8-nitroguanine and Liver-Diseases

8-nitroguanine has been researched along with Liver-Diseases* in 1 studies

Other Studies

1 other study(ies) available for 8-nitroguanine and Liver-Diseases

ArticleYear
8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini.
    Biochemical and biophysical research communications, 2003, Sep-26, Volume: 309, Issue:3

    Nucleic acid damage by reactive nitrogen and oxygen species may contribute to the carcinogenesis associated with chronic infection and inflammation. We examined 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation and nitric oxide (NO) production in hamsters infected with Opisthorchis viverrini (OV). Formation of 8-nitroguanine was assessed immunohistochemically with an antibody specific for 8-nitroguanine. 8-nitroguanine formation was found mainly in the cytoplasm and slightly in the nucleus of inflammatory cells and epithelial lining of bile duct at inflammatory areas in the liver. 8-nitroguanine immunoreactivity reached the highest intensity on day 30. A time profile of 8-nitroguanine formation was closely associated with that of plasma nitrate/nitrite. HPLC with an electrochemical detector revealed that the amount of 8-oxodG in the liver reached the maximal level on day 21. The mechanisms of 8-oxodG and 8-nitroguanine formation via O2*- and NO production triggered by OV infection were discussed in relation to cholangiocarcinoma development.

    Topics: Animals; Cricetinae; Disease Progression; DNA Damage; Guanine; Immunohistochemistry; Liver; Liver Diseases; Male; Mesocricetus; Models, Biological; Nitric Oxide; Opisthorchiasis

2003