8-hydroxyefavirenz has been researched along with Mood-Disorders* in 1 studies
1 other study(ies) available for 8-hydroxyefavirenz and Mood-Disorders
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Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients.
Efavirenz is a drug of choice for adults and children infected with the human immunodeficiency virus. Notably, up to 35% of patients on efavirenz suffer from mood changes. This work aimed to investigate efavirenz biotransformation into 8-hydroxy-efavirenz as an up-stream event of mood changes and to evaluate the suitability of 8-hydroxy-efavirenz biomonitoring for the minimization of these manifestations. A case-control study with two age-matched groups of HIV-infected male patients was performed in a group without adverse central nervous system complaints (28 patients) and a group presenting mood changes (14 patients). The plasma concentration of non-conjugated 8-hydroxy-efavirenz was higher in patients with mood changes (p=0.020). An association between efavirenz and 8-hydroxy-efavirenz-glucuronide was found (Spearman r=0.414, p<0.010), only within therapeutic efavirenz concentrations. This correlation was not observed in patients with toxic (>4mg/L) plasma concentrations of the parent drug. We conclude that metabolism to 8-hydroxy-efavirenz is associated with efavirenz-related mood changes, which suggests that the concentration of this metabolite is a suitable parameter for therapeutic drug monitoring aimed at controlling these manifestations. Moreover, our data suggest that 8-hydroxy-efavirenz is able to cross the blood-brain barrier and that the peripheral detoxification of 8-hydroxy-efavirenz by glucuronidation may be inhibited by toxic efavirenz concentrations. Topics: Adult; Alkynes; Anti-HIV Agents; Anxiety; Benzoxazines; Biomarkers, Pharmacological; Biotransformation; Blood-Brain Barrier; Case-Control Studies; CD4 Lymphocyte Count; Cyclopropanes; Drug Monitoring; Drug Therapy, Combination; Feasibility Studies; Glucuronides; HIV Infections; Humans; Male; Metabolic Detoxication, Phase II; Middle Aged; Mood Disorders; Neurotoxicity Syndromes; Prevalence; Reverse Transcriptase Inhibitors | 2016 |