8-hydroxyadenine and Vomiting

8-hydroxyadenine has been researched along with Vomiting* in 1 studies

Other Studies

1 other study(ies) available for 8-hydroxyadenine and Vomiting

Article	Year
Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects. Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17 Recently we reported the adenine derivatives (2-4) as new interferon (IFN) inducers. In the present study, we conducted a detailed structure and activity relationship study of 4 and its related derivatives on IFN inducing activity. From this study, we found that compound 4 exhibited the most potent IFN inducing activity in vitro with a minimum effective concentration of 0.01 microM, and 4 also showed strong IFN-inducing activity at doses of more than 0.3mg/kg by oral administration in mice. This potency was 10-fold stronger than that of Imiquimod. Moreover, 4 did not cause emesis in ferrets even at doses as high as 10mg/kg, whereas, 80% of animals were emetic when orally administered with the same dose of Imiquimod. These results indicate that compound 4 is superior to Imiquimod with respect to efficacy and safety. Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Imiquimod; Interferon Inducers; Mice; Mice, Inbred BALB C; Spleen; Structure-Activity Relationship; Vomiting	2003

Article

Year

Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects.

Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17

Recently we reported the adenine derivatives (2-4) as new interferon (IFN) inducers. In the present study, we conducted a detailed structure and activity relationship study of 4 and its related derivatives on IFN inducing activity. From this study, we found that compound 4 exhibited the most potent IFN inducing activity in vitro with a minimum effective concentration of 0.01 microM, and 4 also showed strong IFN-inducing activity at doses of more than 0.3mg/kg by oral administration in mice. This potency was 10-fold stronger than that of Imiquimod. Moreover, 4 did not cause emesis in ferrets even at doses as high as 10mg/kg, whereas, 80% of animals were emetic when orally administered with the same dose of Imiquimod. These results indicate that compound 4 is superior to Imiquimod with respect to efficacy and safety.

Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Imiquimod; Interferon Inducers; Mice; Mice, Inbred BALB C; Spleen; Structure-Activity Relationship; Vomiting

2003