8-hydroxyguanosine and Tauopathies

8-hydroxyguanosine has been researched along with Tauopathies* in 1 studies

Other Studies

1 other study(ies) available for 8-hydroxyguanosine and Tauopathies

Article	Year
Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan. Movement disorders : official journal of the Movement Disorder Society, 2009, Jan-15, Volume: 24, Issue:1 Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Creatinine; Endemic Diseases; Female; Guanosine; Humans; Japan; Male; Oxidative Stress; Parkinsonian Disorders; Severity of Illness Index; Tauopathies	2009

Article

Year

Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan.

Movement disorders : official journal of the Movement Disorder Society, 2009, Jan-15, Volume: 24, Issue:1

Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC.

Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Creatinine; Endemic Diseases; Female; Guanosine; Humans; Japan; Male; Oxidative Stress; Parkinsonian Disorders; Severity of Illness Index; Tauopathies

2009