8-methylguanosine and Carcinogenesis

Macroautophagy/autophagy, a physiological process that is involved in tumorigenesis, is regulated at genetic and epigenetic levels. Emerging reports suggest that aberrant RNA modifications cause dysregulated autophagy and affect tumorigenesis, while the role of RNA modifications in the regulation of autophagy in cancers remains unclear. In a recent study, we describe a new role for the tRNA m

Topics: Autophagy; Carcinogenesis; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; GTP-Binding Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; RNA; RNA, Transfer

The emerging "epitranscriptomics" field is providing insights into the biological and pathological roles of different RNA modifications. The RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m

Topics: Carcinogenesis; Guanosine; Humans; Methylation; Methyltransferases; Neoplasms; Oncogenes; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Transfer; tRNA Methyltransferases