8-oxodeoxyguanosine-triphosphate and Neurodegenerative-Diseases

8-oxodeoxyguanosine-triphosphate has been researched along with Neurodegenerative-Diseases* in 2 studies

Reviews

1 review(s) available for 8-oxodeoxyguanosine-triphosphate and Neurodegenerative-Diseases

Article	Year
[MTH1, an oxidized purine nucleoside triphosphatase suppresses mitochondrial dysfunction and cell death caused by oxidative stress]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2005, Volume: 50, Issue:8 Topics: Adenosine Triphosphate; Animals; Cell Death; Deoxyguanine Nucleotides; DNA Repair Enzymes; DNA, Mitochondrial; Genome; Humans; Hydrogen Peroxide; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Phosphoric Monoester Hydrolases; Precancerous Conditions	2005

Article

Year

[MTH1, an oxidized purine nucleoside triphosphatase suppresses mitochondrial dysfunction and cell death caused by oxidative stress].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2005, Volume: 50, Issue:8

Topics: Adenosine Triphosphate; Animals; Cell Death; Deoxyguanine Nucleotides; DNA Repair Enzymes; DNA, Mitochondrial; Genome; Humans; Hydrogen Peroxide; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Phosphoric Monoester Hydrolases; Precancerous Conditions

2005

Other Studies

1 other study(ies) available for 8-oxodeoxyguanosine-triphosphate and Neurodegenerative-Diseases

Article	Year
Oxidized purine nucleotides, genome instability and neurodegeneration. Mutation research, 2010, Nov-28, Volume: 703, Issue:1 Oxidative DNA damage can be the consequence of endogenous metabolic processes and exogenous insults and several DNA repair enzymes provide protection against the toxic effects of oxidized DNA bases. Here we review the increasing knowledge on the relationship between an oxidized dNTPs pool and genome instability. The review also describes some important progress toward understanding the role of oxidative DNA damage and its repair in neurodegenerative diseases. In particular the hMTH1 hydrolase destroys oxidized nucleic acid precursors to prevent their harmful incorporation into DNA and RNA. Based on results obtained in our transgenic mouse overexpressing hMTH1 in the brain we discussed the mechanisms by which this hydrolase protects against neurodegeneration in Huntington disease models. Topics: Animals; Deoxyguanine Nucleotides; DNA Damage; DNA Repair; DNA Repair Enzymes; Genomic Instability; Humans; Neurodegenerative Diseases; Oxidative Stress; Phosphoric Monoester Hydrolases; Purine Nucleotides; Reactive Oxygen Species	2010

Article

Year

Oxidized purine nucleotides, genome instability and neurodegeneration.

Mutation research, 2010, Nov-28, Volume: 703, Issue:1

Oxidative DNA damage can be the consequence of endogenous metabolic processes and exogenous insults and several DNA repair enzymes provide protection against the toxic effects of oxidized DNA bases. Here we review the increasing knowledge on the relationship between an oxidized dNTPs pool and genome instability. The review also describes some important progress toward understanding the role of oxidative DNA damage and its repair in neurodegenerative diseases. In particular the hMTH1 hydrolase destroys oxidized nucleic acid precursors to prevent their harmful incorporation into DNA and RNA. Based on results obtained in our transgenic mouse overexpressing hMTH1 in the brain we discussed the mechanisms by which this hydrolase protects against neurodegeneration in Huntington disease models.

Topics: Animals; Deoxyguanine Nucleotides; DNA Damage; DNA Repair; DNA Repair Enzymes; Genomic Instability; Humans; Neurodegenerative Diseases; Oxidative Stress; Phosphoric Monoester Hydrolases; Purine Nucleotides; Reactive Oxygen Species

2010