9-((2-phosphonylmethoxy)ethyl)guanine and Leukemia--Myeloid

9-((2-phosphonylmethoxy)ethyl)guanine has been researched along with Leukemia--Myeloid* in 1 studies

Other Studies

1 other study(ies) available for 9-((2-phosphonylmethoxy)ethyl)guanine and Leukemia--Myeloid

ArticleYear
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
    International journal of oncology, 1999, Volume: 14, Issue:4

    Acyclic nucleotide analogues perturb DNA replication by terminating the growing DNA chain. The analogues selected for testing on human leukemia cell lines, namely 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP), and 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) exhibited growth-inhibiting activity at low concentrations, and apoptosis-inducing activity at high concentrations. A common feature was a reduction of the proportion of G1 cell cycle phase. Activities of the analogues increased in the order PMEA

    Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Organophosphorus Compounds; Tumor Cells, Cultured

1999