbon Monoxide; Carcinogens; Female; Flavoring Agents; Mice; Mice, Inbred SENCAR; Nicotiana; Nicotine; Nicotinic Agonists; Plants, Toxic; Skin; Skin Neoplasms; Smoke; Smoking; Survival Analysis; Tars | 1999 |
Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Connexin 43; Fibrosarcoma; Gene Deletion; Genes, ras; Mice; Mice, Inbred C57BL; Papilloma; Point Mutation; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Mutation; Oncogene Proteins, Viral; Papilloma; Papillomavirus E7 Proteins; Repressor Proteins; Severity of Illness Index; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Evidence that the epidermal targets of carcinogen action are found in the interfollicular epidermis of infundibulum as well as in the hair follicles.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Female; Hair Follicle; Mice; Mice, Inbred SENCAR; Papilloma; Regeneration; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epidermis; Female; Humans; Isoenzymes; Male; Mice; Mice, Transgenic; Papilloma; Phenotype; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Evaluation of carcinogenic and co-carcinogenic potential Quinalphos in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Alopecia; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insecticides; Male; Mice; Organothiophosphorus Compounds; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate | 2000 |
Evidence against a role of general protein kinase C downregulation in skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Isoenzymes; Mice; Mice, Inbred Strains; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Alcohols; Animals; Antihypertensive Agents; Carcinogens; Ear; Female; Inflammation; Lanosterol; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2000 |
Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Bacteriophage phi X 174; Brain; Carcinogens; DNA, Viral; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; HL-60 Cells; Hot Temperature; Humans; Hydrogen Peroxide; Lipid Peroxidation; Male; Methanol; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Panax; Papilloma; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2000 |
Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antiviral Agents; Body Weight; Carboxylic Acids; Carcinogens; Carcinogens, Environmental; Eucalyptus; Female; Fumonisins; Glycerol; Lung Neoplasms; Mice; Mice, Inbred SENCAR; Neoplasms, Experimental; Phloroglucinol; Phytotherapy; Plants, Medicinal; Skin Neoplasms; Terpenes; Time Factors | 2000 |
Anticarcinogenicity potential of spinasterol isolated from squash flowers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chloroform; Chromatography, Liquid; Cocarcinogenesis; Croton Oil; Cucurbitaceae; Drug Screening Assays, Antitumor; Methanol; Mice; Molecular Structure; Skin Neoplasms; Solvents; Stigmasterol; Time Factors | 2000 |
Chemopreventive effects of sage oil on skin papillomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcinogenic Agents; Cell Division; Cell Survival; Injections, Intraperitoneal; Lamiaceae; Lethal Dose 50; Mice; Papilloma; Plant Oils; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA Mutational Analysis; Female; Genes, Neurofibromatosis 1; Genes, ras; Humans; Mice; Mice, Inbred C57BL; Papilloma; Skin; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate | 2000 |
Allelotype analysis of chemically induced squamous cell carcinomas in F(1) hybrids of two inbred mouse strains with different susceptibility to tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinogens; Carcinoma, Squamous Cell; Chimera; Crosses, Genetic; Disease Progression; Genetic Predisposition to Disease; Genotype; Humans; Loss of Heterozygosity; Mice; Mice, Inbred SENCAR; Microsatellite Repeats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Calcitriol; Calcium; Carcinogens; Enzyme Induction; Female; Growth; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin D | 2000 |
Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cacodylic Acid; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
K6/ODC transgenic mice as a sensitive model for carcinogen identification.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Skin Neoplasms | 2000 |
Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Cells, Cultured; Disease Models, Animal; Female; Glycerol; Lignans; Lung Neoplasms; Mice; Mice, Inbred ICR; Mice, Inbred SENCAR; Neoplasm Transplantation; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momordica charantia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Croton Oil; DNA Damage; Female; Fruit; India; Lipid Peroxidation; Liver; Lymphocytes; Mice; Papilloma; Plant Extracts; Skin Neoplasms | 2000 |
Microsatellite DNA variants between the inbred SENCAR mouse strains.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Genetic Markers; Genetic Predisposition to Disease; Genetic Variation; Genotype; Mice; Mice, Inbred SENCAR; Microsatellite Repeats; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2000 |
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Flow Cytometry; Immunity, Innate; Immunohistochemistry; In Situ Hybridization, Fluorescence; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Papilloma; Proto-Oncogene Proteins p21(ras); Skin; Skin Neoplasms; Telomerase; Telomere; Tetradecanoylphorbol Acetate; Time Factors; Tumor Suppressor Protein p53 | 2000 |
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Diarylheptanoids; Dose-Response Relationship, Drug; Female; Herpesvirus 4, Human; Humans; Hydrocarbons, Cyclic; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Specific Pathogen-Free Organisms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Virus Activation | 2000 |
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Biotransformation; Carcinogens; Dermatitis, Contact; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Hydroxybenzoates; Mice; Mice, Inbred ICR; Monophenol Monooxygenase; Oxidative Stress; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Development of spontaneous hyperplastic skin lesions and chemically induced skin papillomas in transgenic mice expressing human papillomavirus type 16 E6/E7 genes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Female; Gene Expression; Humans; Hyperplasia; Mice; Mice, Inbred ICR; Mice, Transgenic; Monophenol Monooxygenase; Oncogene Proteins, Viral; Papilloma; Papillomaviridae; Papillomavirus E7 Proteins; Pregnancy; Repressor Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Genetics of chemical carcinogenesis: analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Genetic Predisposition to Disease; Hair Color; Male; Mice; Mice, Inbred Strains; Quantitative Trait, Heritable; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2000 |
Kurosu, a traditional vinegar produced from unpolished rice, suppresses lipid peroxidation in vitro and in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetic Acid; Animals; Antioxidants; Bepridil; Biphenyl Compounds; Edema; Female; Free Radical Scavengers; Free Radicals; Hydrogen Peroxide; Inflammation; Lipid Peroxidation; Mice; Mice, Inbred ICR; Oryza; Picrates; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiobarbituric Acid Reactive Substances; Time Factors; Vitamin E | 2000 |
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biotransformation; Carcinogens; Codon; DNA; DNA Adducts; Epidermis; Female; Genes, ras; Mice; Mice, Inbred SENCAR; Mutation; Papilloma; Skin Neoplasms; Stereoisomerism | 2000 |
Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; beta Carotene; Carboxylic Acids; Carcinogens; Diterpenes; Female; Humans; Mice; Mice, Inbred ICR; Naphthalenes; Nasopharyngeal Neoplasms; Neoplasms; Papilloma; Plant Extracts; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees | 2000 |
Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Biological Assay; Carcinogens; Female; Glycolipids; Lipids; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Protective effects of hemin and tetrakis(4-benzoic acid)porphyrin on bacterial mutagenesis and mouse skin carcinogenesis induced by 7, 12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; DNA Adducts; Female; Free Radical Scavengers; Hemin; Humans; Metalloporphyrins; Mice; Mice, Inbred ICR; Mutagenicity Tests; Photochemotherapy; Salmonella typhimurium; Skin; Skin Neoplasms | 2000 |
Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Ethanol; Liliaceae; Mice; Mutagens; Plant Extracts; Polarography; Pyrroles; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Carcinogens; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred SENCAR; Mice, Knockout; Papilloma; Skin Neoplasms | 2001 |
Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Citrus; Female; Flavones; Flavonoids; Mice; Nitro Compounds; Papilloma; Plant Extracts; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Cell Differentiation; Epidermal Cells; Epidermis; Genes, bcl-2; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Keratinocytes; Keratins; Membrane Proteins; Mice; Mice, Knockout; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2001 |
Induction of mouse epidermal ornithine decarboxylase activity and skin tumors by 7,12-dimethylben.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoflavones; Carcinogens; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Female; Hair Follicle; Isoenzymes; Lymphatic Metastasis; Male; Mice; Mice, Transgenic; Protein Kinase C; Protein Kinase C-epsilon; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Differentiation; Crosses, Genetic; Epidermal Cells; Epidermis; Female; Gene Expression; Genetic Predisposition to Disease; Keratinocytes; Male; Mice; Mice, Inbred CBA; Mice, Transgenic; Papilloma; Plasminogen Activator Inhibitor 2; Polymerase Chain Reaction; Rabbits; Skin Neoplasms; Urokinase-Type Plasminogen Activator | 2001 |
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Carcinogens; Curcumin; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, fos; Genes, ras; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Cancer prevention by natural carotenoids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Colonic Neoplasms; Cryptoxanthins; Disease Models, Animal; Fruit; Humans; Lutein; Lycopene; Methylnitrosourea; Mice; Rats; Rats, Inbred F344; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vegetables; Xanthophylls; Zeaxanthins | 2000 |
Tephrosia purpurea alleviates phorbol ester-induced tumor promotion response in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Croton Oil; Dermatologic Agents; Glutathione; Male; Mice; Ornithine Decarboxylase; Phorbol Esters; Plant Extracts; Skin; Skin Neoplasms | 2001 |
[p53 gene mutations in mouse skin tumors induced by DMBA-TPA-MNNG].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Exons; Genes, p53; Methylnitronitrosoguanidine; Mice; Mice, Inbred SENCAR; Papilloma; Point Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Down-Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Keratin-10; Keratins; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Phenotype; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transgenes; Up-Regulation | 2001 |
Effect of Withania somnifera on DMBA induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Mice; Papilloma; Plant Extracts; Skin Neoplasms; Solanaceae | 2001 |
Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Keratinocytes; Mice; Mice, Inbred ICR; Protein Transport; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Skin Neoplasms; Transcription Factors; Transforming Growth Factor beta | 2001 |
Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Genes, ras; Humans; Keratinocytes; Mice; Mice, Transgenic; Mutagenesis; Papilloma; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2001 |
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Carcinogens; Mice; Mice, Transgenic; Neoplasm Staging; Ornithine Decarboxylase; Papilloma; Phenotype; Polyamines; Putrescine; Reference Values; Skin; Skin Neoplasms; Spermidine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bepridil; Biphenyl Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Croton Oil; Cysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial Cells; Fibroblasts; Free Radical Scavengers; Hypoxanthine; In Vitro Techniques; Iron; Lipid Peroxidation; Lung; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Microsomes, Liver; Molecular Structure; Mutagens; Ornithine; Ornithine Decarboxylase; Papilloma; Pentetic Acid; Phenanthrenes; Picrates; Plants, Medicinal; Rats; Salmonella; Skin; Skin Neoplasms; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Xanthine Oxidase | 2001 |
Modulation of DMBA induced genotoxicity in bone marrow by quercetin during skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Bone Marrow Cells; Carcinogens; Chromosome Aberrations; Mice; Mutagens; Quercetin; Skin Neoplasms; Time Factors | 2001 |
Tumourigenic studies on deltamethrin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Female; Insecticides; Male; Mice; Nitriles; Pyrethrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Arsenicals; Cocarcinogenesis; Deoxyguanosine; Female; Mice; Mice, Hairless; Mutagens; Reactive Oxygen Species; Skin Neoplasms; Ultraviolet Rays | 2001 |
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catalytic Domain; Cattle; DNA-Binding Proteins; Female; Gastric Mucosa; Genes, p53; Genetic Therapy; Hyperplasia; Keratinocytes; Keratins; Mice; Mice, Knockout; Mice, Transgenic; Mouth Mucosa; Neoplasms, Experimental; Papilloma; Protein Subunits; RNA; Skin; Skin Neoplasms; Stomach; Telomerase; Telomere; Tetradecanoylphorbol Acetate; Vagina; Wound Healing | 2001 |
Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Adhesion Molecules; Cell Division; Disease Susceptibility; Endothelial Growth Factors; Female; Gene Expression Regulation, Neoplastic; Lymphokines; Mice; Mice, Inbred Strains; Mice, Knockout; Neovascularization, Pathologic; Oligodeoxyribonucleotides, Antisense; Papilloma; Precancerous Conditions; Skin; Skin Neoplasms; Thrombospondins; Time Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Transplacental carcinogenic potential of the carbamate fungicide mancozeb.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Female; Fungicides, Industrial; Male; Maneb; Maternal Exposure; Maternal-Fetal Exchange; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms; Tetradecanoylphorbol Acetate; Zineb | 2001 |
Anti-tumor promoting diterpenes from the stem bark of Thuja standishii (Cupressaceae).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Diterpenes; Female; Mice; Mice, Inbred ICR; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees | 2001 |
Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Antigens, Neoplasm; Basigin; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Female; Integrin alpha3beta1; Integrins; Keratinocytes; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Papilloma; Receptors, Collagen; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tetraspanin 28 | 2001 |
Melanoma induction in a hairless mouse with short-term application of dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Lung Neoplasms; Lymphatic Metastasis; Melanoma, Experimental; Mice; Mice, Hairless; Skin Neoplasms; Time Factors | 2001 |
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Susceptibility; Female; Male; Mice; Mice, Inbred C57BL; Quinone Reductases; Skin Neoplasms | 2001 |
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biogenic Polyamines; Carcinogens; Cattle; Enzyme Induction; Enzyme Inhibitors; Keratin-15; Keratin-5; Keratins; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Promoter Regions, Genetic; Protein Biosynthesis; Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Enzyme Activation; Female; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2001 |
Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antioxidants; Benzo(a)pyrene; Carcinogens; Croton Oil; Female; Mice; Mice, Inbred ICR; Papilloma; Selenium; Skin Neoplasms; Vitamin E | 1970 |
Antioxidative and antitumor promoting effects of [6]-paradol and its homologs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Carcinogens; DNA Damage; Ear, External; Edema; Epidermis; Female; Guaiacol; Hydrogen Peroxide; Ketones; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Epstein-Barr virus encoded latent membrane protein-1 induces epithelial cell proliferation and sensitizes transgenic mice to chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Differentiation; Cell Division; Cocarcinogenesis; Crosses, Genetic; Epidermal Cells; Epidermis; Epithelial Cells; Herpesvirus 4, Human; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Skin Neoplasms; Tongue; Viral Matrix Proteins | 2001 |
RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Animals; Blotting, Western; Carcinogens; Cell Adhesion; Cell Line, Transformed; Dose-Response Relationship, Drug; Fibroblasts; Fibronectins; Gene Deletion; Genetic Predisposition to Disease; Growth Substances; Homozygote; Mice; Mice, Transgenic; Models, Genetic; Neoplasms; rhoB GTP-Binding Protein; Signal Transduction; Skin Neoplasms; Time Factors; Transforming Growth Factor beta | 2001 |
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Female; Humans; Mice; Mice, Inbred ICR; Papilloma; Plants; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Aneuploidy; Animals; Dioxoles; Disease Models, Animal; Female; Genes, ras; Humans; Jurkat Cells; Mice; Mice, Inbred SENCAR; Papilloma; Phenanthridines; Phytotherapy; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Lack of effect of 94 GHz radio frequency radiation exposure in an animal model of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Electromagnetic Fields; Female; Incidence; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chromatography, High Pressure Liquid; Glucosides; Hydrolyzable Tannins; Mice; Mice, Inbred BALB C; Plant Extracts; Plant Leaves; Plants, Medicinal; Skin Neoplasms; Tannins; Tumor Necrosis Factor-alpha | 2001 |
Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred ICR; Naphthoquinones; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 2001 |
Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenocorticotropic Hormone; Animals; Carcinogens; Carcinoma, Squamous Cell; Corticosterone; Electromagnetic Fields; Epidermis; Female; Incidence; Melatonin; Mice; Mice, Inbred ICR; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Dosage; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Papilloma; Protein-Tyrosine Kinases; ras Proteins; Signal Transduction; Skin Neoplasms | 2001 |
ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Kidney; Liver; Mice; Neoplasms, Experimental; Papilloma; Photochemotherapy; Protoporphyrins; Skin; Skin Neoplasms; Spleen | 2001 |
Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Primers; Female; Humans; Interleukin-1; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Okadaic Acid; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Necrosis Factor-alpha | 2002 |
Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Male; Mice; Papilloma; Plant Extracts; Skin Neoplasms; Tumor Cells, Cultured | 2002 |
Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Cell Division; Down-Regulation; Epidermis; Genes, fos; Genes, jun; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Keratinocytes; Mice; Mice, Transgenic; Mutation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Photocarcinogenesis in human adult skin grafts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Carcinogens, Environmental; Genes, ras; Humans; Mice; Mice, SCID; Mutation; Skin; Skin Neoplasms; Skin Transplantation; Tumor Cells, Cultured; Ultraviolet Rays | 2002 |
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Cell Division; Cell Survival; Genes, Reporter; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagens; Mutation; Oncogene Protein p21(ras); Phosphorylation; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation | 2002 |
Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Caseins; Diet; Estradiol; Estrogen Receptor alpha; Female; Genistein; Insulin-Like Growth Factor I; Male; Mammary Neoplasms, Experimental; Medroxyprogesterone Acetate; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Ovary; Receptors, Estrogen; Skin Neoplasms; Uterus; Weight Gain | 2001 |
Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benzo(a)pyrene; Body Weight; Carcinogens; Catalase; Cyanobacteria; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytosol; Gastric Mucosa; Glutathione; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Lipid Metabolism; Lipid Peroxidation; Liver; Mice; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Organ Size; Oxidation-Reduction; Papilloma; Skin; Skin Neoplasms; Superoxide Dismutase; Time Factors | 2001 |
Role of iron-dextran on 7,12-dimethylbenz(a) anthracene-initiated and croton oil-promoted cutaneous tumorigenesis in normal and pregnant mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Croton Oil; Female; Iron Overload; Iron-Dextran Complex; Male; Mice; Papilloma; Pregnancy; Pregnancy Complications, Neoplastic; Skin; Skin Neoplasms | 2001 |
Functional roles of Akt signaling in mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin D1; Cytoplasm; Enzyme Activation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes; MAP Kinase Signaling System; Mice; Mice, Inbred SENCAR; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Papilloma; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Skin Neoplasms; Tumor Suppressor Proteins | 2002 |
Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies; Carcinogens; DNA Damage; Edema; Female; Immunoglobulin G; Interleukin-1; Mice; Mice, Inbred SENCAR; Neutrophils; Oxidative Stress; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2002 |
Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA Adducts; Dose-Response Relationship, Drug; Female; Furocoumarins; Mice; Mice, Inbred SENCAR; Plant Extracts; Skin Neoplasms | 2002 |
JunB negatively regulates AP-1 activity and cell proliferation of malignant mouse keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Electroporation; Gene Expression Regulation; Keratinocytes; Kinetics; Mice; Oligodeoxyribonucleotides, Antisense; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Skin Neoplasms; Transcription Factor AP-1; Transcriptional Activation; Transfection | 2002 |
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Animals; Animals, Genetically Modified; Carcinogens; Cattle; Genetic Predisposition to Disease; Immunohistochemistry; Keratinocytes; Keratins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Plasmids; Promoter Regions, Genetic; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Carcinogens; Cell Differentiation; Cell Division; Cyclin D1; Gene Expression Regulation; Genes, ras; Genetic Predisposition to Disease; Humans; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Skin Neoplasms | 2002 |
Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Biflavonoids; Carcinogens; Catechin; Female; Glucosides; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Nasopharyngeal Neoplasms; Norisoprenoids; Peroxynitrous Acid; Plant Leaves; Proanthocyanidins; Rosaceae; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Virus Activation | 2002 |
Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alopecia; Animals; Carcinogens; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Hair Follicle; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Mice, Transgenic; Phenotype; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 2002 |
A comparison of the anticarcinogenic properties of four red wine polyphenols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Catechin; Flavonoids; Gallic Acid; Mice; Phenols; Polymers; Quercetin; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Wine | 2002 |
Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Brazil; Caesalpinia; Female; Fruit; Gallic Acid; Medicine, Traditional; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Cycle Proteins; Cell Division; Eflornithine; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Isoenzymes; Kinetics; Male; Mice; Mice, Knockout; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Kinase C; Protein Kinase C-delta; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2002 |
A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Enzyme Induction; Matrix Metalloproteinase 3; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Mice, Transgenic; Okadaic Acid; Peptide Fragments; Proto-Oncogene Proteins c-jun; Skin; Skin Neoplasms; Transcription Factor AP-1 | 2002 |
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Adhesion; Cell Cycle; Cells, Cultured; Colony-Forming Units Assay; Diploidy; Disease Models, Animal; DNA Fragmentation; Exocytosis; Female; Flow Cytometry; Keratinocytes; Mice; Microscopy, Electron; Okadaic Acid; Papilloma; Phosphatidylserines; Skin Neoplasms | 2002 |
Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthraquinones; Anticarcinogenic Agents; Cassia; Emodin; Enzyme Inhibitors; Female; Mice; Mice, Inbred ICR; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Carcinoma; Disease Models, Animal; DNA, Neoplasm; Glutathione; Incidence; Iron; Iron, Dietary; Lipid Peroxidation; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms | 2002 |
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Death; Cell Differentiation; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; DNA Adducts; Female; Immunohistochemistry; Isoenzymes; Keratinocytes; Membrane Proteins; Mice; Mice, Inbred C57BL; Papilloma; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Division; Disease Progression; Gene Dosage; Genotype; Guanine Nucleotide Exchange Factors; Immunohistochemistry; Keratins; Mice; Mice, Knockout; Proteins; ras Proteins; Skin Neoplasms; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Tetradecanoylphorbol Acetate | 2002 |
The antipromoting effect of alkyloglycerols from shark liver oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Croton Oil; Disease Models, Animal; Female; Fish Oils; Glyceryl Ethers; Mice; Mice, Inbred BALB C; Papilloma; Sharks; Skin Neoplasms; Treatment Outcome | 2002 |
Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermal Cells; Epidermis; Isoenzymes; Keratinocytes; Kinetics; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mice, Knockout; Protein Kinase C; Protein Kinase C-alpha; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2002 |
[Influence of radiotherapy upon tumor accumulation and organ distribution of 57Co-bleomycin in mice with chemically induced squamous cell carcinoma (author's transl)].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bleomycin; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Male; Mice; Skin Neoplasms | 1979 |
[Comparative studies on the uptake and organ distribution of 57Co-bleomycin and 57Co-bleomycin-A2 in mice with squamous cell tumors of the skin and vagina].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bleomycin; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Female; Male; Mice; Neoplasms, Experimental; Skin Neoplasms; Tissue Distribution; Vaginal Neoplasms | 1979 |
Effects of 7, 8-benzoflavone on skin tumor-initiating activities of various 7- and 12-substituted derivatives of 7, 12-dimethylbenz[a]anthracene in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Female; Flavonoids; Imidazoles; Mice; Neoplasms, Experimental; Papilloma; Quercetin; Skin; Skin Neoplasms | 1978 |
DMBA induced papillomas in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice: contrasts and comparisons with immunologically intact littermates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Immunologic Deficiency Syndromes; Male; Mice; Mice, Inbred Strains; Mice, Nude; Papilloma; Skin Neoplasms; Spleen | 1978 |
Two-stage (initiation-promotion) carcinogenesis in vivo and in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Croton Oil; Female; In Vitro Techniques; Mice; Models, Biological; Neoplasms, Experimental; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1978 |
Transmaternal modification of the Berenblum/Mottram experiment in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fetus; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1978 |
Characteristics of chemically transformed mouse epidermal cells in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; In Vitro Techniques; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Skin Neoplasms; Transplantation, Homologous | 1978 |
Acetic acid pretreatment of initiated epidermis inhibits tumour promotion by a phorbol ester.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Benz(a)Anthracenes; Cell Survival; Croton Oil; Female; Mice; Papilloma; Skin Neoplasms | 1978 |
Low-level X-radiation-induced vascular alterations in normal and DMBA-treated, tumor-bearing cheek pouch epithelium of Syrian hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blood Vessels; Blood Volume; Cheek; Cocarcinogenesis; Cricetinae; Head and Neck Neoplasms; Male; Mesocricetus; Microcirculation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Skin Neoplasms; X-Rays | 1978 |
Effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracene-induced, two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Croton Oil; Deoxycholic Acid; Drug Interactions; Mice; Neoplasms, Experimental; Rats; Skin Neoplasms; Time Factors | 1978 |
Mutagenicity and tumor-initiating activity of fluorinated derivatives of 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cells, Cultured; Female; Male; Mice; Mutagens; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1979 |
2,3,7,8-Tetrachlorodibenzo-P-dioxin: potent anticarcinogenic activity in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dioxins; DNA; Female; Mice; Oxygenases; Polychlorinated Dibenzodioxins; RNA; Skin; Skin Neoplasms | 1979 |
The importance of the "bay region" diol-epoxide in 7,12-dimethylbenz[a]anthracene skin tumor initiation and mutagenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Drug Evaluation, Preclinical; Female; Glycols; Mice; Mutagens; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1979 |
Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aldehydes; Animals; Carcinoma, Squamous Cell; Decanoates; Drug Synergism; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Effect of Salmonella enteritidis 11RX infection on two-stage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Bacterial; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Salmonella enteritidis; Salmonella Infections, Animal; Skin Neoplasms; Species Specificity | 1978 |
[Effect of 7,8-benzoflavone on the incidence of skin tumors induced by polycyclic hydrocarbons].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; Benzopyrenes; Flavonoids; Male; Mice; Neoplasms, Experimental; Skin Neoplasms | 1979 |
Covalent binding of polycyclic aromatic hydrocarbons to adenine correlates with tumorigenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; DNA; Epoxy Compounds; Female; Mice; Neoplasms, Experimental; Poly A; Poly G; Skin; Skin Neoplasms | 1979 |
The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene skin tumor-initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Division; Cocarcinogenesis; DNA; Epidermal Cells; Epidermis; Epoxy Compounds; Female; Fluorenes; Inflammation; Mice; Polycyclic Compounds; Skin Neoplasms | 1979 |
