9-(2-hydroxy-3-nonyl)adenine has been researched along with Myocardial Ischemia in 16 studies
9-(2-hydroxy-3-nonyl)adenine: specific inhibitor of adenosine deaminase
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mounting evidence suggests a protective effect of exogenous adenosine in myocardial ischemia and reperfusion." | 3.68 | Augmentation of endogenous adenosine attenuates myocardial 'stunning' independently of coronary flow or hemodynamic effects. ( Abd-Elfattah, AS; Bolli, R; Jeroudi, MO; Sekili, S; Sun, JZ; Tang, XL; Zughaib, ME, 1993) |
| "Adenosine is suggested to be a potential candidate because of its high uptake and rapid intracellular sequestration." | 1.32 | Tracer adenosine: a novel myocardial flow marker. ( Deussen, A; Lauer, T; Loncar, R, 2003) |
| "Treatment with BW A1433U reduced TOIC [8." | 1.29 | Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia. ( Lasley, RD; Mentzer, RM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abd-Elfattah, AS | 7 |
| Tuchy, GE | 1 |
| Jessen, ME | 5 |
| Salter, DR | 1 |
| Goldstein, JP | 1 |
| Brunsting, LA | 1 |
| Wechsler, AS | 6 |
| Ding, M | 1 |
| Lauer, T | 1 |
| Loncar, R | 1 |
| Deussen, A | 1 |
| Gallagher, KP | 1 |
| McClanahan, TB | 1 |
| Martin, BJ | 1 |
| Saganek, LJ | 1 |
| Ignasiak, DP | 1 |
| Mertz, TE | 1 |
| Van Wylen, DG | 2 |
| Vinten-Johansen, J | 1 |
| Zughaib, ME | 1 |
| Jeroudi, MO | 1 |
| Sun, JZ | 1 |
| Sekili, S | 1 |
| Tang, XL | 1 |
| Bolli, R | 1 |
| Sandhu, GS | 1 |
| Burrier, AC | 1 |
| Janero, DR | 1 |
| Lasley, RD | 1 |
| Mentzer, RM | 1 |
| Xia, Y | 1 |
| Khatchikian, G | 1 |
| Zweier, JL | 1 |
| Mallet, RT | 1 |
| Lee, SC | 1 |
| Downey, HF | 1 |
| Manthei, SA | 1 |
| Reiling, CM | 1 |
| Maddox, RP | 1 |
| Rebeyka, IM | 1 |
| Lekven, J | 1 |
| Hirai, K | 1 |
| Ashraf, M | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
1 review available for 9-(2-hydroxy-3-nonyl)adenine and Myocardial Ischemia
| Article | Year |
|---|---|
Does adenosine deaminase inhibition protect ischemic myocardium?
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Enzyme Inhibitors; Humans; In Vitro Techniques; My | 1994 |
15 other studies available for 9-(2-hydroxy-3-nonyl)adenine and Myocardial Ischemia
| Article | Year |
|---|---|
Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery befor
Topics: Adenine; Adenosine Triphosphate; Animals; Cold Ischemia; Disease Models, Animal; Dogs; Equilibrative | 2013 |
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Chromatography, High Pressure Liquid; Constriction | 2012 |
Tracer adenosine: a novel myocardial flow marker.
Topics: Adenine; Adenosine; Alprostadil; Animals; Carbon Radioisotopes; Coronary Circulation; Dogs; Isotope | 2003 |
Nucleoside trapping during reperfusion prevents ventricular dysfunction, "stunning," in absence of adenosine. Possible separation between ischemic and reperfusion injury.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Affinity Labels; Animals; B | 1994 |
Separation between ischemic and reperfusion injury by site specific entrapment of endogenous adenosine and inosine using NBMPR and EHNA.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Dogs; Female; Heart; Inosi | 1994 |
Augmentation of endogenous adenosine attenuates myocardial 'stunning' independently of coronary flow or hemodynamic effects.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Coronary Circulation; Dogs; Heart; Hemodynamics; M | 1993 |
Adenosine deaminase inhibitors attenuate ischemic injury and preserve energy balance in isolated guinea pig heart.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Coformycin; Creatine Kinase; Energy Metabolism; Gu | 1993 |
Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia.
Topics: Adenine; Adenosine; Animals; Glucose; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardia | 1993 |
Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Electro | 1996 |
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter | 1996 |
Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites: adenosine deaminase inhibition versus adenosine kinase inhibition.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Chromatography, High | 1998 |
Role of nucleoside transport and purine release in a rabbit model of myocardial stunning.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Carrier Proteins; Dogs; Enzym | 1998 |
Differential cardioprotection with selective inhibitors of adenosine metabolism and transport: role of purine release in ischemic and reperfusion injury.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Carrier Proteins; | 1998 |
Modulation of adenosine effects in attenuation of ischemia and reperfusion injury in rat heart.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Enzyme Inhibitors; Heart; Heart Rate; I | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra | 1999 |