8-phenyltheophylline has been researched along with Hypoxia in 25 studies
8-phenyltheophylline: purinergic P1 receptor antagonist
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)." | 7.70 | Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998) |
| " In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg) were recorded before and after the administration of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1 i." | 7.69 | Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. ( Marshall, JM; Thomas, T, 1994) |
| " The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit." | 7.69 | Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994) |
| "The purpose of this study was twofold: 1) to verify a report that a suspension of 8-phenyltheophylline (8-PT) completely abolished hypoxia-induced coronary vasodilation [H." | 7.68 | Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. ( Downey, HF; Lee, SC; Mallet, RT; Shizukuda, Y; Williams, AG, 1992) |
| " In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked by 5 min periods of systemic hypoxia." | 7.68 | The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. ( Marshall, JM; Neylon, M, 1991) |
| " Hypoxia was repeated before and after 8-phenyltheophylline administration (19." | 7.68 | Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. ( Borgdorff, P; Verlato, G, 1990) |
| "The role of adenosine in hypoxia-induced vasodilation was examined in the intestine of pentobarbital sodium-anesthetized cats." | 7.68 | Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated. ( Lautt, WW; Lockhart, LK, 1990) |
| "This study investigated the role of adenosine in the regulation of neonatal cerebral blood flow (CBF) during moderate (arterial PO2 = 47 +/- 9 Torr) and severe (arterial PO2 = 25 +/- 4 Torr) hypoxia." | 7.68 | Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. ( Aranda, JV; Beharry, K; Farri, E; Laudignon, N; Rex, J, 1990) |
| "Anesthetized randomsource mongrel dogs of either sex were instrumented to investigate the effects of 8-phenyltheophylline on changes in coronary perfusion pressure caused by systemic hypoxia under conditions of controlled constant coronary blood flow." | 7.67 | Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline. ( Kang, YH; Merrill, GF; Wei, HM, 1989) |
| "Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs." | 5.30 | Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997) |
| " In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)." | 3.70 | Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998) |
| " In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg) were recorded before and after the administration of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1 i." | 3.69 | Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. ( Marshall, JM; Thomas, T, 1994) |
| " The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit." | 3.69 | Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994) |
| "The role of intracerebral adenosine levels in the control of ventilatory response to hypoxia was explored in 15 spontaneously breathing intubated piglets, 1-5 days old, sedated with chloral hydrate." | 3.69 | Role of adenosine in the hypoxic ventilatory response of the newborn piglet. ( Aranda, JV; Davis, GM; Lopes, JM; Mullahoo, K, 1994) |
| " They were studied under anaesthesia while breathing 12% O2 and during acute hypoxia (breathing 8% O2 for 5 min) before and after addition of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1)." | 3.69 | The roles of adenosine in regulating the respiratory and cardiovascular systems in chronically hypoxic, adult rats. ( Marshall, JM; Thomas, T, 1997) |
| "In electrically driven myocardial preparations obtained from chronically methylxanthine-[aminophylline (APH) and 8-phenyltheophylline (8-PT)] or solvent(DMSO)-treated guinea pigs no differences were found in alteration of mechanical activity under hypoxia and reoxygenation." | 3.69 | Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness. ( Antal, K; Cseppentö, A; Kovács, P; Szabó, JZ; Szegi, J; Szentmiklósi, AJ; Ujfalusi, A, 1996) |
| "The purpose of this study was twofold: 1) to verify a report that a suspension of 8-phenyltheophylline (8-PT) completely abolished hypoxia-induced coronary vasodilation [H." | 3.68 | Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. ( Downey, HF; Lee, SC; Mallet, RT; Shizukuda, Y; Williams, AG, 1992) |
| " On the other hand, 8-phenyltheophylline, an adenosine receptor antagonist, significantly inhibited the stimulatory effects of CHA on both Ep secretion and cAMP accumulation in the Hep 3B cell cultures in response to hypoxia." | 3.68 | Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine. ( Beckman, B; Brookins, J; Fisher, JW; Nakashima, J, 1991) |
| " In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked by 5 min periods of systemic hypoxia." | 3.68 | The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. ( Marshall, JM; Neylon, M, 1991) |
| " Hypoxia was repeated before and after 8-phenyltheophylline administration (19." | 3.68 | Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. ( Borgdorff, P; Verlato, G, 1990) |
| "The role of adenosine in hypoxia-induced vasodilation was examined in the intestine of pentobarbital sodium-anesthetized cats." | 3.68 | Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated. ( Lautt, WW; Lockhart, LK, 1990) |
| "This study investigated the role of adenosine in the regulation of neonatal cerebral blood flow (CBF) during moderate (arterial PO2 = 47 +/- 9 Torr) and severe (arterial PO2 = 25 +/- 4 Torr) hypoxia." | 3.68 | Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. ( Aranda, JV; Beharry, K; Farri, E; Laudignon, N; Rex, J, 1990) |