The association of bacterial mutagenicity of hydrocarbon-derived 'bay-region' dihydrodiols with the Iball indices for carcinogenicity and with the extents of DNA-binding on mouse skin of the parent hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; DNA; Epoxy Compounds; Female; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mutagens; Polycyclic Compounds; Rats; Rats, Inbred Strains; Salmonella typhimurium; Skin; Skin Neoplasms; Structure-Activity Relationship | 1979 |
Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Drug Synergism; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1979 |
Influence of surface lipids on skin carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzopyrenes; Female; Lipids; Methylcholanthrene; Neoplasms, Experimental; Peroxides; Polycyclic Compounds; Rats; Skin; Skin Neoplasms | 1979 |
Life history and histopathology of ultraviolet light-induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Female; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Papilloma; Rats; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1978 |
Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene tumor initiation and its relationship to DNA binding.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Dioxins; DNA; Female; In Vitro Techniques; Mice; Neoplasms, Experimental; Papilloma; Polychlorinated Dibenzodioxins; Skin; Skin Neoplasms | 1979 |
Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats, and guinea pigs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Fibrosarcoma; Guinea Pigs; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Skin Neoplasms; Species Specificity; Transplantation, Isogeneic | 1979 |
Polyadenylate-polyuridylate enhancement of 7,12-dimethylbenz-anthracene skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Neoplasms, Experimental; Poly A-U; Skin Neoplasms | 1979 |
Effects of transplacental exposure to diethylstilbestrol on carcinogenic susceptibility during postnatal life in hamster progeny.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cricetinae; Diethylstilbestrol; Female; Genital Neoplasms, Female; Male; Mammary Neoplasms, Experimental; Maternal-Fetal Exchange; Melanoma; Mesocricetus; Neoplasms, Experimental; Pregnancy; Skin Neoplasms; Stomach Neoplasms | 1979 |
Experimental intra-oral carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Mesocricetus; Mouth Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Skin Neoplasms; Transplantation, Homologous | 1979 |
[Effect of vitamin A and BCG vaccine on the plasma cell and lymphocyte count in the dermis in chemical carcinogenesis of the skin in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; BCG Vaccine; Cell Count; Lymphocytes; Male; Mice; Neoplasms, Experimental; Papilloma; Plasma Cells; Skin; Skin Neoplasms; Time Factors; Vitamin A | 1979 |
The initiation of tumours on mouse skin by dihydrodiols derived from 7,12-dimethylbenz(a)anthracene and 3-methylcholanthrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Phorbol as a possible systemic promoting agent for skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Female; Injections, Intraperitoneal; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Tumor persistence and regression in skin carcinogenesis. An experimental study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Female; Mice; Neoplasm Regression, Spontaneous; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Neoplasms in strains of splenectomized mice after a single 7,12-dimethylbenz[alpha]anthracene treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Adrenal Gland Neoplasms; Amyloidosis; Animals; Benz(a)Anthracenes; Carcinoma, Hepatocellular; Colonic Neoplasms; Female; Hemangioma; Leukemia, Experimental; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Ovarian Neoplasms; Skin Neoplasms; Spleen; Splenectomy; Stomach Neoplasms | 1975 |
Studies on the role of C-type viruses in the development of epithelial tumors induced with DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Female; Keratoacanthoma; Male; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasms, Experimental; Papilloma; Retroviridae; Skin Neoplasms | 1975 |
[Regression of experimental tumours in mice by treatment with two cAMP analogues (author's transl)].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bucladesine; Cyclic AMP; Drug Evaluation, Preclinical; Mice; Neoplasms, Experimental; Skin Neoplasms | 1976 |
The effect of crocetin on skin papillomas and Rous sarcoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carotenoids; Chickens; Mice; Neoplasms, Experimental; Papilloma; Sarcoma, Avian; Skin Neoplasms; Vitamin A | 1976 |
Lack of tumor-promoting ability of certain environmental chemicals in a two-stage mouse skin tumorigenesis assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogens; Environmental Pollutants; Female; Mice; Neoplasms, Experimental; Papilloma; Polybrominated Biphenyls; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Skin Neoplasms | 1978 |
Initiation-promotion skin carcinogenesis: inhibition by cyclic and non-cyclic nucleotides.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Monophosphate; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Croton Oil; Cyclic AMP; Cyclic GMP; Female; Mice; Neoplasms, Experimental; Ribonucleotides; Skin Neoplasms; Time Factors | 1979 |
Studies with chlorinated dibenzo-p-dioxins, polybrominated biphenyls, and polychlorinated biphenyls in a two-stage system of mouse skin tumorigenesis: potent anticarcinogenic effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Dioxins; Drug Interactions; Enzyme Induction; Female; Hydrocarbons, Chlorinated; Mice; Neoplasms, Experimental; Polybrominated Biphenyls; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Changes in mouse skin cyclic nucleotides during chemical carcinogenesis and tumor response to treatment with BCG, L-Dopa and cyclic DBAMP.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; BCG Vaccine; Bucladesine; Cyclic AMP; Levodopa; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Neoplasm Recurrence, Local; Neoplasms, Experimental; Skin Neoplasms | 1979 |
Inhibition of the tumor-initiating ability of the potent carcinogen 7,12-dimethylbenz(a)anthracene by the weak tumor initiator 1,2,3,4-dibenzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Binding, Competitive; Carcinoma; DNA; Enzyme Induction; Female; In Vitro Techniques; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms | 1977 |
Epidermal ribosome accumulation during two-stage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Membranes; Mice; Neoplasms, Experimental; Precancerous Conditions; Ribosomes; RNA, Neoplasm; RNA, Ribosomal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1977 |
Effect of trichloropropene oxide on the ability of polyaromatic hydrocarbons and their "K-region" oxides to initiate skin tumors in mice and to bind to DNA in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Benzopyrenes; Croton Oil; DNA; Drug Administration Schedule; Drug Synergism; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Female; Hydrocarbons, Chlorinated; In Vitro Techniques; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Polycyclic Compounds; Skin Neoplasms; Structure-Activity Relationship | 1977 |
Effect of age of non-skin tissues on susceptibility of skin grafts to 7,12-dimethylbenz[alpha]anthracene (DMBA) carcinogenesis in BALB/c mice, and effect of age of skin graft on susceptibility of surrounding recipient skin to DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Benz(a)Anthracenes; Female; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Skin Transplantation; Transplantation, Isogeneic | 1977 |
The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antioxidants; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Benz(a)Anthracenes; Benzopyrenes; Butylated Hydroxyanisole; Butylated Hydroxytoluene; DNA; Enzyme Induction; Female; Flavonoids; In Vitro Techniques; Mice; Neoplasms, Experimental; Skin; Skin Neoplasms; Vitamin E | 1977 |
Effects of depot injections of retinyl palmitate on 7,12-dimethylbenz[a]anthracene-induced preneoplastic changes in rat skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Diterpenes; Drug Administration Schedule; Injections, Intramuscular; Male; Neoplasms, Experimental; Palmitates; Precancerous Conditions; Rats; Retinyl Esters; Skin; Skin Neoplasms; Vitamin A | 1977 |
Autoradiographic and histopathologic studies on the mode of action of an aromatic retinoid (Ro 10-9359) on chemically induced epithelial tumors in Swiss mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Croton Oil; DNA, Neoplasm; Female; Mice; Necrosis; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tretinoin; Vitamin A | 1977 |
Extrapolation of animal data in carcinogenesis to man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bronchial Neoplasms; Coal Tar; Cricetinae; Diethylstilbestrol; Female; Genital Neoplasms, Female; Humans; Male; Neoplasms; Skin Neoplasms; Smoking | 1977 |
The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinoma; Dose-Response Relationship, Drug; Estradiol; Female; Flavonoids; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Phenobarbital; Rats; Skin; Skin Neoplasms; Testosterone | 1977 |
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate | 1977 |
Tumor-initiating ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Arochlor 1254 in the two-stage system of mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aroclors; Dioxins; Female; Mice; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Skin Neoplasms; Time Factors | 1977 |
Tumor promotion and the induction of epidermal ornithine decarboxylase activity in mechanically stimulated mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carboxy-Lyases; Cell Division; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Physical Stimulation; Skin; Skin Neoplasms | 1978 |
[Change in acetylation activity in 7,12-dimethylbenz(alpha)-anthracene induction].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylation; Acetyltransferases; Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Enzyme Activation; Female; Liver; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Sarcoma, Experimental; Skin Neoplasms | 1978 |
Stimulation of malignant skin cells by antibody to normal skin cells of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Antibodies; Cell Transformation, Neoplastic; Cells, Cultured; Cytotoxicity Tests, Immunologic; Fluorescent Antibody Technique; Graft Survival; Immune Sera; Neoplasm Transplantation; Skin; Skin Neoplasms | 1978 |
Dibenz[a,c]anthracene: a potent inhibitor of skin-tumor initiation by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; DNA; Female; In Vitro Techniques; Mice; Skin Neoplasms; Time Factors | 1978 |
Ultraviolet light irradiation as initiating agent in skin tumor formation by the two-stage method.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinoma, Squamous Cell; Croton Oil; Female; Fibroma; Fibrosarcoma; Hyperplasia; Keratoacanthoma; Male; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1975 |
Therapy of epithelial tumors with an aromatic retinoic acid analog.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tretinoin; Vitamin A | 1975 |
[Carcinogenic effect of 7,12-dimethylbenz(a)anthracene 5,6-oxide in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Carcinogens; Cell Transformation, Neoplastic; Epoxy Compounds; Female; Fibrosarcoma; Hemangioma; Injections, Subcutaneous; Male; Osteoma, Osteoid; Papilloma; Skin; Skin Neoplasms | 1975 |
Carcinogenicity in mice of some fatty acid methyl esters. 2. Peroral and subcutaneous application.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Female; Injections, Subcutaneous; Male; Mice; Neoplasms, Experimental; Oleic Acids; Papilloma; Sarcoma, Experimental; Skin Neoplasms; Stearic Acids; Stomach Neoplasms; Time Factors | 1975 |
Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Chromosome Aberrations; Culture Techniques; Karyotyping; Mouth Neoplasms; Rats; Skin Neoplasms | 1975 |
Initiation-promotion skin carcinogenesis and immunological competence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chlorphenesin; Croton Oil; Female; Graft Rejection; Immunity, Cellular; Lymphocyte Activation; Mice; Mice, Inbred A; Neoplasms, Experimental; Skin Neoplasms | 1975 |
[Effect of 7,12-dimethylbenz(alpha)anthracene metabolites on its capacity to induce skin tumors in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Drug Interactions; Female; Male; Mice; Mice, Nude; Papilloma; Skin Neoplasms; Time Factors | 1975 |
Smooth muscle-associated antigen in experimental cutaneous squamous cell carcinoma, keratoacanthoma, and papilloma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Specificity; Antigens; Basement Membrane; Carcinoma, Squamous Cell; Fluorescent Antibody Technique; Keratoacanthoma; Muscle, Smooth; Neoplasms, Experimental; Papilloma; Rabbits; Rats; Skin Neoplasms | 1975 |
Prophylaxis of chemically induced epithelial tumors with an aromatic retinoic acid analog (Ro 10-9359).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Croton Oil; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tretinoin; Vitamin A | 1975 |
Cocarcinogenic activity of peroxy compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Benzoates; Carcinogens; Drug Synergism; Female; Hydrogen Peroxide; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Peracetic Acid; Peroxides; Skin Neoplasms; Urea | 1975 |
Dermal carcinogenicity study by mouse-skin painting with 2,4-toluendediamine alone or in representative hair dye formulations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Body Weight; Coloring Agents; Diamines; Female; Lung Neoplasms; Male; Mice; Skin; Skin Neoplasms | 1976 |
Tumors of the pilosebaceous unit induced in the rat by the intravenous administration of 7,12-dimethylbenz(A)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benz(a)Anthracenes; Female; Hair; Injections, Intravenous; Keratins; Neoplasms, Experimental; Rats; Sebaceous Gland Neoplasms; Skin Neoplasms | 1976 |
Inhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred ICR; Mustard Compounds; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1976 |
Correlation of cocarcinogenic activity among n-alkanes with their physical effects on phospholipid micelles.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkanes; Animals; Benzopyrenes; Male; Mice; Micelles; Neoplasms, Experimental; Phospholipids; Skin Neoplasms; Structure-Activity Relationship | 1976 |
Regression kinetics of mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antilymphocyte Serum; Dose-Response Relationship, Drug; Female; Half-Life; Mice; Neoplasm Regression, Spontaneous; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
The biochemistry of preneoplasia in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Genes; Hyperplasia; Mice; Neoplasm Proteins; Papilloma; Phorbols; Precancerous Conditions; RNA, Neoplasm; Skin Neoplasms | 1976 |
Letter: Skin tumors produced by systemic administration of chemical carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Methylcholanthrene; Neoplasms, Experimental; Rats; Skin Neoplasms | 1976 |
The effects of dexamethasone on mouse skin initiation and aryl hydrocarbon hydroxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Dexamethasone; Estradiol; Female; Flavonoids; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Papilloma; Pregnadienetriols; Skin Neoplasms; Testosterone | 1976 |
