8-oxocoptisine and Colitis

8-oxocoptisine has been researched along with Colitis* in 1 studies

Other Studies

1 other study(ies) available for 8-oxocoptisine and Colitis

Article	Year
Cembranoids from the Gum Resin of Boswellia carterii as Potential Antiulcerative Colitis Agents. Journal of natural products, 2015, Oct-23, Volume: 78, Issue:10 Eight new cembranoids, boscartins A-H (1, 2, and 4-9), and the known incensole oxide were isolated from the gum resin of Boswellia carterii. The absolute configurations of 1, 2, 4, and incensole oxide were unequivocally resolved using single-crystal X-ray diffraction analysis with Cu Kα radiation, and the absolute configuration of 5 was resolved via electronic circular dichroism data. The antiulcerative colitis activities of the compounds were evaluated in an in vitro x-box-binding protein 1 (XBP 1) transcriptional activity assay using dual luciferase reporter detection. At 10 μM, compounds 1, 5, 6, and 7 significantly activated XBP 1 transcription with EC50 values of 0.34, 1.14, 0.88, and 0.42 μM, respectively, compared with the pGL3-basic vector control. Topics: Anti-Ulcer Agents; Boswellia; Colitis; Crystallography, X-Ray; Diterpenes; DNA-Binding Proteins; Molecular Conformation; Molecular Structure; Regulatory Factor X Transcription Factors; Resins, Plant; Transcription Factors	2015

Article

Year

Cembranoids from the Gum Resin of Boswellia carterii as Potential Antiulcerative Colitis Agents.

Journal of natural products, 2015, Oct-23, Volume: 78, Issue:10

Eight new cembranoids, boscartins A-H (1, 2, and 4-9), and the known incensole oxide were isolated from the gum resin of Boswellia carterii. The absolute configurations of 1, 2, 4, and incensole oxide were unequivocally resolved using single-crystal X-ray diffraction analysis with Cu Kα radiation, and the absolute configuration of 5 was resolved via electronic circular dichroism data. The antiulcerative colitis activities of the compounds were evaluated in an in vitro x-box-binding protein 1 (XBP 1) transcriptional activity assay using dual luciferase reporter detection. At 10 μM, compounds 1, 5, 6, and 7 significantly activated XBP 1 transcription with EC50 values of 0.34, 1.14, 0.88, and 0.42 μM, respectively, compared with the pGL3-basic vector control.

Topics: Anti-Ulcer Agents; Boswellia; Colitis; Crystallography, X-Ray; Diterpenes; DNA-Binding Proteins; Molecular Conformation; Molecular Structure; Regulatory Factor X Transcription Factors; Resins, Plant; Transcription Factors

2015