| "Anesthetized randomsource mongrel dogs of either sex were instrumented to investigate the effects of 8-phenyltheophylline on changes in coronary perfusion pressure caused by systemic hypoxia under conditions of controlled constant coronary blood flow." | 3.67 | Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline. ( Kang, YH; Merrill, GF; Wei, HM, 1989) |
| "Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs." | 1.30 | Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 23 (92.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reid, JM | 1 |
| Davies, AG | 1 |
| Ashcroft, FM | 1 |
| Paterson, DJ | 1 |
| Sawanobori, T | 1 |
| Adaniya, H | 1 |
| Yukisada, H | 1 |
| Hiraoka, M | 1 |
| Nakhostine, N | 1 |
| Lamontagne, D | 1 |
| Hara, A | 1 |
| Abiko, Y | 1 |
| Thomas, T | 5 |
| Marshall, JM | 8 |
| Jiang, C | 1 |
| Collins, P | 1 |
| Lopes, JM | 1 |
| Davis, GM | 1 |
| Mullahoo, K | 1 |
| Aranda, JV | 2 |
| Turner, L | 1 |
| Katchman, AN | 1 |
| Hershkowitz, N | 1 |
| Armstead, WM | 1 |
| Elnazir, B | 1 |
| Kumar, P | 1 |
| Cseppentö, A | 1 |
| Ujfalusi, A | 1 |
| Antal, K | 1 |
| Szegi, J | 1 |
| Szabó, JZ | 1 |
| Kovács, P | 1 |
| Szentmiklósi, AJ | 1 |
| Coney, AM | 1 |
| Lee, SC | 1 |
| Mallet, RT | 1 |
| Shizukuda, Y | 1 |
| Williams, AG | 1 |
| Downey, HF | 1 |
| Nakashima, J | 1 |
| Brookins, J | 1 |
| Beckman, B | 1 |
| Fisher, JW | 1 |
| von Beckerath, N | 1 |
| Cyrys, S | 1 |
| Dischner, A | 1 |
| Daut, J | 1 |
| Neylon, M | 1 |
| Verlato, G | 1 |
| Borgdorff, P | 1 |
| Lockhart, LK | 1 |
| Lautt, WW | 1 |
| Laudignon, N | 1 |
| Farri, E | 1 |
| Beharry, K | 1 |
| Rex, J | 1 |
| Wei, HM | 1 |
| Kang, YH | 1 |
| Merrill, GF | 1 |
| McQueen, DS | 1 |
| Ribeiro, JA | 1 |
25 other studies available for 8-phenyltheophylline and Hypoxia
| Article | Year |
|---|---|
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hyperc | 1995 |
Role for ATP-sensitive K+ channel in the development of A-V block during hypoxia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Atrioventricular Node; Deoxyglucose; Female; Glu | 1995 |
Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cyclic AMP; Diclofenac; Epoprostenol; Heart; Hypoxia; My | 1994 |
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts.
Topics: Animals; Glyburide; Heart; Hydrogen Peroxide; Hypoxia; In Vitro Techniques; Male; Myocardium; Purine | 1995 |
Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine.
Topics: Adenosine; Animals; Cardiovascular System; Carotid Arteries; Cerebrovascular Circulation; Hypoxia; P | 1994 |
Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Capsaicin; Coronary Vessels; Endothelium, Vasc | 1994 |
Role of adenosine in the hypoxic ventilatory response of the newborn piglet.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Cerebrospinal Fluid; Citrates; Dipyridamole; Drug Co | 1994 |
A link between adenosine, ATP-sensitive K+ channels, potassium and muscle vasodilatation in the rat in systemic hypoxia.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Hypoxia; Muscles; Potassiu | 1993 |
Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents.
Topics: Adenosine; Animals; Electrophysiology; Hypoxia; In Vitro Techniques; Models, Neurological; Purinergi | 1993 |
The role of adenosine in hypoxic pulmonary vasoconstriction in the anaesthetized rat.
Topics: Adenosine; Animals; Blood Pressure; Hypoxia; Lung; Pulmonary Artery; Pulmonary Veins; Rats; Rats, Wi | 1993 |
A study on rats of the effects of chronic hypoxia from birth on respiratory and cardiovascular responses evoked by acute hypoxia.
Topics: Adenosine; Animals; Animals, Newborn; Blood Gas Analysis; Cardiovascular System; Hypoxia; Potassium; | 1995 |
Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Cyclic AM | 1997 |
Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: the roles of adenosine.
Topics: 2-Chloroadenosine; Adenosine; Aging; Animals; Animals, Newborn; Cardiovascular System; Hypoxia; Resp | 1996 |
The roles of adenosine in regulating the respiratory and cardiovascular systems in chronically hypoxic, adult rats.
Topics: Adenosine; Animals; Blood Gas Analysis; Cerebrovascular Circulation; Hemodynamics; Hindlimb; Hypoxia | 1997 |
Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness.
Topics: Aminophylline; Animals; Atrial Function; Cardiotonic Agents; Dinoprost; Female; Guinea Pigs; Hypoxia | 1996 |
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler F | 1998 |
Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline.
Topics: Adenosine; Animals; Coronary Circulation; Dogs; Heart; Hemodynamics; Hypoxia; Pressure; Solutions; T | 1992 |
Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine.
Topics: Adenosine; Anaerobiosis; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyclic AM | 1991 |
Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanisms.
Topics: Adenosine; Animals; Arginine; Coronary Vessels; Deoxyglucose; Glycolysis; Guinea Pigs; Hypoxia; Nitr | 1991 |
The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat.
Topics: Adenosine; Animals; Blood Pressure; Female; Heart Rate; Hemodynamics; Hypoxia; Male; Rats; Rats, Inb | 1991 |
Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit.
Topics: Adenosine; Anesthesia; Animals; Depression, Chemical; Female; Heart Rate; Hypoxia; Male; Rabbits; Th | 1990 |
Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated.
Topics: Adenosine; Animals; Cats; Hypoxia; Isoproterenol; Mesenteric Arteries; Oxygen; Partial Pressure; Rec | 1990 |
Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet.
Topics: Adenosine; Animals; Animals, Newborn; Arteries; Cerebrovascular Circulation; Chromatography, High Pr | 1990 |
Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Female; Heart; Hea | 1989 |
Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine.
Topics: Adenosine; Animals; Carotid Body; Cats; Hypoxia; Receptors, Cell Surface; Receptors, Purinergic; Sti | 1986 |