Identification of polynuclear aromatic hydrocarbons in cigarette smoke and their importance as tumorigens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemical Fractionation; Cocarcinogenesis; Drug Synergism; Mice; Neoplasms, Experimental; Polycyclic Compounds; Skin Neoplasms; Smoking | 1976 |
Epidermal cell proliferation and promoting ability of phorbol esters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Edema; Female; Hyperplasia; Inflammation; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Carcinogen-induced cutaneous neoplasms in nonhuman primates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzene Derivatives; Carcinoma, Basal Cell; Cocarcinogenesis; Galago; Haplorhini; Macaca mulatta; Male; Melanosis; Neoplasms, Experimental; Neoplasms, Multiple Primary; Neoplasms, Radiation-Induced; Papilloma; Primates; Sarcoma; Skin Diseases; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1976 |
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Drug Synergism; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Phorbols; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1976 |
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Isoflavones; Lung Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
[Anti-carcinogenic and anti-promoting effects of retinoid R8605].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Croton Oil; Edema; Epidermis; Female; Male; Mice; Ornithine Decarboxylase; Papilloma; Retinoids; Skin Neoplasms | 1992 |
Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Base Sequence; Carcinoma, Squamous Cell; DNA, Neoplasm; Genes, ras; Mice; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Oligodeoxyribonucleotides; Papilloma; Polymorphism, Restriction Fragment Length; Precancerous Conditions; Skin Neoplasms; Urethane | 1992 |
Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antiviral Agents; Chalcone; Chalcones; Female; Herpesvirus 4, Human; Inflammation; Irritants; Lyngbya Toxins; Macromolecular Substances; Mice; Mice, Inbred ICR; Phenols; Plant Extracts; Plants, Medicinal; Skin Neoplasms | 1992 |
Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinoma, Squamous Cell; Female; Genes, ras; Keratins; Methylnitronitrosoguanidine; Mice; Mutation; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1992 |
Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Carcinoma, Squamous Cell; Electrophoresis, Polyacrylamide Gel; Epithelium; Female; Fluorescent Antibody Technique; Gene Expression; Genes, ras; Immunoenzyme Techniques; Keratins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Papilloma; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Immunogenetic influences on the initiation stage of the cutaneous chemical carcinogenesis pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Susceptibility; DNA; DNA Adducts; Enzyme Induction; Female; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Evaluation of the carcinogenic potential of toluidine blue O in the hamster cheek pouch.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell; Cheek; Chi-Square Distribution; Cricetinae; Male; Mesocricetus; Mouth Neoplasms; Skin Neoplasms; Tolonium Chloride | 1992 |
Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; beta Carotene; Carotenoids; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate | 1992 |
Inhibitory effect of green tea on the growth of established skin papillomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catechin; Drug Screening Assays, Antitumor; Female; Flavonoids; Injections, Intraperitoneal; Mice; Papilloma; Phenols; Plant Extracts; Polymers; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of mouse skin tumorigenesis by dexamethasone occurs through a Ha-ras-independent mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenalectomy; Animals; Blotting, Northern; Dexamethasone; Female; Genes, ras; Mice; Papilloma; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Curcumin; DNA; Drug Antagonism; Female; Mice; Skin Neoplasms | 1992 |
Dietary retinoids are essential for skin papilloma formation induced by either the two-stage or the complete tumorigenesis model in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Diet; Diterpenes; Female; Mice; Mice, Inbred Strains; Papilloma; Retinyl Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Vitamin A; Vitamin A Deficiency | 1992 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Female; Lipoxygenase; Mice; Phenols; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Palm carotene inhibits tumor-promoting activity of bile acids and intestinal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carotenoids; Diterpenes; Duodenal Neoplasms; Female; Glycocholic Acid; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Ornithine Decarboxylase; Skin Neoplasms; Terpenes | 1992 |
Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Body Weight; Disulfides; Garlic; Mice; Papilloma; Plants, Medicinal; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1992 |
Phenotypic expression of carcinogen-initiated epidermal cells to tumor cells by 12-O-tetradecanoylphorbol-13-acetate in a manner dependent on 3T3 fibroblast-derived humoral factor(s).
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Transformation, Neoplastic; Cells, Cultured; Epidermis; Macrophages; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; DNA, Neoplasm; Female; Genes, ras; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Papilloma; Polymerase Chain Reaction; Skin Neoplasms | 1992 |
Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Line; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Keratinocytes; Mice; Papilloma; Phorbol Esters; RNA Processing, Post-Transcriptional; RNA, Messenger; Skin Neoplasms; Transforming Growth Factor beta | 1992 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in murine skin by systemic effects of ultraviolet irradiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1992 |
Modification of tumor promotion in the mouse skin by exposure to an alternating magnetic field.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Electromagnetic Fields; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Promotion pattern and tumour types in two-stage rat skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinoma; Croton Oil; Dose-Response Relationship, Drug; Hyperplasia; Male; Papilloma; Rats; Rats, Inbred Lew; Skin; Skin Neoplasms | 1992 |
Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epidermis; Gene Expression; Mice; Mice, Transgenic; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylnitrosamine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasms; Oncogene Proteins; Rats; Rats, Inbred Strains; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Body Weight; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Carcinogenic and cocarcinogenic studies with carbaryl following topical exposure in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carbaryl; Carcinogenicity Tests; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Promoting action of cashew nut shell oil in DMBA-initiated mouse skin tumour model system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Croton Oil; Mice; Nuts; Papilloma; Plant Oils; Skin Neoplasms | 1992 |
A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Fibroblasts; Genes, fos; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Papilloma; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of chemical carcinogenesis in vivo by azatyrosine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alanine; Animals; Antibiotics, Antineoplastic; Drug Screening Assays, Antitumor; Genes, ras; Methylnitrosourea; Mice; Mutation; Papilloma; Skin Neoplasms; Stomach Neoplasms | 1992 |
Dietary energy and fat effects on tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dietary Fats; Energy Intake; Enzyme Activation; Epidermis; Female; Mice; Phosphatidylinositols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dietary Fats; Dinoprostone; Fatty Acids; Female; Linoleic Acid; Linoleic Acids; Mammary Neoplasms, Experimental; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Cutaneous basal cell carcinomas in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Basal Cell; Fibrosarcoma; Methylcholanthrene; Neoplasms, Radiation-Induced; Rats; Skin Neoplasms | 1992 |
Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Curcumin; Diet; Female; Glutathione Transferase; Liver; Mice; Skin Neoplasms; Stomach Neoplasms | 1992 |
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Edema; Enzyme Induction; Female; Flow Cytometry; Hydrogen Peroxide; Hyperplasia; Mice; Ornithine Decarboxylase; Phenols; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Birth and death/differentiation rates of papillomas in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cell Death; Cell Differentiation; Drug Administration Schedule; Likelihood Functions; Mice; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Codon; Diglycerides; Female; Genes, ras; Immune Sera; Isoenzymes; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Papilloma; Peptides; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Differential effects of cryptoporic acids D and E, inhibitors of superoxide anion radical release, on tumor promotion of okadaic acid in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Enzyme Activation; Ethers, Cyclic; Female; Free Radicals; Mice; Okadaic Acid; Protein Kinase C; Protein Kinases; Sesquiterpenes; Skin Neoplasms; Superoxides | 1991 |
The effect of various dietary fats on skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Coconut Oil; Corn Oil; Dietary Fats; DNA; Eating; Fatty Acids; Female; Fish Oils; Mice; Papilloma; Phospholipids; Plant Oils; Skin; Skin Neoplasms | 1991 |
Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; DNA, Neoplasm; Female; gamma-Glutamyltransferase; Lung Neoplasms; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking reg
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Deoxyribonuclease I; DNA, Neoplasm; Epithelial Cells; Epithelium; Female; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Keratins; Methylation; Mice; Molecular Sequence Data; Nucleotides; Organ Specificity; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Transformation, Neoplastic; Chromosome Mapping; Gene Amplification; Genes, ras; Immunoenzyme Techniques; Keratins; Mice; Mice, Inbred Strains; Models, Genetic; Mutation; Nucleic Acid Hybridization; Polymorphism, Restriction Fragment Length; Skin Neoplasms | 1990 |
Early expression of type I K13 keratin in the progression of mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Keratins; Mice; Papilloma; Precancerous Conditions; Skin Neoplasms; Time Factors | 1990 |
TGF-beta 1 and skin carcinogenesis: antiproliferative effect in vitro and TGF-beta 1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Replication; DNA, Neoplasm; Female; Gene Expression; Keratinocytes; Mice; Mice, Inbred Strains; Phorbol Esters; RNA; RNA, Messenger; RNA, Neoplasm; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1991 |
Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Gene Expression Regulation, Neoplastic; Keratins; Mice; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Division; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Keratins; Male; Mice; Mice, Hairless; Microscopy, Fluorescence; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
v-Ha-ras-induced mouse skin papillomas exhibit aberrant expression of keratin K13 as do their 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate -induced analogues.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Fluorescent Antibody Technique; Gene Expression; Genes, ras; Keratinocytes; Keratins; Methylation; Mice; Molecular Sequence Data; Oligonucleotides; Oncogene Protein p21(ras); Oncogene Proteins v-fos; Papilloma; RNA, Messenger; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate | 1991 |
Protection against 7,12-dimethylbenzanthracene-induced tumour initiation by protein A in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Female; Mice; Skin Neoplasms; Staphylococcal Protein A; Survival Analysis | 1992 |
The chlorinated pesticide mirex is a novel nonphorbol ester-type tumor promoter in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Hyperplasia; Mice; Mice, Inbred Strains; Mirex; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Transplacental and transgeneration carcinogenic effect of 7,12-dimethylbenz[a]anthracene: relationship with ras oncogene activation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Male; Mice; Mutation; Neoplasms, Experimental; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Prevalence of tumor prevention rather than tumor enhancement when repetitive UV radiation treatments precede initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drinking; Female; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part II: Quantitation of glutathione and glutathione disulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Topical; Aging; Animals; Carcinoma, Squamous Cell; Epidermis; Female; Glutathione; Glutathione Disulfide; Mice; Oxidation-Reduction; Oxygen; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Effect of ultraviolet (UV) radiation and UVB-absorbing sunscreen ingredients on 7,12-dimethylbenz(a)anthracene-initiated skin tumorigenesis in hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Mice, Hairless; Skin Neoplasms; Sunscreening Agents; Ultraviolet Therapy | 1991 |
Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; Croton Oil; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Papilloma; Plant Extracts; Sarcoma 180; Sarcoma, Experimental; Skin Neoplasms; Soft Tissue Neoplasms | 1991 |
Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: I. Experimental design and exposure system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Electromagnetic Fields; Environmental Exposure; Mice; Research Design; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Electromagnetic Fields; Female; Killer Cells, Natural; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Female; Hyperplasia; Mice; Neoplasm Metastasis; Neoplasms, Multiple Primary; Papilloma; Phorbol Esters; Skin; Skin Neoplasms; Urethane | 1991 |
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Squamous Cell; Cloning, Molecular; DNA; Gene Expression Regulation, Neoplastic; Genes, ras; Keratoacanthoma; Molecular Sequence Data; Mutation; Neoplasm Regression, Spontaneous; Polymerase Chain Reaction; Rabbits; RNA, Messenger; Sequence Homology, Nucleic Acid; Skin Neoplasms | 1991 |
Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Female; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Pentacyclic Triterpenes; Phytosterols; Sitosterols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1991 |
Promoter independence as a feature of most skin papillomas in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Genes, ras; Mice; Mutation; Neoplasm Regression, Spontaneous; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Corn Oil; Dinoprostone; Female; Linoleic Acid; Linoleic Acids; Mice; Mice, Inbred DBA; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Novel coumarins as potential anticarcinogenic agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Coumarins; DNA; Enzyme Induction; Female; Mice; Skin Neoplasms; Structure-Activity Relationship | 1991 |
The potent anti-tumor-promoting agent isoliquiritigenin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Benz(a)Anthracenes; Blood Platelets; Chalcone; Chalcones; Dermatitis, Contact; Enzyme Induction; Female; Mice; Mice, Inbred Strains; Neutrophils; Ornithine Decarboxylase; Phospholipases A; Phospholipases A2; Prostaglandins; Skin; Skin Neoplasms; Sonication; Tetradecanoylphorbol Acetate | 1991 |
