8-isopentenylnaringenin and Pancreatic-Neoplasms

8-isopentenylnaringenin has been researched along with Pancreatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 8-isopentenylnaringenin and Pancreatic-Neoplasms

Article	Year
Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line. Journal of natural products, 2009, Volume: 72, Issue:7 A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC(50) value of 9.3 microg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC(50) 4.3 microM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Myanmar; Pancreatic Neoplasms; Propolis; Stereoisomerism; Triterpenes	2009

Article

Year

Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line.

Journal of natural products, 2009, Volume: 72, Issue:7

A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC(50) value of 9.3 microg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC(50) 4.3 microM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Myanmar; Pancreatic Neoplasms; Propolis; Stereoisomerism; Triterpenes

2009