8-hydroxyadenine and Hepatitis-C

8-hydroxyadenine has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for 8-hydroxyadenine and Hepatitis-C

Article	Year
Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioorganic & medicinal chemistry, 2004, Mar-01, Volume: 12, Issue:5 In order to create novel compounds which possess potent interferon (IFN) inducing activities with excellent oral bioavailabilities, a series of 8-hydroxyadenines, which have various alkoxy or alkylthio moieties at the adenine C(2)-position, were synthesized and evaluated. The introduction of hydrophobic groups was not considered to be effective for potentiating the IFN-inducing activity, but several compounds having hydrophilic groups were effective. Among the compounds tested, compound 13f induced IFN from the dosage of 0.03 mg/kg, which was approximately 100-fold more potent than that of Imiquimod, and showed an excellent oral bioavailability (F=40%) which was 10-fold improved over 5, a lead compound (F=4%). Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Biological Availability; Cells, Cultured; Dose-Response Relationship, Drug; Hepatitis C; Imiquimod; Interferons; Mice; Rats; Structure-Activity Relationship	2004

Article

Year

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities.

Bioorganic & medicinal chemistry, 2004, Mar-01, Volume: 12, Issue:5

In order to create novel compounds which possess potent interferon (IFN) inducing activities with excellent oral bioavailabilities, a series of 8-hydroxyadenines, which have various alkoxy or alkylthio moieties at the adenine C(2)-position, were synthesized and evaluated. The introduction of hydrophobic groups was not considered to be effective for potentiating the IFN-inducing activity, but several compounds having hydrophilic groups were effective. Among the compounds tested, compound 13f induced IFN from the dosage of 0.03 mg/kg, which was approximately 100-fold more potent than that of Imiquimod, and showed an excellent oral bioavailability (F=40%) which was 10-fold improved over 5, a lead compound (F=4%).

Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Biological Availability; Cells, Cultured; Dose-Response Relationship, Drug; Hepatitis C; Imiquimod; Interferons; Mice; Rats; Structure-Activity Relationship

2004