7-Sulfooxymethyl-12-methylbenz[a]anthracene is an electrophilic mutagen, but does not appear to play a role in carcinogenesis by 7,12-dimethylbenz[a]anthracene or 7-hydroxymethyl-12-methylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Administration, Topical; Animals; Chlorides; Cytosol; DNA; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Mutagens; Papilloma; Rats; Rats, Inbred Strains; Salmonella typhimurium; Skin Neoplasms; Sulfotransferases | 1991 |
Evidence for a common genetic pathway controlling susceptibility to mouse skin tumor promotion by diverse classes of promoting agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; DNA; Dose-Response Relationship, Drug; Edema; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1991 |
Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Condiments; Drug Antagonism; Male; Mice; Papilloma; Skin Neoplasms | 1991 |
Influence of diet and calorie restriction on the initiation and promotion of skin carcinogenesis in the SENCAR mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Cocarcinogenesis; Diet; Energy Intake; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
The skin tumorigenic and carcinogenic effects of different doses, numbers of dose fractions and concentrations of 7,12-dimethylbenz[a]anthracene in acetone applied on hairless mouse epidermis. Possible implications for human carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Cutaneous; Animals; Carcinoma; Dose-Response Relationship, Drug; Epidermis; Mice; Papilloma; Sarcoma, Experimental; Skin; Skin Neoplasms; Time Factors | 1991 |
Urethan (ethyl carbamate) is an effective promoter of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis in mouse skin two-stage experiments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Cocarcinogenesis; Female; Lung Neoplasms; Male; Mice; Mice, Hairless; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1991 |
[Activation of the Ha-ras oncogene in tumors induced in mice by transplacental exposure to 7,12-dimethylbenz(a)anthracene].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Codon; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms | 1991 |
Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arginine; DNA; Female; Mice; Ornithine; Ornithine Decarboxylase; Papilloma; Polyamines; Putrescine; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrans; Cocarcinogenesis; Enzyme Activation; Female; Flavonoids; Inflammation; Male; Mice; Mice, Inbred ICR; Papilloma; Phenols; Polymers; Protein Kinase C; Rats; Rats, Inbred WKY; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
[Experimental studies of photodynamic therapy of squamous cell cancers with hematoporphyrin derivative].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cheek; Cricetinae; Hematoporphyrin Photoradiation; Humans; Laryngeal Neoplasms; Male; Mesocricetus; Mice; Mice, Inbred Strains; Mice, Nude; Mouth Mucosa; Mouth Neoplasms; Necrosis; Neoplasm Transplantation; Otorhinolaryngologic Neoplasms; Skin; Skin Neoplasms | 1991 |
Inhibition of chemically-induced skin carcinogenesis in mice by peanut oil preparations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Arachis; Benzo(a)pyrene; Female; Male; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Plant Oils; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Potent inhibitory effects of suicide inhibitors of P450 isozymes on 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene initiated skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme Inhibitors; DNA; Dose-Response Relationship, Drug; Isoenzymes; Mice; Naphthalenes; Polychlorinated Dibenzodioxins; Pyrenes; Skin Neoplasms | 1991 |
A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Presenting Cells; Benzo(a)pyrene; Carcinoma, Squamous Cell; Dermatitis, Contact; Dinitrobenzenes; Immunity, Cellular; Indomethacin; Male; Mice; Mice, Inbred BALB C; Skin; Skin Neoplasms | 1991 |
The role of chronic acanthosis and subacute inflammation in tumor promotion in CD-1 mice by petroleum middle distillates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acanthosis Nigricans; Administration, Topical; Animals; Body Weight; Carcinogens; Chronic Disease; Cocarcinogenesis; Dexamethasone; Dose-Response Relationship, Drug; Inflammation; Kerosene; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of mouse skin tumor-initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Antiviral Agents; DNA, Neoplasm; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Mice; Skin Neoplasms; Tritium; Water | 1991 |
Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Line; Fura-2; Gene Expression; Genes, ras; Keratinocytes; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mutation; Reference Values; Skin Neoplasms; Spectrometry, Fluorescence | 1991 |
Tumor progression of murine epidermal cells after treatment in vitro with 12-O-tetradecanoylphorbol-13-acetate or retinoic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Mice; Mice, Inbred BALB C; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Areca; Female; Inactivation, Metabolic; Male; Mice; Plants, Medicinal; Skin Neoplasms | 1991 |
Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Chromosome Mapping; DNA Probes; Genotype; Globins; Heterozygote; Mice; Mice, Inbred Strains; Mitosis; Molecular Sequence Data; Oligonucleotide Probes; Papilloma; Polymerase Chain Reaction; Recombination, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Alkaloids; Animals; Benzylisoquinolines; Carcinogens; Diterpenes; Drug Interactions; Enzyme Induction; Female; Immunity, Cellular; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1991 |
[Presence of specific mutation of Ha-ras oncogene in skin tumors of mice induced under different experimental conditions].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Codon; Female; Genes, ras; Male; Mice; Mutation; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Guanosine Triphosphate; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Papilloma; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Tumor-promoting activity of ethyl phenylpropiolate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkynes; Animals; Carcinogens; Down-Regulation; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
The effect of the level of dietary corn oil on mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Capillary Permeability; Cocarcinogenesis; Corn Oil; Dietary Fats; Dinoprostone; Fatty Acids; Female; Hyperplasia; Mice; Ornithine Decarboxylase; Phospholipids; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Condiments; Dimethyl Sulfoxide; India; Male; Medicine, Traditional; Mice; Papilloma; Plant Extracts; Plants, Edible; Sarcoma, Experimental; Seeds; Skin Neoplasms; Soft Tissue Neoplasms | 1991 |
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Carcinoma, Squamous Cell; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Culture Media; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Papilloma; Skin Neoplasms; Transfection; Tumor Cells, Cultured | 1991 |
Comparative dose-response tumorigenicity studies of dibenzo[alpha,l]pyrene versus 7,12-dimethylbenz[alpha]anthracene, benzo[alpha]pyrene and two dibenzo[alpha,l]pyrene dihydrodiols in mouse skin and rat mammary gland.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogenicity Tests; Carcinogens; Dihydroxydihydrobenzopyrenes; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Mice; Skin Neoplasms | 1991 |
New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catechin; Cnidaria; Cocarcinogenesis; Diterpenes; Female; Flavonoids; Lyngbya Toxins; Mammary Neoplasms, Experimental; Mice; Skin Neoplasms; Tea | 1990 |
Tissue-specific activating mutations of Ha- and Ki-ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Codon; Female; Fetal Diseases; Genes, ras; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mutation; Organ Specificity; Polymorphism, Restriction Fragment Length; Pregnancy; Skin Neoplasms | 1990 |
Response of mouse skin tumors to doxorubicin is dependent on carcinogen exposure.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinogenicity Tests; Carcinogens; Doxorubicin; Female; Harvey murine sarcoma virus; Membrane Glycoproteins; Mice; Papilloma; Skin Neoplasms | 1990 |
Modulation of the co-promoting activity of gamma interferon in SENCAR and C57BL/6 mouse skin by difluoromethylornithine and the scheduling and duration of interferon treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Eflornithine; Female; Interferon-gamma; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chamomile; Cocarcinogenesis; Dose-Response Relationship, Drug; Enzyme Induction; Epidermis; Flavonoids; Mice; Oils, Volatile; Ornithine Decarboxylase; Papilloma; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1990 |
Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Benzoyl Peroxide; Carcinogens; Catechols; Enzyme Induction; Female; Masoprocol; Mice; Ornithine Decarboxylase Inhibitors; Peroxides; Skin; Skin Neoplasms; Sulfides | 1990 |
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; Codon; DNA, Neoplasm; Female; Genes, ras; Immunoblotting; Methylcholanthrene; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oligonucleotide Probes; Polymerase Chain Reaction; Skin Neoplasms | 1990 |
Enhancement of tumor-initiating activity of DMBA by the carbamate fungicide mancozeb.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fungicides, Industrial; Maneb; Mice; Skin Neoplasms; Thiocarbamates; Zineb | 1990 |
Enhanced malignant conversion of benign mouse skin tumors by cisplatin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cisplatin; DNA; Female; Mice; Papilloma; Skin Neoplasms; Urethane | 1990 |
Anti-tumor promoting action of phthalic acid mono-n-butyl ester cupric salt, a biomimetic superoxide dismutase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Cells, Cultured; Dermatitis, Contact; Dibutyl Phthalate; Ear Diseases; Edema; Enzyme Induction; Epidermal Cells; Epidermis; Female; Mice; Ornithine Decarboxylase; Papilloma; Phthalic Acids; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1990 |
Comparison of the effects of bilobol and 12-O-tetradecanoylphorbol-13-acetate on skin, and test of tumor promoting potential of bilobol in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Irritants; Mice; Resorcinols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Tumour reducing and anticarcinogenic activity of selected spices.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Condiments; Ferula; Garlic; Life Expectancy; Mice; Plants, Medicinal; Plants, Toxic; Skin Neoplasms | 1990 |
Effects of beta-carotene on chemically-induced skin tumors in HRA/Skh hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Body Weight; Carotenoids; Diet; Female; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Antitumor activity in skin of Skh and Sencar mice by two dietary beta-carotene formulations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Body Weight; Carotenoids; Diet; Female; Food, Fortified; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Female; Indomethacin; Inflammation; Masoprocol; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Mouse skin ornithine decarboxylase induction and tumor promotion by cyclohexane.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Cyclohexanes; Cycloheximide; Environmental Exposure; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Protein Biosynthesis; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
S/RV Cri-ba, a hairless mouse strain sensitive to skin tumorigenesis by suboptimal doses of 7,12-dimethylbenz[a]anthracene, initiation-promotion and two stage promotion protocols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Mice, Hairless; Papilloma; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1990 |
Inhibition of skin tumors in DMBA-induced complete carcinogenesis system in mice by garlic (Allium sativum).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Garlic; Male; Mice; Plant Extracts; Plants, Medicinal; Skin Neoplasms | 1990 |
Morphometric evaluation of dark and clear epidermal basal cells during early 2-stage chemical skin carcinogenesis in the hairless mouse using two different fixation methods.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Membrane; Cell Nucleus; Cocarcinogenesis; Cytoplasm; Desmosomes; Epidermis; Extracellular Space; Fixatives; Keratinocytes; Mice; Mice, Mutant Strains; Microscopy, Electron; Mitochondria; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Genetics of chemical carcinogenesis. 1. Bidirectional selective breeding of susceptible and resistant lines of mice to two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Immunity, Innate; Male; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Quinones; Skin; Skin Neoplasms; Structure-Activity Relationship; Time Factors | 1990 |
Papilloma and carcinoma production in DMBA-initiated, onion oil-promoted mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allium; Animals; Carcinoma; Cell Transformation, Neoplastic; Female; Garlic; Mice; Papilloma; Plant Oils; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Increased sensitivity to two-stage skin carcinogenesis of mice heterozygous for the repeated epilation mutation (Er).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair Removal; Heterozygote; Male; Mice; Mice, Inbred BALB C; Mutation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Elevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Carcinogens; Carcinoma; Female; Gene Expression; Metallothionein; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Osteopontin; Papilloma; Proto-Oncogene Proteins; RNA, Messenger; Sialoglycoproteins; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tubulin; Urokinase-Type Plasminogen Activator | 1990 |
Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoquinones; Biphenyl Compounds; Epidermis; Female; Hydroquinones; Incidence; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Evidence that weak promotion of carcinogen-initiated cells prevents their progression to malignancy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoflavones; Benzyl Alcohols; Cell Transformation, Neoplastic; Cortisone; Dose-Response Relationship, Drug; Indoles; Mice; Mice, Inbred BALB C; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin E | 1990 |
Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allium; Allyl Compounds; Animals; DNA, Neoplasm; Female; Garlic; Mice; Papilloma; Plant Oils; Plants, Medicinal; Skin Neoplasms; Sulfides; Thymidine | 1990 |
Effect of ultraviolet (UV) radiation and UVB-absorbing sunscreen ingredients on 7,12-dimethylbenz(a)anthracene-initiated skin tumorigenesis in hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Cocarcinogenesis; Female; Mice; Mice, Hairless; Skin; Skin Neoplasms; Sunscreening Agents; Ultraviolet Rays | 1990 |
Suppression of footpad reaction in mice by anthralin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Erythrocytes; Hindlimb; Hypersensitivity, Delayed; Isoantibodies; Male; Mice; Mice, Inbred BALB C; Skin Neoplasms; Spleen; Tetradecanoylphorbol Acetate | 1990 |
Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminobenzoates; Animals; Antineoplastic Agents; Benzamides; Benzoates; Benzoic Acid; Cell Division; Clone Cells; DNA Replication; Female; Keratinocytes; Kinetics; meta-Aminobenzoates; Mice; Mice, Inbred Strains; Niacinamide; Papilloma; Poly(ADP-ribose) Polymerase Inhibitors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Immunogenicity and cross-reactivity of syngeneic murine melanomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cross Reactions; Croton Oil; Female; Fibrosarcoma; Melanoma, Experimental; Mice; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Skin Neoplasms; Specific Pathogen-Free Organisms | 1990 |
