8-phenyltheophylline has been researched along with Myocardial Ischemia in 15 studies
8-phenyltheophylline: purinergic P1 receptor antagonist
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Persisting coronary vasoconstrictor tone that is responsive to exogenous adenosine administration has been demonstrated during myocardial ischemia." | 7.68 | Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise. ( Bache, RJ; Homans, DC; Laxson, DD, 1993) |
| "Persisting coronary vasoconstrictor tone that is responsive to exogenous adenosine administration has been demonstrated during myocardial ischemia." | 3.68 | Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise. ( Bache, RJ; Homans, DC; Laxson, DD, 1993) |
| "We conclude that 1) in sustained myocardial ischemia, SOD treatment attenuates ischemic injury caused by coronary microembolization by restoration of 5'-nucleotidase activity and augmentation of adenosine release; 2) this beneficial effect of SOD is observed even after coronary microembolization; and 3) the beneficial effects of SOD are attributable to coronary vasodilation produced by augmented adenosine release." | 3.68 | Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization. ( Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Sato, H; Takashima, S, 1993) |
| "To test the hypothesis that the endothelium-derived relaxing factor (EDRF) contributes to coronary vasodilation induced by myocardial ischemia, we examined the effect of NG-nitro-L-arginine (a potent and selective inhibitor of EDRF release) on the coronary reactive hyperemic response in the open-chest dogs." | 3.68 | NG-nitro-L-arginine attenuates flow debt repayment in the reactive hyperemic response of the open-chest dog coronary artery: contribution of endothelium-derived relaxing factor. ( Kajikawa, Y; Kusachi, S; Marutani, M; Tsuji, T; Yamasaki, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (93.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Minamino, T | 1 |
| Kitakaze, M | 2 |
| Morioka, T | 1 |
| Node, K | 1 |
| Shinozaki, Y | 1 |
| Chujo, M | 1 |
| Mori, H | 1 |
| Takeda, H | 1 |
| Inoue, M | 2 |
| Hori, M | 3 |
| Rynning, SE | 1 |
| Brunvand, H | 1 |
| Birkeland, S | 1 |
| Hexeberg, E | 1 |
| Grong, K | 1 |
| Hoshida, S | 1 |
| Kuzuya, T | 1 |
| Nishida, M | 1 |
| Yamashita, N | 1 |
| Oe, H | 1 |
| Kamada, T | 2 |
| Tada, M | 1 |
| Laxson, DD | 2 |
| Homans, DC | 1 |
| Bache, RJ | 2 |
| Duncker, DJ | 1 |
| Lindstrom, P | 1 |
| Urabe, K | 1 |
| Miura, T | 2 |
| Iwamoto, T | 1 |
| Ogawa, T | 1 |
| Goto, M | 1 |
| Sakamoto, J | 2 |
| Iimura, O | 1 |
| Takashima, S | 1 |
| Sato, H | 1 |
| Bouchard, JF | 1 |
| Lamontagne, D | 1 |
| Gryglewski, RJ | 1 |
| Chlopicki, S | 1 |
| Niezabitowski, P | 1 |
| Jakubowski, A | 1 |
| Lomnicka, M | 1 |
| Askenasy, N | 1 |
| Navon, G | 1 |
| Ismail, JA | 1 |
| McDonough, KH | 1 |
| Miki, T | 1 |
| Bünger, R | 1 |
| Suzuki, K | 1 |
| Shimamoto, K | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
| Yamamoto, M | 1 |
| Egashira, K | 1 |
| Arimura, K | 1 |
| Tada, H | 1 |
| Shimokawa, H | 1 |
| Takeshita, A | 1 |
| Marutani, M | 1 |
| Kusachi, S | 1 |
| Kajikawa, Y | 1 |
| Yamasaki, S | 1 |
| Tsuji, T | 1 |
15 other studies available for 8-phenyltheophylline and Myocardial Ischemia
| Article | Year |
|---|---|
Bidirectional effects of aminophylline on myocardial ischemia.
Topics: Adenosine; Aminophylline; Animals; Coronary Circulation; Dogs; Heart; Lactates; Lactic Acid; Myocard | 1995 |
Endogenous adenosine attenuates myocardial stunning by antiadrenergic effects exerted during ischemia and not during reperfusion.
Topics: Adenosine; Animals; Cats; Coronary Circulation; Doxazosin; Heart; Hemodynamics; Male; Myocardial Con | 1995 |
Adenosine blockade during reperfusion reverses the infarct limiting effect in preconditioned canine hearts.
Topics: Animals; Dogs; Female; Leukocyte Count; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium | 1994 |
Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise.
Topics: Adenosine; Adenosine Deaminase; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dog | 1993 |
Endogenous adenosine and coronary vasoconstriction in hypoperfused myocardium during exercise.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Animals; Coronary Ves | 1993 |
Preconditioning enhances myocardial resistance to postischaemic myocardial stunning via adenosine receptor activation.
Topics: Animals; Disease Models, Animal; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reper | 1993 |
Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization.
Topics: 5'-Nucleotidase; Adenosine; Animals; Coronary Circulation; Dogs; Embolism; Injections; Lactates; Lac | 1993 |
Mechanisms of protection afforded by preconditioning to endothelial function against ischemic injury.
Topics: Adenosine Triphosphate; Animals; Coronary Vessels; Endothelium, Vascular; Glyburide; In Vitro Techni | 1996 |
Ischaemic cardiac hyperaemia: role of nitric oxide and other mediators.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Coronary Circulation; Cyclic GMP; Cyclooxygenase I | 1996 |
Intermittent ischemia: energy metabolism, cellular volume regulation, adenosine and insights into preconditioning.
Topics: Adenosine; Animals; Cell Size; Creatine; Energy Metabolism; Glyburide; Glycogen; Glycolysis; In Vitr | 1997 |
The role of coronary flow and adenosine in postischemic recovery of septic rat hearts.
Topics: Animals; Bacteremia; Blood Pressure; Coronary Circulation; Escherichia coli Infections; Heart Rate; | 1998 |
Ecto-5'-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ.
Topics: 5'-Nucleotidase; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Pressure; Enzyme Inh | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra | 1999 |
Coronary vascular K+ATP channels contribute to the maintenance of myocardial perfusion in dogs with pacing-induced heart failure.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relatio | 2000 |
NG-nitro-L-arginine attenuates flow debt repayment in the reactive hyperemic response of the open-chest dog coronary artery: contribution of endothelium-derived relaxing factor.
Topics: Adenosine; Animals; Arginine; Coronary Vessels; Dogs; Myocardial Ischemia; Nitric Oxide; Nitroargini | 1992 |