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9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine and Cytomegalovirus

9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine has been researched along with Cytomegalovirus in 6 studies

*Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS. [MeSH]

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bronson, JJ; Ghazzouli, I; Hitchcock, MJ; Martin, JC; Webb, RR1
Andrei, G; Balzarini, J; De Clercq, E; Dvoráková, H; Holý, A; Masojídková, M; Snoeck, R1
Beadle, JR; Ciesla, SL; Hartline, C; Hostetler, KY; Keith, KA; Kern, ER; Wan, WB1
Andrei, G; Balzarini, J; Camarasa, MJ; de Castro, S; Naesens, L; Peromingo, MT; Snoeck, R; Velázquez, S1
Andrei, G; Balzarini, J; Camarasa, MJ; De Castro, S; García-Aparicio, C; Snoeck, R; Velázquez, S1
Borysko, KZ; Breitenbach, JM; Collins, M; Drach, JC; Hilfinger, JM; Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Serpi, M; Zakharova, VM1

Other Studies

6 other study(ies) available for 9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine and Cytomegalovirus

ArticleYear
Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:7

    Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Cidofovir; Cytomegalovirus; Cytosine; Cytosine Nucleotides; Female; Guinea Pigs; Humans; Mice; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Vero Cells

1989
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents.
    Journal of medicinal chemistry, 1996, Aug-16, Volume: 39, Issue:17

    Topics: 3T3 Cells; Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; HIV-1; HIV-2; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Molecular Structure; Moloney murine sarcoma virus; Organophosphonates; Purine Nucleotides; Pyrimidine Nucleotides; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Vaccinia virus

1996
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
    Journal of medicinal chemistry, 2006, Mar-23, Volume: 49, Issue:6

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Esters; Humans; Organophosphonates; Orthopoxvirus; Stereoisomerism; Structure-Activity Relationship

2006
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Thymidine; Urea

2008
4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cytomegalovirus; Herpesvirus 3, Human; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Naphthalenesulfonates; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Virus Replication

2009
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
    Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16

    Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cidofovir; Cowpox virus; Cytomegalovirus; Cytosine; Fibroblasts; Herpesvirus 1, Human; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Structure; Organophosphonates; Prodrugs; Rats; Tyrosine; Vaccinia virus

2011