Absence of papillomavirus in skin tumors induced in SENCAR mice by a two-stage carcinogenesis protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; DNA, Viral; Female; Mice; Papilloma; Papillomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Binding Sites; Ethers, Cyclic; Female; Marine Toxins; Mice; Mice, Inbred Strains; Molecular Weight; Nuclear Proteins; Nucleolin; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; RNA-Binding Proteins; Skin; Skin Neoplasms | 1990 |
Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylben
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Cell Line; Coumarins; Drugs, Chinese Herbal; Female; HeLa Cells; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Phosphates; Phospholipids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1990 |
[The ultrastructure and histochemical characteristics of the cells of malignant fibrous histiocytoma in rats].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acid Phosphatase; Animals; Esterases; Histiocytoma, Benign Fibrous; Histocytochemistry; Male; Microscopy, Electron; Rats; Skin Neoplasms | 1990 |
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dose-Response Relationship, Drug; Enzyme Induction; Female; Histamine Release; Histidine Decarboxylase; Irritants; Lactones; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Plant Extracts; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 1986 |
Distribution, covalent binding, and DNA adduct formation of 7,12-dimethylbenz(a)anthracene in SENCAR and BALB/c mice following topical and oral administration.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; DNA; Mice; Mice, Inbred BALB C; Protein Binding; RNA; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1987 |
Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Line; Injections, Intraperitoneal; Keratins; Mice; Mice, Nude; Neoplasm Staging; Skin Neoplasms; Skin Transplantation | 1988 |
Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Carcinoma; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Genes; Keratins; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; gamma-Glutamyltransferase; Immunoenzyme Techniques; Keratins; Metaphase; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Quantitation of primary in vitro clonogenic keratinocytes from normal adult murine epidermis, following initiation, and during promotion of epidermal tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Colony-Forming Units Assay; Epidermis; Female; Keratins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay | 1988 |
Gap-junctional intercellular communication in epidermal cell lines from selected stages of SENCAR mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Calcium; Cell Communication; Cell Line; Epidermis; Intercellular Junctions; Keratins; Mice; Microinjections; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
The influence of fixation on the relative amount of cytoplasmic ribosomes in mouse epidermal basal keratinocytes. A morphometric study of so-called "dark cells" and their putative role in epidermal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cytoplasm; Epidermal Cells; Epidermis; Female; Fixatives; Keratins; Male; Mice; Mice, Hairless; Microscopy, Electron; Ribosomes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Dietary fat effects on the initiation and promotion of two-stage skin tumorigenesis in the SENCAR mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Dietary Fats; Energy Intake; Female; Genes, ras; Mice; Papilloma; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Daunorubicin; DNA; Doxorubicin; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trifluoperazine; Verapamil | 1989 |
Multistage chemical carcinogenesis protocols produce spindle cell carcinomas of the mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinoma; Drug Administration Schedule; Immunoenzyme Techniques; Keratins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Induction of terminal differentiation-resistant epidermal cells in mouse skin and in papillomas by different initiators during two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Epidermal Cells; Female; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumor copromoting activity of gamma-interferon in the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Interferon-gamma; Mice; Papilloma; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Differential effects of benzo[a]pyrene and dimethylbenz[a]-anthracene on Langerhans cell distribution and contact sensitization in murine epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cell Count; Dermatitis, Contact; Dinitrofluorobenzene; Epidermal Cells; Epidermis; Female; Langerhans Cells; Mice; Mice, Inbred BALB C; Skin Neoplasms | 1989 |
Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Diterpenes; Female; Lyngbya Toxins; Mice; Skin Neoplasms; Structure-Activity Relationship | 1989 |
Roussin red methyl ester, a tumor promoter isolated from pickled vegetables.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Esophageal Neoplasms; Nitroso Compounds; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Vegetables | 1989 |
Protection against chemically induced skin tumorigenesis in SENCAR mice by tannic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Female; Hydrolyzable Tannins; Methylnitrosourea; Mice; Skin Neoplasms; Tannins | 1989 |
Tumor prevention by a xanthate compound in experimental mouse-skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents; Antiviral Agents; Bridged-Ring Compounds; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Norbornanes; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 1989 |
Dose and frequency effect in mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1989 |
Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chromosome Aberrations; Female; Methyl Methanesulfonate; Mice; Phorbol Esters; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Further characterization of skin tumor promotion and progression by mezerein in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Diterpenes; DNA; Female; Mice; Papilloma; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Acceleration of papilloma growth in mice fed high-fat diets during promotion of two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Weak carcinogenic effect of masheri, a pyrolysed tobacco product, in mouse skin tumor models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Models, Animal; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nicotiana; Plant Extracts; Plants, Toxic; Skin Neoplasms | 1989 |
Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Southern; Carcinoma, Squamous Cell; Genes, ras; Karyotyping; Mice; Models, Genetic; Papilloma; Precancerous Conditions; Skin Neoplasms; Trisomy | 1989 |
Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biphenyl Compounds; Carcinoma; Drug Synergism; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Antitumor-promoting activity of garlic extracts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Garlic; HeLa Cells; Mice; Mice, Inbred ICR; Phospholipids; Phosphorus Radioisotopes; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Effects of oral versus topical administration of cyclosporine on phorbol ester promotion of murine epidermal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Carcinoma, Squamous Cell; Cyclosporins; Hyperplasia; Male; Mice; Neutrophils; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Chromatography, Gel; Epidermis; Female; Humans; Kinetics; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Model systems for defining initiation, promotion, and progression of skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cell Division; Cocarcinogenesis; Cricetinae; Disease Models, Animal; Hyperplasia; Inflammation; Mesocricetus; Mice; Mutagenicity Tests; Neoplasms, Radiation-Induced; Salmonella typhimurium; Skin; Skin Neoplasms; Solvents; Species Specificity; Tetradecanoylphorbol Acetate; Turpentine; Ultraviolet Rays | 1989 |
Tumor initiation in mouse skin by cutting oils.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Hyperplasia; Industrial Oils; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carotenoids; Cocarcinogenesis; Diet; Female; Liver; Male; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A Deficiency; Weight Loss | 1989 |
Studies of the carcinogenesis and tumorigenesis of skin applications of dodecylbenzene on hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Benzene Derivatives; Female; Lymphoma; Male; Mice; Mice, Hairless; Skin Neoplasms | 1989 |
Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytosol; Diet; DNA; DNA Adducts; Female; Gastric Mucosa; Hydrolyzable Tannins; Lung; Lung Neoplasms; Mice; Microsomes; Skin; Skin Neoplasms; Stomach; Stomach Neoplasms; Tannins | 1989 |
Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free-radical-generating compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Amidines; Animals; Benzoyl Peroxide; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radicals; Mice; Mice, Hairless; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Papilloma; Peroxides; Skin; Skin Diseases; Skin Neoplasms; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1989 |
Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Enzyme Activation; Female; Hyperplasia; Mice; Mice, Inbred Strains; Papilloma; Protein Kinase C; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Carcinogens; Codon; DNA Mutational Analysis; DNA-Directed DNA Polymerase; DNA, Neoplasm; Ethers, Cyclic; Genes, ras; Male; Mice; Okadaic Acid; Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Taq Polymerase | 1989 |
Increased tumour incidence and skin tumour promotion in two generations of descendants of 7,12-dimethylbenz[a]anthracene-treated pregnant mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Male; Mice; Neoplasms, Experimental; Pedigree; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumor associated proteins of rat skin tumor induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Carcinoma, Squamous Cell; Cell Membrane; Glycoproteins; Membrane Proteins; Papilloma; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Biological assays for irritant, tumor-initiating and tumor-promoting activities. II. Standardized initiation/promotion protocol and semiquantitative estimation of promoting (or initiating) potencies in skin of NMRI mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of chemical carcinogenesis by curcumin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Catechols; Curcumin; Male; Mice; Mice, Inbred Strains; Papilloma; Plant Extracts; Skin Neoplasms | 1989 |
The role of ultraviolet radiation in the induction of melanocytic skin tumors in inbred mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Croton Oil; Female; Male; Melanocytes; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Sex Factors; Skin Neoplasms; Ultraviolet Rays | 1989 |
Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Dehydroepiandrosterone; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1989 |
Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Edema; Enzyme Induction; Female; Hyperplasia; Inflammation; Kinetics; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Reference Values; Skin; Skin Neoplasms; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
[Anti-tumor promoting activities and inhibitory effects on Epstein-Barr virus activation of Shi-un-kou and its constituents].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Depression, Chemical; Drugs, Chinese Herbal; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1989 |
Malignant transformation of a cloned, nontumorigenic mouse epidermal keratinocyte cell line, MSK-C3H-NU, by 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Neoplastic; Chromosomes; Clone Cells; Keratins; Mice; Mice, Inbred C3H; Mice, Nude; Skin Neoplasms | 1985 |
Expression of long terminal repeat (LTR) sequences in carcinogen-induced murine skin carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Gene Expression Regulation; Mice; Moloney murine leukemia virus; Poly A; Repetitive Sequences, Nucleic Acid; RNA; RNA, Messenger; RNA, Viral; Skin Neoplasms | 1985 |
Tumor-promoting activity of extracts of human semen in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Viral; Cocarcinogenesis; Female; Herpesvirus 4, Human; Humans; Mice; Semen; Skin Neoplasms; Virus Activation | 1987 |
Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Female; Mice; Oncogenes; Papilloma; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1987 |
Sequential study of gamma-glutamyltransferase during complete and two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Female; gamma-Glutamyltransferase; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ethylnitrosourea; Female; gamma-Glutamyltransferase; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamides; Animals; Carcinogens; Cnidarian Venoms; Enzyme Induction; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma; Cocarcinogenesis; DNA, Neoplasm; Female; Mice; Mutation; Papilloma; Polymorphism, Restriction Fragment Length; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Comparative activity of dietary or topical exposure to three retinoids in the promotion of skin tumor induction in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Diet; Female; Fenretinide; Isomerism; Mice; Mice, Inbred Strains; Skin Neoplasms; Structure-Activity Relationship; Tretinoin | 1987 |
[Mechanism of tumor promotion].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calmodulin; Carcinogens; Dehydroepiandrosterone; Female; Flunarizine; Mice; Neoplasms, Experimental; Skin Neoplasms | 1988 |
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ErbB Receptors; Female; Glycyrrhetinic Acid; HeLa Cells; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phorbols; Phospholipids; Phosphorus Radioisotopes; Quercetin; Receptors, Cell Surface; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Cholera toxin, a potent inducer of epidermal hyperplasia but with no tumor promoting activity in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cholera Toxin; Cocarcinogenesis; Cyclic AMP; Diterpenes; Enzyme Induction; Epidermis; Hyperplasia; Mice; Ornithine Decarboxylase; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1986 |
Epidermal changes following application of 7,12-dimethylbenz(a)anthracene and 12-O-tetradecanoylphorbol-13-acetate to human skin transplanted to nude mice studied with histological species markers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aged; Animals; Epidermis; Female; Humans; Hyperplasia; Male; Mice; Mice, Nude; Middle Aged; Skin Neoplasms; Skin Transplantation; Species Specificity; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1986 |
Human cutaneous nevi transplanted onto nude mice: a model for the study of the lesional steps in tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Animals; Humans; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Nevus; Skin Neoplasms | 1986 |
Inhibitory effect of toluene on tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Drug Antagonism; Male; Mice; Mice, Inbred C3H; Phorbols; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate; Toluene | 1986 |
Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin.
