8-nitroguanine and Adenocarcinoma

8-nitroguanine has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for 8-nitroguanine and Adenocarcinoma

Article	Year
Nitrative and oxidative DNA damage caused by K-ras mutation in mice. Biochemical and biophysical research communications, 2011, Sep-23, Volume: 413, Issue:2 Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using conditional transgenic mice. Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by mutated K-ras. 8-Nitroguanine was co-localized with iNOS, eNOS, NF-κB, IKK, MAPK, MEK, and mutated K-ras, suggesting that oncogenic K-ras causes additional DNA damage via signaling pathway involving these molecules. It is noteworthy that K-ras mutation mediates not only cell over-proliferation but also the accumulation of mutagenic DNA lesions, leading to carcinogenesis. Topics: Adenocarcinoma; Animals; Cell Proliferation; Cell Transformation, Neoplastic; DNA Damage; Genes, ras; Guanine; Mice; Mutation; Nitric Oxide Synthase Type II; Oxidative Stress	2011

Article

Year

Nitrative and oxidative DNA damage caused by K-ras mutation in mice.

Biochemical and biophysical research communications, 2011, Sep-23, Volume: 413, Issue:2

Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using conditional transgenic mice. Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by mutated K-ras. 8-Nitroguanine was co-localized with iNOS, eNOS, NF-κB, IKK, MAPK, MEK, and mutated K-ras, suggesting that oncogenic K-ras causes additional DNA damage via signaling pathway involving these molecules. It is noteworthy that K-ras mutation mediates not only cell over-proliferation but also the accumulation of mutagenic DNA lesions, leading to carcinogenesis.

Topics: Adenocarcinoma; Animals; Cell Proliferation; Cell Transformation, Neoplastic; DNA Damage; Genes, ras; Guanine; Mice; Mutation; Nitric Oxide Synthase Type II; Oxidative Stress

2011