8-hydroxyguanosine has been researched along with Parkinsonian-Disorders* in 2 studies
1 review(s) available for 8-hydroxyguanosine and Parkinsonian-Disorders
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MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.
In human and rodent cells, MTH1, an oxidized purine nucleoside triphosphatase, efficiently hydrolyzes oxidized dGTP, GTP, dATP and ATP such as 2'-deoxy-8-oxoguanosine triphosphate (8-oxo-dGTP) and 2'-deoxy-2-hydroxyadenosine triphosphate (2-OH-dATP) in nucleotide pools, thus avoiding their incorporation into DNA or RNA. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus, thus suggesting that MTH1 plays an important role in the prevention of the mutagenicity and cytotoxicity of such oxidized purines as 8-oxoG which are known to accumulate in the cellular genome. Our recent studies with MTH1-deficient mice or cells revealed that MTH1 efficiently minimizes accumulation of 8-oxoG in both nuclear and mitochondrial DNA in the mouse brain as well as in cultured cells, thus contributing to the protection of the brain from oxidative stress. Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Brain; Cytotoxins; DNA Glycosylases; DNA Repair; DNA Repair Enzymes; Guanosine; Humans; Mice; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Parkinsonian Disorders; Phosphoric Monoester Hydrolases; Purine Nucleotides | 2006 |
1 other study(ies) available for 8-hydroxyguanosine and Parkinsonian-Disorders
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Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan.
Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of the Kii peninsula (Kii ALS/PDC) is an endemic and a tauopathy, which shows clinical symptoms of amyotrophy, parkinsonism, and dementia. The objective of this study was to report the role of oxidative stress on Kii ALS/PDC using biochemical analysis. Urinary 8-hydroxydeoxyguanosine (8-OHdG)/creatinine ratio was analyzed in 11 patients with Kii ALS/PDC and 8 normal controls. The mean level of urinary 8-OHdG/creatinine ratio of the patients with Kii ALS/PDC was significantly higher than that of control subjects. Oxidative stress may be implicated in pathogenesis of Kii ALS/PDC. Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Creatinine; Endemic Diseases; Female; Guanosine; Humans; Japan; Male; Oxidative Stress; Parkinsonian Disorders; Severity of Illness Index; Tauopathies | 2009 |