Topics: 3-O-Methylglucose; 9,10-Dimethyl-1,2-benzanthracene; Animals; Berberine; Berberine Alkaloids; Biological Transport; Carcinogens; Cells, Cultured; Female; Fibroblasts; HeLa Cells; In Vitro Techniques; Lyngbya Toxins; Methylglucosides; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phosphates; Phospholipids; Radioisotopes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Histogenesis of the intradermal melanocytic tumor in BDF1 mice induced by topical application of 9,10-dimethyl-1,2-benzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Melanocytes; Melanoma; Mice; Mice, Inbred Strains; Microscopy, Electron; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Influence of the duration of topical 13-cis-retinoic acid treatment on inhibition of mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; DNA; Female; Isotretinoin; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1986 |
Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Cocarcinogenesis; Female; Free Radicals; Keratoacanthoma; Mice; Mice, Inbred Strains; Papilloma; Peroxides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Des-O-methylolivoretin C is a new member of the teleocidin class of tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Molecular Conformation; Skin Neoplasms; Structure-Activity Relationship | 1986 |
Induction of UDP-glucuronyltransferase and arylhydrocarbon hydroxylase activity in mouse skin and in normal and transformed skin cells in culture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Female; Glucuronosyltransferase; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Skin; Skin Neoplasms | 1986 |
Enhancement of beta-propiolactone tumorigenesis in mouse skin by pretreatment with the anti-inflammatory steroid fluocinolone acetonide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Drug Synergism; Female; Fluocinolone Acetonide; Lactones; Mice; Mice, Inbred Strains; Propiolactone; Skin Neoplasms | 1986 |
Inhibition of the prenatal dimethylbenz[a]anthracene-induced tumour initiation in mice by prior administration of 7,8-benzoflavone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Administration, Oral; Animals; Benzoflavones; Cocarcinogenesis; Female; Flavonoids; Lung Neoplasms; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
An approach to the molecular mechanisms of cancer induction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Humans; Mammary Neoplasms, Experimental; Mice; Mutation; Neoplasms; Oncogenes; Papilloma; Skin Neoplasms; Transcription, Genetic | 1986 |
Correlation between formation of a specific hydrocarbon-deoxyribonucleoside adduct and tumor-initiating activity of 7,12-dimethylbenz(a)anthracene and its 9- and 10-monofluoroderivatives in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; DNA; Epidermis; Mice; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1986 |
3-Amino-1-methyl-5H-pyrido[4,3-b]-indole initiates two-stage carcinogenesis in mouse skin but is not a complete carcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbolines; Carcinogens; Cocarcinogenesis; Dimethyl Sulfoxide; Female; Mice; Mice, Inbred Strains; Mutagens; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Basement membranes in experimentally induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basement Membrane; Collagen; Cricetinae; Female; Immunoenzyme Techniques; Laminin; Mesocricetus; Mice; Microscopy, Electron; Rats; Rats, Inbred Strains; Skin Neoplasms | 1986 |
Carcinogen metabolism in human skin grafted onto athymic nude mice: a model system for the study of human skin carcinogenesis.
Topics: 7-Alkoxycoumarin O-Dealkylase; 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Coal Tar; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Disease Models, Animal; Humans; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oxidoreductases; Oxygenases; Polycyclic Compounds; Skin; Skin Neoplasms; Skin Transplantation | 1986 |
Retinoic acid enhancement of an early step in the transformation of mouse epidermal cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Dose-Response Relationship, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Hyperthermia and phorbol ester tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Hyperthermia, Induced; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Skin Temperature; Tetradecanoylphorbol Acetate | 1986 |
Carcinogenesis studies with benzoyl peroxide (Panoxyl gel 5%).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzoyl Peroxide; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relationship, Radiation; Female; Gels; Male; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Peroxides; Skin Neoplasms; Ultraviolet Rays | 1986 |
Cell-mediated immune response in mice during the two-step carcinogenesis experiment by 7,12-dimethylbenz(a)anthracene and 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens; Dinitrofluorobenzene; Erythrocytes; Female; Hypersensitivity, Delayed; Immunity, Cellular; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inhibition and enhancement of skin tumors in mice by dimethyl sulfoxide depending on method of application.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Dimethyl Sulfoxide; Drug Interactions; Male; Mice; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate | 1986 |
Fluorescent lighting enhances chemically induced papilloma formation and increases susceptibility to tumor challenge in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fibrosarcoma; Fluorescence; Immune Tolerance; Mice; Mice, Hairless; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Papilloma; Skin Neoplasms; Ultraviolet Rays | 1986 |
[Changes in the mechanical properties of the epidermis during chemical carcinogenesis].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomechanical Phenomena; Cell Adhesion; Dose-Response Relationship, Drug; Epidermis; Male; Methylnitrosourea; Rats; Skin Neoplasms; Time Factors | 1986 |
Mouse skin tumor promoting activity of orange peel oil and d-limonene: a re-evaluation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Citrus; Cyclohexenes; Female; Limonene; Mice; Mice, Inbred Strains; Oils, Volatile; Papilloma; Plant Oils; Skin Neoplasms; Terpenes | 1986 |
Differential carcinogenic effects of intraperitoneal initiation with 7,12-dimethylbenz(a)anthracene or urethane and topical promotion with 12-O-tetradecanoylphorbol-13-acetate in skin and internal tissues of female SENCAR and BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Cocarcinogenesis; Female; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Urethane | 1986 |
[Activation of oncogenes by chemical modification with carcinogens].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Liver Neoplasms, Experimental; Mice; Mutation; Neoplasms, Experimental; Oncogenes; Papilloma; Proto-Oncogenes; Rats; Skin Neoplasms | 1986 |
Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Diterpenes; Enzyme Induction; Female; Glutathione; Glutathione Peroxidase; Mice; Ornithine Decarboxylase; Papilloma; Selenium; Skin Neoplasms; Terpenes; Time Factors; Vitamin E | 1987 |
Tumorigenesis in athymic nude mouse skin by chemical carcinogens and ultraviolet light.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Susceptibility; Ear Neoplasms; Ethylnitrosourea; Female; Heterozygote; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1987 |
Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinoma; Epidermis; Hyperplasia; Mice; Mice, Nude; Papilloma; Sebaceous Gland Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Structure/activity relationships of polyfunctional diterpenes of the ingenane type. I. Tumor-promoting activity of homologous, aliphatic 3-esters of ingenol and of delta 7,8-isoingenol-3-tetradecanoate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Diterpenes; Dose-Response Relationship, Drug; Female; Isomerism; Mice; Skin; Skin Neoplasms; Structure-Activity Relationship | 1987 |
Histopathological and morphometrical analysis applied to skin changes in NMRI mice induced by dithranol (anthranil) and its acyl analogs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Cell Nucleus; DNA; Female; Hyperplasia; Mice; Papilloma; Skin; Skin Neoplasms | 1986 |
Evaluation of premalignant and malignant lesions during the induction of mouse melanomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Lymph Nodes; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nevus, Pigmented; Precancerous Conditions; Skin; Skin Neoplasms | 1987 |
Sequential studies of skin tumorigenesis in phosphoglycerate kinase mosaic mice: effect of resumption of promotion on regressed papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Promotion of skin tumours by TPA in the progeny of mice exposed pre-natally to DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Female; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Benzoyl peroxide promotes the formation of melanotic tumors in the skin of 7,12-dimethylbenz[a]anthracene-initiated Syrian golden hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Carcinoma; Cricetinae; Drug Synergism; Male; Melanoma; Mesocricetus; Papilloma; Peroxides; Skin; Skin Neoplasms | 1987 |
Effect of Cuscuta chinensis water extract on 7,12-dimethylbenz[a]anthracene-induced skin papillomas and carcinomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Body Weight; Carcinoma; Female; Male; Mice; Neoplasms, Experimental; Papilloma; Plant Extracts; Skin Neoplasms | 1986 |
Historical background of studies on environmental chemical carcinogenesis in Japan and recent progress in toxicology of carcinogens.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Coal Tar; Diet; Environmental Monitoring; Food Handling; History, 20th Century; Humans; Japan; Mutagenicity Tests; Nitrites; Skin Neoplasms; Sulfonamides | 1986 |
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Lyngbya Toxins; Maternal-Fetal Exchange; Mice; Pregnancy; Skin Neoplasms; Stomach Neoplasms | 1987 |
Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Carcinoma, Squamous Cell; Cell Nucleus; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Irritants; Mice; Ornithine Decarboxylase; Plant Oils; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thailand | 1987 |
Evaluation of epidermal cell kinetics following freezing or wounding of mouse skin and their potential as initiators of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Epidermal Cells; Female; Freezing; Hyperplasia; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate; Time Factors; Wounds, Penetrating | 1987 |
Benzo(e)pyrene-induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene to DNA in Sencar mouse epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Cocarcinogenesis; DNA; Epidermis; Female; Mice; Skin Neoplasms | 1987 |
Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
A novel system for studying in vivo effects of tumor promoters on DNA tumor viruses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cocarcinogenesis; Cricetinae; DNA Tumor Viruses; DNA, Viral; Drug Interactions; Male; Mesocricetus; Papilloma; Papillomaviridae; Polyomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Morphological characterization of cellular and extracellular components of 7,12 dimethylbenz[a]anthracene induced melanoma tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cricetinae; Male; Melanoma; Mesocricetus; Microscopy, Electron; Skin Neoplasms | 1987 |
Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Female; Methylcholanthrene; Mice; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1987 |
Sequential studies of skin tumorigenesis in PGK mosaic mice: the effect of repeated exposure to a carcinogen on regressed mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Interactions; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phenotype; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Skin tumor initiating activities of the 9- and 10-fluoro derivatives of 7- or 12-methylbenz[a]anthracene and the 9- and 10-trifluoromethyl derivatives of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Fluorine; Mice; Skin Neoplasms; Structure-Activity Relationship | 1987 |
Elevated expression and point mutation of the Ha-ras proto-oncogene in mouse skin tumors promoted by benzoyl peroxide and other promoting agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Female; Gene Expression Regulation; Mice; Mutation; Papilloma; Peroxides; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
A hypothesis on the etiology of malignant melanoma: the role of chemicals interfering with melanin synthesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Female; Humans; Levodopa; Male; Melanoma; Occupational Diseases; Polychlorinated Biphenyls; Skin Neoplasms; Sunlight | 1987 |
Effects of sex and age on DMBA:DNA binding in epidermis of SENCAR mice following topical administration of dimethylbenz[a] anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; DNA; Mice; Mice, Mutant Strains; Sex Factors; Skin; Skin Neoplasms | 1987 |
Comparison of sensitivity of Swiss albino and hairless Swiss bare mice to two stage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Susceptibility; Female; Male; Mice; Mice, Hairless; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1987 |
