9-((2-hydroxy-1-3-2-dioxaphosphorinan-5-yl)oxymethyl)guanine-p-oxide and Adenovirus-Infections--Human

9-((2-hydroxy-1-3-2-dioxaphosphorinan-5-yl)oxymethyl)guanine-p-oxide has been researched along with Adenovirus-Infections--Human* in 1 studies

Other Studies

1 other study(ies) available for 9-((2-hydroxy-1-3-2-dioxaphosphorinan-5-yl)oxymethyl)guanine-p-oxide and Adenovirus-Infections--Human

Article	Year
Inhibitory effect of (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP on clinical ocular adenoviral isolates is serotype-dependent in vitro. Antiviral research, 1991, Volume: 16, Issue:1 Currently, there is no effective treatment for ocular adenoviral infections that occur in epidemics worldwide, produce significant patient morbidity, and cause substantial economic losses. We tested several new antivirals in vitro, and found that (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP demonstrated significant serotype-dependent inhibitory activity by plaque reduction assay (ID50 = 0.017-17.0 micrograms/ml) against common clinical ocular isolates and standard adenoviral serotypes (Ad 1, Ad 5, Ad 8, and Ad 19). (S)-HPMPC was the least toxic (CD50 in A549 cells = 306 micrograms/ml), and (S)-HPMPC and (S)-HPMPA had high selectivity indices. Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Antiviral Agents; Cidofovir; Conjunctivitis, Viral; Cytosine; DNA; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Serotyping; Tumor Cells, Cultured; Viral Plaque Assay	1991

Article

Year

Inhibitory effect of (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP on clinical ocular adenoviral isolates is serotype-dependent in vitro.

Antiviral research, 1991, Volume: 16, Issue:1

Currently, there is no effective treatment for ocular adenoviral infections that occur in epidemics worldwide, produce significant patient morbidity, and cause substantial economic losses. We tested several new antivirals in vitro, and found that (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP demonstrated significant serotype-dependent inhibitory activity by plaque reduction assay (ID50 = 0.017-17.0 micrograms/ml) against common clinical ocular isolates and standard adenoviral serotypes (Ad 1, Ad 5, Ad 8, and Ad 19). (S)-HPMPC was the least toxic (CD50 in A549 cells = 306 micrograms/ml), and (S)-HPMPC and (S)-HPMPA had high selectivity indices.

Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Antiviral Agents; Cidofovir; Conjunctivitis, Viral; Cytosine; DNA; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Serotyping; Tumor Cells, Cultured; Viral Plaque Assay

1991