8-hydroxyadenine has been researched along with Liver-Neoplasms* in 2 studies
2 other study(ies) available for 8-hydroxyadenine and Liver-Neoplasms
| Article | Year |
|---|---|
Mutagenic DNA base modifications are correlated with lesions in nonneoplastic hepatic tissue of the English sole carcinogenesis model.
Hydroxyl radical-induced mutagenic base modifications have been linked to neoplasia in a number of biological systems, including English sole from chemically contaminated urban environments. However, virtually no information exists on the relationship between the mutagenic base modifications and preneoplastic and other lesions found in tumor-free tissues prone to cancer. We studied six hepatic lesions in immature, neoplasm-free English sole exposed to an urban and reference environment and established correlations between the lesion incidence and concentrations of the mutagenic base modifications 8-hydroxyguanine and 8-hydroxyadenine. The lesions were putatively preneoplastic basophilic foci, hepatocellular karyomegaly, megalocytic hepatosis, hepatocellular vacuolar change, hyalin droplet formation, and apoptosis. With the exception of hepatocellular vacuolar change, significant positive correlations were found between the lesions and the mutagenic base modifications. The hydroxyl radical may be a common etiological factor in the formation of the base modifications and hepatic lesions. Topics: Adenine; Age Factors; Animals; Confounding Factors, Epidemiologic; Fish Diseases; Guanine; Liver Diseases; Liver Neoplasms; Mutagenesis; Precancerous Conditions | 1996 |
4,6-Diamino-5-formamidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of English sole exposed to carcinogens.
Attack of the hydroxyl radical on the 8-carbon of guanine results in the formation of 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua). This modified nucleotide was recently found in neoplastic livers of wild English sole exposed to aromatic hydrocarbons (Malins et al., Carcinogenesis, 11, 1045-1047, 1990). Gas-chromatographic-mass spectrometric evidence reported here indicates that three other modified nucleotides are also present in the neoplastic liver: 4,6-diamino-5-formamidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine. These findings support the hypothesis that the purine nucleotides were modified by the hydroxyl radical and that these changes play a crucial role in tumor formation. Topics: Adenine; Animals; Carcinogens; DNA, Neoplasm; Flatfishes; Free Radicals; Hydroxides; Hydroxyl Radical; Liver Neoplasms; Pyrimidines | 1990 |