Induction of melanogenesis in Schwann cell and perineural epithelium by 9,10-dimethyl-1,2-benzanthracene (DMBA) and 12-o-tetradecanoylphorbol-13-acetate (TPA) in BDF1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epithelium; Female; Melanocytes; Mice; Mice, Inbred Strains; Schwann Cells; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Tumorigenesis and carcinogenesis in mouse skin treated with hyperthermia during stage I or stage II of tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hyperthermia, Induced; Mice; Peptide Hydrolases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hot Temperature; Linoleic Acid; Linoleic Acids; Magnetic Resonance Spectroscopy; Meat; Mice; Skin Neoplasms; Spectrophotometry, Ultraviolet | 1987 |
Persistence of carcinogenic effect in intact progeny of mice treated transplacentally with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Pregnancy; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Calcium; Cell Line; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Oncogenes; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1988 |
In vivo behavior of murine epidermal cell lines derived from initiated and noninitiated skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Line; Epithelium; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Skin; Skin Neoplasms; Skin Transplantation | 1988 |
The tumor-initiating and -promoting effects of ionizing radiations in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Radiation, Ionizing; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Inhibition of mouse skin tumor promotion and of promoter-induced epidermal polyamine biosynthesis by methylglyoxal bis(butylamidinohydrazone).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine Decarboxylase Inhibitors; Papilloma; Polyamines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
The influence of a hyperthermia treatment on chemically induced tumor initiation and progression in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; DNA Repair; Female; Glutathione; Hyperthermia, Induced; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Enzyme Induction; Ethers, Cyclic; Humans; Leukemia, Myeloid, Acute; Lyngbya Toxins; Mice; Okadaic Acid; Ornithine Decarboxylase; Porifera; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Impaired immunological surveillance by 7,12-dimethylbenz(a)anthracene augments its skin tumorigenicity in C3H mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Immunity, Cellular; Immunization; Immunologic Surveillance; Immunosuppression Therapy; Mice; Mice, Inbred C3H; Skin Neoplasms | 1988 |
The protein kinase C activator L-alpha-dioctanoylglycerol: a potent stage II mouse skin tumor promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Induction; Glycerides; Glycerol; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Terpenes | 1988 |
Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthraquinones; Benzo(a)pyrene; DNA; Female; Flavonoids; Hydrolyzable Tannins; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred BALB C; Quercetin; Skin Neoplasms; Tannins | 1988 |
Survey of cytotoxicities and antimutagenic and antitumor initiating activities of Cu(II)(3,5-diisopropylsalicylate)2 and its analogs in a keratinocyte-mediated mutation assay and the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benzo(a)pyrene; Cell Line; Cell Survival; Cells, Cultured; Copper; Copper Sulfate; Epidermal Cells; Epidermis; Mice; Mice, Inbred Strains; Mutation; Papilloma; Salicylates; Skin Neoplasms | 1988 |
Susceptibility to phorbol ester skin tumor promotion in (C57BL/6 x DBA/2) F1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Genes, Dominant; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Epidermal papillomas and carcinomas induced in uninitiated mouse skin by tumor promoters alone contain a point mutation in the 61st codon of the Ha-ras oncogene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Codon; DNA, Neoplasm; Genes, ras; Mice; Mice, Inbred Strains; Mutation; Nucleic Acid Hybridization; Papilloma; Skin Neoplasms | 1988 |
Clonal origin of chemically induced papillomas: separate analysis of epidermal and dermal components.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epidermis; Female; Isoenzymes; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplastic Stem Cells; Papilloma; Phosphoglycerate Kinase; Skin Neoplasms | 1987 |
Influence of dose of initiator on two-stage skin carcinogenesis in BALB/c mice with cellular mosaicism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phenotype; Phosphoglycerate Kinase; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Skin tumorigenesis and carcinogenesis studies with 7,12-dimethylbenz[a]anthracene, ultraviolet light, benzoyl peroxide (Panoxyl gel 5%) and ointment gel.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Cocarcinogenesis; Female; Gels; Male; Mice; Mice, Hairless; Ointments; Peroxides; Skin Neoplasms; Ultraviolet Rays | 1988 |
Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-promoted tumor formation in CD-1 and Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Mice; Mice, Inbred Strains; Papilloma; Retinoids; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1988 |
A chemical analysis of dust in the leather industry with reference to the presence of possible oncogenic agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dust; Humans; Industry; Liver; Mice; Necrosis; Occupational Diseases; Respiratory Tract Neoplasms; Skin Neoplasms | 1988 |
Sensitivity of HRA/Skh hairless mice to initiation/promotion of skin tumors by chemical treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Enzyme Activation; Lyngbya Toxins; Mice; Protein Kinase C; Skin Neoplasms; Stereoisomerism | 1988 |
Tumour-promoting ability of mancozeb, a carbamate fungicide, on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fungicides, Industrial; Maneb; Mice; Skin Neoplasms; Thiocarbamates; Zineb | 1988 |
Effect of exogenous glutathione on tumor progression in the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Animals; Antioxidants; Carcinoma; Disulfiram; Free Radicals; Glutathione; Mice; Oxidation-Reduction; Papilloma; Precancerous Conditions; Skin Neoplasms | 1988 |
Sensitivity of the skin of different mouse strains to the promoting effect of 12-0-tetradecanoyl-phorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Papilloma; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Catechols; Chlorogenic Acid; Cinnamates; Coumaric Acids; Curcumin; DNA; Edema; Female; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
The early effects of a single application of acetone and various doses of 7,12-dimethylbenz(alpha)anthracene on CD-1 and hairless mouse epidermis. A cell kinetic study of so-called initiation and complete carcinogenesis (initiation plus promotion) in chem
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Cell Cycle; Cocarcinogenesis; DNA Replication; Female; Flow Cytometry; Male; Mice; Mice, Inbred Strains; Mitotic Index; Skin; Skin Neoplasms; Time Factors | 1988 |
Presence of a functionally altered ornithine decarboxylase activity in chrysarobin-promoted mouse epidermal papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Carcinogens; Enzyme Activation; Epidermis; Female; Guanine Nucleotides; Hot Temperature; Kinetics; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms | 1988 |
Tumor promotion by a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone, in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Butylated Hydroxytoluene; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Papilloma; Peroxides; Quinones; Skin; Skin Neoplasms | 1988 |
Role of cutaneous GSH in 12-O-tetradecanoyl-phorbol 13-acetate-induced mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Glutathione; Maleates; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cimetidine; Cocarcinogenesis; Lung Neoplasms; Mice; Neoplasms, Experimental; Skin Neoplasms; Urethane | 1988 |
Tumor progression in Sencar mouse skin as a function of initiator dose and promoter dose, duration, and type.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Enzyme Induction; Ethers, Cyclic; Female; Irritants; Marine Toxins; Mice; Okadaic Acid; Ornithine Decarboxylase; Pyrans; Skin Neoplasms; Structure-Activity Relationship | 1988 |
Epithelial cutaneous lesions induced in Dunkin-Hartley albino guinea-pigs by means of 7,12-dimethyl-benzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Disease Models, Animal; Epidermal Cyst; Epithelium; Guinea Pigs; Hyperplasia; Male; Skin; Skin Diseases; Skin Neoplasms | 1988 |
[Studies on the promoting and initiating effects of Fusarium T-2 toxin].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Male; Mice; Mice, Inbred BALB C; Papilloma; Sesquiterpenes; Skin Neoplasms; T-2 Toxin | 1988 |
[Inhibitory effect of glycyrrhizin and caffeine on two-stage carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Infective Agents; Caffeine; Cocarcinogenesis; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; Cloning, Molecular; DNA, Neoplasm; Female; Gene Amplification; Gene Rearrangement; Immunoblotting; Matrix Metalloproteinase 3; Metalloendopeptidases; Mice; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Papilloma; Peptide Hydrolases; Plasmids; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Tumorigenic and molecular characterization of novel phorbol ester-resistant and -sensitive lines of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autoradiography; Brain; Breeding; Carcinogenicity Tests; Drug Resistance; Epidermis; Female; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbol Esters; Phosphorylation; Protein Kinase C; Skin Neoplasms; Substrate Specificity; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas by dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Androstenes; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Female; Mice; Papilloma; Skin Neoplasms | 1985 |
Effects of short-term exposure to the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Epidermis; Female; Mice; Phthalic Acids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Correlation of initiating potency of skin carcinogens with potency to induce resistance to terminal differentiation in cultured mouse keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Carcinogens; Cell Differentiation; Cells, Cultured; Methylnitronitrosoguanidine; Mice; Skin; Skin Neoplasms; Ultraviolet Rays | 1985 |
Association of resistance to terminal differentiation with initiation of carcinogenesis in adult mouse epidermal cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Differentiation; Cell Division; Epidermal Cells; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Skin Neoplasms | 1985 |
Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benz(a)Anthracenes; Benzoflavones; Dose-Response Relationship, Drug; Ellipticines; Female; Flavonoids; Mice; Skin Neoplasms | 1985 |
A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cattle; Meat; Mice; Mutagenicity Tests; Mutagens; Skin Neoplasms | 1985 |
Proto-oncogene expression during two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Female; Gene Expression Regulation; Mice; Oncogenes; Papilloma; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Two-stage tumor promotion in mouse skin: an alternative interpretation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Croton Oil; Fluocinolone Acetonide; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1985 |
12-O-tetradecanoylphorbol-13-acetate-induced rapid loss of persistent 7,12-dimethylbenz[a]anthracene-DNA adducts in mouse epidermis and dermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Epidermis; Female; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Mouse skin melanoma induced in two stage chemical carcinogenesis with 7,12-dimethylbenz[a]anthracene and croton oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Croton Oil; Female; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin Neoplasms | 1985 |
Soft agar colony formation of mouse epidermal cells during the early phase of two-stage chemically induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Cocarcinogenesis; Colony-Forming Units Assay; Epidermis; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Stem Cell Assay | 1985 |
Carcinogen-induced depletion of cutaneous Langerhans cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cell Survival; Dose-Response Relationship, Drug; Langerhans Cells; Male; Mice; Mice, Inbred BALB C; Skin Neoplasms; Time Factors | 1985 |
Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biotransformation; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1985 |
Stimulatory effect of 1 alpha, 25-dihydroxyvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Body Weight; Calcitriol; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Diterpenes; Female; Mice; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Enzyme Induction; Female; Mice; Models, Biological; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Initiation and promotion in young and old animals. Implications for human tumour formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Autopsy; Female; Humans; Mathematics; Mice; Models, Biological; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |